diff --git a/change/@fluentui-react-button-e7f98b68-84a6-495a-81fa-cc5ac0eda06f.json b/change/@fluentui-react-button-e7f98b68-84a6-495a-81fa-cc5ac0eda06f.json
new file mode 100644
index 0000000000000..0b370ccbbb793
--- /dev/null
+++ b/change/@fluentui-react-button-e7f98b68-84a6-495a-81fa-cc5ac0eda06f.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "fix: medium and large SplitButton menuButton is at least 24px wide",
+  "packageName": "@fluentui/react-button",
+  "email": "sarah.higley@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/react-components/react-button/library/src/components/SplitButton/useSplitButtonStyles.styles.ts b/packages/react-components/react-button/library/src/components/SplitButton/useSplitButtonStyles.styles.ts
index 6b6826712ac3d..f3ebfaf3efa88 100644
--- a/packages/react-components/react-button/library/src/components/SplitButton/useSplitButtonStyles.styles.ts
+++ b/packages/react-components/react-button/library/src/components/SplitButton/useSplitButtonStyles.styles.ts
@@ -10,6 +10,10 @@ export const splitButtonClassNames: SlotClassNames<SplitButtonSlots> = {
   primaryActionButton: 'fui-SplitButton__primaryActionButton',
 };
 
+// WCAG minimum target size for pointer targets that are immediately adjacent to other targets:
+// https://w3c.github.io/wcag/guidelines/22/#target-size-minimum
+const MIN_TARGET_SIZE = '24px';
+
 const useFocusStyles = makeStyles({
   primaryActionButton: createCustomFocusIndicatorStyle({
     borderTopRightRadius: 0,
@@ -40,7 +44,7 @@ const useRootStyles = makeStyles({
       borderLeftWidth: 0,
       borderTopLeftRadius: 0,
       borderBottomLeftRadius: 0,
-      minWidth: 0,
+      minWidth: MIN_TARGET_SIZE,
     },
   },