diff --git a/packages/editor-ui/src/composables/__tests__/useRunWorkflow.spec.ts b/packages/editor-ui/src/composables/__tests__/useRunWorkflow.spec.ts
index 608fc36e870e7..08fa852b3926e 100644
--- a/packages/editor-ui/src/composables/__tests__/useRunWorkflow.spec.ts
+++ b/packages/editor-ui/src/composables/__tests__/useRunWorkflow.spec.ts
@@ -23,6 +23,7 @@ vi.mock('@/stores/workflows.store', () => ({
 		getCurrentWorkflow: vi.fn().mockReturnValue({ id: '123' }),
 		getNodeByName: vi.fn(),
 		getExecution: vi.fn(),
+		nodeIssuesExit: vi.fn(),
 	}),
 }));
 
@@ -124,6 +125,21 @@ describe('useRunWorkflow({ router })', () => {
 			expect(uiStore.addActiveAction).toHaveBeenCalledWith('workflowRunning');
 		});
 
+		it('should prevent running a webhook-based workflow that has issues', async () => {
+			const { runWorkflowApi } = useRunWorkflow({ router });
+			vi.mocked(workflowsStore).nodesIssuesExist = true;
+			vi.mocked(workflowsStore).runWorkflow.mockResolvedValue({
+				executionId: '123',
+				waitingForWebhook: true,
+			});
+
+			await expect(runWorkflowApi({} as IStartRunData)).rejects.toThrow(
+				'workflowRun.showError.resolveOutstandingIssues',
+			);
+
+			vi.mocked(workflowsStore).nodesIssuesExist = false;
+		});
+
 		it('should handle workflow run failure', async () => {
 			const { runWorkflowApi } = useRunWorkflow({ router });
 
diff --git a/packages/editor-ui/src/composables/useRunWorkflow.ts b/packages/editor-ui/src/composables/useRunWorkflow.ts
index 8369921f8a119..658e35b3c6229 100644
--- a/packages/editor-ui/src/composables/useRunWorkflow.ts
+++ b/packages/editor-ui/src/composables/useRunWorkflow.ts
@@ -81,6 +81,11 @@ export function useRunWorkflow(useRunWorkflowOpts: { router: ReturnType<typeof u
 			workflowsStore.activeExecutionId = response.executionId;
 		}
 
+		if (response.waitingForWebhook === true && useWorkflowsStore().nodesIssuesExist) {
+			uiStore.removeActiveAction('workflowRunning');
+			throw new Error(i18n.baseText('workflowRun.showError.resolveOutstandingIssues'));
+		}
+
 		if (response.waitingForWebhook === true) {
 			workflowsStore.executionWaitingForWebhook = true;
 		}
diff --git a/packages/editor-ui/src/plugins/i18n/locales/en.json b/packages/editor-ui/src/plugins/i18n/locales/en.json
index 74d63233f2ad9..be7ff266f7ea0 100644
--- a/packages/editor-ui/src/plugins/i18n/locales/en.json
+++ b/packages/editor-ui/src/plugins/i18n/locales/en.json
@@ -2130,6 +2130,7 @@
 	"workflowRun.noActiveConnectionToTheServer": "Lost connection to the server",
 	"workflowRun.showError.title": "Problem running workflow",
 	"workflowRun.showError.payloadTooLarge": "Please execute the whole workflow, rather than just the node. (Existing execution data is too large.)",
+	"workflowRun.showError.resolveOutstandingIssues": "Please resolve outstanding issues before you activate it",
 	"workflowRun.showMessage.message": "Please fix them before executing",
 	"workflowRun.showMessage.title": "Workflow has issues",
 	"workflowSettings.callerIds": "IDs of workflows that can call this one",