diff --git a/CMakeLists.txt b/CMakeLists.txt
index 5ad2516..11173b6 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -46,6 +46,10 @@ file(WRITE "${generatedFilesDir}/project_version_from_cmake.hpp"
     "constexpr const char* project_version = \"${PROJECT_VERSION}\";\n")
 
 add_executable(cse
+    "src/cache.hpp"
+    "src/cache.cpp"
+    "src/clean_cache.hpp"
+    "src/clean_cache.cpp"
     "src/cli_application.hpp"
     "src/cli_application.cpp"
     "src/console_utils.hpp"
diff --git a/src/cache.cpp b/src/cache.cpp
new file mode 100644
index 0000000..9a8158e
--- /dev/null
+++ b/src/cache.cpp
@@ -0,0 +1,93 @@
+#include "cache.hpp"
+
+#include <boost/filesystem.hpp>
+#include <cse/file_cache.hpp>
+#include <cse/log/logger.hpp>
+
+#include <cstdlib>
+#include <optional>
+#include <stdexcept>
+
+
+namespace
+{
+
+// A wrapper for `std::getenv()` that checks for both null and emptiness,
+// and logs a debug message and returns null in either case.
+const char* getenv(const char* variableName)
+{
+    const auto e = std::getenv(variableName);
+    if (e && *e) return e;
+    BOOST_LOG_SEV(cse::log::logger(), cse::log::debug)
+        << "Environment variable '" << variableName << "' not set.";
+    return nullptr;
+}
+
+// Obtain the (platform-specific) application cache path for the current user.
+std::optional<boost::filesystem::path> user_cache_directory_path()
+{
+#if defined(_WIN32)
+    if (const auto localAppData = getenv("LocalAppData")) {
+        return boost::filesystem::path(localAppData);
+    }
+    if (const auto userProfile = getenv("UserProfile")) {
+        return boost::filesystem::path(userProfile) / "AppData" / "Local";
+    }
+
+#elif defined(__APPLE__)
+    if (const auto home = getenv("HOME")) {
+        return boost::filesystem::path(home) / "Library" / "Caches";
+    }
+
+#else // some other UNIX-like system
+    if (const auto xdgCacheHome = getenv("XDG_CACHE_HOME")) {
+        return boost::filesystem::path(xdgCacheHome);
+    }
+    if (const auto home = getenv("HOME")) {
+        return boost::filesystem::path(home) / ".cache";
+    }
+
+#endif
+    return std::nullopt;
+}
+
+// Returns the (platform-specific) user cache path for this application.
+std::optional<boost::filesystem::path> cache_directory_path()
+{
+    if (const auto userCache = user_cache_directory_path()) {
+        return *userCache / "cse";
+    } else {
+        return std::nullopt;
+    }
+}
+
+} // namespace
+
+
+std::shared_ptr<cse::model_uri_resolver> caching_model_uri_resolver()
+{
+    if (const auto cachePath = cache_directory_path()) {
+        const auto cache = std::make_shared<cse::persistent_file_cache>(*cachePath);
+        BOOST_LOG_SEV(cse::log::logger(), cse::log::info)
+            << "Using cache directory: " << *cachePath;
+        return cse::default_model_uri_resolver(cache);
+    } else {
+        BOOST_LOG_SEV(cse::log::logger(), cse::log::warning)
+            << "Unable to determine user cache directory; caching is disabled.";
+        return cse::default_model_uri_resolver();
+    }
+}
+
+
+void clean_cache()
+{
+    if (const auto cachePath = cache_directory_path()) {
+        const auto cache = std::make_shared<cse::persistent_file_cache>(*cachePath);
+        BOOST_LOG_SEV(cse::log::logger(), cse::log::info)
+            << "Cleaning cache directory: " << *cachePath;
+        cache->cleanup();
+    } else {
+        throw std::runtime_error(
+            "Unable to determine user cache directory; cannot delete it.");
+    }
+}
diff --git a/src/cache.hpp b/src/cache.hpp
new file mode 100644
index 0000000..153f245
--- /dev/null
+++ b/src/cache.hpp
@@ -0,0 +1,17 @@
+#ifndef CSECLI_CACHE_HPP
+#define CSECLI_CACHE_HPP
+
+#include <cse/orchestration.hpp>
+
+#include <memory>
+
+
+/// Returns a caching model URI resolver.
+std::shared_ptr<cse::model_uri_resolver> caching_model_uri_resolver();
+
+
+/// Removes unused data from the application cache directory.
+void clean_cache();
+
+
+#endif // header guard
diff --git a/src/clean_cache.cpp b/src/clean_cache.cpp
new file mode 100644
index 0000000..8a37339
--- /dev/null
+++ b/src/clean_cache.cpp
@@ -0,0 +1,20 @@
+#include "clean_cache.hpp"
+
+#include "cache.hpp"
+
+
+void clean_cache_subcommand::setup_options(
+    boost::program_options::options_description& /*options*/,
+    boost::program_options::options_description& /*positionalOptions*/,
+    boost::program_options::positional_options_description& /*positions*/)
+    const noexcept
+{
+    // no options
+}
+
+
+int clean_cache_subcommand::run(const boost::program_options::variables_map& /*args*/) const
+{
+    clean_cache();
+    return 0;
+}
diff --git a/src/clean_cache.hpp b/src/clean_cache.hpp
new file mode 100644
index 0000000..3180c7c
--- /dev/null
+++ b/src/clean_cache.hpp
@@ -0,0 +1,49 @@
+#ifndef CSECLI_CLEAN_CACHE_HPP
+#define CSECLI_CLEAN_CACHE_HPP
+
+#include "cli_application.hpp"
+
+
+/// The `clean-cache` subcommand.
+class clean_cache_subcommand : public cli_subcommand
+{
+public:
+    std::string name() const noexcept override
+    {
+        return "clean-cache";
+    }
+
+    std::string brief_description() const noexcept override
+    {
+        return "Removes unused data from the program cache";
+    }
+
+    std::string long_description() const noexcept override
+    {
+        return "This command removes unused files from the directory that "
+               "contains cached CSE data for the current user.\n"
+               "\n"
+               "The primary use for the cache is to unpack FMUs in a "
+               "persistent location, "
+               "so they don't have to be unpacked over and over for each run.  "
+               "This can be a major time saver, "
+               "especially when working with large FMUs.  "
+               "Over time, however, the cache can grow to take up "
+               "a significant amount of disk space.\n"
+               "\n"
+               "This command allows for safe removal of files from the cache.  "
+               "It will remove all files that are not currently in use by a "
+               "CSE process.";
+    }
+
+    void setup_options(
+        boost::program_options::options_description& options,
+        boost::program_options::options_description& positionalOptions,
+        boost::program_options::positional_options_description& positions)
+        const noexcept override;
+
+    int run(const boost::program_options::variables_map& args) const override;
+};
+
+
+#endif
diff --git a/src/inspect.cpp b/src/inspect.cpp
index 4ea07f7..929cb2a 100644
--- a/src/inspect.cpp
+++ b/src/inspect.cpp
@@ -1,5 +1,6 @@
 #include "inspect.hpp"
 
+#include "cache.hpp"
 #include "tools.hpp"
 
 #include <boost/filesystem.hpp>
@@ -69,7 +70,7 @@ int inspect_subcommand::run(const boost::program_options::variables_map& args) c
     currentPath += boost::filesystem::path::preferred_separator;
     const auto baseUri = cse::path_to_file_uri(currentPath);
     const auto uriReference = to_uri(args["uri_or_path"].as<std::string>());
-    const auto uriResolver = cse::default_model_uri_resolver();
+    const auto uriResolver = caching_model_uri_resolver();
     const auto model = uriResolver->lookup_model(baseUri, uriReference);
     print_model_description(*model->description());
     if (args.count("no-vars") == 0) {
diff --git a/src/main.cpp b/src/main.cpp
index 3b18cef..08e3979 100644
--- a/src/main.cpp
+++ b/src/main.cpp
@@ -1,3 +1,4 @@
+#include "clean_cache.hpp"
 #include "cli_application.hpp"
 #include "inspect.hpp"
 #include "logging_options.hpp"
@@ -31,6 +32,7 @@ int main(int argc, char const* const* argv)
         "The Core Simulation Environment is free and open-source software for running distributed co-simulations.");
     app.add_global_options(std::make_unique<logging_options>());
     app.add_global_options(std::make_unique<version_option>("CSE CLI", project_version));
+    app.add_subcommand(std::make_unique<clean_cache_subcommand>());
     app.add_subcommand(std::make_unique<inspect_subcommand>());
     app.add_subcommand(std::make_unique<run_subcommand>());
     app.add_subcommand(std::make_unique<run_single_subcommand>());
diff --git a/src/run.cpp b/src/run.cpp
index 744a576..7cad727 100644
--- a/src/run.cpp
+++ b/src/run.cpp
@@ -1,5 +1,6 @@
 #include "run.hpp"
 
+#include "cache.hpp"
 #include "run_common.hpp"
 
 #include <boost/filesystem.hpp>
@@ -170,7 +171,7 @@ int run_subcommand::run(const boost::program_options::variables_map& args) const
     const auto systemStructurePath =
         boost::filesystem::path(args["system_structure_path"].as<std::string>());
 
-    const auto uriResolver = cse::default_model_uri_resolver();
+    const auto uriResolver = caching_model_uri_resolver();
     auto execution = load_system_structure(
         systemStructurePath,
         *uriResolver,
diff --git a/src/run_single.cpp b/src/run_single.cpp
index 914a2f2..5eee691 100644
--- a/src/run_single.cpp
+++ b/src/run_single.cpp
@@ -3,6 +3,7 @@
 #endif
 #include "run_single.hpp"
 
+#include "cache.hpp"
 #include "run_common.hpp"
 #include "tools.hpp"
 
@@ -253,7 +254,7 @@ int run_single_subcommand::run(const boost::program_options::variables_map& args
     currentPath += boost::filesystem::path::preferred_separator;
     const auto baseUri = cse::path_to_file_uri(currentPath);
     const auto uriReference = to_uri(args["uri_or_path"].as<std::string>());
-    const auto uriResolver = cse::default_model_uri_resolver();
+    const auto uriResolver = caching_model_uri_resolver();
     const auto model = uriResolver->lookup_model(baseUri, uriReference);
 
     std::optional<variable_values> initialValues;