diff --git a/docs/src/pages/components/autocomplete/autocomplete.md b/docs/src/pages/components/autocomplete/autocomplete.md
index 8a688a9ba950bf..dc1e1047e3f269 100644
--- a/docs/src/pages/components/autocomplete/autocomplete.md
+++ b/docs/src/pages/components/autocomplete/autocomplete.md
@@ -275,6 +275,22 @@ Search within 10,000 randomly generated options. The list is virtualized thanks
 
 {{"demo": "pages/components/autocomplete/Virtualize.js"}}
 
+## Events
+
+If you would like to prevent the default key handler behavior, you can set the event's `defaultMuiPrevented` property to `true`:
+
+```jsx
+<Autocomplete
+  onKeyDown={(event) => {
+    if (event.key === 'Enter') {
+      // Prevent's default 'Enter' behavior.
+      event.defaultMuiPrevented = false;
+      // your handler code
+    }
+  }}
+/>
+```
+
 ## Limitations
 
 ### autocomplete/autofill
diff --git a/packages/material-ui/src/Autocomplete/Autocomplete.test.js b/packages/material-ui/src/Autocomplete/Autocomplete.test.js
index 44c179555c19af..997c5a35d8a503 100644
--- a/packages/material-ui/src/Autocomplete/Autocomplete.test.js
+++ b/packages/material-ui/src/Autocomplete/Autocomplete.test.js
@@ -533,17 +533,22 @@ describe('<Autocomplete />', () => {
 
   it('should trigger a form expectedly', () => {
     const handleSubmit = spy();
-    const { setProps } = render(
-      <Autocomplete
-        options={['one', 'two']}
+    const Test = (props) => (
+      <div
         onKeyDown={(event) => {
           if (!event.defaultPrevented && event.key === 'Enter') {
             handleSubmit();
           }
         }}
-        renderInput={(props2) => <TextField {...props2} autoFocus />}
-      />,
+      >
+        <Autocomplete
+          options={['one', 'two']}
+          renderInput={(props2) => <TextField {...props2} autoFocus />}
+          {...props}
+        />
+      </div>
     );
+    const { setProps } = render(<Test />);
     let textbox = screen.getByRole('textbox');
 
     fireEvent.keyDown(textbox, { key: 'Enter' });
@@ -580,19 +585,22 @@ describe('<Autocomplete />', () => {
       const handleSubmit = spy();
       const handleChange = spy();
       const { getAllByRole } = render(
-        <Autocomplete
-          disabledItemsFocusable
-          getOptionDisabled={(option) => option === 'two'}
+        <div
           onKeyDown={(event) => {
             if (!event.defaultPrevented && event.key === 'Enter') {
               handleSubmit();
             }
           }}
-          onChange={handleChange}
-          openOnFocus
-          options={['one', 'two', 'three']}
-          renderInput={(props2) => <TextField {...props2} autoFocus />}
-        />,
+        >
+          <Autocomplete
+            disabledItemsFocusable
+            getOptionDisabled={(option) => option === 'two'}
+            onChange={handleChange}
+            openOnFocus
+            options={['one', 'two', 'three']}
+            renderInput={(props2) => <TextField {...props2} autoFocus />}
+          />
+        </div>,
       );
 
       let options;
@@ -2099,4 +2107,25 @@ describe('<Autocomplete />', () => {
 
     expect(getAllByRole('option')).to.have.length(1);
   });
+
+  it('should prevent the default event handlers', () => {
+    const handleChange = spy();
+    render(
+      <Autocomplete
+        options={['one', 'two']}
+        onChange={handleChange}
+        onKeyDown={(event) => {
+          if (event.key === 'Enter') {
+            event.defaultMuiPrevented = true;
+          }
+        }}
+        renderInput={(params) => <TextField autoFocus {...params} />}
+      />,
+    );
+    const textbox = screen.getByRole('textbox');
+    fireEvent.keyDown(textbox, { key: 'ArrowDown' });
+    fireEvent.keyDown(textbox, { key: 'ArrowDown' });
+    fireEvent.keyDown(textbox, { key: 'Enter' });
+    expect(handleChange.callCount).to.equal(0);
+  });
 });
diff --git a/packages/material-ui/src/SwipeableDrawer/SwipeableDrawer.js b/packages/material-ui/src/SwipeableDrawer/SwipeableDrawer.js
index 0a9394410cfb35..c1690a6b130f88 100644
--- a/packages/material-ui/src/SwipeableDrawer/SwipeableDrawer.js
+++ b/packages/material-ui/src/SwipeableDrawer/SwipeableDrawer.js
@@ -429,7 +429,7 @@ const SwipeableDrawer = React.forwardRef(function SwipeableDrawer(inProps, ref)
     }
 
     // We can only have one node at the time claiming ownership for handling the swipe.
-    if (event.muiHandled) {
+    if (event.defaultMuiPrevented) {
       return;
     }
 
@@ -466,7 +466,7 @@ const SwipeableDrawer = React.forwardRef(function SwipeableDrawer(inProps, ref)
       }
     }
 
-    event.muiHandled = true;
+    event.defaultMuiPrevented = true;
     nodeThatClaimedTheSwipe = null;
     swipeInstance.current.startX = currentX;
     swipeInstance.current.startY = currentY;
diff --git a/packages/material-ui/src/useAutocomplete/useAutocomplete.js b/packages/material-ui/src/useAutocomplete/useAutocomplete.js
index 5dd73579276e0e..97769b6460b94d 100644
--- a/packages/material-ui/src/useAutocomplete/useAutocomplete.js
+++ b/packages/material-ui/src/useAutocomplete/useAutocomplete.js
@@ -208,7 +208,7 @@ export default function useAutocomplete(props) {
   const listboxAvailable = open && filteredOptions.length > 0;
 
   if (process.env.NODE_ENV !== 'production') {
-    if (value !== null && !freeSolo && options?.length > 0) {
+    if (value !== null && !freeSolo && options.length > 0) {
       const missingValue = (multiple ? value : [value]).filter(
         (value2) => !options.some((option) => getOptionSelected(option, value2)),
       );
@@ -657,6 +657,14 @@ export default function useAutocomplete(props) {
   };
 
   const handleKeyDown = (other) => (event) => {
+    if (other.onKeyDown) {
+      other.onKeyDown(event);
+    }
+
+    if (event.defaultMuiPrevented) {
+      return;
+    }
+
     if (focusedTag !== -1 && ['ArrowLeft', 'ArrowRight'].indexOf(event.key) === -1) {
       setFocusedTag(-1);
       focusTag(-1);
@@ -776,10 +784,6 @@ export default function useAutocomplete(props) {
         default:
       }
     }
-
-    if (other.onKeyDown) {
-      other.onKeyDown(event);
-    }
   };
 
   const handleFocus = (event) => {