Title: Rhea, the Reaction Knowledgebase in 2022
Authors: Parit Bansal, Anne Morgat, Kristian B. Axelsen, Venkatesh Muthukrishnan, Elisabeth Coudert, Lucila Aimo,
Nevila Hyka-Nouspikel, Elisabeth Gasteiger, Arnaud Kerhornou, Teresa B. Neto, Monica Pozzato, Marie-Claude Blatter, Alex
Ignatchenko, Nicole Redaschi, Alan Bridge
Publication Date: 2023/11/10
Publication Link: Nucleic Acids Research
Alternative Publication Links: Europe PMC |
PubMed Central |
ResearchGate
Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.