diff --git a/.github/workflows/CI.yml b/.github/workflows/CI.yml
index c2911aa8..5b56e5a0 100644
--- a/.github/workflows/CI.yml
+++ b/.github/workflows/CI.yml
@@ -12,7 +12,7 @@ jobs:
     runs-on: macos-latest
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: ['3.6', '3.7', '3.8', '3.9', '3.10']
     steps:
       - uses: actions/checkout@v2
       - uses: actions/setup-python@v2
@@ -60,7 +60,7 @@ jobs:
     runs-on: windows-latest
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: ['3.6', '3.7', '3.8', '3.9', '3.10']
         target: [x64, x86]
     steps:
       - uses: actions/checkout@v2
@@ -104,7 +104,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: ['3.6', '3.7', '3.8', '3.9', '3.10']
         target: [x86_64, i686]
     steps:
     - uses: actions/checkout@v2
@@ -159,6 +159,7 @@ jobs:
           { version: '3.7', abi: 'cp37-cp37m' },
           { version: '3.8', abi: 'cp38-cp38' },
           { version: '3.9', abi: 'cp39-cp39' },
+          { version: '3.10', abi: 'cp310-cp310' },
         ]
         target: [aarch64, armv7, s390x, ppc64le, ppc64]
     steps:
@@ -184,16 +185,17 @@ jobs:
           --volume "${PWD}/dist:/artifacts"
         install: |
           apt-get update
-          apt-get install -y --no-install-recommends python3 python3-pip software-properties-common
+          apt-get install -y --no-install-recommends python3 python3-venv software-properties-common
           add-apt-repository ppa:deadsnakes/ppa
           apt-get update
-          apt-get install -y python3.6 python3.7 python3.9
+          apt-get install -y curl python3.6-venv python3.7-venv python3.9-venv python3.10-venv
         run: |
           ls -lrth /artifacts
           PYTHON=python${{ matrix.python.version }}
-          $PYTHON -m pip install -U pip
-          $PYTHON -m pip install cramjam --no-index --find-links /artifacts --force-reinstall
-          $PYTHON -c 'import cramjam'
+          $PYTHON -m venv venv
+          venv/bin/pip install -U pip
+          venv/bin/pip install cramjam --no-index --find-links /artifacts --force-reinstall
+          venv/bin/python -c 'import cramjam'
     - name: Upload wheels
       uses: actions/upload-artifact@v2
       with:
diff --git a/Cargo.lock b/Cargo.lock
index 65cc63c7..2a81f2c2 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -63,9 +63,9 @@ dependencies = [
 
 [[package]]
 name = "cc"
-version = "1.0.70"
+version = "1.0.71"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d26a6ce4b6a484fa3edb70f7efa6fc430fd2b87285fe8b84304fd0936faa0dc0"
+checksum = "79c2681d6594606957bbb8631c4b90a7fcaaa72cdb714743a437b156d6a7eedd"
 dependencies = [
  "jobserver",
 ]
@@ -108,9 +108,9 @@ dependencies = [
 
 [[package]]
 name = "flate2"
-version = "1.0.21"
+version = "1.0.22"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "80edafed416a46fb378521624fab1cfa2eb514784fd8921adbe8a8d8321da811"
+checksum = "1e6988e897c1c9c485f43b47a529cef42fde0547f9d8d41a7062518f1d8fc53f"
 dependencies = [
  "cfg-if 1.0.0",
  "crc32fast",
@@ -143,9 +143,9 @@ dependencies = [
 
 [[package]]
 name = "instant"
-version = "0.1.10"
+version = "0.1.12"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bee0328b1209d157ef001c94dd85b4f8f64139adb0eac2659f4b08382b2f474d"
+checksum = "7a5bbe824c507c5da5956355e86a746d82e0e1464f65d862cc5e71da70e94b2c"
 dependencies = [
  "cfg-if 1.0.0",
 ]
@@ -161,9 +161,9 @@ dependencies = [
 
 [[package]]
 name = "libc"
-version = "0.2.101"
+version = "0.2.106"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3cb00336871be5ed2c8ed44b60ae9959dc5b9f08539422ed43f09e34ecaeba21"
+checksum = "a60553f9a9e039a333b4e9b20573b9e9b9c0bb3a11e201ccc48ef4283456d673"
 
 [[package]]
 name = "libmimalloc-sys"
@@ -275,8 +275,7 @@ dependencies = [
 [[package]]
 name = "numpy"
 version = "0.14.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "09c15af63aa0c74e0f7230d4e95d9a3d71a23449905f30f50b055df9a6a6a3e6"
+source = "git+https://github.com/PyO3/rust-numpy.git?branch=main#2cab9df30cf9cc1bb2f370cb069b87465308b1ea"
 dependencies = [
  "cfg-if 0.1.10",
  "libc",
@@ -338,9 +337,9 @@ dependencies = [
 
 [[package]]
 name = "pkg-config"
-version = "0.3.19"
+version = "0.3.22"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3831453b3449ceb48b6d9c7ad7c96d5ea673e9b470a1dc578c2ce6521230884c"
+checksum = "12295df4f294471248581bc09bef3c38a5e46f1e36d6a37353621a0c6c357e1f"
 
 [[package]]
 name = "proc-macro-hack"
@@ -350,18 +349,18 @@ checksum = "dbf0c48bc1d91375ae5c3cd81e3722dff1abcf81a30960240640d223f59fe0e5"
 
 [[package]]
 name = "proc-macro2"
-version = "1.0.29"
+version = "1.0.32"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b9f5105d4fdaab20335ca9565e106a5d9b82b6219b5ba735731124ac6711d23d"
+checksum = "ba508cc11742c0dc5c1659771673afbab7a0efab23aa17e854cbab0837ed0b43"
 dependencies = [
  "unicode-xid",
 ]
 
 [[package]]
 name = "pyo3"
-version = "0.14.5"
+version = "0.15.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "35100f9347670a566a67aa623369293703322bb9db77d99d7df7313b575ae0c8"
+checksum = "64664505ce285a59b8b7e940fbe54ad65b1758a0810eddc5bc26df6f6ec8c557"
 dependencies = [
  "cfg-if 1.0.0",
  "indoc",
@@ -375,18 +374,18 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.14.5"
+version = "0.15.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d12961738cacbd7f91b7c43bc25cfeeaa2698ad07a04b3be0aa88b950865738f"
+checksum = "5f1e4a72de84cdcd69f62211b62f62753d0c11b7b5715f3467f3754dab22a7ca"
 dependencies = [
  "once_cell",
 ]
 
 [[package]]
 name = "pyo3-macros"
-version = "0.14.5"
+version = "0.15.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "fc0bc5215d704824dfddddc03f93cb572e1155c68b6761c37005e1c288808ea8"
+checksum = "244f21d0a3887a9c02018b94e3b78d693dc7eca5c56839b7796a499cc364deb4"
 dependencies = [
  "pyo3-macros-backend",
  "quote",
@@ -395,9 +394,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.14.5"
+version = "0.15.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "71623fc593224afaab918aa3afcaf86ed2f43d34f6afde7f3922608f253240df"
+checksum = "b3d3d18ac41d05199bb82645d56e39f8c8b4909a0137c6f2640f03685b29f672"
 dependencies = [
  "proc-macro2",
  "pyo3-build-config",
@@ -407,9 +406,9 @@ dependencies = [
 
 [[package]]
 name = "quote"
-version = "1.0.9"
+version = "1.0.10"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c3d0b9745dc2debf507c8422de05d7226cc1f0644216dfdfead988f9b1ab32a7"
+checksum = "38bc8cc6a5f2e3655e0899c1b848643b2562f853f114bfec7be120678e3ace05"
 dependencies = [
  "proc-macro2",
 ]
@@ -437,9 +436,9 @@ checksum = "d29ab0c6d3fc0ee92fe66e2d99f700eab17a8d57d1c1d3b748380fb20baa78cd"
 
 [[package]]
 name = "smallvec"
-version = "1.6.1"
+version = "1.7.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "fe0f37c9e8f3c5a4a66ad655a93c74daac4ad00c441533bf5c6e7990bb42604e"
+checksum = "1ecab6c735a6bb4139c0caafd0cc3635748bbb3acf4550e8138122099251f309"
 
 [[package]]
 name = "snap"
@@ -449,9 +448,9 @@ checksum = "45456094d1983e2ee2a18fdfebce3189fa451699d0502cb8e3b49dba5ba41451"
 
 [[package]]
 name = "syn"
-version = "1.0.75"
+version = "1.0.81"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b7f58f7e8eaa0009c5fec437aabf511bd9933e4b2d7407bd05273c01a8906ea7"
+checksum = "f2afee18b8beb5a596ecb4a2dce128c719b4ba399d34126b9e4396e3f9860966"
 dependencies = [
  "proc-macro2",
  "quote",
diff --git a/Cargo.toml b/Cargo.toml
index cfc1c405..28604412 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -23,14 +23,14 @@ codegen-units = 1
 opt-level = 3
 
 [dependencies]
-pyo3 = { version = "0.14.1", default-features = false, features = ["macros"] }
+pyo3 = { version = "0.15", default-features = false, features = ["macros"] }
 snap = "^1"
 brotli2 = "^0.3"
 bzip2 = "^0.4"
 lz4 = "^1"
 flate2 = "^1"
 zstd = "0.9.0+zstd.1.5.0"
-numpy = "0.14.0"
+numpy = "0.15"
 
 [dependencies.mimalloc]
 version = "0.1.24"
diff --git a/benchmark-requirements.txt b/benchmark-requirements.txt
index d8331363..5059b39c 100644
--- a/benchmark-requirements.txt
+++ b/benchmark-requirements.txt
@@ -2,6 +2,6 @@ pytest-benchmark==3.2.3
 python-snappy==0.5.4
 lz4==3.1.0
 brotlipy==0.7.0
-zstd==1.4.5.1
+zstd==1.5.0.2
 numpy
 memory-profiler