diff --git a/src/OpenTelemetry.AutoInstrumentation.Loader/StartupLogger.cs b/src/OpenTelemetry.AutoInstrumentation.Loader/StartupLogger.cs
index b24fa9ab44..9e60d9782d 100644
--- a/src/OpenTelemetry.AutoInstrumentation.Loader/StartupLogger.cs
+++ b/src/OpenTelemetry.AutoInstrumentation.Loader/StartupLogger.cs
@@ -152,7 +152,7 @@ private static string SetStartupLogFilePath()
         catch
         {
             // We can't get the process info
-            return Path.Combine(LogDirectory, "dotnet-tracer-loader.log");
+            return Path.Combine(LogDirectory, $"dotnet-tracer-loader-{Guid.NewGuid()}.log");
         }
     }