diff --git a/.evergreen/config.yml b/.evergreen/config.yml
index 9a504f2a2f..0b25cdf427 100644
--- a/.evergreen/config.yml
+++ b/.evergreen/config.yml
@@ -1734,6 +1734,10 @@ axes:
   - id: version
     display_name: MongoDB Version
     values:
+      - id: "5.0"
+        display_name: "5.0"
+        variables:
+          VERSION: "5.0"
       - id: "4.4"
         display_name: "4.4"
         variables:
@@ -1961,7 +1965,7 @@ buildvariants:
       - name: ".test !.enterprise-auth !.snappy !.zstd"
 
   - matrix_name: "tests-42-plus-zlib-zstd-support"
-    matrix_spec: { version: ["4.2", "4.4", "latest"], os-ssl-40: "*" }
+    matrix_spec: { version: ["4.2", "4.4", "5.0", "latest"], os-ssl-40: "*" }
     display_name: "${version} ${os-ssl-40}"
     tasks:
       - name: ".test !.enterprise-auth !.snappy"
@@ -1974,20 +1978,20 @@ buildvariants:
 
   - matrix_name: "aws-auth-test"
     matrix_spec: { os-aws-auth: "*" }
-    matrix_spec: { version: ["4.4", "latest"], os-aws-auth: "*" }
+    matrix_spec: { version: ["4.4", "5.0", "latest"], os-aws-auth: "*" }
     display_name: "MONGODB-AWS Auth ${version} ${os-aws-auth}"
     tasks:
       - name: "aws-auth-test"
 
   - matrix_name: "ocsp-test"
-    matrix_spec: { version: ["4.4", "latest"], ocsp-rhel-70: ["rhel70-go-1-16"] }
+    matrix_spec: { version: ["4.4", "5.0", "latest"], ocsp-rhel-70: ["rhel70-go-1-16"] }
     display_name: "OCSP ${version} ${ocsp-rhel-70}"
     batchtime: 20160 # 14 days
     tasks:
       - name: ".ocsp"
 
   - matrix_name: "ocsp-test-windows"
-    matrix_spec: { version: ["4.4", "latest"], os-ssl-40: ["windows-64-go-1-16"] }
+    matrix_spec: { version: ["4.4", "5.0", "latest"], os-ssl-40: ["windows-64-go-1-16"] }
     display_name: "OCSP ${version} ${os-ssl-40}"
     batchtime: 20160 # 14 days
     tasks:
@@ -1995,7 +1999,7 @@ buildvariants:
       - name: ".ocsp-rsa !.ocsp-staple"
 
   - matrix_name: "ocsp-test-macos"
-    matrix_spec: { version: ["4.4", "latest"], os-ssl-40: ["osx-go-1-16"] }
+    matrix_spec: { version: ["4.4", "5.0", "latest"], os-ssl-40: ["osx-go-1-16"] }
     display_name: "OCSP ${version} ${os-ssl-40}"
     batchtime: 20160 # 14 days
     tasks:
@@ -2003,20 +2007,20 @@ buildvariants:
       - name: ".ocsp-rsa !.ocsp-staple"
 
   - matrix_name: "versioned-api-test"
-    matrix_spec: { version: ["latest"], os-ssl-40: "*" }
-    display_name: "API Version ${os-ssl-40}"
+    matrix_spec: { version: ["5.0", "latest"], os-ssl-40: "*" }
+    display_name: "API Version ${version} ${os-ssl-40}"
     tasks:
       - name: ".versioned-api"
 
   - matrix_name: "kms-tls-test"
     matrix_spec: { version: ["latest"], os-ssl-40: ["ubuntu1804-64-go-1-16"] }
-    display_name: "KMS TLS ${version} ${os-ssl-40}"
+    display_name: "KMS TLS ${os-ssl-40}"
     tasks:
       - name: ".kms-tls"
 
   - matrix_name: "load-balancer-test"
     # The LB software is only available on Ubuntu 18.04, so we don't test on all OSes.
-    matrix_spec: { version: ["latest"], os-ssl-40: ["ubuntu1804-64-go-1-16"] }
+    matrix_spec: { version: ["5.0", "latest"], os-ssl-40: ["ubuntu1804-64-go-1-16"] }
     display_name: "Load Balancer Support ${version} ${os-ssl-40}"
     tasks:
       - name: ".load-balancer"