diff --git a/Directory.Packages.props b/Directory.Packages.props
index 926ab7f6684..626320dbe96 100644
--- a/Directory.Packages.props
+++ b/Directory.Packages.props
@@ -7,7 +7,7 @@
   <ItemGroup>
     <PackageVersion Include="Google.Protobuf" Version="[3.19.4,4.0)" />
     <PackageVersion Include="Grpc" Version="[2.44.0,3.0)" />
-    <PackageVersion Include="Grpc.Net.Client" Version="[2.43.0,3.0)" />
+    <PackageVersion Include="Grpc.Net.Client" Version="[2.45.0,3.0)" />
     <PackageVersion Include="Grpc.Tools" Version="[2.44.0,3.0)" />
     <PackageVersion Include="Microsoft.AspNetCore.Http.Abstractions" Version="[2.1.1,6.0)" />
     <PackageVersion Include="Microsoft.AspNetCore.Http.Features" Version="[2.1.1,6.0)" />
diff --git a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/CHANGELOG.md b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/CHANGELOG.md
index ce193fde282..5aeb54dd858 100644
--- a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/CHANGELOG.md
@@ -14,6 +14,10 @@
   for instructions to enable exemplars.
   ([#4553](https://github.com/open-telemetry/opentelemetry-dotnet/pull/4553))
 
+* Updated Grpc.Net.Client to v2.45 to fix unobserved exception
+  from failed calls.
+  ([#4573](https://github.com/open-telemetry/opentelemetry-dotnet/pull/4573))
+
 * Updated to support `Severity` and `SeverityText` when exporting `LogRecord`s.
   ([#4568](https://github.com/open-telemetry/opentelemetry-dotnet/pull/4568))