diff --git a/src/BinSkim.Rules/PERules/BA2021.DoNotMarkWritableSectionsAsExecutable.cs b/src/BinSkim.Rules/PERules/BA2021.DoNotMarkWritableSectionsAsExecutable.cs
index ead85037..d76b3e1d 100644
--- a/src/BinSkim.Rules/PERules/BA2021.DoNotMarkWritableSectionsAsExecutable.cs
+++ b/src/BinSkim.Rules/PERules/BA2021.DoNotMarkWritableSectionsAsExecutable.cs
@@ -47,6 +47,17 @@ public override AnalysisApplicability CanAnalyzePE(PEBinary target, BinaryAnalyz
             PE portableExecutable = target.PE;
             AnalysisApplicability result = AnalysisApplicability.NotApplicableToSpecifiedTarget;
 
+            if (portableExecutable.PEHeaders.CorHeader != null)
+            {
+                CoffHeader coffHeader = portableExecutable.PEHeaders.CoffHeader;
+
+                // .NET does not follow Windows layout rules on non-Windows platforms.
+                // The Machine value in the CoffHeader for Windows ARM64 will not be the same for Linux ARM64.
+                // As a result, we can detect .NET PE's that are non-Windows and skip.
+                reasonForNotAnalyzing = MetadataConditions.ImageIsNonWindowsDotNetAssembly;
+                if (IsNonWindowsMachineTarget(coffHeader.Machine)) { return result; }
+            }
+
             reasonForNotAnalyzing = MetadataConditions.ImageIsKernelModeBinary;
             if (portableExecutable.IsKernelMode) { return result; }
 
@@ -116,5 +127,10 @@ public override void Analyze(BinaryAnalyzerContext context)
                     context.CurrentTarget.Uri.GetFileName(),
                     badSectionsText));
         }
+
+        private bool IsNonWindowsMachineTarget(Machine machine)
+        {
+            return machine != Machine.Amd64 && machine != Machine.I386 && machine != Machine.Arm && machine != Machine.Arm64;
+        }
     }
 }
diff --git a/src/BinSkim.Sdk/MetadataConditions.cs b/src/BinSkim.Sdk/MetadataConditions.cs
index f83a9ae7..db911f9d 100644
--- a/src/BinSkim.Sdk/MetadataConditions.cs
+++ b/src/BinSkim.Sdk/MetadataConditions.cs
@@ -41,6 +41,7 @@ public static class MetadataConditions
         public static readonly string ImageIsDotNetCoreEntryPointDll = SdkResources.MetadataCondition_ImageIsDotNetCoreEntryPointDll;
         public static readonly string ImageCompiledWithOutdatedTools = SdkResources.MetadataCondition_ImageCompiledWithOutdatedTools;
         public static readonly string ImageIsDotNetNativeBootstrapExe = SdkResources.MetadataCondition_ImageIsDotNetNativeBootstrapExe;
+        public static readonly string ImageIsNonWindowsDotNetAssembly = SdkResources.MetadataCondition_ImageIsNonWindowsDotNetAssembly;
         public static readonly string ImageIsPreVersion7WindowsCEBinary = SdkResources.MetadataCondition_ImageIsPreVersion7WindowsCEBinary;
         public static readonly string MachOIsNotExecutableDynamicLibraryOrObject = SdkResources.MetadataCondition_MachOIsNotExecutableDynamicLibraryOrObject;
         public static readonly string ImageIsNativeUniversalWindowsPlatformBinary = SdkResources.MetadataCondition_ImageIsNativeUniversalWindowsPlatformBinary;
diff --git a/src/BinSkim.Sdk/SdkResources.Designer.cs b/src/BinSkim.Sdk/SdkResources.Designer.cs
index 053e19b4..64551b2c 100644
--- a/src/BinSkim.Sdk/SdkResources.Designer.cs
+++ b/src/BinSkim.Sdk/SdkResources.Designer.cs
@@ -230,6 +230,15 @@ internal static string MetadataCondition_ImageIsDotNetNativeBootstrapExe {
                 return ResourceManager.GetString("MetadataCondition_ImageIsDotNetNativeBootstrapExe", resourceCulture);
             }
         }
+
+        /// <summary>
+        ///   Looks up a localized string similar to image is non Windows .NET assembly.
+        /// </summary>
+        internal static string MetadataCondition_ImageIsNonWindowsDotNetAssembly {
+            get {
+                return ResourceManager.GetString("MetadataCondition_ImageIsNonWindowsDotNetAssembly", resourceCulture);
+            }
+        }
         
         /// <summary>
         ///   Looks up a localized string similar to image is a managed IL library (i.e., ahead of time compiled) assembly.
diff --git a/src/BinSkim.Sdk/SdkResources.resx b/src/BinSkim.Sdk/SdkResources.resx
index d55ad47f..db0a521a 100644
--- a/src/BinSkim.Sdk/SdkResources.resx
+++ b/src/BinSkim.Sdk/SdkResources.resx
@@ -222,6 +222,9 @@
   <data name="MetadataCondition_ImageIsDotNetNativeBootstrapExe" xml:space="preserve">
     <value>image is a .NET native bootstrap exe</value>
   </data>
+  <data name="MetadataCondition_ImageIsNonWindowsDotNetAssembly" xml:space="preserve">
+    <value>image is a non-Windows .NET R2R or NativeAOT assembly</value>
+  </data>
   <data name="Verbose_ReplaceWithLevelAndKind" xml:space="preserve">
     <value>use --level and --kind</value>
   </data>