diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/.publicApi/PublicAPI.Unshipped.txt b/src/OpenTelemetry.Instrumentation.GrpcNetClient/.publicApi/PublicAPI.Unshipped.txt
index db708294cc8..32e717dc82b 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/.publicApi/PublicAPI.Unshipped.txt
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/.publicApi/PublicAPI.Unshipped.txt
@@ -1,12 +1,12 @@
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.EnrichWithHttpRequestMessage.get -> System.Action<System.Diagnostics.Activity, System.Net.Http.HttpRequestMessage>
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.EnrichWithHttpRequestMessage.set -> void
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.EnrichWithHttpResponseMessage.get -> System.Action<System.Diagnostics.Activity, System.Net.Http.HttpResponseMessage>
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.EnrichWithHttpResponseMessage.set -> void
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.GrpcClientInstrumentationOptions() -> void
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.SuppressDownstreamInstrumentation.get -> bool
-OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions.SuppressDownstreamInstrumentation.set -> void
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.EnrichWithHttpRequestMessage.get -> System.Action<System.Diagnostics.Activity, System.Net.Http.HttpRequestMessage>
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.EnrichWithHttpRequestMessage.set -> void
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.EnrichWithHttpResponseMessage.get -> System.Action<System.Diagnostics.Activity, System.Net.Http.HttpResponseMessage>
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.EnrichWithHttpResponseMessage.set -> void
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.GrpcClientTraceInstrumentationOptions() -> void
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.SuppressDownstreamInstrumentation.get -> bool
+OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions.SuppressDownstreamInstrumentation.set -> void
 OpenTelemetry.Trace.TracerProviderBuilderExtensions
 static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddGrpcClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder) -> OpenTelemetry.Trace.TracerProviderBuilder
-static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddGrpcClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, string name, System.Action<OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions> configure) -> OpenTelemetry.Trace.TracerProviderBuilder
-static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddGrpcClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, System.Action<OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientInstrumentationOptions> configure) -> OpenTelemetry.Trace.TracerProviderBuilder
\ No newline at end of file
+static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddGrpcClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, string name, System.Action<OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions> configure) -> OpenTelemetry.Trace.TracerProviderBuilder
+static OpenTelemetry.Trace.TracerProviderBuilderExtensions.AddGrpcClientInstrumentation(this OpenTelemetry.Trace.TracerProviderBuilder builder, System.Action<OpenTelemetry.Instrumentation.GrpcNetClient.GrpcClientTraceInstrumentationOptions> configure) -> OpenTelemetry.Trace.TracerProviderBuilder
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
index 56946c1533e..66390b0daab 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
@@ -15,6 +15,9 @@
   Now that this suite of attributes are stable, this instrumentation will only
   emit the new attributes.
   ([#5259](https://github.com/open-telemetry/opentelemetry-dotnet/pull/5259))
+* **Breaking Change**: Renamed `GrpcClientInstrumentationOptions` to
+  `GrpcClientTraceInstrumentationOptions`.
+  ([#5272](https://github.com/open-telemetry/opentelemetry-dotnet/pull/5272))
 
 ## 1.6.0-beta.3
 
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentation.cs b/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentation.cs
index 7c9ee1ffede..961ddc17749 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentation.cs
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentation.cs
@@ -16,7 +16,7 @@ internal sealed class GrpcClientInstrumentation : IDisposable
     /// Initializes a new instance of the <see cref="GrpcClientInstrumentation"/> class.
     /// </summary>
     /// <param name="options">Configuration options for Grpc client instrumentation.</param>
-    public GrpcClientInstrumentation(GrpcClientInstrumentationOptions options = null)
+    public GrpcClientInstrumentation(GrpcClientTraceInstrumentationOptions options = null)
     {
         this.diagnosticSourceSubscriber = new DiagnosticSourceSubscriber(new GrpcClientDiagnosticListener(options), isEnabledFilter: null, GrpcInstrumentationEventSource.Log.UnknownErrorProcessingEvent);
         this.diagnosticSourceSubscriber.Subscribe();
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentationOptions.cs b/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientTraceInstrumentationOptions.cs
similarity index 96%
rename from src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentationOptions.cs
rename to src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientTraceInstrumentationOptions.cs
index 415bf8f0f71..b4cd871980b 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientInstrumentationOptions.cs
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/GrpcClientTraceInstrumentationOptions.cs
@@ -8,7 +8,7 @@ namespace OpenTelemetry.Instrumentation.GrpcNetClient;
 /// <summary>
 /// Options for GrpcClient instrumentation.
 /// </summary>
-public class GrpcClientInstrumentationOptions
+public class GrpcClientTraceInstrumentationOptions
 {
     /// <summary>
     /// Gets or sets a value indicating whether down stream instrumentation is suppressed (disabled).
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/Implementation/GrpcClientDiagnosticListener.cs b/src/OpenTelemetry.Instrumentation.GrpcNetClient/Implementation/GrpcClientDiagnosticListener.cs
index 9ac826921d8..0804f57363b 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/Implementation/GrpcClientDiagnosticListener.cs
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/Implementation/GrpcClientDiagnosticListener.cs
@@ -25,9 +25,9 @@ internal sealed class GrpcClientDiagnosticListener : ListenerHandler
     private static readonly PropertyFetcher<HttpRequestMessage> StartRequestFetcher = new("Request");
     private static readonly PropertyFetcher<HttpResponseMessage> StopResponseFetcher = new("Response");
 
-    private readonly GrpcClientInstrumentationOptions options;
+    private readonly GrpcClientTraceInstrumentationOptions options;
 
-    public GrpcClientDiagnosticListener(GrpcClientInstrumentationOptions options)
+    public GrpcClientDiagnosticListener(GrpcClientTraceInstrumentationOptions options)
         : base("Grpc.Net.Client")
     {
         this.options = options;
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/TracerProviderBuilderExtensions.cs b/src/OpenTelemetry.Instrumentation.GrpcNetClient/TracerProviderBuilderExtensions.cs
index 567bdb72c14..aa87988869c 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/TracerProviderBuilderExtensions.cs
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/TracerProviderBuilderExtensions.cs
@@ -27,11 +27,11 @@ public static TracerProviderBuilder AddGrpcClientInstrumentation(this TracerProv
     /// Enables gRPC client instrumentation.
     /// </summary>
     /// <param name="builder"><see cref="TracerProviderBuilder"/> being configured.</param>
-    /// <param name="configure">Callback action for configuring <see cref="GrpcClientInstrumentationOptions"/>.</param>
+    /// <param name="configure">Callback action for configuring <see cref="GrpcClientTraceInstrumentationOptions"/>.</param>
     /// <returns>The instance of <see cref="TracerProviderBuilder"/> to chain the calls.</returns>
     public static TracerProviderBuilder AddGrpcClientInstrumentation(
         this TracerProviderBuilder builder,
-        Action<GrpcClientInstrumentationOptions> configure)
+        Action<GrpcClientTraceInstrumentationOptions> configure)
         => AddGrpcClientInstrumentation(builder, name: null, configure);
 
     /// <summary>
@@ -39,12 +39,12 @@ public static TracerProviderBuilder AddGrpcClientInstrumentation(
     /// </summary>
     /// <param name="builder"><see cref="TracerProviderBuilder"/> being configured.</param>
     /// <param name="name">Name which is used when retrieving options.</param>
-    /// <param name="configure">Callback action for configuring <see cref="GrpcClientInstrumentationOptions"/>.</param>
+    /// <param name="configure">Callback action for configuring <see cref="GrpcClientTraceInstrumentationOptions"/>.</param>
     /// <returns>The instance of <see cref="TracerProviderBuilder"/> to chain the calls.</returns>
     public static TracerProviderBuilder AddGrpcClientInstrumentation(
         this TracerProviderBuilder builder,
         string name,
-        Action<GrpcClientInstrumentationOptions> configure)
+        Action<GrpcClientTraceInstrumentationOptions> configure)
     {
         Guard.ThrowIfNull(builder);
 
@@ -60,7 +60,7 @@ public static TracerProviderBuilder AddGrpcClientInstrumentation(
 
         return builder.AddInstrumentation(sp =>
         {
-            var options = sp.GetRequiredService<IOptionsMonitor<GrpcClientInstrumentationOptions>>().Get(name);
+            var options = sp.GetRequiredService<IOptionsMonitor<GrpcClientTraceInstrumentationOptions>>().Get(name);
 
             return new GrpcClientInstrumentation(options);
         });
diff --git a/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs b/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
index 35fd982a7bd..3799ef73a7f 100644
--- a/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
+++ b/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
@@ -413,9 +413,9 @@ public void AddGrpcClientInstrumentationNamedOptionsSupported()
         using var tracerProvider = Sdk.CreateTracerProviderBuilder()
             .ConfigureServices(services =>
             {
-                services.Configure<GrpcClientInstrumentationOptions>(o => defaultExporterOptionsConfigureOptionsInvocations++);
+                services.Configure<GrpcClientTraceInstrumentationOptions>(o => defaultExporterOptionsConfigureOptionsInvocations++);
 
-                services.Configure<GrpcClientInstrumentationOptions>("Instrumentation2", o => namedExporterOptionsConfigureOptionsInvocations++);
+                services.Configure<GrpcClientTraceInstrumentationOptions>("Instrumentation2", o => namedExporterOptionsConfigureOptionsInvocations++);
             })
             .AddGrpcClientInstrumentation()
             .AddGrpcClientInstrumentation("Instrumentation2", configure: null)