diff --git a/src/Makefile b/src/Makefile
index a9f0512a..888fb14c 100644
--- a/src/Makefile
+++ b/src/Makefile
@@ -44,6 +44,8 @@ COPT += -O3 -DNDEBUG
 endif
 
 JSFLAGS += -s ASYNCIFY
+# This stack limit can be triggered by nesting in user Python code
+JSFLAGS += -s ASYNCIFY_STACK_SIZE=65536
 JSFLAGS += -s EXIT_RUNTIME
 JSFLAGS += -s MODULARIZE=1
 JSFLAGS += -s EXPORT_NAME=createModule