diff --git a/src/OpenTelemetry.Instrumentation.Http/.publicApi/netstandard2.0/PublicAPI.Shipped.txt b/src/OpenTelemetry.Instrumentation.Http/.publicApi/net6.0/PublicAPI.Shipped.txt
similarity index 100%
rename from src/OpenTelemetry.Instrumentation.Http/.publicApi/netstandard2.0/PublicAPI.Shipped.txt
rename to src/OpenTelemetry.Instrumentation.Http/.publicApi/net6.0/PublicAPI.Shipped.txt
diff --git a/src/OpenTelemetry.Instrumentation.Http/.publicApi/netstandard2.0/PublicAPI.Unshipped.txt b/src/OpenTelemetry.Instrumentation.Http/.publicApi/net6.0/PublicAPI.Unshipped.txt
similarity index 70%
rename from src/OpenTelemetry.Instrumentation.Http/.publicApi/netstandard2.0/PublicAPI.Unshipped.txt
rename to src/OpenTelemetry.Instrumentation.Http/.publicApi/net6.0/PublicAPI.Unshipped.txt
index 8ac18d7a6e1..0224a11a2e5 100644
--- a/src/OpenTelemetry.Instrumentation.Http/.publicApi/netstandard2.0/PublicAPI.Unshipped.txt
+++ b/src/OpenTelemetry.Instrumentation.Http/.publicApi/net6.0/PublicAPI.Unshipped.txt
@@ -9,4 +9,6 @@ OpenTelemetry.Instrumentation.Http.HttpClientInstrumentationOptions.RecordExcept
 OpenTelemetry.Metrics.MeterProviderBuilderExtensions
 OpenTelemetry.Trace.TracerProviderBuilderExtensions
 static OpenTelemetry.Metrics.MeterProviderBuilderExtensions.AddHttpClientInstrumentation(this OpenTelemetry.Metrics.MeterProviderBuilder builder) -> OpenTelemetry.Metrics.MeterProviderBuilder
-static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddHttpClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, System.Action<OpenTelemetry.Instrumentation.Http.HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions = null) -> OpenTelemetry.Trace.TracerProviderBuilder
+static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddHttpClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder) -> OpenTelemetry.Trace.TracerProviderBuilder
+static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddHttpClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, string name, System.Action<OpenTelemetry.Instrumentation.Http.HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions) -> OpenTelemetry.Trace.TracerProviderBuilder
+static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddHttpClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, System.Action<OpenTelemetry.Instrumentation.Http.HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions) -> OpenTelemetry.Trace.TracerProviderBuilder
diff --git a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
index c7ce6fdac9b..4777e306a67 100644
--- a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
@@ -2,6 +2,14 @@
 
 ## Unreleased
 
+* Dropped `netstandard2.0` target and added `net6.0`
+  ([#3664](https://github.com/open-telemetry/opentelemetry-dotnet/pull/3664))
+
+* Added overloads which accept a name to the `TracerProviderBuilder`
+  `AddHttpClientInstrumentation` extension to allow for more fine-grained
+  options management
+  ([#3664](https://github.com/open-telemetry/opentelemetry-dotnet/pull/3664))
+
 ## 1.0.0-rc9.6
 
 Released 2022-Aug-18
diff --git a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
index 3665f2c85e0..621422a822b 100644
--- a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
+++ b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
@@ -2,12 +2,17 @@
 
   <PropertyGroup>
     <!-- OmniSharp/VS Code requires TargetFrameworks to be in descending order for IntelliSense and analysis. -->
-    <TargetFrameworks>netstandard2.0;net462</TargetFrameworks>
+    <TargetFrameworks>net6.0;net462</TargetFrameworks>
     <Description>Http instrumentation for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing</PackageTags>
     <IncludeDiagnosticSourceInstrumentationHelpers>true</IncludeDiagnosticSourceInstrumentationHelpers>
   </PropertyGroup>
 
+  <!--Do not run ApiCompat for net6.0 as this is newly added. Remove this property once we have released a stable version.-->
+  <PropertyGroup Condition="'$(TargetFramework)' == 'net6.0'">
+    <RunApiCompat>false</RunApiCompat>
+  </PropertyGroup>
+
   <ItemGroup>
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Api\Internal\Guard.cs" Link="Includes\Guard.cs" />
   </ItemGroup>
diff --git a/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs b/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
index 3a6640c61c1..619035e82bc 100644
--- a/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
@@ -61,22 +61,45 @@ public static TracerProviderBuilder AddHttpClientInstrumentation(
         /// Enables HttpClient instrumentation.
         /// </summary>
         /// <param name="builder"><see cref="TracerProviderBuilder"/> being configured.</param>
-        /// <param name="configureHttpClientInstrumentationOptions">HttpClient configuration options.</param>
+        /// <returns>The instance of <see cref="TracerProviderBuilder"/> to chain the calls.</returns>
+        public static TracerProviderBuilder AddHttpClientInstrumentation(this TracerProviderBuilder builder)
+            => AddHttpClientInstrumentation(builder, name: null, configureHttpClientInstrumentationOptions: null);
+
+        /// <summary>
+        /// Enables HttpClient instrumentation.
+        /// </summary>
+        /// <param name="builder"><see cref="TracerProviderBuilder"/> being configured.</param>
+        /// <param name="configureHttpClientInstrumentationOptions">Callback action for configuring <see cref="HttpClientInstrumentationOptions"/>.</param>
         /// <returns>The instance of <see cref="TracerProviderBuilder"/> to chain the calls.</returns>
         public static TracerProviderBuilder AddHttpClientInstrumentation(
             this TracerProviderBuilder builder,
-            Action<HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions = null)
+            Action<HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions)
+            => AddHttpClientInstrumentation(builder, name: null, configureHttpClientInstrumentationOptions);
+
+        /// <summary>
+        /// Enables HttpClient instrumentation.
+        /// </summary>
+        /// <param name="builder"><see cref="TracerProviderBuilder"/> being configured.</param>
+        /// <param name="name">Name which is used when retrieving options.</param>
+        /// <param name="configureHttpClientInstrumentationOptions">Callback action for configuring <see cref="HttpClientInstrumentationOptions"/>.</param>
+        /// <returns>The instance of <see cref="TracerProviderBuilder"/> to chain the calls.</returns>
+        public static TracerProviderBuilder AddHttpClientInstrumentation(
+            this TracerProviderBuilder builder,
+            string name,
+            Action<HttpClientInstrumentationOptions> configureHttpClientInstrumentationOptions)
         {
             Guard.ThrowIfNull(builder);
 
+            name ??= Options.DefaultName;
+
             if (configureHttpClientInstrumentationOptions != null)
             {
-                builder.ConfigureServices(services => services.Configure(configureHttpClientInstrumentationOptions));
+                builder.ConfigureServices(services => services.Configure(name, configureHttpClientInstrumentationOptions));
             }
 
             return builder.ConfigureBuilder((sp, builder) =>
             {
-                var options = sp.GetRequiredService<IOptions<HttpClientInstrumentationOptions>>().Value;
+                var options = sp.GetRequiredService<IOptionsMonitor<HttpClientInstrumentationOptions>>().Get(name);
 
                 AddHttpClientInstrumentation(builder, new HttpClientInstrumentation(options));
             });
diff --git a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
index c06a18bc89f..3b49cac0348 100644
--- a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
+++ b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
@@ -19,6 +19,7 @@
 using System.Linq;
 using System.Net.Http;
 using System.Threading.Tasks;
+using Microsoft.Extensions.DependencyInjection;
 using Moq;
 using OpenTelemetry.Context.Propagation;
 using OpenTelemetry.Instrumentation.Http.Implementation;
@@ -47,6 +48,27 @@ public HttpClientTests()
             this.url = $"http://{host}:{port}/";
         }
 
+        [Fact]
+        public void AddHttpClientInstrumentation_NamedOptions()
+        {
+            int defaultExporterOptionsConfigureOptionsInvocations = 0;
+            int namedExporterOptionsConfigureOptionsInvocations = 0;
+
+            using var tracerProvider = Sdk.CreateTracerProviderBuilder()
+                .ConfigureServices(services =>
+                {
+                    services.Configure<HttpClientInstrumentationOptions>(o => defaultExporterOptionsConfigureOptionsInvocations++);
+
+                    services.Configure<HttpClientInstrumentationOptions>("Instrumentation2", o => namedExporterOptionsConfigureOptionsInvocations++);
+                })
+                .AddHttpClientInstrumentation()
+                .AddHttpClientInstrumentation("Instrumentation2", configureHttpClientInstrumentationOptions: null)
+                .Build();
+
+            Assert.Equal(1, defaultExporterOptionsConfigureOptionsInvocations);
+            Assert.Equal(1, namedExporterOptionsConfigureOptionsInvocations);
+        }
+
         [Fact]
         public void AddHttpClientInstrumentation_BadArgs()
         {