diff --git a/CHANGES.md b/CHANGES.md
index 07018809ef4..3743c618276 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -53,6 +53,9 @@ Unreleased
   `copy#` and `copy_files#`. The old heuristic of looking for a module in
   parent directories is removed (#6594, @rgrinberg)
 
+- Fix inline tests with js_of_ocaml and whole program compilation mode enabled
+  (#6645, @hhugo)
+
 3.6.0 (2022-11-14)
 ------------------
 
diff --git a/src/dune_rules/inline_tests.ml b/src/dune_rules/inline_tests.ml
index 54fd88861e9..868feb3a119 100644
--- a/src/dune_rules/inline_tests.ml
+++ b/src/dune_rules/inline_tests.ml
@@ -161,13 +161,17 @@ include Sub_system.Register_end_point (struct
           Mode_conf.Set.add info.modes Byte
         else info.modes
       in
-      List.map (Mode_conf.Set.to_list modes) ~f:(fun (mode : Mode_conf.t) ->
+      List.concat_map (Mode_conf.Set.to_list modes)
+        ~f:(fun (mode : Mode_conf.t) ->
           match mode with
-          | Native -> Exe.Linkage.native
-          | Best -> Exe.Linkage.native_or_custom (Super_context.context sctx)
+          | Native -> [ Exe.Linkage.native ]
+          | Best ->
+            [ Exe.Linkage.native_or_custom (Super_context.context sctx) ]
           | Byte ->
-            Exe.Linkage.custom_with_ext ~ext:".bc" (Super_context.context sctx)
-          | Javascript -> Exe.Linkage.js)
+            [ Exe.Linkage.custom_with_ext ~ext:".bc"
+                (Super_context.context sctx)
+            ]
+          | Javascript -> [ Exe.Linkage.js; Exe.Linkage.byte_for_jsoo ])
     in
     let* (_ : Exe.dep_graphs) =
       let link_args =
diff --git a/test/blackbox-tests/test-cases/jsoo/inline-tests.t/run.t b/test/blackbox-tests/test-cases/jsoo/inline-tests.t/run.t
index 1b2d70bab0b..fff4e506fa5 100644
--- a/test/blackbox-tests/test-cases/jsoo/inline-tests.t/run.t
+++ b/test/blackbox-tests/test-cases/jsoo/inline-tests.t/run.t
@@ -11,3 +11,9 @@ Run inline tests using node js
   inline tests (JS)
   inline tests (Native)
   inline tests (Native)
+
+  $ dune runtest --profile release
+  inline tests (JS)
+  inline tests (JS)
+  inline tests (Native)
+  inline tests (Native)