diff --git a/src/mockServiceWorker.js b/src/mockServiceWorker.js
index 364d44023..7d768456c 100644
--- a/src/mockServiceWorker.js
+++ b/src/mockServiceWorker.js
@@ -199,7 +199,19 @@ async function getResponse(event, client, requestId) {
     // Remove the "accept" header value that marked this request as passthrough.
     // This prevents request alteration and also keeps it compliant with the
     // user-defined CORS policies.
-    headers.delete('accept', 'msw/passthrough')
+    const acceptHeader = headers.get('accept')
+    if (acceptHeader) {
+      const values = acceptHeader.split(',').map((value) => value.trim())
+      const filteredValues = values.filter(
+        (value) => value !== 'msw/passthrough',
+      )
+
+      if (filteredValues.length > 0) {
+        headers.set('accept', filteredValues.join(', '))
+      } else {
+        headers.delete('accept')
+      }
+    }
 
     return fetch(requestClone, { headers })
   }
diff --git a/test/browser/msw-api/setup-worker/worker-passthrough-header.mocks.ts b/test/browser/msw-api/setup-worker/worker-passthrough-header.mocks.ts
new file mode 100644
index 000000000..e7303fb79
--- /dev/null
+++ b/test/browser/msw-api/setup-worker/worker-passthrough-header.mocks.ts
@@ -0,0 +1,10 @@
+import { http, passthrough } from 'msw'
+import { setupWorker } from 'msw/browser'
+
+const worker = setupWorker(
+  http.get('*/resource', function originalResolver() {
+    return passthrough()
+  }),
+)
+
+worker.start()
diff --git a/test/browser/msw-api/setup-worker/worker-passthrough-header.test.ts b/test/browser/msw-api/setup-worker/worker-passthrough-header.test.ts
new file mode 100644
index 000000000..783e8c571
--- /dev/null
+++ b/test/browser/msw-api/setup-worker/worker-passthrough-header.test.ts
@@ -0,0 +1,57 @@
+import { HttpServer } from '@open-draft/test-server/lib/http'
+import { test, expect } from '../../playwright.extend'
+
+const httpServer = new HttpServer((app) => {
+  app.get('/resource', (req, res) => {
+    res.set(req.headers)
+    res.send('hello world')
+  })
+})
+
+test.beforeAll(async () => {
+  await httpServer.listen()
+})
+
+test.afterAll(async () => {
+  await httpServer.close()
+})
+
+test('removes the internal passthrough request header', async ({
+  loadExample,
+  fetch,
+}) => {
+  await loadExample(require.resolve('./worker-passthrough-header.mocks.ts'))
+
+  const response = await fetch(httpServer.http.url('/resource'), {
+    headers: { 'x-custom-header': 'yes' },
+  })
+  const headers = await response.allHeaders()
+
+  expect(headers).toMatchObject({
+    // The default header value.
+    accept: '*/*',
+    'x-custom-header': 'yes',
+  })
+  await expect(response.text()).resolves.toBe('hello world')
+})
+
+test('preserves existing "accept" header values when removing the internal passthrough request header', async ({
+  loadExample,
+  fetch,
+}) => {
+  await loadExample(require.resolve('./worker-passthrough-header.mocks.ts'))
+
+  const response = await fetch(httpServer.http.url('/resource'), {
+    headers: {
+      accept: 'text/plain, application/json',
+      'x-custom-header': 'yes',
+    },
+  })
+  const headers = await response.allHeaders()
+
+  expect(headers).toMatchObject({
+    accept: 'text/plain, application/json',
+    'x-custom-header': 'yes',
+  })
+  await expect(response.text()).resolves.toBe('hello world')
+})