diff --git a/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md b/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
index 352288c42a8..eb922b12f2b 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## Unreleased
 
+* Added support for loading environment variables from `IConfiguration` when
+  using the `AddZipkinExporter` extension
+  ([#3759](https://github.com/open-telemetry/opentelemetry-dotnet/pull/3759))
+
 ## 1.4.0-beta.1
 
 Released 2022-Sep-29
diff --git a/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj b/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
index 0aee4bd6334..c5e14a100de 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
+++ b/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
@@ -14,7 +14,7 @@
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Api\Internal\ActivityHelperExtensions.cs" Link="Includes\ActivityHelperExtensions.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Api\Internal\StatusHelper.cs" Link="Includes\StatusHelper.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Api\Internal\Guard.cs" Link="Includes\Guard.cs" />
-    <Compile Include="$(RepoRoot)\src\OpenTelemetry\Internal\EnvironmentVariableHelper.cs" Link="Includes\EnvironmentVariableHelper.cs" />
+    <Compile Include="$(RepoRoot)\src\OpenTelemetry\Internal\ConfigurationExtensions.cs" Link="Includes\ConfigurationExtensions.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry\Internal\OpenTelemetrySdkEventSource.cs" Link="Includes\OpenTelemetrySdkEventSource.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry\Internal\PooledList.cs" Link="Includes\PooledList.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry\Internal\PeerServiceResolver.cs" Link="Includes\PeerServiceResolver.cs" />
diff --git a/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterHelperExtensions.cs b/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterHelperExtensions.cs
index 261cecd1a64..93a43014874 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterHelperExtensions.cs
+++ b/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterHelperExtensions.cs
@@ -62,10 +62,15 @@ public static TracerProviderBuilder AddZipkinExporter(
 
             name ??= Options.DefaultName;
 
-            if (configure != null)
+            builder.ConfigureServices(services =>
             {
-                builder.ConfigureServices(services => services.Configure(name, configure));
-            }
+                if (configure != null)
+                {
+                    services.Configure(name, configure);
+                }
+
+                services.RegisterOptionsFactory(configuration => new ZipkinExporterOptions(configuration));
+            });
 
             return builder.ConfigureBuilder((sp, builder) =>
             {
diff --git a/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterOptions.cs b/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterOptions.cs
index 9c354574a72..d51eb007b81 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterOptions.cs
+++ b/src/OpenTelemetry.Exporter.Zipkin/ZipkinExporterOptions.cs
@@ -17,6 +17,7 @@
 using System;
 using System.Diagnostics;
 using System.Net.Http;
+using Microsoft.Extensions.Configuration;
 using OpenTelemetry.Internal;
 using OpenTelemetry.Trace;
 
@@ -44,8 +45,13 @@ public sealed class ZipkinExporterOptions
         /// Initializes zipkin endpoint.
         /// </summary>
         public ZipkinExporterOptions()
+             : this(new ConfigurationBuilder().AddEnvironmentVariables().Build())
         {
-            if (EnvironmentVariableHelper.LoadUri(ZipkinEndpointEnvVar, out Uri endpoint))
+        }
+
+        internal ZipkinExporterOptions(IConfiguration configuration)
+        {
+            if (configuration.TryGetUriValue(ZipkinEndpointEnvVar, out var endpoint))
             {
                 this.Endpoint = endpoint;
             }
diff --git a/test/OpenTelemetry.Exporter.Zipkin.Tests/ZipkinExporterTests.cs b/test/OpenTelemetry.Exporter.Zipkin.Tests/ZipkinExporterTests.cs
index 4cd2d97d2e5..3c19c2c106c 100644
--- a/test/OpenTelemetry.Exporter.Zipkin.Tests/ZipkinExporterTests.cs
+++ b/test/OpenTelemetry.Exporter.Zipkin.Tests/ZipkinExporterTests.cs
@@ -23,6 +23,7 @@
 using System.Net;
 using System.Net.Http;
 using System.Text;
+using Microsoft.Extensions.Configuration;
 using Microsoft.Extensions.DependencyInjection;
 using OpenTelemetry.Exporter.Zipkin.Implementation;
 using OpenTelemetry.Resources;
@@ -207,6 +208,23 @@ public void ErrorGettingUriFromEnvVarSetsDefaultEndpointValue()
             }
         }
 
+        [Fact]
+        public void EndpointConfigurationUsingIConfiguration()
+        {
+            var values = new Dictionary<string, string>()
+            {
+                [ZipkinExporterOptions.ZipkinEndpointEnvVar] = "http://custom-endpoint:12345",
+            };
+
+            var configuration = new ConfigurationBuilder()
+                .AddInMemoryCollection(values)
+                .Build();
+
+            var options = new ZipkinExporterOptions(configuration);
+
+            Assert.Equal(new Uri("http://custom-endpoint:12345"), options.Endpoint);
+        }
+
         [Fact]
         public void UserHttpFactoryCalled()
         {