diff --git a/src/node_buffer.cc b/src/node_buffer.cc
index e7e3ead4416a40..527a4cf4a078d6 100644
--- a/src/node_buffer.cc
+++ b/src/node_buffer.cc
@@ -57,6 +57,7 @@ using v8::ArrayBufferView;
 using v8::BackingStore;
 using v8::Context;
 using v8::EscapableHandleScope;
+using v8::FastApiTypedArray;
 using v8::FunctionCallbackInfo;
 using v8::Global;
 using v8::HandleScope;
@@ -1071,37 +1072,57 @@ void IndexOfBuffer(const FunctionCallbackInfo<Value>& args) {
       result == haystack_length ? -1 : static_cast<int>(result));
 }
 
-void IndexOfNumber(const FunctionCallbackInfo<Value>& args) {
+int32_t IndexOfNumber(const uint8_t* buffer_data,
+                      size_t buffer_length,
+                      uint32_t needle,
+                      int64_t offset_i64,
+                      bool is_forward) {
+  int64_t opt_offset = IndexOfOffset(buffer_length, offset_i64, 1, is_forward);
+  if (opt_offset <= -1 || buffer_length == 0) {
+    return -1;
+  }
+  size_t offset = static_cast<size_t>(opt_offset);
+  CHECK_LT(offset, buffer_length);
+
+  const void* ptr;
+  if (is_forward) {
+    ptr = memchr(buffer_data + offset, needle, buffer_length - offset);
+  } else {
+    ptr = node::stringsearch::MemrchrFill(buffer_data, needle, offset + 1);
+  }
+  const uint8_t* ptr_uint8 = static_cast<const uint8_t*>(ptr);
+  return ptr != nullptr ? static_cast<int32_t>(ptr_uint8 - buffer_data) : -1;
+}
+
+void SlowIndexOfNumber(const FunctionCallbackInfo<Value>& args) {
   CHECK(args[1]->IsUint32());
   CHECK(args[2]->IsNumber());
   CHECK(args[3]->IsBoolean());
 
   THROW_AND_RETURN_UNLESS_BUFFER(Environment::GetCurrent(args), args[0]);
-  ArrayBufferViewContents<char> buffer(args[0]);
+  ArrayBufferViewContents<uint8_t> buffer(args[0]);
 
   uint32_t needle = args[1].As<Uint32>()->Value();
   int64_t offset_i64 = args[2].As<Integer>()->Value();
   bool is_forward = args[3]->IsTrue();
 
-  int64_t opt_offset =
-      IndexOfOffset(buffer.length(), offset_i64, 1, is_forward);
-  if (opt_offset <= -1 || buffer.length() == 0) {
-    return args.GetReturnValue().Set(-1);
-  }
-  size_t offset = static_cast<size_t>(opt_offset);
-  CHECK_LT(offset, buffer.length());
+  args.GetReturnValue().Set(IndexOfNumber(
+      buffer.data(), buffer.length(), needle, offset_i64, is_forward));
+}
 
-  const void* ptr;
-  if (is_forward) {
-    ptr = memchr(buffer.data() + offset, needle, buffer.length() - offset);
-  } else {
-    ptr = node::stringsearch::MemrchrFill(buffer.data(), needle, offset + 1);
-  }
-  const char* ptr_char = static_cast<const char*>(ptr);
-  args.GetReturnValue().Set(ptr ? static_cast<int>(ptr_char - buffer.data())
-                                : -1);
+int32_t FastIndexOfNumber(v8::Local<v8::Value>,
+                          const FastApiTypedArray<uint8_t>& buffer,
+                          uint32_t needle,
+                          int64_t offset_i64,
+                          bool is_forward) {
+  uint8_t* buffer_data;
+  CHECK(buffer.getStorageIfAligned(&buffer_data));
+  return IndexOfNumber(
+      buffer_data, buffer.length(), needle, offset_i64, is_forward);
 }
 
+static v8::CFunction fast_index_of_number(
+    v8::CFunction::Make(FastIndexOfNumber));
 
 void Swap16(const FunctionCallbackInfo<Value>& args) {
   Environment* env = Environment::GetCurrent(args);
@@ -1413,7 +1434,11 @@ void Initialize(Local<Object> target,
   SetMethodNoSideEffect(context, target, "compareOffset", CompareOffset);
   SetMethod(context, target, "fill", Fill);
   SetMethodNoSideEffect(context, target, "indexOfBuffer", IndexOfBuffer);
-  SetMethodNoSideEffect(context, target, "indexOfNumber", IndexOfNumber);
+  SetFastMethodNoSideEffect(context,
+                            target,
+                            "indexOfNumber",
+                            SlowIndexOfNumber,
+                            &fast_index_of_number);
   SetMethodNoSideEffect(context, target, "indexOfString", IndexOfString);
 
   SetMethod(context, target, "detachArrayBuffer", DetachArrayBuffer);
@@ -1472,7 +1497,9 @@ void RegisterExternalReferences(ExternalReferenceRegistry* registry) {
   registry->Register(CompareOffset);
   registry->Register(Fill);
   registry->Register(IndexOfBuffer);
-  registry->Register(IndexOfNumber);
+  registry->Register(SlowIndexOfNumber);
+  registry->Register(FastIndexOfNumber);
+  registry->Register(fast_index_of_number.GetTypeInfo());
   registry->Register(IndexOfString);
 
   registry->Register(Swap16);
diff --git a/src/node_external_reference.h b/src/node_external_reference.h
index a3317d25ad6a96..4e2ad9024020fa 100644
--- a/src/node_external_reference.h
+++ b/src/node_external_reference.h
@@ -27,6 +27,12 @@ using CFunctionCallbackWithStrings =
     bool (*)(v8::Local<v8::Value>,
              const v8::FastOneByteString& input,
              const v8::FastOneByteString& base);
+using CFunctionCallbackWithUint8ArrayUint32Int64Bool =
+    int32_t (*)(v8::Local<v8::Value>,
+                const v8::FastApiTypedArray<uint8_t>&,
+                uint32_t,
+                int64_t,
+                bool);
 using CFunctionWithUint32 = uint32_t (*)(v8::Local<v8::Value>,
                                          const uint32_t input);
 using CFunctionWithDoubleReturnDouble = double (*)(v8::Local<v8::Value>,
@@ -51,6 +57,7 @@ class ExternalReferenceRegistry {
   V(CFunctionCallbackWithBool)                                                 \
   V(CFunctionCallbackWithString)                                               \
   V(CFunctionCallbackWithStrings)                                              \
+  V(CFunctionCallbackWithUint8ArrayUint32Int64Bool)                            \
   V(CFunctionWithUint32)                                                       \
   V(CFunctionWithDoubleReturnDouble)                                           \
   V(CFunctionWithInt64Fallback)                                                \