diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..e98aed6
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,45 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "buscolite"
+version = "24.7.29"
+description = "busco analysis for gene predictions"
+readme = {file = "README.md", content-type = "text/markdown"}
+authors = [
+    {name = "Jon Palmer", email = "nextgenusfs@gmail.com"}
+]
+requires-python = ">=3.6.0"
+dependencies = [
+    "natsort",
+    "pyhmmer>=0.10.15",
+    "pyfastx>=2.0.0",
+]
+license = {file = "LICENSE"}
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "License :: OSI Approved :: BSD License",
+    "Programming Language :: Python",
+    "Operating System :: Unix",
+    "Intended Audience :: Science/Research",
+    "Topic :: Scientific/Engineering :: Bio-Informatics",
+]
+keywords = ["bioinformatics", "genome", "annotation", "completeness"]
+
+[project.urls]
+Homepage = "https://github.com/nextgenusfs/buscolite"
+Repository = "https://github.com/nextgenusfs/buscolitegit"
+
+[project.scripts]
+buscolite = "buscolite.__main__:main"
+
+[tool.hatch.build.targets.sdist]
+include = [
+  "bucolite/data/*",
+  "README.md",
+  "LICENSE.md"
+]
+exclude = [
+  "tests/*",
+]
diff --git a/setup.py b/setup.py
deleted file mode 100755
index 06e64a6..0000000
--- a/setup.py
+++ /dev/null
@@ -1,77 +0,0 @@
-#!/usr/bin/env python
-# -*- coding: utf-8 -*-
-
-import io
-import os
-from setuptools import find_packages, setup, Command
-
-# Package meta-data.
-NAME = "buscolite"
-DESCRIPTION = "buscolite: busco analysis for gene predictions"
-URL = "https://github.com/nextgenusfs/buscolite"
-EMAIL = "nextgenusfs@gmail.com"
-AUTHOR = "Jon Palmer"
-REQUIRES_PYTHON = ">=3.6.0"
-VERSION = None
-
-# What packages are required for this module to be executed?
-REQUIRED = ["natsort", "pyhmmer", "pyfastx"]
-
-# What packages are optional?
-EXTRAS = {
-    # 'fancy feature': ['django'],
-}
-
-# The rest you shouldn't have to touch too much :)
-# ------------------------------------------------
-# Except, perhaps the License and Trove Classifiers!
-# If you do change the License, remember to change the Trove Classifier for that!
-
-here = os.path.abspath(os.path.dirname(__file__))
-
-# Import the README and use it as the long-description.
-# Note: this will only work if 'README.md' is present in your MANIFEST.in file!
-try:
-    with io.open(os.path.join(here, "README.md"), encoding="utf-8") as f:
-        long_description = "\n" + f.read()
-except FileNotFoundError:
-    long_description = DESCRIPTION
-
-# Load the package's __version__.py module as a dictionary.
-about = {}
-if not VERSION:
-    with open(os.path.join(here, NAME, "__version__.py")) as f:
-        exec(f.read(), about)
-else:
-    about["__version__"] = VERSION
-
-
-# Where the magic happens:
-setup(
-    name=NAME,
-    version=about["__version__"],
-    description=DESCRIPTION,
-    long_description=long_description,
-    long_description_content_type="text/markdown",
-    author=AUTHOR,
-    author_email=EMAIL,
-    python_requires=REQUIRES_PYTHON,
-    url=URL,
-    packages=find_packages(exclude=("tests",)),
-    entry_points={"console_scripts": ["buscolite = buscolite.__main__:main"]},
-    install_requires=REQUIRED,
-    extras_require=EXTRAS,
-    include_package_data=True,
-    license="BSD-2",
-    # scripts=[],
-    classifiers=[
-        # Trove classifiers
-        # Full list: https://pypi.python.org/pypi?%3Aaction=list_classifiers
-        "Development Status :: 4 - Beta",
-        "License :: OSI Approved :: BSD License",
-        "Programming Language :: Python",
-        "Operating System :: Unix",
-        "Intended Audience :: Science/Research",
-        "Topic :: Scientific/Engineering :: Bio-Informatics",
-    ],
-)