diff --git a/src/OpenTelemetry/Instrumentation/DiagnosticSourceListener.cs b/src/OpenTelemetry/Instrumentation/DiagnosticSourceListener.cs
index 2ebb330b3ac..d7112b9365f 100644
--- a/src/OpenTelemetry/Instrumentation/DiagnosticSourceListener.cs
+++ b/src/OpenTelemetry/Instrumentation/DiagnosticSourceListener.cs
@@ -39,6 +39,11 @@ public void OnError(Exception error)
 
         public void OnNext(KeyValuePair<string, object> value)
         {
+            if (Sdk.SuppressInstrumentation)
+            {
+                return;
+            }
+
             if (!this.handler.SupportsNullActivity && Activity.Current == null)
             {
                 InstrumentationEventSource.Log.NullActivity(value.Key);
diff --git a/src/OpenTelemetry/Trace/TracerProviderSdk.cs b/src/OpenTelemetry/Trace/TracerProviderSdk.cs
index 84f5b2fd8e0..7eb0aa53a68 100644
--- a/src/OpenTelemetry/Trace/TracerProviderSdk.cs
+++ b/src/OpenTelemetry/Trace/TracerProviderSdk.cs
@@ -92,18 +92,21 @@ internal TracerProviderSdk(
 
             if (sampler is AlwaysOnSampler)
             {
-                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) => ActivityDataRequest.AllDataAndRecorded;
+                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) =>
+                    !Sdk.SuppressInstrumentation ? ActivityDataRequest.AllDataAndRecorded : ActivityDataRequest.None;
             }
             else if (sampler is AlwaysOffSampler)
             {
                 /*TODO: Change options.Parent.SpanId to options.Parent.TraceId
                         once AutoGenerateRootContextTraceId is removed.*/
-                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) => PropagateOrIgnoreData(options.Parent.SpanId);
+                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) =>
+                    !Sdk.SuppressInstrumentation ? PropagateOrIgnoreData(options.Parent.SpanId) : ActivityDataRequest.None;
             }
             else
             {
                 // This delegate informs ActivitySource about sampling decision when the parent context is an ActivityContext.
-                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) => ComputeActivityDataRequest(options, sampler);
+                listener.GetRequestedDataUsingContext = (ref ActivityCreationOptions<ActivityContext> options) =>
+                    !Sdk.SuppressInstrumentation ? ComputeActivityDataRequest(options, sampler) : ActivityDataRequest.None;
             }
 
             if (sources.Any())
diff --git a/test/OpenTelemetry.Tests/Instrumentation/DiagnosticSourceListenerTest.cs b/test/OpenTelemetry.Tests/Instrumentation/DiagnosticSourceListenerTest.cs
new file mode 100644
index 00000000000..424c0f50dbb
--- /dev/null
+++ b/test/OpenTelemetry.Tests/Instrumentation/DiagnosticSourceListenerTest.cs
@@ -0,0 +1,60 @@
+// <copyright file="DiagnosticSourceListenerTest.cs" company="OpenTelemetry Authors">
+// Copyright The OpenTelemetry Authors
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+// </copyright>
+
+using System.Diagnostics;
+using Xunit;
+
+namespace OpenTelemetry.Instrumentation.Tests
+{
+    public class DiagnosticSourceListenerTest
+    {
+        private const string TestSourceName = "TestSourceName";
+        private DiagnosticSource diagnosticSource;
+        private TestListenerHandler testListenerHandler;
+        private DiagnosticSourceSubscriber testDiagnosticSourceSubscriber;
+
+        public DiagnosticSourceListenerTest()
+        {
+            this.diagnosticSource = new DiagnosticListener(TestSourceName);
+            this.testListenerHandler = new TestListenerHandler(TestSourceName);
+            this.testDiagnosticSourceSubscriber = new DiagnosticSourceSubscriber(this.testListenerHandler, null);
+            this.testDiagnosticSourceSubscriber.Subscribe();
+        }
+
+        [Theory]
+        [InlineData(true)]
+        [InlineData(false)]
+        public void ListenerHandlerIsNotInvokedWhenSuppressInstrumentationTrue(bool suppressInstrumentation)
+        {
+            using var scope = SuppressInstrumentationScope.Begin(suppressInstrumentation);
+
+            var activity = new Activity("Main");
+            this.diagnosticSource.StartActivity(activity, null);
+            this.diagnosticSource.StopActivity(activity, null);
+
+            if (suppressInstrumentation)
+            {
+                Assert.Equal(0, this.testListenerHandler.OnStartInvokedCount);
+                Assert.Equal(0, this.testListenerHandler.OnStopInvokedCount);
+            }
+            else
+            {
+                Assert.Equal(1, this.testListenerHandler.OnStartInvokedCount);
+                Assert.Equal(1, this.testListenerHandler.OnStopInvokedCount);
+            }
+        }
+    }
+}
diff --git a/test/OpenTelemetry.Tests/Instrumentation/TestListenerHandler.cs b/test/OpenTelemetry.Tests/Instrumentation/TestListenerHandler.cs
new file mode 100644
index 00000000000..aee4188ef3f
--- /dev/null
+++ b/test/OpenTelemetry.Tests/Instrumentation/TestListenerHandler.cs
@@ -0,0 +1,53 @@
+// <copyright file="TestListenerHandler.cs" company="OpenTelemetry Authors">
+// Copyright The OpenTelemetry Authors
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+// </copyright>
+
+using System.Diagnostics;
+
+namespace OpenTelemetry.Instrumentation.Tests
+{
+    public class TestListenerHandler : ListenerHandler
+    {
+        public int OnStartInvokedCount = 0;
+        public int OnStopInvokedCount = 0;
+        public int OnExceptionInvokedCount = 0;
+        public int OnCustomInvokedCount = 0;
+
+        public TestListenerHandler(string sourceName)
+            : base(sourceName)
+        {
+        }
+
+        public override void OnStartActivity(Activity activity, object payload)
+        {
+            this.OnStartInvokedCount++;
+        }
+
+        public override void OnStopActivity(Activity activity, object payload)
+        {
+            this.OnStopInvokedCount++;
+        }
+
+        public override void OnException(Activity activity, object payload)
+        {
+            this.OnExceptionInvokedCount++;
+        }
+
+        public override void OnCustom(string name, Activity activity, object payload)
+        {
+            this.OnCustomInvokedCount++;
+        }
+    }
+}
diff --git a/test/OpenTelemetry.Tests/Trace/TracerProvideSdkTest.cs b/test/OpenTelemetry.Tests/Trace/TracerProvideSdkTest.cs
index 442000cea65..00276e9581a 100644
--- a/test/OpenTelemetry.Tests/Trace/TracerProvideSdkTest.cs
+++ b/test/OpenTelemetry.Tests/Trace/TracerProvideSdkTest.cs
@@ -147,6 +147,24 @@ public void TracerSdkSetsActivityDataRequestBasedOnSamplingDecision()
             }
         }
 
+        [Fact]
+        public void TracerSdkSetsActivityDataRequestToNoneWhenSuppressInstrumentationIsTrue()
+        {
+            using var scope = SuppressInstrumentationScope.Begin();
+
+            var testSampler = new TestSampler();
+            using var activitySource = new ActivitySource(ActivitySourceName);
+            using var sdk = Sdk.CreateTracerProviderBuilder()
+                    .AddSource(ActivitySourceName)
+                    .SetSampler(testSampler)
+                    .Build();
+
+            using (var activity = activitySource.StartActivity("root"))
+            {
+                Assert.Null(activity);
+            }
+        }
+
         [Fact]
         public void ProcessorDoesNotReceiveNotRecordDecisionSpan()
         {