diff --git a/src/OpenTelemetry.Instrumentation.AspNet/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.AspNet/CHANGELOG.md
index 71a4bfa708..76782773cf 100644
--- a/src/OpenTelemetry.Instrumentation.AspNet/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.AspNet/CHANGELOG.md
@@ -2,6 +2,9 @@
 
 ## Unreleased
 
+* Migrate to native Activity `Status` and `StatusDesciption`.
+  ([#651](https://github.com/open-telemetry/opentelemetry-dotnet-contrib/pull/651))
+
 ## 1.0.0-rc9.5 (source code moved to contrib repo)
 
 Released 2022-Jun-21
diff --git a/src/OpenTelemetry.Instrumentation.AspNet/Implementation/HttpInListener.cs b/src/OpenTelemetry.Instrumentation.AspNet/Implementation/HttpInListener.cs
index 716b9c0136..a8c1ddb9a4 100644
--- a/src/OpenTelemetry.Instrumentation.AspNet/Implementation/HttpInListener.cs
+++ b/src/OpenTelemetry.Instrumentation.AspNet/Implementation/HttpInListener.cs
@@ -128,9 +128,9 @@ private void OnStopActivity(Activity activity, HttpContext context)
 
             activity.SetTag(SemanticConventions.AttributeHttpStatusCode, response.StatusCode);
 
-            if (activity.GetStatus().StatusCode == StatusCode.Unset)
+            if (activity.Status == ActivityStatusCode.Unset)
             {
-                activity.SetStatus(SpanHelper.ResolveSpanStatusForHttpStatusCode(activity.Kind, response.StatusCode));
+                activity.SetStatus(SpanHelper.ResolveActivityStatusForHttpStatusCode(activity.Kind, response.StatusCode));
             }
 
             var routeData = context.Request.RequestContext.RouteData;
@@ -181,7 +181,7 @@ private void OnException(Activity activity, HttpContext context, Exception excep
                 activity.RecordException(exception);
             }
 
-            activity.SetStatus(Status.Error.WithDescription(exception.Message));
+            activity.SetStatus(ActivityStatusCode.Error, exception.Message);
 
             try
             {
diff --git a/src/OpenTelemetry.Instrumentation.AspNet/OpenTelemetry.Instrumentation.AspNet.csproj b/src/OpenTelemetry.Instrumentation.AspNet/OpenTelemetry.Instrumentation.AspNet.csproj
index 03f775a3d7..060706d0c6 100644
--- a/src/OpenTelemetry.Instrumentation.AspNet/OpenTelemetry.Instrumentation.AspNet.csproj
+++ b/src/OpenTelemetry.Instrumentation.AspNet/OpenTelemetry.Instrumentation.AspNet.csproj
@@ -14,7 +14,6 @@
   </ItemGroup>
 
   <ItemGroup>
-    <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\SpanHelper.cs" Link="Includes\SpanHelper.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\SemanticConventions.cs" Link="Includes\SemanticConventions.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\ExceptionExtensions.cs" Link="Includes\ExceptionExtensions.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\DiagnosticSourceInstrumentation\PropertyFetcher.cs" Link="Includes\PropertyFetcher.cs" />
diff --git a/src/OpenTelemetry.Instrumentation.AspNet/SpanHelper.cs b/src/OpenTelemetry.Instrumentation.AspNet/SpanHelper.cs
new file mode 100644
index 0000000000..14e6bc4e2c
--- /dev/null
+++ b/src/OpenTelemetry.Instrumentation.AspNet/SpanHelper.cs
@@ -0,0 +1,43 @@
+// <copyright file="SpanHelper.cs" company="OpenTelemetry Authors">
+// Copyright The OpenTelemetry Authors
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+// </copyright>
+
+using System.Diagnostics;
+
+namespace OpenTelemetry.Instrumentation.AspNet;
+
+/// <summary>
+/// A collection of helper methods to be used when building spans.
+/// </summary>
+internal static class SpanHelper
+{
+    /// <summary>
+    /// Helper method that populates Activity Status from http status code according
+    /// to https://github.com/open-telemetry/opentelemetry-specification/blob/main/specification/trace/semantic_conventions/http.md#status.
+    /// </summary>
+    /// <param name="kind">The span kind.</param>
+    /// <param name="httpStatusCode">Http status code.</param>
+    /// <returns>Resolved span <see cref="ActivityStatusCode"/> for the Http status code.</returns>
+    public static ActivityStatusCode ResolveActivityStatusForHttpStatusCode(ActivityKind kind, int httpStatusCode)
+    {
+        var upperBound = kind == ActivityKind.Client ? 399 : 499;
+        if (httpStatusCode >= 100 && httpStatusCode <= upperBound)
+        {
+            return ActivityStatusCode.Unset;
+        }
+
+        return ActivityStatusCode.Error;
+    }
+}
diff --git a/test/OpenTelemetry.Instrumentation.AspNet.Tests/HttpInListenerTests.cs b/test/OpenTelemetry.Instrumentation.AspNet.Tests/HttpInListenerTests.cs
index 0e3bd5eef2..70d477c627 100644
--- a/test/OpenTelemetry.Instrumentation.AspNet.Tests/HttpInListenerTests.cs
+++ b/test/OpenTelemetry.Instrumentation.AspNet.Tests/HttpInListenerTests.cs
@@ -137,7 +137,7 @@ public void AspNetRequestsAreCollectedSuccessfully(
                            return httpContext.Request.Path != filter;
                        };
 
-                       options.Enrich = GetEnrichmentAction(setStatusToErrorInEnrich ? Status.Error : default);
+                       options.Enrich = GetEnrichmentAction(setStatusToErrorInEnrich ? ActivityStatusCode.Error : default);
 
                        options.RecordException = recordException;
                    })
@@ -217,27 +217,27 @@ public void AspNetRequestsAreCollectedSuccessfully(
 
         if (recordException)
         {
-            var status = span.GetStatus();
-            Assert.Equal(Status.Error.StatusCode, status.StatusCode);
-            Assert.Equal("Operation is not valid due to the current state of the object.", status.Description);
+            var status = span.Status;
+            Assert.Equal(ActivityStatusCode.Error, span.Status);
+            Assert.Equal("Operation is not valid due to the current state of the object.", span.StatusDescription);
         }
         else if (setStatusToErrorInEnrich)
         {
             // This validates that users can override the
             // status in Enrich.
-            Assert.Equal(Status.Error, span.GetStatus());
+            Assert.Equal(ActivityStatusCode.Error, span.Status);
 
             // Instrumentation is not expected to set status description
             // as the reason can be inferred from SemanticConventions.AttributeHttpStatusCode
-            Assert.True(string.IsNullOrEmpty(span.GetStatus().Description));
+            Assert.True(string.IsNullOrEmpty(span.StatusDescription));
         }
         else
         {
-            Assert.Equal(Status.Unset, span.GetStatus());
+            Assert.Equal(ActivityStatusCode.Unset, span.Status);
 
             // Instrumentation is not expected to set status description
             // as the reason can be inferred from SemanticConventions.AttributeHttpStatusCode
-            Assert.True(string.IsNullOrEmpty(span.GetStatus().Description));
+            Assert.True(string.IsNullOrEmpty(span.StatusDescription));
         }
     }
 
@@ -324,7 +324,7 @@ public void ExtractContextIrrespectiveOfTheFilterApplied()
         Assert.True(isPropagatorCalled);
     }
 
-    private static Action<Activity, string, object> GetEnrichmentAction(Status statusToBeSet)
+    private static Action<Activity, string, object> GetEnrichmentAction(ActivityStatusCode statusToBeSet)
     {
         void EnrichAction(Activity activity, string method, object obj)
         {
diff --git a/test/OpenTelemetry.Instrumentation.AspNet.Tests/OpenTelemetry.Instrumentation.AspNet.Tests.csproj b/test/OpenTelemetry.Instrumentation.AspNet.Tests/OpenTelemetry.Instrumentation.AspNet.Tests.csproj
index e3499a281e..50803ac337 100644
--- a/test/OpenTelemetry.Instrumentation.AspNet.Tests/OpenTelemetry.Instrumentation.AspNet.Tests.csproj
+++ b/test/OpenTelemetry.Instrumentation.AspNet.Tests/OpenTelemetry.Instrumentation.AspNet.Tests.csproj
@@ -27,7 +27,6 @@
 
   <ItemGroup>
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\StatusHelper.cs" Link="Includes\StatusHelper.cs" />
-    <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\SpanHelper.cs" Link="Includes\SpanHelper.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\SpanAttributeConstants.cs" Link="Includes\SpanAttributeConstants.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\EnumerationHelper.cs" Link="Includes\EnumerationHelper.cs" />
     <Compile Include="$(RepoRoot)\src\OpenTelemetry.Contrib.Shared\Api\IActivityEnumerator.cs" Link="Includes\IActivityEnumerator.cs"/>