diff --git a/CHANGELOG.md b/CHANGELOG.md
index 73761723f10a..e8ee090f36b8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,12 +8,19 @@ This project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.htm
 
 ## [Unreleased]
 
+### Added
+
+- Return a `Registration` from the `RegisterCallback` method of a `Meter` in the `go.opentelemetry.io/otel/metric` package.
+  This `Registration` can be used to unregister callbacks. (#3522)
+- Add `Producer` interface and `Reader.RegisterProducer(Producer)` to `go.opentelemetry.io/otel/sdk/metric` to enable external metric Producers. (#3524)
+
 ### Removed
 
 - The deprecated `go.opentelemetry.io/otel/sdk/metric/view` package is removed. (#3520)
 
-### Added
+### Changed
 
+- Global error handler uses an atomic value instead of a mutex. (#3543)
 - Add `Producer` interface and `Reader.RegisterProducer(Producer)` to `go.opentelemetry.io/otel/sdk/metric` to enable external metric Producers. (#3524)
 - Add `NewMetricProducer` to `go.opentelemetry.io/otel/bridge/opencensus`, which can be used to pass OpenCensus metrics to an OpenTelemetry Reader. (#3541)
 
diff --git a/example/prometheus/main.go b/example/prometheus/main.go
index bc15f0414862..390159945175 100644
--- a/example/prometheus/main.go
+++ b/example/prometheus/main.go
@@ -68,7 +68,7 @@ func main() {
 	if err != nil {
 		log.Fatal(err)
 	}
-	err = meter.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
+	_, err = meter.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
 		n := -10. + rand.Float64()*(90.) // [-10, 100)
 		gauge.Observe(ctx, n, attrs...)
 	})
diff --git a/handler.go b/handler.go
index 36cf09f72908..ecd363ab5165 100644
--- a/handler.go
+++ b/handler.go
@@ -17,7 +17,8 @@ package otel // import "go.opentelemetry.io/otel"
 import (
 	"log"
 	"os"
-	"sync"
+	"sync/atomic"
+	"unsafe"
 )
 
 var (
@@ -34,28 +35,26 @@ var (
 )
 
 type delegator struct {
-	lock *sync.RWMutex
-	eh   ErrorHandler
+	delegate unsafe.Pointer
 }
 
 func (d *delegator) Handle(err error) {
-	d.lock.RLock()
-	defer d.lock.RUnlock()
-	d.eh.Handle(err)
+	d.getDelegate().Handle(err)
+}
+
+func (d *delegator) getDelegate() ErrorHandler {
+	return *(*ErrorHandler)(atomic.LoadPointer(&d.delegate))
 }
 
 // setDelegate sets the ErrorHandler delegate.
 func (d *delegator) setDelegate(eh ErrorHandler) {
-	d.lock.Lock()
-	defer d.lock.Unlock()
-	d.eh = eh
+	atomic.StorePointer(&d.delegate, unsafe.Pointer(&eh))
 }
 
 func defaultErrorHandler() *delegator {
-	return &delegator{
-		lock: &sync.RWMutex{},
-		eh:   &errLogger{l: log.New(os.Stderr, "", log.LstdFlags)},
-	}
+	d := &delegator{}
+	d.setDelegate(&errLogger{l: log.New(os.Stderr, "", log.LstdFlags)})
+	return d
 }
 
 // errLogger logs errors if no delegate is set, otherwise they are delegated.
diff --git a/handler_test.go b/handler_test.go
index 32906198f8cf..b6b9b20cae0b 100644
--- a/handler_test.go
+++ b/handler_test.go
@@ -54,7 +54,7 @@ type HandlerTestSuite struct {
 
 func (s *HandlerTestSuite) SetupSuite() {
 	s.errCatcher = new(testErrCatcher)
-	s.origHandler = globalErrorHandler.eh
+	s.origHandler = globalErrorHandler.getDelegate()
 
 	globalErrorHandler.setDelegate(&errLogger{l: log.New(s.errCatcher, "", 0)})
 }
@@ -111,12 +111,12 @@ func (s *HandlerTestSuite) TestAllowMultipleSets() {
 	secondary := &errLogger{l: log.New(notUsed, "", 0)}
 	SetErrorHandler(secondary)
 	s.Require().Same(GetErrorHandler(), globalErrorHandler, "set changed globalErrorHandler")
-	s.Require().Same(globalErrorHandler.eh, secondary, "new Handler not set")
+	s.Require().Same(globalErrorHandler.getDelegate(), secondary, "new Handler not set")
 
 	tertiary := &errLogger{l: log.New(notUsed, "", 0)}
 	SetErrorHandler(tertiary)
 	s.Require().Same(GetErrorHandler(), globalErrorHandler, "set changed globalErrorHandler")
-	s.Assert().Same(globalErrorHandler.eh, tertiary, "user Handler not overridden")
+	s.Assert().Same(globalErrorHandler.getDelegate(), tertiary, "user Handler not overridden")
 }
 
 func TestHandlerTestSuite(t *testing.T) {
diff --git a/metric/example_test.go b/metric/example_test.go
index bc94d7572efb..dc22989f6277 100644
--- a/metric/example_test.go
+++ b/metric/example_test.go
@@ -61,7 +61,7 @@ func ExampleMeter_asynchronous_single() {
 		panic(err)
 	}
 
-	err = meter.RegisterCallback([]instrument.Asynchronous{memoryUsage},
+	_, err = meter.RegisterCallback([]instrument.Asynchronous{memoryUsage},
 		func(ctx context.Context) {
 			// instrument.WithCallbackFunc(func(ctx context.Context) {
 			//Do Work to get the real memoryUsage
@@ -86,7 +86,7 @@ func ExampleMeter_asynchronous_multiple() {
 	gcCount, _ := meter.AsyncInt64().Counter("gcCount")
 	gcPause, _ := meter.SyncFloat64().Histogram("gcPause")
 
-	err := meter.RegisterCallback([]instrument.Asynchronous{
+	_, err := meter.RegisterCallback([]instrument.Asynchronous{
 		heapAlloc,
 		gcCount,
 	},
diff --git a/metric/internal/global/meter.go b/metric/internal/global/meter.go
index 0fa924f397c8..e8c83578459a 100644
--- a/metric/internal/global/meter.go
+++ b/metric/internal/global/meter.go
@@ -15,6 +15,7 @@
 package global // import "go.opentelemetry.io/otel/metric/internal/global"
 
 import (
+	"container/list"
 	"context"
 	"sync"
 	"sync/atomic"
@@ -109,7 +110,8 @@ type meter struct {
 
 	mtx         sync.Mutex
 	instruments []delegatedInstrument
-	callbacks   []delegatedCallback
+
+	registry list.List
 
 	delegate atomic.Value // metric.Meter
 }
@@ -135,12 +137,14 @@ func (m *meter) setDelegate(provider metric.MeterProvider) {
 		inst.setDelegate(meter)
 	}
 
-	for _, callback := range m.callbacks {
-		callback.setDelegate(meter)
+	for e := m.registry.Front(); e != nil; e = e.Next() {
+		r := e.Value.(*registration)
+		r.setDelegate(meter)
+		m.registry.Remove(e)
 	}
 
 	m.instruments = nil
-	m.callbacks = nil
+	m.registry.Init()
 }
 
 // AsyncInt64 is the namespace for the Asynchronous Integer instruments.
@@ -167,20 +171,24 @@ func (m *meter) AsyncFloat64() asyncfloat64.InstrumentProvider {
 //
 // It is only valid to call Observe within the scope of the passed function,
 // and only on the instruments that were registered with this call.
-func (m *meter) RegisterCallback(insts []instrument.Asynchronous, function func(context.Context)) error {
+func (m *meter) RegisterCallback(insts []instrument.Asynchronous, f func(context.Context)) (metric.Registration, error) {
 	if del, ok := m.delegate.Load().(metric.Meter); ok {
 		insts = unwrapInstruments(insts)
-		return del.RegisterCallback(insts, function)
+		return del.RegisterCallback(insts, f)
 	}
 
 	m.mtx.Lock()
 	defer m.mtx.Unlock()
-	m.callbacks = append(m.callbacks, delegatedCallback{
-		instruments: insts,
-		function:    function,
-	})
 
-	return nil
+	reg := &registration{instruments: insts, function: f}
+	e := m.registry.PushBack(reg)
+	reg.unreg = func() error {
+		m.mtx.Lock()
+		_ = m.registry.Remove(e)
+		m.mtx.Unlock()
+		return nil
+	}
+	return reg, nil
 }
 
 type wrapped interface {
@@ -217,17 +225,44 @@ func (m *meter) SyncFloat64() syncfloat64.InstrumentProvider {
 	return (*sfInstProvider)(m)
 }
 
-type delegatedCallback struct {
+type registration struct {
 	instruments []instrument.Asynchronous
 	function    func(context.Context)
+
+	unreg   func() error
+	unregMu sync.Mutex
 }
 
-func (c *delegatedCallback) setDelegate(m metric.Meter) {
+func (c *registration) setDelegate(m metric.Meter) {
 	insts := unwrapInstruments(c.instruments)
-	err := m.RegisterCallback(insts, c.function)
+
+	c.unregMu.Lock()
+	defer c.unregMu.Unlock()
+
+	if c.unreg == nil {
+		// Unregister already called.
+		return
+	}
+
+	reg, err := m.RegisterCallback(insts, c.function)
 	if err != nil {
 		otel.Handle(err)
 	}
+
+	c.unreg = reg.Unregister
+}
+
+func (c *registration) Unregister() error {
+	c.unregMu.Lock()
+	defer c.unregMu.Unlock()
+	if c.unreg == nil {
+		// Unregister already called.
+		return nil
+	}
+
+	var err error
+	err, c.unreg = c.unreg(), nil
+	return err
 }
 
 type afInstProvider meter
diff --git a/metric/internal/global/meter_test.go b/metric/internal/global/meter_test.go
index 8865f06d57ba..15a0bf877afe 100644
--- a/metric/internal/global/meter_test.go
+++ b/metric/internal/global/meter_test.go
@@ -68,7 +68,7 @@ func TestMeterRace(t *testing.T) {
 			_, _ = mtr.SyncInt64().Counter(name)
 			_, _ = mtr.SyncInt64().UpDownCounter(name)
 			_, _ = mtr.SyncInt64().Histogram(name)
-			_ = mtr.RegisterCallback(nil, func(ctx context.Context) {})
+			_, _ = mtr.RegisterCallback(nil, func(ctx context.Context) {})
 			if !once {
 				wg.Done()
 				once = true
@@ -86,6 +86,35 @@ func TestMeterRace(t *testing.T) {
 	close(finish)
 }
 
+func TestUnregisterRace(t *testing.T) {
+	mtr := &meter{}
+	reg, err := mtr.RegisterCallback(nil, func(ctx context.Context) {})
+	require.NoError(t, err)
+
+	wg := &sync.WaitGroup{}
+	wg.Add(1)
+	finish := make(chan struct{})
+	go func() {
+		for i, once := 0, false; ; i++ {
+			_ = reg.Unregister()
+			if !once {
+				wg.Done()
+				once = true
+			}
+			select {
+			case <-finish:
+				return
+			default:
+			}
+		}
+	}()
+	_ = reg.Unregister()
+
+	wg.Wait()
+	mtr.setDelegate(metric.NewNoopMeterProvider())
+	close(finish)
+}
+
 func testSetupAllInstrumentTypes(t *testing.T, m metric.Meter) (syncfloat64.Counter, asyncfloat64.Counter) {
 	afcounter, err := m.AsyncFloat64().Counter("test_Async_Counter")
 	require.NoError(t, err)
@@ -101,9 +130,10 @@ func testSetupAllInstrumentTypes(t *testing.T, m metric.Meter) (syncfloat64.Coun
 	_, err = m.AsyncInt64().Gauge("test_Async_Gauge")
 	assert.NoError(t, err)
 
-	require.NoError(t, m.RegisterCallback([]instrument.Asynchronous{afcounter}, func(ctx context.Context) {
+	_, err = m.RegisterCallback([]instrument.Asynchronous{afcounter}, func(ctx context.Context) {
 		afcounter.Observe(ctx, 3)
-	}))
+	})
+	require.NoError(t, err)
 
 	sfcounter, err := m.SyncFloat64().Counter("test_Async_Counter")
 	require.NoError(t, err)
@@ -257,3 +287,51 @@ func TestMeterDefersDelegations(t *testing.T) {
 	assert.IsType(t, &afCounter{}, actr)
 	assert.Equal(t, 1, mp.count)
 }
+
+func TestRegistrationDelegation(t *testing.T) {
+	// globalMeterProvider := otel.GetMeterProvider
+	globalMeterProvider := &meterProvider{}
+
+	m := globalMeterProvider.Meter("go.opentelemetry.io/otel/metric/internal/global/meter_test")
+	require.IsType(t, &meter{}, m)
+	mImpl := m.(*meter)
+
+	actr, err := m.AsyncFloat64().Counter("test_Async_Counter")
+	require.NoError(t, err)
+
+	var called0 bool
+	reg0, err := m.RegisterCallback([]instrument.Asynchronous{actr}, func(context.Context) {
+		called0 = true
+	})
+	require.NoError(t, err)
+	require.Equal(t, 1, mImpl.registry.Len(), "callback not registered")
+	// This means reg0 should not be delegated.
+	assert.NoError(t, reg0.Unregister())
+	assert.Equal(t, 0, mImpl.registry.Len(), "callback not unregistered")
+
+	var called1 bool
+	reg1, err := m.RegisterCallback([]instrument.Asynchronous{actr}, func(context.Context) {
+		called1 = true
+	})
+	require.NoError(t, err)
+	require.Equal(t, 1, mImpl.registry.Len(), "second callback not registered")
+
+	mp := &testMeterProvider{}
+
+	// otel.SetMeterProvider(mp)
+	globalMeterProvider.setDelegate(mp)
+
+	testCollect(t, m) // This is a hacky way to emulate a read from an exporter
+	require.False(t, called0, "pre-delegation unregistered callback called")
+	require.True(t, called1, "callback not called")
+
+	called1 = false
+	assert.NoError(t, reg1.Unregister(), "unregister second callback")
+
+	testCollect(t, m) // This is a hacky way to emulate a read from an exporter
+	assert.False(t, called1, "unregistered callback called")
+
+	assert.NotPanics(t, func() {
+		assert.NoError(t, reg1.Unregister(), "duplicate unregister calls")
+	})
+}
diff --git a/metric/internal/global/meter_types_test.go b/metric/internal/global/meter_types_test.go
index ac6e93ebe38b..53dfbc7528dd 100644
--- a/metric/internal/global/meter_types_test.go
+++ b/metric/internal/global/meter_types_test.go
@@ -64,8 +64,21 @@ func (m *testMeter) AsyncFloat64() asyncfloat64.InstrumentProvider {
 //
 // It is only valid to call Observe within the scope of the passed function,
 // and only on the instruments that were registered with this call.
-func (m *testMeter) RegisterCallback(insts []instrument.Asynchronous, function func(context.Context)) error {
-	m.callbacks = append(m.callbacks, function)
+func (m *testMeter) RegisterCallback(i []instrument.Asynchronous, f func(context.Context)) (metric.Registration, error) {
+	m.callbacks = append(m.callbacks, f)
+	return testReg{
+		f: func(idx int) func() {
+			return func() { m.callbacks[idx] = nil }
+		}(len(m.callbacks) - 1),
+	}, nil
+}
+
+type testReg struct {
+	f func()
+}
+
+func (r testReg) Unregister() error {
+	r.f()
 	return nil
 }
 
@@ -85,6 +98,10 @@ func (m *testMeter) SyncFloat64() syncfloat64.InstrumentProvider {
 func (m *testMeter) collect() {
 	ctx := context.Background()
 	for _, f := range m.callbacks {
+		if f == nil {
+			// Unregister.
+			continue
+		}
 		f(ctx)
 	}
 }
diff --git a/metric/meter.go b/metric/meter.go
index 23e6853afbb6..3a505264ca0f 100644
--- a/metric/meter.go
+++ b/metric/meter.go
@@ -51,14 +51,30 @@ type Meter interface {
 	// To Observe data with instruments it must be registered in a callback.
 	AsyncFloat64() asyncfloat64.InstrumentProvider
 
-	// RegisterCallback captures the function that will be called during Collect.
-	//
-	// It is only valid to call Observe within the scope of the passed function,
-	// and only on the instruments that were registered with this call.
-	RegisterCallback(insts []instrument.Asynchronous, function func(context.Context)) error
-
 	// SyncInt64 is the namespace for the Synchronous Integer instruments
 	SyncInt64() syncint64.InstrumentProvider
 	// SyncFloat64 is the namespace for the Synchronous Float instruments
 	SyncFloat64() syncfloat64.InstrumentProvider
+
+	// RegisterCallback registers f to be called during the collection of a
+	// measurement cycle.
+	//
+	// If Unregister of the returned Registration is called, f needs to be
+	// unregistered and not called during collection.
+	//
+	// The instruments f is registered with are the only instruments that f may
+	// observe values for.
+	//
+	// If no instruments are passed, f should not be registered nor called
+	// during collection.
+	RegisterCallback(instruments []instrument.Asynchronous, f func(context.Context)) (Registration, error)
+}
+
+// Registration is an token representing the unique registration of a callback
+// for a set of instruments with a Meter.
+type Registration interface {
+	// Unregister removes the callback registration from a Meter.
+	//
+	// This method needs to be idempotent and concurrent safe.
+	Unregister() error
 }
diff --git a/metric/noop.go b/metric/noop.go
index e8b9a9a14588..7454a790337f 100644
--- a/metric/noop.go
+++ b/metric/noop.go
@@ -64,10 +64,14 @@ func (noopMeter) SyncFloat64() syncfloat64.InstrumentProvider {
 }
 
 // RegisterCallback creates a register callback that does not record any metrics.
-func (noopMeter) RegisterCallback([]instrument.Asynchronous, func(context.Context)) error {
-	return nil
+func (noopMeter) RegisterCallback([]instrument.Asynchronous, func(context.Context)) (Registration, error) {
+	return noopReg{}, nil
 }
 
+type noopReg struct{}
+
+func (noopReg) Unregister() error { return nil }
+
 type nonrecordingAsyncFloat64Instrument struct {
 	instrument.Asynchronous
 }
diff --git a/sdk/metric/meter.go b/sdk/metric/meter.go
index 418827e9672d..c2c515af35c6 100644
--- a/sdk/metric/meter.go
+++ b/sdk/metric/meter.go
@@ -69,7 +69,7 @@ func (m *meter) AsyncFloat64() asyncfloat64.InstrumentProvider {
 
 // RegisterCallback registers the function f to be called when any of the
 // insts Collect method is called.
-func (m *meter) RegisterCallback(insts []instrument.Asynchronous, f func(context.Context)) error {
+func (m *meter) RegisterCallback(insts []instrument.Asynchronous, f func(context.Context)) (metric.Registration, error) {
 	for _, inst := range insts {
 		// Only register if at least one instrument has a non-drop aggregation.
 		// Otherwise, calling f during collection will be wasted computation.
@@ -91,14 +91,21 @@ func (m *meter) RegisterCallback(insts []instrument.Asynchronous, f func(context
 		}
 	}
 	// All insts use drop aggregation.
-	return nil
+	return noopRegister{}, nil
 }
 
-func (m *meter) registerCallback(f func(context.Context)) error {
-	m.pipes.registerCallback(f)
+type noopRegister struct{}
+
+func (noopRegister) Unregister() error {
 	return nil
 }
 
+type callback func(context.Context)
+
+func (m *meter) registerCallback(c callback) (metric.Registration, error) {
+	return m.pipes.registerCallback(c), nil
+}
+
 // SyncInt64 returns the synchronous integer instrument provider.
 func (m *meter) SyncInt64() syncint64.InstrumentProvider {
 	return syncInt64Provider{m.instProviderInt64}
diff --git a/sdk/metric/meter_test.go b/sdk/metric/meter_test.go
index 013a52e59245..d904b118ad4c 100644
--- a/sdk/metric/meter_test.go
+++ b/sdk/metric/meter_test.go
@@ -103,11 +103,63 @@ func TestMeterCallbackCreationConcurrency(t *testing.T) {
 	m := NewMeterProvider().Meter("callback-concurrency")
 
 	go func() {
-		_ = m.RegisterCallback([]instrument.Asynchronous{}, func(ctx context.Context) {})
+		_, _ = m.RegisterCallback([]instrument.Asynchronous{}, func(ctx context.Context) {})
 		wg.Done()
 	}()
 	go func() {
-		_ = m.RegisterCallback([]instrument.Asynchronous{}, func(ctx context.Context) {})
+		_, _ = m.RegisterCallback([]instrument.Asynchronous{}, func(ctx context.Context) {})
+		wg.Done()
+	}()
+	wg.Wait()
+}
+
+func TestNoopCallbackUnregisterConcurrency(t *testing.T) {
+	m := NewMeterProvider().Meter("noop-unregister-concurrency")
+	reg, err := m.RegisterCallback(nil, func(ctx context.Context) {})
+	require.NoError(t, err)
+
+	wg := &sync.WaitGroup{}
+	wg.Add(2)
+	go func() {
+		_ = reg.Unregister()
+		wg.Done()
+	}()
+	go func() {
+		_ = reg.Unregister()
+		wg.Done()
+	}()
+	wg.Wait()
+}
+
+func TestCallbackUnregisterConcurrency(t *testing.T) {
+	reader := NewManualReader()
+	provider := NewMeterProvider(WithReader(reader))
+	meter := provider.Meter("unregister-concurrency")
+
+	actr, err := meter.AsyncFloat64().Counter("counter")
+	require.NoError(t, err)
+
+	ag, err := meter.AsyncInt64().Gauge("gauge")
+	require.NoError(t, err)
+
+	i := []instrument.Asynchronous{actr}
+	regCtr, err := meter.RegisterCallback(i, func(ctx context.Context) {})
+	require.NoError(t, err)
+
+	i = []instrument.Asynchronous{ag}
+	regG, err := meter.RegisterCallback(i, func(ctx context.Context) {})
+	require.NoError(t, err)
+
+	wg := &sync.WaitGroup{}
+	wg.Add(2)
+	go func() {
+		_ = regCtr.Unregister()
+		_ = regG.Unregister()
+		wg.Done()
+	}()
+	go func() {
+		_ = regCtr.Unregister()
+		_ = regG.Unregister()
 		wg.Done()
 	}()
 	wg.Wait()
@@ -126,7 +178,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				ctr, err := m.AsyncInt64().Counter("aint")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 3)
 				})
 				assert.NoError(t, err)
@@ -150,7 +202,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				ctr, err := m.AsyncInt64().UpDownCounter("aint")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 11)
 				})
 				assert.NoError(t, err)
@@ -174,7 +226,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				gauge, err := m.AsyncInt64().Gauge("agauge")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
 					gauge.Observe(ctx, 11)
 				})
 				assert.NoError(t, err)
@@ -196,7 +248,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				ctr, err := m.AsyncFloat64().Counter("afloat")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 3)
 				})
 				assert.NoError(t, err)
@@ -220,7 +272,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				ctr, err := m.AsyncFloat64().UpDownCounter("afloat")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 11)
 				})
 				assert.NoError(t, err)
@@ -244,7 +296,7 @@ func TestMeterCreatesInstruments(t *testing.T) {
 			fn: func(t *testing.T, m metric.Meter) {
 				gauge, err := m.AsyncFloat64().Gauge("agauge")
 				assert.NoError(t, err)
-				err = m.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
+				_, err = m.RegisterCallback([]instrument.Asynchronous{gauge}, func(ctx context.Context) {
 					gauge.Observe(ctx, 11)
 				})
 				assert.NoError(t, err)
@@ -418,7 +470,7 @@ func TestMetersProvideScope(t *testing.T) {
 	m1 := mp.Meter("scope1")
 	ctr1, err := m1.AsyncFloat64().Counter("ctr1")
 	assert.NoError(t, err)
-	err = m1.RegisterCallback([]instrument.Asynchronous{ctr1}, func(ctx context.Context) {
+	_, err = m1.RegisterCallback([]instrument.Asynchronous{ctr1}, func(ctx context.Context) {
 		ctr1.Observe(ctx, 5)
 	})
 	assert.NoError(t, err)
@@ -426,7 +478,7 @@ func TestMetersProvideScope(t *testing.T) {
 	m2 := mp.Meter("scope2")
 	ctr2, err := m2.AsyncInt64().Counter("ctr2")
 	assert.NoError(t, err)
-	err = m1.RegisterCallback([]instrument.Asynchronous{ctr2}, func(ctx context.Context) {
+	_, err = m1.RegisterCallback([]instrument.Asynchronous{ctr2}, func(ctx context.Context) {
 		ctr2.Observe(ctx, 7)
 	})
 	assert.NoError(t, err)
@@ -480,6 +532,53 @@ func TestMetersProvideScope(t *testing.T) {
 	metricdatatest.AssertEqual(t, want, got, metricdatatest.IgnoreTimestamp())
 }
 
+func TestUnregisterUnregisters(t *testing.T) {
+	r := NewManualReader()
+	mp := NewMeterProvider(WithReader(r))
+	m := mp.Meter("TestUnregisterUnregisters")
+
+	int64Counter, err := m.AsyncInt64().Counter("int64.counter")
+	require.NoError(t, err)
+
+	int64UpDownCounter, err := m.AsyncInt64().UpDownCounter("int64.up_down_counter")
+	require.NoError(t, err)
+
+	int64Gauge, err := m.AsyncInt64().Gauge("int64.gauge")
+	require.NoError(t, err)
+
+	floag64Counter, err := m.AsyncFloat64().Counter("floag64.counter")
+	require.NoError(t, err)
+
+	floag64UpDownCounter, err := m.AsyncFloat64().UpDownCounter("floag64.up_down_counter")
+	require.NoError(t, err)
+
+	floag64Gauge, err := m.AsyncFloat64().Gauge("floag64.gauge")
+	require.NoError(t, err)
+
+	var called bool
+	reg, err := m.RegisterCallback([]instrument.Asynchronous{
+		int64Counter,
+		int64UpDownCounter,
+		int64Gauge,
+		floag64Counter,
+		floag64UpDownCounter,
+		floag64Gauge,
+	}, func(context.Context) { called = true })
+	require.NoError(t, err)
+
+	ctx := context.Background()
+	_, err = r.Collect(ctx)
+	require.NoError(t, err)
+	assert.True(t, called, "callback not called for registered callback")
+
+	called = false
+	require.NoError(t, reg.Unregister(), "unregister")
+
+	_, err = r.Collect(ctx)
+	require.NoError(t, err)
+	assert.False(t, called, "callback called for unregistered callback")
+}
+
 func TestRegisterCallbackDropAggregations(t *testing.T) {
 	aggFn := func(InstrumentKind) aggregation.Aggregation {
 		return aggregation.Drop{}
@@ -507,14 +606,15 @@ func TestRegisterCallbackDropAggregations(t *testing.T) {
 	require.NoError(t, err)
 
 	var called bool
-	require.NoError(t, m.RegisterCallback([]instrument.Asynchronous{
+	_, err = m.RegisterCallback([]instrument.Asynchronous{
 		int64Counter,
 		int64UpDownCounter,
 		int64Gauge,
 		floag64Counter,
 		floag64UpDownCounter,
 		floag64Gauge,
-	}, func(context.Context) { called = true }))
+	}, func(context.Context) { called = true })
+	require.NoError(t, err)
 
 	data, err := r.Collect(context.Background())
 	require.NoError(t, err)
@@ -538,10 +638,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 1.0, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 2.0, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "afcounter",
@@ -564,10 +665,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 1.0, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 2.0, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "afupdowncounter",
@@ -590,10 +692,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 1.0, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 2.0, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "afgauge",
@@ -614,10 +717,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 10, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 20, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "aicounter",
@@ -640,10 +744,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 10, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 20, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "aiupdowncounter",
@@ -666,10 +771,11 @@ func TestAttributeFilter(t *testing.T) {
 				if err != nil {
 					return err
 				}
-				return mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
+				_, err = mtr.RegisterCallback([]instrument.Asynchronous{ctr}, func(ctx context.Context) {
 					ctr.Observe(ctx, 10, attribute.String("foo", "bar"), attribute.Int("version", 1))
 					ctr.Observe(ctx, 20, attribute.String("foo", "bar"), attribute.Int("version", 2))
 				})
+				return err
 			},
 			wantMetric: metricdata.Metrics{
 				Name: "aigauge",
diff --git a/sdk/metric/pipeline.go b/sdk/metric/pipeline.go
index bc6901e57757..f9938bf617f3 100644
--- a/sdk/metric/pipeline.go
+++ b/sdk/metric/pipeline.go
@@ -15,6 +15,7 @@
 package metric // import "go.opentelemetry.io/otel/sdk/metric"
 
 import (
+	"container/list"
 	"context"
 	"errors"
 	"fmt"
@@ -22,6 +23,7 @@ import (
 	"sync"
 
 	"go.opentelemetry.io/otel/internal/global"
+	"go.opentelemetry.io/otel/metric"
 	"go.opentelemetry.io/otel/metric/unit"
 	"go.opentelemetry.io/otel/sdk/instrumentation"
 	"go.opentelemetry.io/otel/sdk/metric/aggregation"
@@ -75,7 +77,7 @@ type pipeline struct {
 
 	sync.Mutex
 	aggregations map[instrumentation.Scope][]instrumentSync
-	callbacks    []func(context.Context)
+	callbacks    list.List
 }
 
 // addSync adds the instrumentSync to pipeline p with scope. This method is not
@@ -94,10 +96,15 @@ func (p *pipeline) addSync(scope instrumentation.Scope, iSync instrumentSync) {
 }
 
 // addCallback registers a callback to be run when `produce()` is called.
-func (p *pipeline) addCallback(callback func(context.Context)) {
+func (p *pipeline) addCallback(c callback) (unregister func()) {
 	p.Lock()
 	defer p.Unlock()
-	p.callbacks = append(p.callbacks, callback)
+	e := p.callbacks.PushBack(c)
+	return func() {
+		p.Lock()
+		p.callbacks.Remove(e)
+		p.Unlock()
+	}
 }
 
 // callbackKey is a context key type used to identify context that came from the SDK.
@@ -112,14 +119,15 @@ const produceKey callbackKey = 0
 //
 // This method is safe to call concurrently.
 func (p *pipeline) produce(ctx context.Context) (metricdata.ResourceMetrics, error) {
+	ctx = context.WithValue(ctx, produceKey, struct{}{})
+
 	p.Lock()
 	defer p.Unlock()
 
-	ctx = context.WithValue(ctx, produceKey, struct{}{})
-
-	for _, callback := range p.callbacks {
+	for e := p.callbacks.Front(); e != nil; e = e.Next() {
 		// TODO make the callbacks parallel. ( #3034 )
-		callback(ctx)
+		f := e.Value.(callback)
+		f(ctx)
 		if err := ctx.Err(); err != nil {
 			// This means the context expired before we finished running callbacks.
 			return metricdata.ResourceMetrics{}, err
@@ -439,10 +447,21 @@ func newPipelines(res *resource.Resource, readers []Reader, views []View) pipeli
 	return pipes
 }
 
-func (p pipelines) registerCallback(fn func(context.Context)) {
-	for _, pipe := range p {
-		pipe.addCallback(fn)
+func (p pipelines) registerCallback(c callback) metric.Registration {
+	unregs := make([]func(), len(p))
+	for i, pipe := range p {
+		unregs[i] = pipe.addCallback(c)
+	}
+	return unregisterFuncs(unregs)
+}
+
+type unregisterFuncs []func()
+
+func (u unregisterFuncs) Unregister() error {
+	for _, f := range u {
+		f()
 	}
+	return nil
 }
 
 // resolver facilitates resolving Aggregators an instrument needs to aggregate