diff --git a/x-pack/plugins/ingest_manager/server/services/epm/packages/remove.ts b/x-pack/plugins/ingest_manager/server/services/epm/packages/remove.ts
index 0d9db1697d886..23e63f0a89a5e 100644
--- a/x-pack/plugins/ingest_manager/server/services/epm/packages/remove.ts
+++ b/x-pack/plugins/ingest_manager/server/services/epm/packages/remove.ts
@@ -6,11 +6,12 @@
 
 import { SavedObjectsClientContract } from 'src/core/server';
 import Boom from 'boom';
-import { PACKAGES_SAVED_OBJECT_TYPE } from '../../../constants';
+import { PACKAGES_SAVED_OBJECT_TYPE, DATASOURCE_SAVED_OBJECT_TYPE } from '../../../constants';
 import { AssetReference, AssetType, ElasticsearchAssetType } from '../../../types';
 import { CallESAsCurrentUser } from '../../../types';
 import { getInstallation, savedObjectTypes } from './index';
 import { installIndexPatterns } from '../kibana/index_pattern/install';
+import { datasourceService } from '../..';
 
 export async function removeInstallation(options: {
   savedObjectsClient: SavedObjectsClientContract;
@@ -26,6 +27,17 @@ export async function removeInstallation(options: {
     throw Boom.badRequest(`${pkgName} is installed by default and cannot be removed`);
   const installedObjects = installation.installed || [];
 
+  const { total } = await datasourceService.list(savedObjectsClient, {
+    kuery: `${DATASOURCE_SAVED_OBJECT_TYPE}.package.name:${pkgName}`,
+    page: 0,
+    perPage: 0,
+  });
+
+  if (total > 0)
+    throw Boom.badRequest(
+      `unable to remove package with existing datasource(s) in use by agent(s)`
+    );
+
   // Delete the manager saved object with references to the asset objects
   // could also update with [] or some other state
   await savedObjectsClient.delete(PACKAGES_SAVED_OBJECT_TYPE, pkgName);