diff --git a/llvm/lib/Transforms/Utils/ScalarEvolutionExpander.cpp b/llvm/lib/Transforms/Utils/ScalarEvolutionExpander.cpp
index ed55a13072aaa3..34597e6b6e83a1 100644
--- a/llvm/lib/Transforms/Utils/ScalarEvolutionExpander.cpp
+++ b/llvm/lib/Transforms/Utils/ScalarEvolutionExpander.cpp
@@ -1398,6 +1398,13 @@ canReuseInstruction(ScalarEvolution &SE, const SCEV *S, Instruction *I,
     if (!I)
       return false;
 
+    // Disjoint or instructions are interpreted as adds by SCEV. However, we
+    // can't replace an arbitrary add with disjoint or, even if we drop the
+    // flag. We would need to convert the or into an add.
+    if (auto *PDI = dyn_cast<PossiblyDisjointInst>(I))
+      if (PDI->isDisjoint())
+        return false;
+
     // FIXME: Ignore vscale, even though it technically could be poison. Do this
     // because SCEV currently assumes it can't be poison. Remove this special
     // case once we proper model when vscale can be poison.
diff --git a/llvm/test/Transforms/IndVarSimplify/pr79861.ll b/llvm/test/Transforms/IndVarSimplify/pr79861.ll
index a8e2aa42a365ce..7e267d04c94cc8 100644
--- a/llvm/test/Transforms/IndVarSimplify/pr79861.ll
+++ b/llvm/test/Transforms/IndVarSimplify/pr79861.ll
@@ -75,14 +75,15 @@ define void @expander_or_disjoint(i64 %n) {
 ; CHECK-LABEL: define void @expander_or_disjoint(
 ; CHECK-SAME: i64 [[N:%.*]]) {
 ; CHECK-NEXT:  entry:
-; CHECK-NEXT:    [[OR:%.*]] = or i64 [[N]], 1
+; CHECK-NEXT:    [[OR:%.*]] = or disjoint i64 [[N]], 1
+; CHECK-NEXT:    [[TMP0:%.*]] = add i64 [[N]], 1
 ; CHECK-NEXT:    br label [[LOOP:%.*]]
 ; CHECK:       loop:
 ; CHECK-NEXT:    [[IV:%.*]] = phi i64 [ 0, [[ENTRY:%.*]] ], [ [[IV_INC:%.*]], [[LOOP]] ]
 ; CHECK-NEXT:    [[IV_INC]] = add i64 [[IV]], 1
 ; CHECK-NEXT:    [[ADD:%.*]] = add i64 [[IV]], [[OR]]
 ; CHECK-NEXT:    call void @use(i64 [[ADD]])
-; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[IV_INC]], [[OR]]
+; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[IV_INC]], [[TMP0]]
 ; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP]], label [[EXIT:%.*]]
 ; CHECK:       exit:
 ; CHECK-NEXT:    ret void