apo-edit.obo

format-version: 1.2
date: 02:02:2021 14:22
subsetdef: AspGD "APO terms in use at AspGD"
subsetdef: CGD "APO terms in use at CGD"
subsetdef: CryptoGD "APO terms in use at CryptoGD"
subsetdef: SGD "APO terms in use at SGD"
subsetdef: phenotypeslim_cerevisiae "Phenotype Slim terms for S. cerevisiae"
default-namespace: ascomycete_phenotype_ontology
ontology: apo
property_value: http://purl.org/dc/elements/1.1/modified "02:01:2021" xsd:string
property_value: http://purl.org/dc/elements/1.1/contributor "Suzi Aleksander" xsd:string
property_value: http://purl.org/dc/elements/1.1/contributor "Maria Costanzo" xsd:string
property_value: http://purl.org/dc/elements/1.1/title "Ascomycete Phenotype Ontology (APO)" xsd:string
property_value: http://purl.org/dc/elements/1.1/description "A structured controlled vocabulary for the phenotypes of Ascomycete fungi." xsd:string
property_value: http://purl.org/dc/elements/1.1/creator https://www.yeastgenome.org/
property_value: http://purl.org/dc/terms/license http://creativecommons.org/licenses/by/4.0/
remark: Filtered by Subset contains "SGD"; contact sgd-helpdesk@lists.stanford.edu
auto-generated-by: OBO-Edit 2.1
namespace-id-rule: * APO:$sequence(7,0000001,9999999)$

[Term]
id: APO:0000001
name: qualifier
namespace: qualifier
alt_id: YPO:0000001
def: "The direction of change in the mutant compared to wild type." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD

[Term]
id: APO:0000002
name: abnormal
namespace: qualifier
alt_id: YPO:0000002
def: "The observed phenotype is detectably different from that in the wild type." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000001 ! qualifier

[Term]
id: APO:0000003
name: decreased
namespace: qualifier
alt_id: YPO:0000003
def: "The observed feature is decreased compared to that in the wild type (slower, weaker, lower, smaller, etc.)." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000004
name: increased
namespace: qualifier
alt_id: YPO:0000004
def: "The observed feature is increased compared to that in the wild type (faster, stronger, higher, larger, etc.)." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000005
name: absent
namespace: qualifier
alt_id: YPO:0000005
def: "The observed feature is not detectable in the mutant." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000003 ! decreased

[Term]
id: APO:0000006
name: mutant_type
namespace: mutant_type
alt_id: YPO:0000006
def: "A description of the effect of the mutation on the gene product function." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD

[Term]
id: APO:0000007
name: misexpression
namespace: mutant_type
alt_id: YPO:0000007
def: "The mutation results in expression of the gene product at a developmental stage, in a cell type, or at a subcellular location different from that at which the wild-type gene is expressed." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000008
name: overexpression
namespace: mutant_type
alt_id: YPO:0000008
def: "The mutation causes expression of the otherwise normal gene product to higher levels than wild-type." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000009
name: activation
namespace: mutant_type
alt_id: YPO:0000009
def: "The mutation increases the normal activity of a gene product." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000010
name: gain of function
namespace: mutant_type
alt_id: YPO:0000010
def: "The mutation confers a new activity on the gene product." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000011
name: null mutant
namespace: mutant_type
alt_id: YPO:0000011
def: "The mutation abolishes completely the function of the gene product." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "loss of function" RELATED [SGD:RSN]
synonym: "null" EXACT []
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000012
name: repressible
namespace: mutant_type
alt_id: YPO:0000012
def: "The mutation leads to reduction of levels of the gene product, often through the use of a repressible promoter." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "depletion" EXACT [SGD:RSN]
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000013
name: reduction of function
namespace: mutant_type
alt_id: YPO:0000013
def: "The mutation reduces the activity of the gene product." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000014
name: conditional
namespace: mutant_type
alt_id: YPO:0000014
def: "The activity of the gene product is normal under some conditions and altered under others." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000015
name: unspecified
namespace: mutant_type
alt_id: YPO:0000015
def: "The mutation type is not specified in the reference." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000016
name: not yet recorded
namespace: mutant_type
alt_id: YPO:0000016
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because there was overlap with another term unspecified. The term unspecified will be used in cases where a more appropriate descriptor cannot be identified.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000017
name: observable
namespace: observable
alt_id: YPO:0000017
def: "Features of ascomycete fungal cells, cultures, or colonies that can be detected, observed, measured, or monitored." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD

[Term]
id: APO:0000018
name: experiment_type
namespace: experiment_type
alt_id: YPO:0000018
def: "A description of the experimental approach." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD

[Term]
id: APO:0000019
name: systematic null mutation set
namespace: experiment_type
alt_id: YPO:0000019
def: "OBSOLETE. Robotic generation and analysis of large-scale, genome-wide knockout sets." [SGD:RSN]
comment: This term was made obsolete as it is a compound term containing information on the both the scope of the experiment as well as the mutant type.
subset: AspGD
subset: SGD
is_obsolete: true
replaced_by: APO:0000011
replaced_by: APO:0000235

[Term]
id: APO:0000020
name: classical genetics
namespace: experiment_type
alt_id: YPO:0000020
def: "Phenotypic analysis of one or a few mutant strains in small-scale, focused experiments that do not require knowledge of the entire genome sequence." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000192 ! phenotype assays

[Term]
id: APO:0000021
name: competitive growth
namespace: experiment_type
alt_id: YPO:0000021
def: "Quantitative data on survival of a mutant strain, obtained in large scale experiments where mutants are grown together with wild type or other mutants for many generations." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000022
name: protein activity
namespace: observable
alt_id: YPO:0000022
def: "The enzymatic or other activity of a protein." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000023
name: development
namespace: observable
alt_id: YPO:0000023
def: "Developmental processes." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000024
name: budding
namespace: observable
alt_id: YPO:0000024
def: "The formation of a bud, which develops into a daughter cell during asexual reproduction." [SGD:mcc]
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000025
name: axial budding pattern
namespace: observable
alt_id: YPO:0000025
def: "Localization of the newly emerging bud near the site of the previous bud." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "haploid budding pattern" RELATED [SGD:RSN]
is_a: APO:0000200 ! budding pattern

[Term]
id: APO:0000026
name: bipolar budding pattern
namespace: observable
alt_id: YPO:0000026
def: "Localization of the emerging bud at the cell pole opposite the previous bud site." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "diploid budding pattern" RELATED [SGD:RSN]
is_a: APO:0000200 ! budding pattern

[Term]
id: APO:0000027
name: filamentous growth
namespace: observable
alt_id: YPO:0000027
def: "Growth in a threadlike, filamentous shape." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000028
name: invasive growth
namespace: observable
alt_id: YPO:0000028
def: "Penetration of cells into a solid substrate during filamentous growth." [SGD:rsn]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000027 ! filamentous growth

[Term]
id: APO:0000029
name: pseudohyphal growth
namespace: observable
alt_id: YPO:0000029
def: "Growth in a pattern that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [SGD:krc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000027 ! filamentous growth

[Term]
id: APO:0000030
name: lifespan
namespace: observable
alt_id: YPO:0000030
def: "The duration of the life of an individual organism." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000031
name: sexual cycle
namespace: observable
alt_id: YPO:0000031
def: "The process of sexual reproduction." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000032
name: mating response
namespace: observable
alt_id: YPO:0000032
def: "The interaction between organisms leading to mating." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000031 ! sexual cycle

[Term]
id: APO:0000033
name: cell fusion
namespace: observable
alt_id: YPO:0000033
def: "The fusion of individual cells from each partner during mating." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000034
name: mating efficiency
namespace: observable
alt_id: YPO:0000034
def: "The proportion of cells within a population that are able to mate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000035
name: nuclear fusion during mating
namespace: observable
alt_id: YPO:0000035
def: "The fusion of the nuclei of two mating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "karyogamy" EXACT []
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000036
name: pheromone production
namespace: observable
alt_id: YPO:0000036
def: "The production of mating pheromones." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000037
name: pheromone sensitivity
namespace: observable
alt_id: YPO:0000037
def: "Sensitivity to mating pheromones produced by cells of the opposite mating type." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000038
name: shmoo formation
namespace: observable
alt_id: YPO:0000038
def: "An alteration of morphology such that the cell has a mating projection, formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000032 ! mating response

[Term]
id: APO:0000039
name: meiosis
namespace: observable
alt_id: YPO:0000039
def: "A specialized cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell." [GOC:dph]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000031 ! sexual cycle

[Term]
id: APO:0000040
name: meiotic recombination
namespace: observable
alt_id: YPO:0000040
def: "The exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes during meiosis." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000039 ! meiosis

[Term]
id: APO:0000041
name: sporulation
namespace: observable
alt_id: YPO:0000041
def: "The formation of ascospores, which are the products of meiosis." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000031 ! sexual cycle

[Term]
id: APO:0000042
name: spore germination
namespace: observable
alt_id: YPO:0000042
def: "The production of viable cells arising from sexual spores." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000041 ! sporulation

[Term]
id: APO:0000043
name: spore wall formation
namespace: observable
alt_id: YPO:0000043
def: "The biogenesis of specialized cell walls around developing ascospores." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000041 ! sporulation

[Term]
id: APO:0000044
name: sporulation efficiency
namespace: observable
alt_id: YPO:0000044
def: "The percentage of diploid cells in a population that undergo meiosis and form spores under sporulation-inducing conditions." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000041 ! sporulation

[Term]
id: APO:0000045
name: sterile
namespace: observable
alt_id: YPO:0000045
def: "The sterile phenotype is the inability to mate with cells of the opposite mating type under conditions that normally promote mating." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000031 ! sexual cycle

[Term]
id: APO:0000046
name: silencing
namespace: observable
alt_id: YPO:0000046
def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000047
name: transposable element transposition
namespace: observable
alt_id: YPO:0000047
def: "Integration of a transposable element  into new positions in the genome." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000048
name: virulence
namespace: observable
alt_id: YPO:0000048
def: "The ability to cause disease in another organism." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000287 ! interaction with host/environment

[Term]
id: APO:0000049
name: morphology
namespace: observable
alt_id: YPO:0000049
def: "The size or shape of subcellular structures, cells, or multicellular structures." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000050
name: cellular morphology
namespace: observable
alt_id: YPO:0000050
def: "The size or shape of cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000049 ! morphology

[Term]
id: APO:0000051
name: cell shape
namespace: observable
alt_id: YPO:0000051
def: "The shape of the cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000052
name: cell size
namespace: observable
alt_id: YPO:0000052
def: "The size of the cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000053
name: cell wall morphology
namespace: observable
alt_id: YPO:0000053
def: "The size, shape, or appearance of the cell wall." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000054
name: cytoskeleton morphology
namespace: observable
alt_id: YPO:0000054
def: "The size, shape, or appearance of the cytoskeleton." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000055
name: mitochondrial morphology
namespace: observable
alt_id: YPO:0000055
def: "The size, shape, or appearance of the mitochondria." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000056
name: bud neck morphology
namespace: observable
alt_id: YPO:0000056
def: "The size or shape of the bud neck, which is the region where the bud joins the mother cell." [SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000057
name: nuclear morphology
namespace: observable
alt_id: YPO:0000057
def: "The size, shape, or appearance of the nucleus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000303 ! endomembrane system morphology

[Term]
id: APO:0000058
name: peroxisomal morphology
namespace: observable
alt_id: YPO:0000058
def: "The size, shape, or appearance of the peroxisomes." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000303 ! endomembrane system morphology

[Term]
id: APO:0000059
name: vacuolar morphology
namespace: observable
alt_id: YPO:0000059
def: "The size, shape, or appearance of the vacuole." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000303 ! endomembrane system morphology

[Term]
id: APO:0000060
name: colony appearance
namespace: observable
alt_id: YPO:0000060
def: "The appearance of colonies of cells growing on a solid substrate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000158 ! culture appearance

[Term]
id: APO:0000061
name: colony color
namespace: observable
alt_id: YPO:0000061
def: "The color of colonies of cells growing on a solid substrate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000060 ! colony appearance

[Term]
id: APO:0000062
name: colony shape
namespace: observable
alt_id: YPO:0000062
def: "The shape of colonies of cells growing on a solid substrate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000060 ! colony appearance

[Term]
id: APO:0000063
name: colony size
namespace: observable
alt_id: YPO:0000063
def: "The size of colonies of cells growing on a solid substrate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000060 ! colony appearance

[Term]
id: APO:0000064
name: liquid culture appearance
namespace: observable
alt_id: YPO:0000064
def: "The appearance of a liquid culture of cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000158 ! culture appearance

[Term]
id: APO:0000065
name: flocculation
namespace: observable
alt_id: YPO:0000065
def: "Adhesion and aggregation of cells in liquid culture to produce clumps of cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000064 ! liquid culture appearance

[Term]
id: APO:0000066
name: cellular processes
namespace: observable
alt_id: YPO:0000066
def: "Processes occurring at the cellular level." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000067
name: cell cycle arrest in G1 phase
namespace: observable
alt_id: YPO:0000067
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000255

[Term]
id: APO:0000068
name: cell cycle arrest at G2 phase
namespace: observable
alt_id: YPO:0000068
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000254

[Term]
id: APO:0000069
name: cell cycle arrest at START
namespace: observable
alt_id: YPO:0000069
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000256

[Term]
id: APO:0000070
name: cell cycle arrest
namespace: observable
alt_id: YPO:0000070
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000253

[Term]
id: APO:0000071
name: cytokinesis
namespace: observable
alt_id: YPO:0000071
def: "The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells." [GOC:mtg_cell_cycle]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000072 ! mitotic cell cycle

[Term]
id: APO:0000072
name: mitotic cell cycle
namespace: observable
alt_id: YPO:0000072
def: "A cycle of DNA replication and cell division via mitosis." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000073
name: intracellular transport
namespace: observable
alt_id: YPO:0000073
def: "Transport of substances within cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000074
name: autophagy
namespace: observable
alt_id: YPO:0000074
def: "The delivery and degradation of autophagy markers to the vacuole via the autophagic pathway." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000075
name: endocytosis
namespace: observable
alt_id: YPO:0000075
def: "The uptake and delivery of external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000076
name: mitochondrial transport
namespace: observable
alt_id: YPO:0000076
def: "Import of proteins into mitochondria." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000129 ! protein transport

[Term]
id: APO:0000077
name: nuclear transport
namespace: observable
alt_id: YPO:0000077
def: "Transport of proteins or RNAs into or out of the nucleus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000129 ! protein transport

[Term]
id: APO:0000078
name: protein secretion
namespace: observable
alt_id: YPO:0000078
def: "Transport of proteins out of the cell by fusion of a membrane-bounded vesicle containing the proteins by fusion of the vesicle with the plasma membrane." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "exocytosis" RELATED []
is_a: APO:0000129 ! protein transport

[Term]
id: APO:0000079
name: vacuolar transport
namespace: observable
alt_id: YPO:0000079
def: "Transport of proteins into the vacuole." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000129 ! protein transport

[Term]
id: APO:0000080
name: stress resistance
namespace: observable
alt_id: YPO:0000080
def: "The level of resistance to stress conditions." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
synonym: "resistance to stress" EXACT []
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000081
name: killer toxin resistance
namespace: observable
alt_id: YPO:0000081
def: "The level of resistance to killer toxin, which is encoded on double-stranded RNA viruses carried by some yeast strains." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to killer toxin" EXACT []
is_a: APO:0000215 ! toxin resistance

[Term]
id: APO:0000082
name: osmotic stress resistance
namespace: observable
alt_id: YPO:0000082
def: "The level of resistance to high or low osmolarity." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to osmotic stress" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000083
name: oxidative stress resistance
namespace: observable
alt_id: YPO:0000083
def: "The level of resistance to oxidative stress." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to oxidative stress" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000084
name: radiation resistance
namespace: observable
alt_id: YPO:0000084
def: "The level of resistance to radiation." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to radiation" EXACT []
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000085
name: UV resistance
namespace: observable
alt_id: YPO:0000085
def: "The level of resistance to ultraviolet radiation." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to UV" EXACT []
is_a: APO:0000084 ! radiation resistance

[Term]
id: APO:0000086
name: X ray resistance
namespace: observable
alt_id: YPO:0000086
def: "The level of resistance to X ray exposure." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to X rays" EXACT []
is_a: APO:0000194 ! ionizing radiation resistance

[Term]
id: APO:0000087
name: resistance to chemicals
namespace: observable
alt_id: YPO:0000087
def: "The level of resistance to exposure to chemicals." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000088
name: drug resistance
namespace: observable
alt_id: YPO:0000088
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete, as resistance to chemicals was deemed a better choice.
subset: AspGD
subset: SGD
is_obsolete: true
replaced_by: APO:0000087

[Term]
id: APO:0000089
name: budding index
namespace: observable
alt_id: YPO:0000089
def: "The percentage or fraction of budded cells in a population." [SGD:curators]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000024 ! budding

[Term]
id: APO:0000090
name: metal resistance
namespace: observable
alt_id: YPO:0000090
def: "The level of resistance to a specific metal or metals." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to metal" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000091
name: starvation resistance
namespace: observable
alt_id: YPO:0000091
def: "The level of resistance to starvation conditions." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to starvation" EXACT []
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000092
name: temperature sensitive growth
namespace: observable
alt_id: YPO:0000092
def: "Sensitivity to temperatures that are higher or lower than optimal growth temperature." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000093
name: thermotolerance
namespace: observable
alt_id: YPO:0000093
def: "The ability to survive a period of exposure to extremely high temperature (heat shock)." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000094
name: metabolism and growth
namespace: observable
alt_id: YPO:0000094
def: "Processes relating to metabolism and growth." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000095
name: chemical compound accumulation
namespace: observable
alt_id: YPO:0000095
def: "The production and/or storage of a specified chemical compound." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000096
name: nutrient utilization
namespace: observable
alt_id: YPO:0000096
def: "The ability to utilize specified substances as nutrients." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000097
name: auxotrophy
namespace: observable
alt_id: YPO:0000097
def: "The inability of an organism to synthesize a specified organic compound required for its growth." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000098
name: utilization of carbon source
namespace: observable
alt_id: YPO:0000098
def: "The ability to utilize the specified compound as a carbon source." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000099
name: utilization of nitrogen source
namespace: observable
alt_id: YPO:0000099
def: "The ability to utilize the specified compound as a source of nitrogen." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000100
name: nutrient uptake
namespace: observable
alt_id: YPO:0000100
def: "Uptake of nutrients into a cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000101
name: fermentative metabolism
namespace: observable
alt_id: YPO:0000101
def: "Growth with energy derived from fermentation; growth on a fermentable carbon source such as glucose." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "fermentable carbon source utilization" RELATED [SGD:RSN]
is_a: APO:0000098 ! utilization of carbon source

[Term]
id: APO:0000102
name: respiratory metabolism
namespace: observable
alt_id: YPO:0000102
def: "Growth with energy derived from respiration; growth on a non-fermentable carbon source. Examples of non-fermentable carbon sources include glycerol, ethanol, and lactate." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "non-fermentable carbon source utilization" RELATED [SGD:RSN]
is_a: APO:0000098 ! utilization of carbon source

[Term]
id: APO:0000103
name: respiratory growth rate
namespace: observable
alt_id: YPO:0000103
def: "OBSOLETE." []
subset: AspGD
subset: CryptoGD
subset: SGD
is_obsolete: true
consider: APO:0000309

[Term]
id: APO:0000104
name: mitochondrial rho- mutation frequency
namespace: observable
alt_id: YPO:0000104
def: "The frequency with rho- (rho minus) mutations occur, In this process, all of the mitochondrial genome except for a relatively short segment is lost. The retained segment is amplified and reiterated in a circular genome that is roughly the size of the wild-type genome." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000105 ! mitochondrial genome maintenance

[Term]
id: APO:0000105
name: mitochondrial genome maintenance
namespace: observable
alt_id: YPO:0000105
def: "The maintenance of a stable and complete mitochondrial genome." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000102 ! respiratory metabolism

[Term]
id: APO:0000106
name: vegetative growth
namespace: observable
alt_id: YPO:0000106
def: "Growth under standard culture conditions (liquid or solid media)." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000107
name: growth rate in exponential phase
namespace: observable
alt_id: YPO:0000107
def: "OBSOLETE: Growth rate in liquid culture during the exponential phase." [SGD:curators]
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000310

[Term]
id: APO:0000108
name: growth rate in post-diauxic phase
namespace: observable
alt_id: YPO:0000108
def: "OBSOLETE: Growth rate in liquid culture during the post-diauxic phase." [SGD:curators]
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000311

[Term]
id: APO:0000109
name: survival rate in stationary phase
namespace: observable
alt_id: YPO:0000109
def: "The rate of survival in liquid stationary phase cultures." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000106 ! vegetative growth

[Term]
id: APO:0000110
name: competitive fitness
namespace: observable
alt_id: YPO:0000110
def: "The ability of a mutant strain to grow or survive under conditions of direct competition with wild type or other mutants." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000216 ! fitness

[Term]
id: APO:0000111
name: viability
namespace: observable
alt_id: YPO:0000111
def: "The proportion of cells in a sample that are viable, i.e. able to form colonies. Often measured by spotting aliquots of a dilution series on a plate." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000216 ! fitness

[Term]
id: APO:0000112
name: inviable
namespace: observable
alt_id: YPO:0000112
def: "The inability to grow under standard growth conditions. For S. cerevisiae, this means that visible colonies are not formed from single cells on complete glucose medium (YPD) plates at 30 deg C under normal atmospheric conditions." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000217 ! essentiality

[Term]
id: APO:0000113
name: viable
namespace: observable
alt_id: YPO:0000113
def: "The ability to grow under standard growth conditions. For S. cerevisiae, this means that visible colonies are formed from single cells on complete glucose medium (YPD) plates at 30 deg C under normal atmospheric conditions." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000217 ! essentiality

[Term]
id: APO:0000114
name: large-scale survey
namespace: experiment_type
alt_id: YPO:0000114
def: "Generation and analysis of genome-wide sets of mutants that typically utilizes robotic methods." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000192 ! phenotype assays

[Term]
id: APO:0000115
name: other method
namespace: experiment_type
alt_id: YPO:0000115
def: "OBSOLETE. This term defined as 'novel techniques' has been obsoleted as it was a remnant of the original mutant types that has not been used." [SGD:curators]
comment: This term was made obsolete because it was a remnant of the original mutant types that has never been used. We will replace this using either a classical genetics or large-scale survey experiment type.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000116
name: other mutant type
namespace: mutant_type
alt_id: YPO:0000116
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it does not fit within the new descriptor terminology. In cases where a specific descriptor term cannot be identified use the term unspecified.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000117
name: normal
namespace: qualifier
alt_id: YPO:0000117
def: "The observed phenotype shows no detectable difference between the mutant and the wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "wild type" RELATED [SGD:RSN]
is_a: APO:0000001 ! qualifier

[Term]
id: APO:0000118
name: nuclear position
namespace: observable
alt_id: YPO:0000118
def: "The location of the nucleus or nuclei within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000119
name: size of nucleus
namespace: observable
alt_id: YPO:0000119
def: "The size of the nucleus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000057 ! nuclear morphology

[Term]
id: APO:0000120
name: actin cytoskeleton morphology
namespace: observable
alt_id: YPO:0000120
def: "The size, shape, or appearance of the actin cytoskeleton." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000054 ! cytoskeleton morphology

[Term]
id: APO:0000121
name: bud direction
namespace: observable
alt_id: YPO:0000121
def: "OBSOLETE: This term was not defined before being obsoleted." []
subset: CGD
subset: CryptoGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000122
name: cell cycle arrest in M phase
namespace: observable
alt_id: YPO:0000122
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000258

[Term]
id: APO:0000123
name: recovery from pheromone-induced cell cycle arrest
namespace: observable
alt_id: YPO:0000123
def: "Resumption of the cell cycle after the arrest that occurs in response to the presence of mating pheromones from cells of the opposite mating type." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000037 ! pheromone sensitivity

[Term]
id: APO:0000124
name: pheromone-induced cell cycle arrest
namespace: observable
alt_id: YPO:0000124
def: "Arrest of the cell cycle that occurs in response to the presence of mating pheromones from cells of the opposite mating type." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000037 ! pheromone sensitivity

[Term]
id: APO:0000125
name: utilization of phosphorus source
namespace: observable
alt_id: YPO:0000125
def: "The ability to utilize the specified compound as a source of phosphorus." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000126
name: nuclear import
namespace: observable
alt_id: YPO:0000126
def: "Transport of proteins or RNAs into or out of the nucleus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000077 ! nuclear transport

[Term]
id: APO:0000127
name: nuclear export
namespace: observable
alt_id: YPO:0000127
def: "Export of proteins or RNAs from the nucleus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000077 ! nuclear transport

[Term]
id: APO:0000128
name: peroxisomal transport
namespace: observable
alt_id: YPO:0000128
def: "Import of proteins into peroxisomes." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000129 ! protein transport

[Term]
id: APO:0000129
name: protein transport
namespace: observable
alt_id: YPO:0000129
def: "Delivery of proteins to specific locations." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "protein localization" RELATED [SGD:RSN]
synonym: "protein targeting" RELATED [SGD:RSN]
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000130
name: small molecule transport
namespace: observable
alt_id: YPO:0000130
def: "Transport of small molecules into, out of, or within the cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000131
name: protein/peptide modification
namespace: observable
alt_id: YPO:0000131
def: "The covalent modification of a specified protein." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000132
name: RNA localization
namespace: observable
alt_id: YPO:0000132
def: "Localization of specific RNAs within the cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000133
name: cell cycle arrest in metaphase
namespace: observable
alt_id: YPO:0000133
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000264

[Term]
id: APO:0000134
name: cell cycle arrest at the metaphase - anaphase transition
namespace: observable
alt_id: YPO:0000134
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000259

[Term]
id: APO:0000135
name: cell cycle arrest in anaphase
namespace: observable
alt_id: YPO:0000135
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000260

[Term]
id: APO:0000136
name: cell cycle arrest in early anaphase
namespace: observable
alt_id: YPO:0000136
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000261

[Term]
id: APO:0000137
name: cell cycle arrest in mid anaphase
namespace: observable
alt_id: YPO:0000137
def: "OBSOLETE. This term was not defined before being made obsolete." [RSN:SGD]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000262

[Term]
id: APO:0000138
name: cell cycle arrest in late anaphase
namespace: observable
alt_id: YPO:0000138
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000263

[Term]
id: APO:0000139
name: cell cycle arrest in telophase
namespace: observable
alt_id: YPO:0000139
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000265

[Term]
id: APO:0000140
name: cell cycle arrest in G0 (stationary phase)
namespace: observable
alt_id: YPO:0000140
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000267
consider: APO:0000268

[Term]
id: APO:0000141
name: critical cell size at START (G1 cell-size checkpoint)
namespace: observable
alt_id: YPO:0000141
def: "The cell volume (or size) which must be attained before cells can pass through START, a checkpoint which operates in G1, and commit to a full round of cell division." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000052 ! cell size

[Term]
id: APO:0000142
name: critical cell size at G2/M (cryptic G2/M cell size checkpoint)
namespace: observable
alt_id: YPO:0000142
def: "The cell volume (or size) which must be attained before cells can pass from G2 into M phase and commit to the completion of mitosis. This normally cryptic checkpoint negatively regulates passage from G2 into M phase." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000052 ! cell size

[Term]
id: APO:0000143
name: chromosome/plasmid maintenance
namespace: observable
alt_id: YPO:0000143
def: "The stable maintenance of chromosomes or plasmids." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000144
name: telomere length
namespace: observable
alt_id: YPO:0000144
def: "The average length of telomeres." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000145
name: oxidative phosphorylation
namespace: observable
alt_id: YPO:0000145
def: "The oxidation of nutrients to generate ATP, performed by enzymes of the mitochondrial inner membrane." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "respiration" RELATED [SGD:RSN]
is_a: APO:0000102 ! respiratory metabolism

[Term]
id: APO:0000146
name: systematic repressible mutation set
namespace: experiment_type
alt_id: YPO:0000146
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete as it is a compound term containing information on both the scope of the experiment as well as the repressible nature of the mutant_type.
subset: AspGD
subset: CryptoGD
subset: SGD
is_obsolete: true
replaced_by: APO:0000012
replaced_by: APO:0000235

[Term]
id: APO:0000147
name: heat sensitivity
namespace: observable
alt_id: YPO:0000147
def: "Sensitivity to temperatures that are higher than optimal growth temperature." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "temperature sensitivity" RELATED [SGD:RSN]
is_a: APO:0000092 ! temperature sensitive growth

[Term]
id: APO:0000148
name: cold sensitivity
namespace: observable
alt_id: YPO:0000148
def: "Sensitivity to temperatures that are lower than optimal growth temperature." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000092 ! temperature sensitive growth

[Term]
id: APO:0000149
name: protein/peptide accumulation
namespace: observable
alt_id: YPO:0000149
def: "Abundance of a specified peptide/protein; production to a certain level." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "protein/peptide abundance" RELATED [SGD:RSN]
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000150
name: null homozygous diploid
namespace: mutant_type
alt_id: YPO:0000150
def: "OBSOLETE. Mutation abolishes function of both alleles of the gene in a diploid strain." [SGD:RSN]
comment: This term was made obsolete because it is a compound term, with plody related information captured through the experiment_type and null captured as a mutant_type.
subset: AspGD
subset: SGD
is_obsolete: true
replaced_by: APO:0000011

[Term]
id: APO:0000151
name: null heterozygous diploid
namespace: mutant_type
alt_id: YPO:0000151
def: "OBSOLETE. Mutation abolishes function of one allele of the gene in a diploid strain." [SGD:RSN]
comment: This term was made obsolete because it is a compound term, with plody related information captured through the experiment_type and null captured as a mutant_type.
subset: AspGD
subset: SGD
is_obsolete: true
replaced_by: APO:0000011

[Term]
id: APO:0000152
name: haploinsufficient
namespace: observable
alt_id: YPO:0000152
def: "The heterozygous diploid displays a decreased growth rate relative to a diploid that is homozygous wild type at that locus." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000216 ! fitness

[Term]
id: APO:0000153
name: petite
namespace: observable
alt_id: YPO:0000153
def: "The formation of smaller than wild-type colonies on fermentable carbon sources (e.g., glucose), due to a respiratory defect. The respiratory defect could result from mutation or loss of the mitochondrial genome, or from a nuclear mutation affecting respiration. The fermentation of glucose produces ethanol, which is metabolized by the respiratory pathway in wild-type cells and contributes to colony size; respiratory-deficient mutants are unable to utilize this ethanol." [PMID:9301019, SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000102 ! respiratory metabolism

[Term]
id: APO:0000154
name: petite-negative
namespace: observable
alt_id: YPO:0000154
def: "The petite-negative phenotype arises from mutation in a nuclear gene that is not essential in an otherwise wild-type strain with an intact mitochondrial genome, but becomes essential in strains lacking the mitochondrial genome, referred to as rho- or rho0. Petite-negative strains cannot grow on fermentable carbon sources (e.g., glucose) in the absence of an intact mitochondrial genome. This phenotype is often assayed as the inability grow in the presence of ethidium bromide, which causes the loss of the mitochondrial genome." [PMID:16267274, SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000102 ! respiratory metabolism

[Term]
id: APO:0000155
name: apoptosis
namespace: observable
alt_id: YPO:0000155
def: "An energy-dependent, programmed form of cell death that is characterized by phenotypic markers such as increased levels of reactive oxygen species (often detected via DHE staining), externalization of phosphatidylserine (measured by annexin V staining), and DNA fragmentation (detected using the TUNEL assay). Other processes observed during apoptosis include chromosome condensation and breakdown of mitochondria, including loss of membrane potential and release of cytochrome c. Cells undergoing apoptosis do not lose plasma membrane integrity (measured by propidium iodide staining) until late in the process." [PMID:15556039, PMID:18452540, PMID:18500447, PMID:18782613, PMID:19416362, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000312 ! cell death

[Term]
id: APO:0000156
name: fermentative growth rate
namespace: observable
alt_id: YPO:0000156
def: "OBSOLETE: The rate of growth in the presence of a fermentable carbon source." [SGD:curators]
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000308

[Term]
id: APO:0000157
name: utilization of iron source
namespace: observable
alt_id: YPO:0000157
def: "The ability to utilize the specified compound as a source of iron." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000158
name: culture appearance
namespace: observable
alt_id: YPO:0000158
def: "The appearance of a population of cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000049 ! morphology

[Term]
id: APO:0000159
name: biofilm formation
namespace: observable
alt_id: YPO:0000159
def: "The ability to form a layer on solid surfaces with or without other microorganisms." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000158 ! culture appearance

[Term]
id: APO:0000160
name: hyphal growth
namespace: observable
alt_id: YPO:0000160
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000027 ! filamentous growth

[Term]
id: APO:0000161
name: multiple
namespace: mutant_type
alt_id: YPO:0000161
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because it was a remnant of the original mutant types that does not fit within the new descriptor choices.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000162
name: Affinity Capture-MS
namespace: experiment_type
alt_id: YPO:0000162
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000163
name: Affinity Capture-RNA
namespace: experiment_type
alt_id: YPO:0000163
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000164
name: interactions
namespace: experiment_type
alt_id: YPO:0000164
subset: SGD
is_a: APO:0000018 ! experiment_type

[Term]
id: APO:0000165
name: Affinity Capture-Western
namespace: experiment_type
alt_id: YPO:0000165
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000166
name: Biochemical Activity
namespace: experiment_type
alt_id: YPO:0000166
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000167
name: Co-crystal Structure
namespace: experiment_type
alt_id: YPO:0000167
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000168
name: Co-fractionation
namespace: experiment_type
alt_id: YPO:0000168
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000169
name: Co-localization
namespace: experiment_type
alt_id: YPO:0000169
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000170
name: Co-purification
namespace: experiment_type
alt_id: YPO:0000170
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000171
name: Dosage Growth Defect
namespace: experiment_type
alt_id: YPO:0000171
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000172
name: Dosage Lethality
namespace: experiment_type
alt_id: YPO:0000172
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000173
name: Dosage Rescue
namespace: experiment_type
alt_id: YPO:0000173
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000174
name: Epistatic MiniArray Profile
namespace: experiment_type
alt_id: YPO:0000174
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000175
name: FRET
namespace: experiment_type
alt_id: YPO:0000175
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000176
name: Far Western
namespace: experiment_type
alt_id: YPO:0000176
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000177
name: Phenotypic Enhancement
namespace: experiment_type
alt_id: YPO:0000177
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000178
name: Phenotypic Suppression
namespace: experiment_type
alt_id: YPO:0000178
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000179
name: Protein-RNA
namespace: experiment_type
alt_id: YPO:0000179
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000180
name: Protein-peptide
namespace: experiment_type
alt_id: YPO:0000180
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000181
name: Reconstituted Complex
namespace: experiment_type
alt_id: YPO:0000181
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000182
name: Synthetic Growth Defect
namespace: experiment_type
alt_id: YPO:0000182
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000183
name: Synthetic Lethality
namespace: experiment_type
alt_id: YPO:0000183
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000184
name: Synthetic Rescue
namespace: experiment_type
alt_id: YPO:0000184
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000185
name: Two-hybrid
namespace: experiment_type
alt_id: YPO:0000185
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000186
name: genetic interactions
namespace: experiment_type
alt_id: YPO:0000186
subset: SGD
is_a: APO:0000164 ! interactions

[Term]
id: APO:0000187
name: physical interactions
namespace: experiment_type
alt_id: YPO:0000187
subset: SGD
is_a: APO:0000164 ! interactions

[Term]
id: APO:0000188
name: Affinity Chromatography
namespace: experiment_type
alt_id: YPO:0000188
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000189
name: Affinity Precipitation
namespace: experiment_type
alt_id: YPO:0000189
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000190
name: Biochemical Assay
namespace: experiment_type
alt_id: YPO:0000190
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000191
name: Purified Complex
namespace: experiment_type
alt_id: YPO:0000191
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000192
name: phenotype assays
namespace: experiment_type
alt_id: YPO:0000192
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000018 ! experiment_type

[Term]
id: APO:0000193
name: resistance to enzymatic treatment
namespace: observable
alt_id: YPO:0000193
def: "The level of resistance to treatment with enzymes." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000194
name: ionizing radiation resistance
namespace: observable
alt_id: YPO:0000194
def: "The level of resistance to ionizing radiation." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to ionizing radiation" EXACT []
is_a: APO:0000084 ! radiation resistance

[Term]
id: APO:0000195
name: gamma ray resistance
namespace: observable
alt_id: YPO:0000195
def: "The level of resistance to gamma radiation." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to gamma rays" EXACT []
is_a: APO:0000194 ! ionizing radiation resistance

[Term]
id: APO:0000196
name: mating type switching
namespace: observable
alt_id: YPO:0000196
def: "Conversion of a cell of one mating type to a different mating type." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000031 ! sexual cycle

[Term]
id: APO:0000197
name: colony sectoring
namespace: observable
alt_id: YPO:0000197
def: "Formation of wedge-shaped sectors, with a different color or appearance, in colonies of cells growing on a solid substrate." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000060 ! colony appearance

[Term]
id: APO:0000198
name: mutation frequency
namespace: observable
alt_id: YPO:0000198
def: "The frequency with which mutations occur." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000199
name: chitin deposition
namespace: observable
alt_id: YPO:0000199
def: "The pattern of chitin deposition in the cell wall." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000053 ! cell wall morphology

[Term]
id: APO:0000200
name: budding pattern
namespace: observable
alt_id: YPO:0000200
def: "The pattern with which buds emerge from a mother cell." [SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000024 ! budding

[Term]
id: APO:0000201
name: acid pH resistance
namespace: observable
alt_id: YPO:0000201
def: "The level of resistance to acidic pH." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to acid pH" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000202
name: alkaline pH resistance
namespace: observable
alt_id: YPO:0000202
def: "The level of resistance to alkaline pH." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to alkaline pH" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000203
name: hypoosmotic stress resistance
namespace: observable
alt_id: YPO:0000203
def: "The level of resistance to low osmolarity." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to hypoosmotic stress" EXACT []
is_a: APO:0000082 ! osmotic stress resistance

[Term]
id: APO:0000204
name: hyperosmotic stress resistance
namespace: observable
alt_id: YPO:0000204
def: "The level of resistance to high osmolarity." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to hyperosmotic stress" EXACT []
is_a: APO:0000082 ! osmotic stress resistance

[Term]
id: APO:0000205
name: ionic stress resistance
namespace: observable
alt_id: YPO:0000205
def: "The level of resistance to ionic stress." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to ionic stress" EXACT []
is_a: APO:0000087 ! resistance to chemicals

[Term]
id: APO:0000206
name: heterozygous diploid
namespace: mutant_type
alt_id: YPO:0000206
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because all ploidy related terms will be integrated into experiment_type terms.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000207
name: homozygous diploid
namespace: mutant_type
alt_id: YPO:0000207
def: "OBSOLETE. This term was not defined before being made obsolete." [SGD:RSN]
comment: This term was made obsolete because all ploidy related terms will be integrated into experiment_type terms.
subset: AspGD
subset: SGD
is_obsolete: true

[Term]
id: APO:0000208
name: chromosome segregation
namespace: observable
alt_id: YPO:0000208
def: "The physical separation of chromosomes and their distribution to two or more sets during mitosis or meiosis." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000209
name: protein/peptide distribution
namespace: observable
alt_id: YPO:0000209
def: "The location(s) where the specified protein is found within the cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000210
name: anaerobic metabolism
namespace: observable
alt_id: YPO:0000210
def: "Metabolism during growth in the absence of oxygen." [SGD:curators]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000211
name: anaerobic growth rate
namespace: observable
alt_id: YPO:0000211
def: "OBSOLETE: The rate of growth in the absence of oxygen." [SGD:curators]
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000307

[Term]
id: APO:0000212
name: bud morphology
namespace: observable
alt_id: YPO:0000212
def: "The size or shape of the bud." [SGD:curators]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000213
name: spindle morphology
namespace: observable
alt_id: YPO:0000213
def: "The size, shape, or appearance of the mitotic or meiotic spindle." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000054 ! cytoskeleton morphology

[Term]
id: APO:0000214
name: position of spindle pole body
namespace: observable
alt_id: YPO:0000214
def: "The position of the mitotic or meiotic spindle pole body." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000213 ! spindle morphology

[Term]
id: APO:0000215
name: toxin resistance
namespace: observable
alt_id: YPO:0000215
def: "The level of resistance to toxins, poisonous compounds that are produced by cells or organisms." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to toxin" EXACT []
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000216
name: fitness
namespace: observable
alt_id: YPO:0000216
def: "The ability of an organism to reproduce and to produce viable progeny." [SGD:curators]
comment: This is a top-level term that is not to be used for curation.
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000217
name: essentiality
namespace: observable
alt_id: YPO:0000217
def: "The essentiality of a gene for survival under standard conditions for growth of that organism." [SGD:curators]
comment: This is a top-level term, not to be used for curation.
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000218
name: redox state
namespace: observable
alt_id: YPO:0000218
def: "The balance of oxidized and reduced molecules in the cell. Respiration and various environmental factors cause formation of reactive oxygen species which can oxidize and damage cellular components." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000219
name: utilization of sulfur source
namespace: observable
alt_id: YPO:0000219
def: "The ability to utilize the specified compound as a source of sulfur." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000220
name: necrotic cell death
namespace: observable
alt_id: YPO:0000220
def: "A form of cell death that is distinct from apoptosis. Cells undergoing necrotic cell death undergo overall destruction. They can be distinguished from apoptotic cells because they lose membrane integrity, which only happens late in apoptosis (positive propidium iodide staining), and do not externalize phosphatidylserine (measured by annexin V staining) as do apoptotic cells." [PMID:11535781, PMID:18656474, PMID:18782613, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000312 ! cell death

[Term]
id: APO:0000221
name: septum formation
namespace: observable
alt_id: YPO:0000221
def: "Formation of a septum between dividing cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000053 ! cell wall morphology

[Term]
id: APO:0000222
name: chemical compound excretion
namespace: observable
alt_id: YPO:0000222
def: "The excretion from the cell of a specified chemical compound." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000223
name: mating projection morphology
namespace: observable
alt_id: YPO:0000223
def: "The outward appearance or shape of the mating projection." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000224
name: RNA accumulation
namespace: observable
alt_id: YPO:0000224
def: "Abundance of a specified RNA or class of RNAs." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000225
name: mitotic recombination
namespace: observable
alt_id: YPO:0000225
def: "Measures of the rate of recombination or total recombination observed during the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000072 ! mitotic cell cycle
is_a: APO:0000143 ! chromosome/plasmid maintenance

[Term]
id: APO:0000226
name: subcellular morphology
namespace: observable
alt_id: YPO:0000226
def: "The size, shape, or appearance of subcellular organelles or structures." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000050 ! cellular morphology

[Term]
id: APO:0000227
name: cell cycle arrest in S phase
namespace: observable
alt_id: YPO:0000227
def: "OBSOLETE. Arrest of cells in the S phase of the cell cycle, the phase in which DNA replication occurs." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000266

[Term]
id: APO:0000228
name: dominant negative
namespace: mutant_type
alt_id: YPO:0000228
def: "The mutation results in a gene product that interferes with the function of the normal, wild-type gene product." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000006 ! mutant_type

[Term]
id: APO:0000229
name: homozygous diploid
namespace: experiment_type
alt_id: YPO:0000229
def: "Classical genetics experiments carried out in a diploid background, where both alleles of the gene being described are identical." [SGD:RSN]
subset: CryptoGD
subset: SGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000230
name: heterozygous diploid
namespace: experiment_type
alt_id: YPO:0000230
def: "Classical genetics experiments carried out in a diploid background, where alleles of the gene being described are not identical." [SGD:RSN]
subset: CryptoGD
subset: SGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000231
name: homozygous diploid, large-scale survey
namespace: experiment_type
alt_id: YPO:0000231
def: "Any large-scale survey where the experiments are carried out in a homozygous diploid background." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000232
name: heterozygous diploid, large-scale survey
namespace: experiment_type
alt_id: YPO:0000232
def: "Any large-scale survey where the experiments carried our are in a heterozygous diploid background." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000233
name: homozygous diploid, competitive growth
namespace: experiment_type
alt_id: YPO:0000233
def: "Any competitive growth experiment carried out in a homozygous diploid background." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000021 ! competitive growth

[Term]
id: APO:0000234
name: heterozygous diploid, competitive growth
namespace: experiment_type
alt_id: YPO:0000234
def: "Any competitive growth experiment carried out in a heterozygous diploid background." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000021 ! competitive growth

[Term]
id: APO:0000235
name: systematic mutation set
namespace: experiment_type
alt_id: YPO:0000235
def: "Robotic generation and analysis of large-scale, genome-wide haploid knockout sets." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000236
name: homozygous diploid, systematic mutation set
namespace: experiment_type
alt_id: YPO:0000236
def: "Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in a homozygous diploid background." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000235 ! systematic mutation set

[Term]
id: APO:0000237
name: heterozygous diploid, systematic mutation set
namespace: experiment_type
alt_id: YPO:0000237
def: "Robotic generation and analysis of large-scale, genome-wide mutation sets carried out in a heterozygous diploid." [SGD:RSN]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000235 ! systematic mutation set

[Term]
id: APO:0000238
name: cell cycle arrest at the G2/M phase transition
namespace: observable
alt_id: YPO:0000238
def: "OBSOLETE. Arrest of cells at the transition between the G2 and M phases of the mitotic cell cycle." [SGD:RSN]
comment: This term was made obsolete because it incorporates a temporal aspect (arrest), and will therefore be replaced by a combination of an analagous observable that does not contain temporal information and a temporal qualifier.
subset: AspGD
subset: SGD
is_obsolete: true
consider: APO:0000250
consider: APO:0000257

[Term]
id: APO:0000239
name: pexophagy
namespace: observable
alt_id: YPO:0000239
def: "A form of autophagy selective for peroxisomes that occurs in response to starvation, damage or as a homeostatic mechanism to regulate the levels of this organelle. Pexophagy can be further subdivided into micropexophagy, the engulfment of a cluster of peroxisomes at the vacuole surface and macropexophagy, the sequestration of individual peroxisomes by a double-membrane vesicle, followed by fusion with the vacuole." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy

[Term]
id: APO:0000240
name: mitophagy
namespace: observable
alt_id: YPO:0000240
def: "A form of autophagy selective for mitochondria that occurs in response to starvation, damage or during a shift in environmental conditions. The process can be further subdivided into micromitophagy, the engulfment of a cluster of mitochondria at the vacuole surface, and macromitophagy, the sequestration of individual mitochondria by a double-membrane vesicle, followed by fusion with the vacuole." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy

[Term]
id: APO:0000241
name: freeze-thaw resistance
namespace: observable
alt_id: YPO:0000241
def: "The level of resistance to one or more cycles of freezing and thawing." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to freeze-thaw treatment" EXACT []
is_a: APO:0000080 ! stress resistance

[Term]
id: APO:0000242
name: lipid particle morphology
namespace: observable
alt_id: YPO:0000242
def: "The size, shape, or appearance of lipid particles or droplets, subcellular structures consisting of a hydrophobic core of neutral lipids (triacylglycerol and steryl esters), surrounded by a phospholipid monolayer with a small quantity of embedded proteins including enzymes involved in lipid biosynthesis. Lipid particles function as a storage compartment for lipid components." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "lipid body" EXACT [SGD:RSN]
synonym: "lipid droplet" EXACT [SGD:RSN]
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000243
name: Golgi morphology
namespace: observable
alt_id: YPO:0000243
def: "The size, shape or appearance of the Golgi apparatus or its parts." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000303 ! endomembrane system morphology

[Term]
id: APO:0000244
name: PCA
namespace: experiment_type
alt_id: YPO:0000244
subset: SGD
xref: BioGRID:curators
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000245
name: decreased rate
namespace: qualifier
alt_id: curators
def: "Observed feature is decreased with respect to time compared to that in the wild type (slower)." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "slower" EXACT [SGD:RSN]
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000246
name: increased rate
namespace: qualifier
alt_id: YPO:0000246
def: "Observed feature is increased with respect to time compared to that in the wild type (faster, accelerated)." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "accelerated" RELATED [SGD:RSN]
synonym: "faster" EXACT [SGD:RSN]
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000247
name: decreased duration
namespace: qualifier
alt_id: YPO:0000247
def: "Observed feature occurs over a decreased period of time relative to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "decreased length" EXACT [SGD:RSN]
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000248
name: increased duration
namespace: qualifier
alt_id: YPO:0000248
def: "Observed feature occurs over an increased period of time relative to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "increased length" EXACT [SGD:RSN]
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000249
name: delayed
namespace: qualifier
alt_id: YPO:0000249
def: "Observed feature occurs after being postponed for a period of time relative to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "postponed" EXACT [SGD:RSN]
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000250
name: arrested
namespace: qualifier
alt_id: YPO:0000250
def: "Observed feature does not occur in a given time period relative to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000251
name: premature
namespace: qualifier
alt_id: YPO:0000251
def: "Observed feature occurs too soon, existing before the proper or usual time compared to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000002 ! abnormal

[Term]
id: APO:0000252
name: normal rate
namespace: qualifier
alt_id: YPO:0000252
def: "Observed feature occurs at the same time relative to wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000117 ! normal

[Term]
id: APO:0000253
name: cell cycle progression
namespace: observable
alt_id: YPO:0000253
def: "Progression of cells through the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000072 ! mitotic cell cycle

[Term]
id: APO:0000254
name: cell cycle progression in G2 phase
namespace: observable
alt_id: YPO:0000254
def: "Progression of cells through the G2 phase or second gap phase of the mitotic cell cycle, the interval between the completion of DNA synthesis and the beginning of mitosis." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000255
name: cell cycle progression in G1 phase
namespace: observable
alt_id: YPO:0000255
def: "Progression of cells through the G1 or first gap phase of the mitotic cell cycle, the interval between the completion of mitosis and the beginning of DNA synthesis." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000256
name: cell cycle passage through START
namespace: observable
alt_id: YPO:0000256
def: "Passage of cells through cell cycle control point or checkpoint located late in the G1 phase of the mitotic cell cycle just prior to S phase entry; passage through START results in commits cells to progression through the entire cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "G1 checkpoint" EXACT [SGD:RSN]
is_a: APO:0000255 ! cell cycle progression in G1 phase

[Term]
id: APO:0000257
name: cell cycle progression through the G2/M phase transition
namespace: observable
alt_id: YPO:0000257
def: "Progression of cells from G2 phase to M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000258
name: cell cycle progression in M phase
namespace: observable
alt_id: YPO:0000258
def: "Progression of cells through the M phase of the mitotic cell cycle, the phase in which mitosis occurs." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000259
name: cell cycle passage through the metaphase-anaphase transition
namespace: observable
alt_id: YPO:0000259
def: "Progression of cells from metaphase to anaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000258 ! cell cycle progression in M phase

[Term]
id: APO:0000260
name: cell cycle progression in anaphase
namespace: observable
alt_id: YPO:0000260
def: "Progression of cells through anaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000258 ! cell cycle progression in M phase

[Term]
id: APO:0000261
name: cell cycle progression in early anaphase
namespace: observable
alt_id: YPO:0000261
def: "Progression of cells through early anaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000260 ! cell cycle progression in anaphase

[Term]
id: APO:0000262
name: cell cycle progression in mid anaphase
namespace: observable
alt_id: YPO:0000262
def: "Progression of cells through mid anaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000260 ! cell cycle progression in anaphase

[Term]
id: APO:0000263
name: cell cycle progression in late anaphase
namespace: observable
alt_id: YPO:0000263
def: "Progression of cells through late anaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000260 ! cell cycle progression in anaphase

[Term]
id: APO:0000264
name: cell cycle progression in metaphase
namespace: observable
alt_id: YPO:0000264
def: "Progression of cells through metaphase during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000258 ! cell cycle progression in M phase

[Term]
id: APO:0000265
name: cell cycle progression in telophase
namespace: observable
alt_id: YPO:0000265
def: "Progression of cells through telophase, the last of the stages of mitosis during M phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000258 ! cell cycle progression in M phase

[Term]
id: APO:0000266
name: cell cycle progression in S phase
namespace: observable
alt_id: YPO:0000266
def: "Progression of cells through S phase, the part of the mitotic cell cycle where DNA synthesis occurs." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000267
name: entry into G0 (stationary phase)
namespace: observable
alt_id: YPO:0000267
def: "Entry of cells into the G0 or stationary phase of the mitotic cell cycle, where they enter a quiescent state." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000072 ! mitotic cell cycle

[Term]
id: APO:0000268
name: exit from G0 (stationary phase)
namespace: observable
alt_id: YPO:0000268
def: "Exit of cells from the G0 or stationary phase of the mitotic cell cycle, where they move from a quiescent state to one where growth and division resumes in the G1 phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000072 ! mitotic cell cycle

[Term]
id: APO:0000269
name: cell cycle progression through the G1/S phase transition
namespace: observable
alt_id: YPO:0000269
def: "Progression of cells from G1 phase to S phase of the mitotic cell cycle." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000253 ! cell cycle progression

[Term]
id: APO:0000270
name: endoplasmic reticulum morphology
namespace: observable
alt_id: YPO:0000270
def: "The size, shape, or appearance of the endoplasmic reticulum (ER) or its parts." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000303 ! endomembrane system morphology

[Term]
id: APO:0000271
name: RNA modification
namespace: observable
alt_id: YPO:0000271
def: "Covalent modification of a specified RNA; type of modification specified." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000272
name: Synthetic Haploinsufficiency
namespace: experiment_type
alt_id: YPO:0000272
subset: SGD
xref: BioGRID:curators
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000273
name: nucleolar morphology
namespace: observable
alt_id: curators
def: "The size, shape, or appearance of the nucleolus or its parts." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000057 ! nuclear morphology

[Term]
id: APO:0000274
name: prion state
namespace: observable
alt_id: YPO:0000274
def: "The presence or absence of prions." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000275
name: prion inheritance
namespace: observable
alt_id: YPO:0000275
def: "The transmission of prions from a mother cell to a daughter cell during budding." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000274 ! prion state

[Term]
id: APO:0000276
name: prion formation
namespace: observable
alt_id: YPO:0000276
def: "The conversion from the state of being prion-free to the state of having prions." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "prion acquisition" EXACT []
is_a: APO:0000274 ! prion state

[Term]
id: APO:0000277
name: prion loss
namespace: observable
alt_id: YPO:0000277
def: "The conversion from the state of having prions to the state of being prion-free." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "prion curing" RELATED []
is_a: APO:0000274 ! prion state

[Term]
id: APO:0000278
name: normal duration
namespace: qualifier
alt_id: YPO:0000278
def: "Observed feature does not change with respect to time compared to that in the wild type." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000117 ! normal

[Term]
id: APO:0000279
name: haploid, classical genetics
namespace: experiment_type
def: "Any classical genetics experiment carried out in a haploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000280
name: haploid, competitive growth
namespace: experiment_type
def: "Any competitive growth experiment carried out in a haploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000021 ! competitive growth

[Term]
id: APO:0000281
name: haploid, large-scale survey
namespace: experiment_type
def: "Any large-scale survey experiment carried out in a haploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000282
name: aneuploid, classical genetics
namespace: experiment_type
def: "Any classical genetics experiment carried out in an aneuploid background, where the strain carries more or fewer copies than normal of a large chromosomal region, or of one or more entire chromosomes." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000283
name: aneuploid, large-scale survey
namespace: experiment_type
def: "Any large-scale survey experiment carried out in an aneuploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000114 ! large-scale survey

[Term]
id: APO:0000284
name: aneuploid, competitive growth
namespace: experiment_type
def: "Any competitive growth experiment carried out in an aneuploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000021 ! competitive growth

[Term]
id: APO:0000285
name: haploid, systematic mutation set
namespace: experiment_type
def: "Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in a haploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000235 ! systematic mutation set

[Term]
id: APO:0000286
name: aneuploid, systematic mutation set
namespace: experiment_type
def: "Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in an aneuploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000235 ! systematic mutation set

[Term]
id: APO:0000287
name: interaction with host/environment
namespace: observable
def: "Processes relating to interaction with the environment or with a host organism." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000017 ! observable

[Term]
id: APO:0000288
name: adhesion
namespace: observable
def: "Adherence to a substrate in the environment or in a host." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000287 ! interaction with host/environment

[Term]
id: APO:0000289
name: response to light
namespace: observable
def: "The response to visible light." [AspGD:mcc]
subset: AspGD
subset: CryptoGD
is_a: APO:0000287 ! interaction with host/environment

[Term]
id: APO:0000290
name: allergy induction
namespace: observable
def: "OBSOLETE: The induction of an allergic response in the host organism." [AspGD:mcc]
subset: AspGD
subset: CryptoGD
is_obsolete: true

[Term]
id: APO:0000291
name: formation of anatomical structure
namespace: observable
def: "The development of a discrete anatomical structure." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000292
name: secondary metabolite production
namespace: observable
def: "The production of secondary metabolites, which are compounds that are not directly involved in normal growth, development or reproduction." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000094 ! metabolism and growth

[Term]
id: APO:0000293
name: utilization of zinc source
namespace: observable
def: "The ability to utilize the specified compound as a source of zinc." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000294
name: utilization of magnesium source
namespace: observable
def: "The ability to utilize the specified compound as a source of magnesium." [AspGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000096 ! nutrient utilization

[Term]
id: APO:0000295
name: conidiation
namespace: observable
def: "The formation of conidia, which are asexual spores." [AspGD:mcc]
subset: AspGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000296
name: organelle distribution
namespace: observable
def: "The localization and placement of a particular organelle." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000073 ! intracellular transport

[Term]
id: APO:0000297
name: mitochondrial distribution
namespace: observable
def: "The localization and placement of mitochondria within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000298
name: peroxisomal distribution
namespace: observable
def: "The localization and placement of peroxisomes within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000299
name: vacuolar distribution
namespace: observable
def: "The localization and placement of vacuoles within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000300
name: endoplasmic reticulum distribution
namespace: observable
def: "The localization and placement of endoplasmic reticulum (ER) within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000301
name: Golgi distribution
namespace: observable
def: "The localization and placement of the Golgi apparatus within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000302
name: vesicle distribution
namespace: observable
def: "The localization and placement of secretory, endocytic, or undefined vesicles within a cell or between separating cells." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000296 ! organelle distribution

[Term]
id: APO:0000303
name: endomembrane system morphology
namespace: observable
def: "The size, shape, or appearance of components of the endomembrane system, which includes the nuclear envelope, endoplasmic reticulum, Golgi apparatus, peroxisomes, vacuoles, and endocytic and exocytic vesicles." [PMID:19121819, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000304
name: heterozygous diploid, classical genetics
namespace: experiment_type
def: "Any classical genetics experiment carried out in a heterozygous diploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000305
name: homozygous diploid, classical genetics
namespace: experiment_type
def: "Any classical genetics experiment carried out in a homozygous diploid background." [AspGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000020 ! classical genetics

[Term]
id: APO:0000306
name: conidial germination
namespace: observable
def: "The production of viable cells arising from conidia, or asexual spores." [AspGD:mcc]
subset: AspGD
is_a: APO:0000295 ! conidiation

[Term]
id: APO:0000307
name: anaerobic growth
namespace: observable
def: "Growth in the absence of oxygen." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000210 ! anaerobic metabolism

[Term]
id: APO:0000308
name: fermentative growth
namespace: observable
def: "Growth while utilizing a fermentable carbon source." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000101 ! fermentative metabolism

[Term]
id: APO:0000309
name: respiratory growth
namespace: observable
def: "Growth while utilizing a nonfermentable carbon source." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000102 ! respiratory metabolism

[Term]
id: APO:0000310
name: growth in exponential phase
namespace: observable
def: "Growth in liquid culture during the exponential phase." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000106 ! vegetative growth

[Term]
id: APO:0000311
name: growth in post-diauxic phase
namespace: observable
def: "Growth in liquid culture during the post-diauxic phase." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000106 ! vegetative growth

[Term]
id: APO:0000312
name: cell death
namespace: observable
def: "The cessation of the life of an individual cell." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000066 ! cellular processes

[Term]
id: APO:0000313
name: autolysis
namespace: observable
def: "A regulated form of cell death that occurs in stationary phase mycelial cultures of filamentous fungi, often in response to carbon starvation. It is characterized by cell wall degradation, hyphal fragmentation and vacuolization, production of intracellular and extracellular hydrolases, and release of ammonia." [AspGD:mcc, PMID:12892635, PMID:18975147, PMID:19286987]
subset: AspGD
is_a: APO:0000312 ! cell death

[Term]
id: APO:0000314
name: cell lysis
namespace: observable
def: "The breaking apart of a fully formed cell." [AspGD:di]
subset: AspGD
subset: CryptoGD
is_a: APO:0000312 ! cell death

[Term]
id: APO:0000315
name: plasma membrane morphology
namespace: observable
def: "The size, shape, or appearance of the plasma membrane." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000226 ! subcellular morphology

[Term]
id: APO:0000316
name: chronological lifespan
namespace: observable
def: "The number of days that a culture remains viable in stationary phase." [PMID:17634577, SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000030 ! lifespan

[Term]
id: APO:0000317
name: replicative lifespan
namespace: observable
def: "The number of divisions that a cell undergoes before dying." [PMID:17634577, SGD:mcc]
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000030 ! lifespan

[Term]
id: APO:0000318
name: Affinity Capture-Luminescence
namespace: experiment_type
def: "An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag." [BioGRID:mcc]
subset: SGD
is_a: APO:0000187 ! physical interactions

[Term]
id: APO:0000319
name: chlamydospore formation
namespace: observable
def: "Formation of chlamydospores, which are large, asexual, one-celled spores with a thickened, refractile cell wall that are borne on the ends of suspensor cells attached to hyphae or pseudohyphae." [CGD:mcc, PMID:14663094]
subset: CGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000320
name: germ tube formation
namespace: observable
def: "Formation of an elongated evagination that develops from a yeast-form cell and continues growth to become a hyphal cell. The initiation of germ tube growth is referred to as the yeast-to-hyphal transition." [CGD:mcc, PMID:17506678]
subset: CGD
is_a: APO:0000027 ! filamentous growth

[Term]
id: APO:0000321
name: phenotypic switching
namespace: observable
def: "The ability to undergo a reversible change from one distinct phenotype to another, resulting from changes in gene expression rather than from mutation. Cells in a specific phenotypic state have a distinct cellular morphology, which may be reflected in distinct colony morphology and different cellular properties, such as the ability to mate. A well-known example of phenotypic switching is the white-opaque switch of Candida albicans." [CGD:mcc, PMID:16313617, PMID:17506678]
subset: CGD
subset: CryptoGD
is_a: APO:0000023 ! development

[Term]
id: APO:0000322
name: Negative Genetic
namespace: experiment_type
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000323
name: Positive Genetic
namespace: experiment_type
subset: SGD
is_a: APO:0000186 ! genetic interactions

[Term]
id: APO:0000324
name: resistance to killing by host cells
namespace: observable
def: "The ability of a pathogen to survive an attack by host cells such as neutrophils." [CGD:mcc, PMID:20415594]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000287 ! interaction with host/environment
created_by: Maria
creation_date: 2010-05-12T09:18:26Z

[Term]
id: APO:0000325
name: resistance to phagocytosis
namespace: observable
def: "The ability of a pathogen to evade or escape phagocytosis by host cells such as macrophages." [CGD:mcc, PMID:16759234]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000287 ! interaction with host/environment
created_by: Maria
creation_date: 2010-05-12T09:20:05Z

[Term]
id: APO:0000326
name: desiccation resistance
namespace: observable
def: "The level of resistance to air-drying or desiccation stress." [PMID:18224659, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to desiccation" EXACT []
is_a: APO:0000080 ! stress resistance
created_by: Maria
creation_date: 2010-05-12T09:22:02Z

[Term]
id: APO:0000327
name: hydrostatic pressure resistance
namespace: observable
def: "The level of resistance to increased hydrostatic pressure." [PMID:11027279, PMID:18245339, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "resistance to hydrostatic pressure" EXACT []
is_a: APO:0000080 ! stress resistance
created_by: Maria
creation_date: 2010-05-12T09:22:53Z

[Term]
id: APO:0000328
name: unknown ploidy, classical genetics
namespace: experiment_type
def: "Any classical genetics experiment carried out in a background where the ploidy of the mutation or strain is unknown." [CGD:mcc]
subset: CGD
subset: CryptoGD
is_a: APO:0000020 ! classical genetics
created_by: Maria
creation_date: 2010-10-26T03:35:09Z

[Term]
id: APO:0000329
name: induction of host response
namespace: observable
def: "The induction of host immune cell differentiation, cytokine secretion, cytokine transcriptional regulation or other related host responses to infection by or contact with a microbe." [AspGD:doi]
subset: AspGD
subset: CGD
subset: CryptoGD
is_a: APO:0000287 ! interaction with host/environment
created_by: Maria
creation_date: 2011-01-28T09:00:49Z

[Term]
id: APO:0000330
name: haploproficient
namespace: observable
def: "The heterozygous diploid displays an increased growth rate relative to a diploid that is homozygous wild type at that locus." [PMID:23531409, SGD:mcc]
subset: AspGD
subset: CryptoGD
subset: phenotypeslim_cerevisiae
subset: SGD
is_a: APO:0000216 ! fitness
created_by: mariacostanzo
creation_date: 2013-04-16T01:29:09Z

[Term]
id: APO:0000331
name: capsule formation
namespace: observable
def: "The formation of a coating of extracellular polysaccharide material, as in fungi such a Cryptococcus." [CryptoGD:doi]
subset: CryptoGD
is_a: APO:0000291 ! formation of anatomical structure
created_by: mariacostanzo
creation_date: 2013-04-16T02:21:42Z

[Term]
id: APO:0000332
name: peg formation
namespace: observable
def: "Formation of a protrusion in a subapical hyphal cell that fuses with a clamp cell to form a fused clamp, in Basidiomycetes." [CryptoGD:doi]
subset: CryptoGD
is_a: APO:0000291 ! formation of anatomical structure
created_by: mariacostanzo
creation_date: 2013-04-16T02:23:17Z

[Term]
id: APO:0000333
name: acquired thermotolerance
namespace: observable
def: "The ability to survive a period of exposure to an acute heat shock after brief pretreatment at a mildly elevated temperature." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000093 ! thermotolerance
created_by: mariacostanzo
creation_date: 2014-06-30T03:27:33Z

[Term]
id: APO:0000334
name: innate thermotolerance
namespace: observable
def: "The natural or innate ability of a cell to survive a period of exposure to an acute heat shock without pretreatment." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000093 ! thermotolerance
created_by: mariacostanzo
creation_date: 2014-06-30T03:28:34Z

[Term]
id: APO:0000335
name: size of nucleolus
namespace: observable
def: "The size of the nucleolus." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000273 ! nucleolar morphology
created_by: mariacostanzo
creation_date: 2014-06-30T03:30:01Z

[Term]
id: APO:0000336
name: aneuploidy
namespace: observable
def: "The gain or loss of a chromosome, so that the cell has a number of chromosomes that is not a multiple of the usual complement. Aneuploidy may also be partial, affecting a large segment of a chromosome that is lost or translocated to a different chromosome." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance
created_by: mariacostanzo
creation_date: 2014-06-30T03:30:54Z

[Term]
id: APO:0000337
name: polyploidy
namespace: observable
def: "The gain of an entire set or sets of chromosomes beyond the usual complement." [SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000143 ! chromosome/plasmid maintenance
created_by: mariacostanzo
creation_date: 2014-06-30T03:31:39Z

[Term]
id: APO:0000338
name: micronucleophagy
namespace: observable
def: "A form of microautophagy selective for the nucleus that occurs in response to starvation, damage or during a shift in environmental conditions." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
synonym: "piecemeal microautophagy of the nucleus" EXACT [SGD:mcc]
is_a: APO:0000074 ! autophagy
created_by: mariacostanzo
creation_date: 2014-06-30T03:32:30Z

[Term]
id: APO:0000339
name: ribophagy
namespace: observable
def: "A form of macroautophagy selective for ribosomes that occurs in response to starvation, damage or during a shift in environmental conditions." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy
created_by: mariacostanzo
creation_date: 2014-06-30T03:33:49Z

[Term]
id: APO:0000340
name: reticulophagy
namespace: observable
def: "A form of macroautophagy selective for the endoplasmic reticulum that occurs in response to starvation, ER stress, aggregate accumulation or during a shift in environmental conditions." [SGD:RSN]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy
created_by: mariacostanzo
creation_date: 2014-06-30T03:34:39Z

[Term]
id: APO:0000341
name: nucleophagy
namespace: observable
def: "Selective degradation of nucleoplasm that occurs upon nitrogen starvation, in which parts of the nucleus and perinuclear ER are packaged into autophagosomes and delivered to the vacuole for degradation. In S. cerevisiae, Atg39p is involved in this process." [PMID:26040717, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy
created_by: mariacostanzo
creation_date: 2015-06-12T01:58:26Z

[Term]
id: APO:0000342
name: late nucleophagy
namespace: observable
def: "The autophagic degradation of bulk nucleoplasm that occurs after prolonged nitrogen starvation. In late nucleophagy, delivery of the nuclear cargo to the vacuole does not involve autophagosomes." [PMID:22768199, PMID:24013549, SGD:mcc]
subset: AspGD
subset: CGD
subset: CryptoGD
subset: SGD
is_a: APO:0000074 ! autophagy
created_by: mariacostanzo
creation_date: 2015-06-12T01:59:32Z