diff --git a/instrumentation/jdbc/javaagent/src/test/groovy/JdbcInstrumentationTest.groovy b/instrumentation/jdbc/javaagent/src/test/groovy/JdbcInstrumentationTest.groovy
index 72692ddbe844..ec10458c7df1 100644
--- a/instrumentation/jdbc/javaagent/src/test/groovy/JdbcInstrumentationTest.groovy
+++ b/instrumentation/jdbc/javaagent/src/test/groovy/JdbcInstrumentationTest.groovy
@@ -10,6 +10,7 @@ import io.opentelemetry.api.trace.SpanKind
 import io.opentelemetry.instrumentation.jdbc.TestConnection
 import io.opentelemetry.instrumentation.jdbc.TestDriver
 import io.opentelemetry.instrumentation.test.AgentInstrumentationSpecification
+import io.opentelemetry.javaagent.instrumentation.jdbc.test.ProxyStatementFactory
 import io.opentelemetry.semconv.trace.attributes.SemanticAttributes
 import org.apache.derby.jdbc.EmbeddedDataSource
 import org.apache.derby.jdbc.EmbeddedDriver
@@ -820,4 +821,36 @@ class JdbcInstrumentationTest extends AgentInstrumentationSpecification {
       return super.getMetaData()
     }
   }
+
+  // regression test for https://github.com/open-telemetry/opentelemetry-java-instrumentation/issues/6015
+  def "test proxy statement"() {
+    def connection = new Driver().connect(jdbcUrls.get("h2"), null)
+    Statement statement = connection.createStatement()
+    Statement proxyStatement = ProxyStatementFactory.proxyStatement(statement)
+    ResultSet resultSet = runWithSpan("parent") {
+      return proxyStatement.executeQuery("SELECT 3")
+    }
+
+    expect:
+    resultSet.next()
+    resultSet.getInt(1) == 3
+    assertTraces(1) {
+      trace(0, 2) {
+        span(0) {
+          name "parent"
+          kind SpanKind.INTERNAL
+          hasNoParent()
+        }
+        span(1) {
+          name "SELECT $dbNameLower"
+          kind CLIENT
+          childOf span(0)
+        }
+      }
+    }
+
+    cleanup:
+    statement.close()
+    connection.close()
+  }
 }
diff --git a/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/ProxyStatementFactory.java b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/ProxyStatementFactory.java
new file mode 100644
index 000000000000..88ef3cb93a8f
--- /dev/null
+++ b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/ProxyStatementFactory.java
@@ -0,0 +1,36 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+package io.opentelemetry.javaagent.instrumentation.jdbc.test;
+
+import java.lang.reflect.InvocationHandler;
+import java.lang.reflect.Proxy;
+import java.sql.Statement;
+
+public class ProxyStatementFactory {
+
+  public static Statement proxyStatement(Statement statement) throws Exception {
+    TestClassLoader classLoader = new TestClassLoader(ProxyStatementFactory.class.getClassLoader());
+    Class<?> testInterface = classLoader.loadClass(TestInterface.class.getName());
+    if (testInterface.getClassLoader() != classLoader) {
+      throw new IllegalStateException("wrong class loader");
+    }
+    InvocationHandler invocationHandler = (proxy, method, args) -> method.invoke(statement, args);
+    Statement proxyStatement =
+        (Statement)
+            Proxy.newProxyInstance(
+                classLoader, new Class<?>[] {Statement.class, testInterface}, invocationHandler);
+    // adding package private interface TestInterface to jdk proxy forces defining the proxy class
+    // in the same package as the package private interface
+    if (!proxyStatement
+        .getClass()
+        .getName()
+        .startsWith("io.opentelemetry.javaagent.instrumentation.jdbc.test")) {
+      throw new IllegalStateException("proxy statement is in wrong package");
+    }
+
+    return proxyStatement;
+  }
+}
diff --git a/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestClassLoader.java b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestClassLoader.java
new file mode 100644
index 000000000000..a6a1704b53ad
--- /dev/null
+++ b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestClassLoader.java
@@ -0,0 +1,35 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+package io.opentelemetry.javaagent.instrumentation.jdbc.test;
+
+import java.net.URL;
+import java.net.URLClassLoader;
+
+public class TestClassLoader extends URLClassLoader {
+
+  public TestClassLoader(ClassLoader parent) {
+    super(
+        new URL[] {TestClassLoader.class.getProtectionDomain().getCodeSource().getLocation()},
+        parent);
+  }
+
+  @Override
+  protected synchronized Class<?> loadClass(String name, boolean resolve)
+      throws ClassNotFoundException {
+    Class<?> clazz = findLoadedClass(name);
+    if (clazz != null) {
+      return clazz;
+    }
+    if (name.startsWith("io.opentelemetry.javaagent.instrumentation.jdbc.test")) {
+      try {
+        return findClass(name);
+      } catch (ClassNotFoundException exception) {
+        // ignore
+      }
+    }
+    return super.loadClass(name, resolve);
+  }
+}
diff --git a/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestInterface.java b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestInterface.java
new file mode 100644
index 000000000000..ee246133e013
--- /dev/null
+++ b/instrumentation/jdbc/javaagent/src/test/java/io/opentelemetry/javaagent/instrumentation/jdbc/test/TestInterface.java
@@ -0,0 +1,12 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+package io.opentelemetry.javaagent.instrumentation.jdbc.test;
+
+// Adding a package private interface to jdk proxy forces defining the proxy class in the package
+// of the package private class. Usually proxy classes are defined in a package that we exclude from
+// instrumentation. We use this class to force proxy into a different package so it would get
+// instrumented.
+interface TestInterface {}