diff --git a/pkg/compiler/syscall.go b/pkg/compiler/syscall.go
index 910847a942..026cb1b8b4 100644
--- a/pkg/compiler/syscall.go
+++ b/pkg/compiler/syscall.go
@@ -35,6 +35,7 @@ var syscalls = map[string]map[string]Syscall{
 		"ECDSASecp256k1CheckMultisig": {"Neo.Crypto.CheckMultisigWithECDsaSecp256k1", false},
 		"ECDsaSecp256r1Verify":        {"Neo.Crypto.VerifyWithECDsaSecp256r1", false},
 		"ECDSASecp256r1CheckMultisig": {"Neo.Crypto.CheckMultisigWithECDsaSecp256r1", false},
+		"RIPEMD160":                   {"Neo.Crypto.RIPEMD160", false},
 	},
 	"enumerator": {
 		"Concat": {"System.Enumerator.Concat", false},
diff --git a/pkg/core/interop/crypto/hash.go b/pkg/core/interop/crypto/hash.go
index 836d7d6937..30936706f9 100644
--- a/pkg/core/interop/crypto/hash.go
+++ b/pkg/core/interop/crypto/hash.go
@@ -13,3 +13,11 @@ func Sha256(ic *interop.Context, v *vm.VM) error {
 	v.Estack().PushVal(h)
 	return nil
 }
+
+// RipeMD160 returns RipeMD160 hash of the data.
+func RipeMD160(ic *interop.Context, v *vm.VM) error {
+	msg := getMessage(ic, v.Estack().Pop().Item())
+	h := hash.RipeMD160(msg).BytesBE()
+	v.Estack().PushVal(h)
+	return nil
+}
diff --git a/pkg/core/interop/crypto/hash_test.go b/pkg/core/interop/crypto/hash_test.go
index 479eb17421..566bcfb6e9 100644
--- a/pkg/core/interop/crypto/hash_test.go
+++ b/pkg/core/interop/crypto/hash_test.go
@@ -28,3 +28,19 @@ func TestSHA256(t *testing.T) {
 	assert.Equal(t, 1, v.Estack().Len())
 	assert.Equal(t, res, hex.EncodeToString(v.Estack().Pop().Bytes()))
 }
+
+func TestRIPEMD160(t *testing.T) {
+	// 0x0100 hashes to 213492c0c6fc5d61497cf17249dd31cd9964b8a3
+	res := "213492c0c6fc5d61497cf17249dd31cd9964b8a3"
+	buf := io.NewBufBinWriter()
+	emit.Bytes(buf.BinWriter, []byte{1, 0})
+	emit.Syscall(buf.BinWriter, "Neo.Crypto.RIPEMD160")
+	prog := buf.Bytes()
+	v := vm.New()
+	ic := &interop.Context{Trigger: trigger.Verification}
+	v.RegisterInteropGetter(GetInterop(ic))
+	v.Load(prog)
+	require.NoError(t, v.Run())
+	assert.Equal(t, 1, v.Estack().Len())
+	assert.Equal(t, res, hex.EncodeToString(v.Estack().Pop().Bytes()))
+}
diff --git a/pkg/core/interop/crypto/interop.go b/pkg/core/interop/crypto/interop.go
index 77dc58479b..aff3410d41 100644
--- a/pkg/core/interop/crypto/interop.go
+++ b/pkg/core/interop/crypto/interop.go
@@ -10,6 +10,7 @@ var (
 	ecdsaSecp256r1VerifyID        = emit.InteropNameToID([]byte("Neo.Crypto.VerifyWithECDsaSecp256r1"))
 	ecdsaSecp256r1CheckMultisigID = emit.InteropNameToID([]byte("Neo.Crypto.CheckMultisigWithECDsaSecp256r1"))
 	sha256ID                      = emit.InteropNameToID([]byte("Neo.Crypto.SHA256"))
+	ripemd160ID                   = emit.InteropNameToID([]byte("Neo.Crypto.RIPEMD160"))
 )
 
 // GetInterop returns interop getter for crypto-related stuff.
@@ -34,6 +35,12 @@ func GetInterop(ic *interop.Context) func(uint32) *vm.InteropFuncPrice {
 					return Sha256(ic, v)
 				},
 			}
+		case ripemd160ID:
+			return &vm.InteropFuncPrice{
+				Func: func(v *vm.VM) error {
+					return RipeMD160(ic, v)
+				},
+			}
 		default:
 			return nil
 		}
diff --git a/pkg/core/interops.go b/pkg/core/interops.go
index 750713ce5a..f7e7f1cb6a 100644
--- a/pkg/core/interops.go
+++ b/pkg/core/interops.go
@@ -147,6 +147,7 @@ var neoInterops = []interop.Function{
 	{Name: "Neo.Crypto.CheckMultisigWithECDsaSecp256r1", Func: crypto.ECDSASecp256r1CheckMultisig, Price: 0},
 	{Name: "Neo.Crypto.CheckMultisigWithECDsaSecp256k1", Func: crypto.ECDSASecp256k1CheckMultisig, Price: 0},
 	{Name: "Neo.Crypto.SHA256", Func: crypto.Sha256, Price: 1000000},
+	{Name: "Neo.Crypto.RIPEMD160", Func: crypto.RipeMD160, Price: 1000000},
 	{Name: "Neo.Native.Deploy", Func: native.Deploy, Price: 0,
 		AllowedTriggers: trigger.Application, RequiredFlags: smartcontract.AllowModifyStates},
 }
diff --git a/pkg/interop/crypto/crypto.go b/pkg/interop/crypto/crypto.go
index 6e894465be..4f986f1286 100644
--- a/pkg/interop/crypto/crypto.go
+++ b/pkg/interop/crypto/crypto.go
@@ -8,6 +8,11 @@ func SHA256(b []byte) []byte {
 	return nil
 }
 
+// RIPEMD160 computes RIPEMD160 hash of b. It uses `Neo.Crypto.RIPEMD160` syscall.
+func RIPEMD160(b []byte) []byte {
+	return nil
+}
+
 // ECDsaSecp256r1Verify checks that sig is correct msg's signature for a given pub
 // (serialized public key). It uses `Neo.Crypto.VerifyWithECDsaSecp256r1` syscall.
 func ECDsaSecp256r1Verify(msg []byte, pub []byte, sig []byte) bool {