diff --git a/NF.jsonld b/NF.jsonld
index 802c569b..03f3eaa1 100644
--- a/NF.jsonld
+++ b/NF.jsonld
@@ -21609,6 +21609,15 @@
                 {
                     "@id": "bts:HS05"
                 },
+                {
+                    "@id": "bts:Primaryculturedfibroblastcell"
+                },
+                {
+                    "@id": "bts:Prss56Cre/+;Tom/+;Nf1fl/fl"
+                },
+                {
+                    "@id": "bts:Prss56Cre/+;Tom/+"
+                },
                 {
                     "@id": "bts:B6;129S2-Trp53tm1TyjNf1tm1Tyj/J"
                 },
@@ -23982,6 +23991,57 @@
             "sms:required": "sms:false",
             "sms:validationRules": []
         },
+        {
+            "@id": "bts:Primaryculturedfibroblastcell",
+            "@type": "rdfs:Class",
+            "rdfs:comment": "TBD",
+            "rdfs:label": "Primaryculturedfibroblastcell",
+            "rdfs:subClassOf": [
+                {
+                    "@id": "bts:ModelSystemName"
+                }
+            ],
+            "schema:isPartOf": {
+                "@id": "http://schema.biothings.io"
+            },
+            "sms:displayName": "primary cultured fibroblast cell",
+            "sms:required": "sms:false",
+            "sms:validationRules": []
+        },
+        {
+            "@id": "bts:Prss56Cre/+;Tom/+;Nf1fl/fl",
+            "@type": "rdfs:Class",
+            "rdfs:comment": "TBD",
+            "rdfs:label": "Prss56Cre/+;Tom/+;Nf1fl/fl",
+            "rdfs:subClassOf": [
+                {
+                    "@id": "bts:ModelSystemName"
+                }
+            ],
+            "schema:isPartOf": {
+                "@id": "http://schema.biothings.io"
+            },
+            "sms:displayName": "Prss56Cre/+;Tom/+;Nf1fl/fl",
+            "sms:required": "sms:false",
+            "sms:validationRules": []
+        },
+        {
+            "@id": "bts:Prss56Cre/+;Tom/+",
+            "@type": "rdfs:Class",
+            "rdfs:comment": "TBD",
+            "rdfs:label": "Prss56Cre/+;Tom/+",
+            "rdfs:subClassOf": [
+                {
+                    "@id": "bts:ModelSystemName"
+                }
+            ],
+            "schema:isPartOf": {
+                "@id": "http://schema.biothings.io"
+            },
+            "sms:displayName": "Prss56Cre/+;Tom/+",
+            "sms:required": "sms:false",
+            "sms:validationRules": []
+        },
         {
             "@id": "bts:B6;129S2-Trp53tm1TyjNf1tm1Tyj/J",
             "@type": "rdfs:Class",
diff --git a/modules/Sample/CellLineModel.yaml b/modules/Sample/CellLineModel.yaml
index b8ebf637..87909a22 100644
--- a/modules/Sample/CellLineModel.yaml
+++ b/modules/Sample/CellLineModel.yaml
@@ -345,3 +345,9 @@ enums:
       HS05:
         description: 'NF2 schwannoma model'
         source: Sage Bionetworks
+      primary cultured fibroblast cell: 
+        description: A primary cultured cell that is derived from fibroblast cell in vivo.
+        meaning: http://purl.obolibrary.org/obo/CLO_0037301
+
+ 
+        
diff --git a/modules/Sample/MouseModel.yaml b/modules/Sample/MouseModel.yaml
index 3fcada4e..d12d7f47 100644
--- a/modules/Sample/MouseModel.yaml
+++ b/modules/Sample/MouseModel.yaml
@@ -1,6 +1,10 @@
 enums:
   MouseModel:
     permissible_values:
+      Prss56Cre/+;Tom/+;Nf1fl/fl:
+        description: The Prss56Cre/+;Tom/+;Nf1fl/fl mouse model is genetically engineered to express Cre recombinase under the Prss56 promoter, enabling tissue-specific deletion of the Nf1 gene, alongside a visual reporter, Tomato fluorescent protein, for tracing Cre activity.
+      Prss56Cre/+;Tom/+:
+        description: The Prss56Cre/+;Tom/+ mouse model is genetically engineered to express Cre recombinase under the Prss56 promoter, enabling tissue-specific gene modification, alongside a Tomato fluorescent protein reporter to visualize Cre activity.
       B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J:
         description: ''
         meaning: https://www.jax.org/strain/008191