diff --git a/.github/workflows/reviewers.yml b/.github/workflows/reviewers.yml
new file mode 100644
index 000000000..2ae5e3514
--- /dev/null
+++ b/.github/workflows/reviewers.yml
@@ -0,0 +1,47 @@
+name: Assign Reviewers for Uberon
+
+on:
+  pull_request:
+    types: [opened, synchronize]
+    paths:
+      - src/ontology/uberon-edit.obo
+
+jobs:
+  assign-reviewer:
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Checkout code
+        uses: actions/checkout@v3
+        with:
+          fetch-depth: 0  # Fetch the entire history for all branches
+      
+      - name: Fetch base branch
+        run: |
+          git fetch origin ${{ github.base_ref }}  # Fetch base branch explicitly
+      
+      - name: Check if equivalent class axiom was edited
+        id: check_intersection_of
+        run: |
+          git diff origin/${{ github.base_ref }}...HEAD -- src/ontology/uberon-edit.obo > diff.txt
+          if grep -E '^(-|\+)intersection_of:' diff.txt; then
+            echo "intersection_of_found=true" >> $GITHUB_ENV
+          else
+            echo "intersection_of_found=false" >> $GITHUB_ENV
+          fi
+
+      - name: Assign reviewer
+        if: env.intersection_of_found == 'true'
+        env:
+          GH_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        run: |
+          gh api repos/${{ github.repository }}/pulls/${{ github.event.pull_request.number }}/requested_reviewers \
+            --method POST \
+            --field reviewers[]=cmungall
+
+      - name: Block PR by requesting changes
+        if: env.intersection_of_found == 'true'
+        env:
+          GH_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        run: |
+          gh pr review ${{ github.event.pull_request.number }} --request-changes --body "Changes detected in \`src/ontology/uberon-edit.obo\` involving \`intersection_of\`. Review by specific Uberon Core Team member is required."