diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 0a9740a73e414..3427f5036b814 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -17715,8 +17715,9 @@ namespace ts {
                 let result = Ternary.True;
                 const saveErrorInfo = captureErrorCalculationState();
                 const incompatibleReporter = kind === SignatureKind.Construct ? reportIncompatibleConstructSignatureReturn : reportIncompatibleCallSignatureReturn;
-
-                if (getObjectFlags(source) & ObjectFlags.Instantiated && getObjectFlags(target) & ObjectFlags.Instantiated && source.symbol === target.symbol) {
+                const sourceObjectFlags = getObjectFlags(source);
+                const targetObjectFlags = getObjectFlags(target);
+                if (sourceObjectFlags & ObjectFlags.Instantiated && targetObjectFlags & ObjectFlags.Instantiated && source.symbol === target.symbol) {
                     // We have instantiations of the same anonymous type (which typically will be the type of a
                     // method). Simply do a pairwise comparison of the signatures in the two signature lists instead
                     // of the much more expensive N * M comparison matrix we explore below. We erase type parameters
@@ -17736,7 +17737,19 @@ namespace ts {
                     // this regardless of the number of signatures, but the potential costs are prohibitive due
                     // to the quadratic nature of the logic below.
                     const eraseGenerics = relation === comparableRelation || !!compilerOptions.noStrictGenericChecks;
-                    result = signatureRelatedTo(sourceSignatures[0], targetSignatures[0], eraseGenerics, reportErrors, incompatibleReporter(sourceSignatures[0], targetSignatures[0]));
+                    const sourceSignature = first(sourceSignatures);
+                    const targetSignature = first(targetSignatures);
+                    result = signatureRelatedTo(sourceSignature, targetSignature, eraseGenerics, reportErrors, incompatibleReporter(sourceSignature, targetSignature));
+                    if (!result && reportErrors && kind === SignatureKind.Construct && (sourceObjectFlags & targetObjectFlags)) {
+                        const declaration = targetSignature.declaration || sourceSignature.declaration;
+                        if (declaration && (isConstructorDeclaration(declaration) || isConstructSignatureDeclaration(declaration))) {
+                            const constructSignatureToString = (signature: Signature) =>
+                                signatureToString(signature, /*enclosingDeclaration*/ undefined, TypeFormatFlags.WriteArrowStyleSignature, kind);
+                            reportError(Diagnostics.Type_0_is_not_assignable_to_type_1, constructSignatureToString(sourceSignature), constructSignatureToString(targetSignature));
+                            reportError(Diagnostics.Types_of_construct_signature_are_incompatible);
+                            return result;
+                        }
+                    }
                 }
                 else {
                     outer: for (const t of targetSignatures) {
diff --git a/src/compiler/diagnosticMessages.json b/src/compiler/diagnosticMessages.json
index 82f3cb4ce579b..59fe0654d703c 100644
--- a/src/compiler/diagnosticMessages.json
+++ b/src/compiler/diagnosticMessages.json
@@ -1686,6 +1686,10 @@
         "category": "Error",
         "code": 2418
     },
+    "Types of construct signature are incompatible.": {
+        "category": "Error",
+        "code": 2419
+    },
     "Class '{0}' incorrectly implements interface '{1}'.": {
         "category": "Error",
         "code": 2420
diff --git a/tests/baselines/reference/assignmentCompatability44.errors.txt b/tests/baselines/reference/assignmentCompatability44.errors.txt
new file mode 100644
index 0000000000000..7fa21174f7da0
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability44.errors.txt
@@ -0,0 +1,16 @@
+tests/cases/compiler/assignmentCompatability44.ts(5,7): error TS2322: Type 'typeof Foo' is not assignable to type 'new () => Foo'.
+  Types of construct signature are incompatible.
+    Type 'new (x: number) => Foo' is not assignable to type 'new () => Foo'.
+
+
+==== tests/cases/compiler/assignmentCompatability44.ts (1 errors) ====
+    class Foo {
+        constructor(x: number) {}
+    }
+    
+    const foo: { new(): Foo } = Foo;
+          ~~~
+!!! error TS2322: Type 'typeof Foo' is not assignable to type 'new () => Foo'.
+!!! error TS2322:   Types of construct signature are incompatible.
+!!! error TS2322:     Type 'new (x: number) => Foo' is not assignable to type 'new () => Foo'.
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/assignmentCompatability44.js b/tests/baselines/reference/assignmentCompatability44.js
new file mode 100644
index 0000000000000..ccdbf0827c353
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability44.js
@@ -0,0 +1,15 @@
+//// [assignmentCompatability44.ts]
+class Foo {
+    constructor(x: number) {}
+}
+
+const foo: { new(): Foo } = Foo;
+
+
+//// [assignmentCompatability44.js]
+var Foo = /** @class */ (function () {
+    function Foo(x) {
+    }
+    return Foo;
+}());
+var foo = Foo;
diff --git a/tests/baselines/reference/assignmentCompatability44.symbols b/tests/baselines/reference/assignmentCompatability44.symbols
new file mode 100644
index 0000000000000..182bb1b049011
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability44.symbols
@@ -0,0 +1,13 @@
+=== tests/cases/compiler/assignmentCompatability44.ts ===
+class Foo {
+>Foo : Symbol(Foo, Decl(assignmentCompatability44.ts, 0, 0))
+
+    constructor(x: number) {}
+>x : Symbol(x, Decl(assignmentCompatability44.ts, 1, 16))
+}
+
+const foo: { new(): Foo } = Foo;
+>foo : Symbol(foo, Decl(assignmentCompatability44.ts, 4, 5))
+>Foo : Symbol(Foo, Decl(assignmentCompatability44.ts, 0, 0))
+>Foo : Symbol(Foo, Decl(assignmentCompatability44.ts, 0, 0))
+
diff --git a/tests/baselines/reference/assignmentCompatability44.types b/tests/baselines/reference/assignmentCompatability44.types
new file mode 100644
index 0000000000000..a62bf37184b96
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability44.types
@@ -0,0 +1,12 @@
+=== tests/cases/compiler/assignmentCompatability44.ts ===
+class Foo {
+>Foo : Foo
+
+    constructor(x: number) {}
+>x : number
+}
+
+const foo: { new(): Foo } = Foo;
+>foo : new () => Foo
+>Foo : typeof Foo
+
diff --git a/tests/baselines/reference/assignmentCompatability45.errors.txt b/tests/baselines/reference/assignmentCompatability45.errors.txt
new file mode 100644
index 0000000000000..d4f1e219a75b4
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability45.errors.txt
@@ -0,0 +1,18 @@
+tests/cases/compiler/assignmentCompatability45.ts(7,7): error TS2322: Type 'typeof B' is not assignable to type 'typeof A'.
+  Types of construct signature are incompatible.
+    Type 'new (x: number) => B' is not assignable to type 'new () => A'.
+
+
+==== tests/cases/compiler/assignmentCompatability45.ts (1 errors) ====
+    abstract class A {}
+    class B extends A {
+        constructor(x: number) {
+            super();
+        }
+    }
+    const b: typeof A = B;
+          ~
+!!! error TS2322: Type 'typeof B' is not assignable to type 'typeof A'.
+!!! error TS2322:   Types of construct signature are incompatible.
+!!! error TS2322:     Type 'new (x: number) => B' is not assignable to type 'new () => A'.
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/assignmentCompatability45.js b/tests/baselines/reference/assignmentCompatability45.js
new file mode 100644
index 0000000000000..559714d1f40e5
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability45.js
@@ -0,0 +1,37 @@
+//// [assignmentCompatability45.ts]
+abstract class A {}
+class B extends A {
+    constructor(x: number) {
+        super();
+    }
+}
+const b: typeof A = B;
+
+
+//// [assignmentCompatability45.js]
+var __extends = (this && this.__extends) || (function () {
+    var extendStatics = function (d, b) {
+        extendStatics = Object.setPrototypeOf ||
+            ({ __proto__: [] } instanceof Array && function (d, b) { d.__proto__ = b; }) ||
+            function (d, b) { for (var p in b) if (Object.prototype.hasOwnProperty.call(b, p)) d[p] = b[p]; };
+        return extendStatics(d, b);
+    };
+    return function (d, b) {
+        extendStatics(d, b);
+        function __() { this.constructor = d; }
+        d.prototype = b === null ? Object.create(b) : (__.prototype = b.prototype, new __());
+    };
+})();
+var A = /** @class */ (function () {
+    function A() {
+    }
+    return A;
+}());
+var B = /** @class */ (function (_super) {
+    __extends(B, _super);
+    function B(x) {
+        return _super.call(this) || this;
+    }
+    return B;
+}(A));
+var b = B;
diff --git a/tests/baselines/reference/assignmentCompatability45.symbols b/tests/baselines/reference/assignmentCompatability45.symbols
new file mode 100644
index 0000000000000..009e89cd044e2
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability45.symbols
@@ -0,0 +1,20 @@
+=== tests/cases/compiler/assignmentCompatability45.ts ===
+abstract class A {}
+>A : Symbol(A, Decl(assignmentCompatability45.ts, 0, 0))
+
+class B extends A {
+>B : Symbol(B, Decl(assignmentCompatability45.ts, 0, 19))
+>A : Symbol(A, Decl(assignmentCompatability45.ts, 0, 0))
+
+    constructor(x: number) {
+>x : Symbol(x, Decl(assignmentCompatability45.ts, 2, 16))
+
+        super();
+>super : Symbol(A, Decl(assignmentCompatability45.ts, 0, 0))
+    }
+}
+const b: typeof A = B;
+>b : Symbol(b, Decl(assignmentCompatability45.ts, 6, 5))
+>A : Symbol(A, Decl(assignmentCompatability45.ts, 0, 0))
+>B : Symbol(B, Decl(assignmentCompatability45.ts, 0, 19))
+
diff --git a/tests/baselines/reference/assignmentCompatability45.types b/tests/baselines/reference/assignmentCompatability45.types
new file mode 100644
index 0000000000000..c095da8e8605c
--- /dev/null
+++ b/tests/baselines/reference/assignmentCompatability45.types
@@ -0,0 +1,21 @@
+=== tests/cases/compiler/assignmentCompatability45.ts ===
+abstract class A {}
+>A : A
+
+class B extends A {
+>B : B
+>A : A
+
+    constructor(x: number) {
+>x : number
+
+        super();
+>super() : void
+>super : typeof A
+    }
+}
+const b: typeof A = B;
+>b : typeof A
+>A : typeof A
+>B : typeof B
+
diff --git a/tests/baselines/reference/classSideInheritance3.errors.txt b/tests/baselines/reference/classSideInheritance3.errors.txt
index c845defa5b89c..563093c4dec41 100644
--- a/tests/baselines/reference/classSideInheritance3.errors.txt
+++ b/tests/baselines/reference/classSideInheritance3.errors.txt
@@ -1,4 +1,6 @@
 tests/cases/compiler/classSideInheritance3.ts(16,5): error TS2322: Type 'typeof B' is not assignable to type 'typeof A'.
+  Types of construct signature are incompatible.
+    Type 'new (x: string, data: string) => B' is not assignable to type 'new (x: string) => A'.
 tests/cases/compiler/classSideInheritance3.ts(17,5): error TS2322: Type 'typeof B' is not assignable to type 'new (x: string) => A'.
 
 
@@ -21,6 +23,8 @@ tests/cases/compiler/classSideInheritance3.ts(17,5): error TS2322: Type 'typeof
     var r1: typeof A = B; // error
         ~~
 !!! error TS2322: Type 'typeof B' is not assignable to type 'typeof A'.
+!!! error TS2322:   Types of construct signature are incompatible.
+!!! error TS2322:     Type 'new (x: string, data: string) => B' is not assignable to type 'new (x: string) => A'.
     var r2: new (x: string) => A = B; // error
         ~~
 !!! error TS2322: Type 'typeof B' is not assignable to type 'new (x: string) => A'.
diff --git a/tests/cases/compiler/assignmentCompatability44.ts b/tests/cases/compiler/assignmentCompatability44.ts
new file mode 100644
index 0000000000000..c92ad9a4d5029
--- /dev/null
+++ b/tests/cases/compiler/assignmentCompatability44.ts
@@ -0,0 +1,5 @@
+class Foo {
+    constructor(x: number) {}
+}
+
+const foo: { new(): Foo } = Foo;
diff --git a/tests/cases/compiler/assignmentCompatability45.ts b/tests/cases/compiler/assignmentCompatability45.ts
new file mode 100644
index 0000000000000..177a3188c669f
--- /dev/null
+++ b/tests/cases/compiler/assignmentCompatability45.ts
@@ -0,0 +1,7 @@
+abstract class A {}
+class B extends A {
+    constructor(x: number) {
+        super();
+    }
+}
+const b: typeof A = B;