Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Add an option to optionally use the GATK VariantFiltration instead of VQSR #1586

Open
cmatKhan opened this issue Jul 9, 2024 · 1 comment
Labels
enhancement New feature or request

Comments

@cmatKhan
Copy link
Contributor

cmatKhan commented Jul 9, 2024

Description of feature

For haplotypecaller, if known snps or indels are not passed, then VQSR can't be used.

VQSR should be set by default. But, the user should be able to select VariantFiltration if they would rather set filter thresholds explicitly. If known snps or indels are not passed in, and haplotypecaller is selected, then VariantFiltration should be used automatically.

https://gatk.broadinstitute.org/hc/en-us/articles/360035531112--How-to-Filter-variants-either-with-VQSR-or-by-hard-filtering#2

@cmatKhan cmatKhan added the enhancement New feature or request label Jul 9, 2024
@cmatKhan cmatKhan added this to the 3.5 milestone Jul 9, 2024
@FriederikeHanssen FriederikeHanssen removed this from the 3.5 milestone Aug 19, 2024
@Ons14
Copy link

Ons14 commented Dec 27, 2024

Hello,

Thank you for bringing this up. I am currently working on germline variants, and it would be great if the VariantFiltration feature could be added to the Sarek pipeline.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
enhancement New feature or request
Projects
None yet
Development

No branches or pull requests

3 participants