diff --git a/.changeset/brave-tigers-occur.md b/.changeset/brave-tigers-occur.md
new file mode 100644
index 000000000..f52a9ef2d
--- /dev/null
+++ b/.changeset/brave-tigers-occur.md
@@ -0,0 +1,5 @@
+---
+"@rnx-kit/metro-serializer-esbuild": patch
+---
+
+Bump esbuild to 0.18 to include a number of `tsconfig.json` related fixes (see https://github.com/evanw/esbuild/releases/tag/v0.18.0)
diff --git a/packages/esbuild-plugin-import-path-remapper/package.json b/packages/esbuild-plugin-import-path-remapper/package.json
index e68f22499..879b93b7d 100644
--- a/packages/esbuild-plugin-import-path-remapper/package.json
+++ b/packages/esbuild-plugin-import-path-remapper/package.json
@@ -22,7 +22,7 @@
   },
   "devDependencies": {
     "@rnx-kit/scripts": "*",
-    "esbuild": "^0.17.0",
+    "esbuild": "^0.18.0",
     "eslint": "^8.0.0",
     "jest": "^29.2.1",
     "prettier": "^2.8.0",
diff --git a/packages/metro-serializer-esbuild/package.json b/packages/metro-serializer-esbuild/package.json
index 8350bc677..4c1cbb0d0 100644
--- a/packages/metro-serializer-esbuild/package.json
+++ b/packages/metro-serializer-esbuild/package.json
@@ -24,7 +24,7 @@
     "@rnx-kit/console": "^1.0.11",
     "@rnx-kit/tools-node": "^2.0.0",
     "@rnx-kit/tools-react-native": "^1.3.1",
-    "esbuild": "^0.17.0",
+    "esbuild": "^0.18.0",
     "esbuild-plugin-lodash": "^1.2.0",
     "fast-glob": "^3.2.7",
     "semver": "^7.0.0"
diff --git a/scripts/align-deps-preset.js b/scripts/align-deps-preset.js
index ff06c8b21..dc38571a4 100644
--- a/scripts/align-deps-preset.js
+++ b/scripts/align-deps-preset.js
@@ -31,7 +31,7 @@ const profile = {
   },
   esbuild: {
     name: "esbuild",
-    version: "^0.17.0",
+    version: "^0.18.0",
   },
   eslint: {
     name: "eslint",
diff --git a/scripts/package.json b/scripts/package.json
index a494ca918..423496633 100644
--- a/scripts/package.json
+++ b/scripts/package.json
@@ -14,7 +14,7 @@
   },
   "dependencies": {
     "depcheck": "^1.0.0",
-    "esbuild": "^0.17.0",
+    "esbuild": "^0.18.0",
     "eslint": "^8.0.0",
     "jest": "^29.2.1",
     "markdown-table": "^3.0.0",
diff --git a/yarn.lock b/yarn.lock
index 5595d6855..a4c307155 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1984,156 +1984,156 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@esbuild/android-arm64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/android-arm64@npm:0.17.18"
+"@esbuild/android-arm64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/android-arm64@npm:0.18.2"
   conditions: os=android & cpu=arm64
   languageName: node
   linkType: hard
 
-"@esbuild/android-arm@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/android-arm@npm:0.17.18"
+"@esbuild/android-arm@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/android-arm@npm:0.18.2"
   conditions: os=android & cpu=arm
   languageName: node
   linkType: hard
 
-"@esbuild/android-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/android-x64@npm:0.17.18"
+"@esbuild/android-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/android-x64@npm:0.18.2"
   conditions: os=android & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/darwin-arm64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/darwin-arm64@npm:0.17.18"
+"@esbuild/darwin-arm64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/darwin-arm64@npm:0.18.2"
   conditions: os=darwin & cpu=arm64
   languageName: node
   linkType: hard
 
-"@esbuild/darwin-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/darwin-x64@npm:0.17.18"
+"@esbuild/darwin-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/darwin-x64@npm:0.18.2"
   conditions: os=darwin & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/freebsd-arm64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/freebsd-arm64@npm:0.17.18"
+"@esbuild/freebsd-arm64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/freebsd-arm64@npm:0.18.2"
   conditions: os=freebsd & cpu=arm64
   languageName: node
   linkType: hard
 
-"@esbuild/freebsd-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/freebsd-x64@npm:0.17.18"
+"@esbuild/freebsd-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/freebsd-x64@npm:0.18.2"
   conditions: os=freebsd & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/linux-arm64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-arm64@npm:0.17.18"
+"@esbuild/linux-arm64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-arm64@npm:0.18.2"
   conditions: os=linux & cpu=arm64
   languageName: node
   linkType: hard
 
-"@esbuild/linux-arm@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-arm@npm:0.17.18"
+"@esbuild/linux-arm@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-arm@npm:0.18.2"
   conditions: os=linux & cpu=arm
   languageName: node
   linkType: hard
 
-"@esbuild/linux-ia32@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-ia32@npm:0.17.18"
+"@esbuild/linux-ia32@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-ia32@npm:0.18.2"
   conditions: os=linux & cpu=ia32
   languageName: node
   linkType: hard
 
-"@esbuild/linux-loong64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-loong64@npm:0.17.18"
+"@esbuild/linux-loong64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-loong64@npm:0.18.2"
   conditions: os=linux & cpu=loong64
   languageName: node
   linkType: hard
 
-"@esbuild/linux-mips64el@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-mips64el@npm:0.17.18"
+"@esbuild/linux-mips64el@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-mips64el@npm:0.18.2"
   conditions: os=linux & cpu=mips64el
   languageName: node
   linkType: hard
 
-"@esbuild/linux-ppc64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-ppc64@npm:0.17.18"
+"@esbuild/linux-ppc64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-ppc64@npm:0.18.2"
   conditions: os=linux & cpu=ppc64
   languageName: node
   linkType: hard
 
-"@esbuild/linux-riscv64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-riscv64@npm:0.17.18"
+"@esbuild/linux-riscv64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-riscv64@npm:0.18.2"
   conditions: os=linux & cpu=riscv64
   languageName: node
   linkType: hard
 
-"@esbuild/linux-s390x@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-s390x@npm:0.17.18"
+"@esbuild/linux-s390x@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-s390x@npm:0.18.2"
   conditions: os=linux & cpu=s390x
   languageName: node
   linkType: hard
 
-"@esbuild/linux-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/linux-x64@npm:0.17.18"
+"@esbuild/linux-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/linux-x64@npm:0.18.2"
   conditions: os=linux & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/netbsd-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/netbsd-x64@npm:0.17.18"
+"@esbuild/netbsd-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/netbsd-x64@npm:0.18.2"
   conditions: os=netbsd & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/openbsd-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/openbsd-x64@npm:0.17.18"
+"@esbuild/openbsd-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/openbsd-x64@npm:0.18.2"
   conditions: os=openbsd & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/sunos-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/sunos-x64@npm:0.17.18"
+"@esbuild/sunos-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/sunos-x64@npm:0.18.2"
   conditions: os=sunos & cpu=x64
   languageName: node
   linkType: hard
 
-"@esbuild/win32-arm64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/win32-arm64@npm:0.17.18"
+"@esbuild/win32-arm64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/win32-arm64@npm:0.18.2"
   conditions: os=win32 & cpu=arm64
   languageName: node
   linkType: hard
 
-"@esbuild/win32-ia32@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/win32-ia32@npm:0.17.18"
+"@esbuild/win32-ia32@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/win32-ia32@npm:0.18.2"
   conditions: os=win32 & cpu=ia32
   languageName: node
   linkType: hard
 
-"@esbuild/win32-x64@npm:0.17.18":
-  version: 0.17.18
-  resolution: "@esbuild/win32-x64@npm:0.17.18"
+"@esbuild/win32-x64@npm:0.18.2":
+  version: 0.18.2
+  resolution: "@esbuild/win32-x64@npm:0.18.2"
   conditions: os=win32 & cpu=x64
   languageName: node
   linkType: hard
@@ -3539,7 +3539,7 @@ __metadata:
   resolution: "@rnx-kit/esbuild-plugin-import-path-remapper@workspace:packages/esbuild-plugin-import-path-remapper"
   dependencies:
     "@rnx-kit/scripts": "*"
-    esbuild: ^0.17.0
+    esbuild: ^0.18.0
     eslint: ^8.0.0
     jest: ^29.2.1
     prettier: ^2.8.0
@@ -3747,7 +3747,7 @@ __metadata:
     "@types/metro-config": ^0.76.0
     "@types/metro-transform-worker": ^0.76.0
     "@types/semver": ^7.0.0
-    esbuild: ^0.17.0
+    esbuild: ^0.18.0
     esbuild-plugin-lodash: ^1.2.0
     eslint: ^8.0.0
     fast-glob: ^3.2.7
@@ -3945,7 +3945,7 @@ __metadata:
   dependencies:
     "@types/jest": ^29.2.1
     depcheck: ^1.0.0
-    esbuild: ^0.17.0
+    esbuild: ^0.18.0
     eslint: ^8.0.0
     jest: ^29.2.1
     markdown-table: ^3.0.0
@@ -6798,32 +6798,32 @@ __metadata:
   languageName: node
   linkType: hard
 
-"esbuild@npm:^0.17.0":
-  version: 0.17.18
-  resolution: "esbuild@npm:0.17.18"
-  dependencies:
-    "@esbuild/android-arm": 0.17.18
-    "@esbuild/android-arm64": 0.17.18
-    "@esbuild/android-x64": 0.17.18
-    "@esbuild/darwin-arm64": 0.17.18
-    "@esbuild/darwin-x64": 0.17.18
-    "@esbuild/freebsd-arm64": 0.17.18
-    "@esbuild/freebsd-x64": 0.17.18
-    "@esbuild/linux-arm": 0.17.18
-    "@esbuild/linux-arm64": 0.17.18
-    "@esbuild/linux-ia32": 0.17.18
-    "@esbuild/linux-loong64": 0.17.18
-    "@esbuild/linux-mips64el": 0.17.18
-    "@esbuild/linux-ppc64": 0.17.18
-    "@esbuild/linux-riscv64": 0.17.18
-    "@esbuild/linux-s390x": 0.17.18
-    "@esbuild/linux-x64": 0.17.18
-    "@esbuild/netbsd-x64": 0.17.18
-    "@esbuild/openbsd-x64": 0.17.18
-    "@esbuild/sunos-x64": 0.17.18
-    "@esbuild/win32-arm64": 0.17.18
-    "@esbuild/win32-ia32": 0.17.18
-    "@esbuild/win32-x64": 0.17.18
+"esbuild@npm:^0.18.0":
+  version: 0.18.2
+  resolution: "esbuild@npm:0.18.2"
+  dependencies:
+    "@esbuild/android-arm": 0.18.2
+    "@esbuild/android-arm64": 0.18.2
+    "@esbuild/android-x64": 0.18.2
+    "@esbuild/darwin-arm64": 0.18.2
+    "@esbuild/darwin-x64": 0.18.2
+    "@esbuild/freebsd-arm64": 0.18.2
+    "@esbuild/freebsd-x64": 0.18.2
+    "@esbuild/linux-arm": 0.18.2
+    "@esbuild/linux-arm64": 0.18.2
+    "@esbuild/linux-ia32": 0.18.2
+    "@esbuild/linux-loong64": 0.18.2
+    "@esbuild/linux-mips64el": 0.18.2
+    "@esbuild/linux-ppc64": 0.18.2
+    "@esbuild/linux-riscv64": 0.18.2
+    "@esbuild/linux-s390x": 0.18.2
+    "@esbuild/linux-x64": 0.18.2
+    "@esbuild/netbsd-x64": 0.18.2
+    "@esbuild/openbsd-x64": 0.18.2
+    "@esbuild/sunos-x64": 0.18.2
+    "@esbuild/win32-arm64": 0.18.2
+    "@esbuild/win32-ia32": 0.18.2
+    "@esbuild/win32-x64": 0.18.2
   dependenciesMeta:
     "@esbuild/android-arm":
       optional: true
@@ -6871,7 +6871,7 @@ __metadata:
       optional: true
   bin:
     esbuild: bin/esbuild
-  checksum: 900b333f649fd89804216fb61fb5a0ffadc6dc37a2ec3b5981b588f72821676ea649a7c0ec785f0dbe6e774080b084c8af5f6ee7adbc1b138faf2a8c35e2c69c
+  checksum: 64d82cc5fa1280f1730f96fdb9a74a23effb01de63d020c99f9090ea792fe78199daf083e842eccd3a55ccbad3d1bafb2f4b86280b6c8ce203fa309f06312597
   languageName: node
   linkType: hard