diff --git a/project/json/nmdc_submission_schema.json b/project/json/nmdc_submission_schema.json
index 21f95fcf..aa2cd71b 100644
--- a/project/json/nmdc_submission_schema.json
+++ b/project/json/nmdc_submission_schema.json
@@ -359,80 +359,18 @@
     "MIXS_yaml": {
       "prefix_prefix": "MIXS_yaml",
       "prefix_reference": "https://raw.githubusercontent.com/microbiomedata/mixs/main/model/schema/"
-    }
-  },
-  "default_prefix": "nmdc_sub_schema",
-  "default_range": "string",
-  "subsets": {
-    "mixs_environmental_triad": {
-      "name": "mixs_environmental_triad",
-      "title": "MIxS Environmental Triad",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "mixs extension": {
-      "name": "mixs extension",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "checklist": {
-      "name": "checklist",
-      "description": "A MIxS checklist. These can be combined with packages",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "package": {
-      "name": "package",
-      "description": "A MIxS package. These can be combined with checklists",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "checklist_package_combination": {
-      "name": "checklist_package_combination",
-      "description": "A combination of a checklist and a package",
-      "from_schema": "https://example.com/nmdc_submission_schema"
     },
-    "data object subset": {
-      "name": "data object subset",
-      "description": "Subset consisting of the data objects that either inputs or outputs of processes or workflows.",
-      "from_schema": "https://example.com/nmdc_submission_schema"
+    "BFO": {
+      "prefix_prefix": "BFO",
+      "prefix_reference": "http://purl.obolibrary.org/obo/BFO_"
     },
-    "data_portal_subset": {
-      "name": "data_portal_subset",
-      "description": "Subset consisting of entities that Kitware/nmdc-server use to populate the data portal.",
-      "comments": [
-        "Schema authors are responsible for alerting and supporting Kitware and nmdc-server authors about changes they will have to make if entities labeled with data_portal_subset are modified.",
-        "Assignment of the data_portal_subset is incomplete in the schema."
-      ],
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "environment": {
-      "name": "environment",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "investigation": {
-      "name": "investigation",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "nucleic acid sequence source": {
-      "name": "nucleic acid sequence source",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "proteases": {
-      "name": "proteases",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "sample subset": {
-      "name": "sample subset",
-      "description": "Subset consisting of entities linked to the processing of samples.  Currently, this subset consists of study, omics process, and biosample.",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "sequencing": {
-      "name": "sequencing",
-      "from_schema": "https://example.com/nmdc_submission_schema"
-    },
-    "workflow subset": {
-      "name": "workflow subset",
-      "description": "Subset consisting of just the workflow execution activities",
-      "from_schema": "https://example.com/nmdc_submission_schema"
+    "owl": {
+      "prefix_prefix": "owl",
+      "prefix_reference": "http://www.w3.org/2002/07/owl#"
     }
   },
+  "default_prefix": "nmdc_sub_schema",
+  "default_range": "string",
   "types": {
     "unit": {
       "name": "unit",
@@ -462,19 +400,6 @@
       "base": "str",
       "uri": "xsd:language"
     },
-    "decimal": {
-      "name": "decimal",
-      "description": "A real number with arbitrary precision that conforms to the xsd:decimal specification",
-      "notes": [
-        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"decimal\"."
-      ],
-      "from_schema": "https://example.com/nmdc_submission_schema",
-      "broad_mappings": [
-        "schema:Number"
-      ],
-      "base": "Decimal",
-      "uri": "xsd:decimal"
-    },
     "double": {
       "name": "double",
       "description": "A real number that conforms to the xsd:double specification",
@@ -488,6 +413,40 @@
       "base": "float",
       "uri": "xsd:double"
     },
+    "decimal_degree": {
+      "name": "decimal_degree",
+      "description": "A decimal degree expresses latitude or longitude as decimal fractions.",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "see_also": [
+        "https://en.wikipedia.org/wiki/Decimal_degrees"
+      ],
+      "base": "float",
+      "uri": "xsd:decimal"
+    },
+    "uriorcurie": {
+      "name": "uriorcurie",
+      "description": "a URI or a CURIE",
+      "notes": [
+        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"uriorcurie\"."
+      ],
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "base": "URIorCURIE",
+      "uri": "xsd:anyURI",
+      "repr": "str"
+    },
+    "float": {
+      "name": "float",
+      "description": "A real number that conforms to the xsd:float specification",
+      "notes": [
+        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"float\"."
+      ],
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "exact_mappings": [
+        "schema:Float"
+      ],
+      "base": "float",
+      "uri": "xsd:float"
+    },
     "integer": {
       "name": "integer",
       "description": "An integer",
@@ -501,6 +460,16 @@
       "base": "int",
       "uri": "xsd:integer"
     },
+    "language_code": {
+      "name": "language_code",
+      "description": "A language code conforming to ISO_639-1",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "see_also": [
+        "https://en.wikipedia.org/wiki/ISO_639-1"
+      ],
+      "base": "str",
+      "uri": "xsd:language"
+    },
     "string": {
       "name": "string",
       "description": "A character string",
@@ -514,29 +483,18 @@
       "base": "str",
       "uri": "xsd:string"
     },
-    "float": {
-      "name": "float",
-      "description": "A real number that conforms to the xsd:float specification",
+    "decimal": {
+      "name": "decimal",
+      "description": "A real number with arbitrary precision that conforms to the xsd:decimal specification",
       "notes": [
-        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"float\"."
+        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"decimal\"."
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
-      "exact_mappings": [
-        "schema:Float"
-      ],
-      "base": "float",
-      "uri": "xsd:float"
-    },
-    "uriorcurie": {
-      "name": "uriorcurie",
-      "description": "a URI or a CURIE",
-      "notes": [
-        "If you are authoring schemas in LinkML YAML, the type is referenced with the lower case \"uriorcurie\"."
+      "broad_mappings": [
+        "schema:Number"
       ],
-      "from_schema": "https://example.com/nmdc_submission_schema",
-      "base": "URIorCURIE",
-      "uri": "xsd:anyURI",
-      "repr": "str"
+      "base": "Decimal",
+      "uri": "xsd:decimal"
     },
     "boolean": {
       "name": "boolean",
@@ -4042,11 +4000,23 @@
         "hermaphrodite": {
           "text": "hermaphrodite"
         },
+        "non-binary": {
+          "text": "non-binary"
+        },
         "male": {
           "text": "male"
         },
-        "neuter": {
-          "text": "neuter"
+        "transgender": {
+          "text": "transgender"
+        },
+        "transgender (female to male)": {
+          "text": "transgender (female to male)"
+        },
+        "transgender (male to female)": {
+          "text": "transgender (male to female)"
+        },
+        "undeclared": {
+          "text": "undeclared"
         }
       }
     },
@@ -4078,6 +4048,11 @@
         },
         "bulk chemistry": {
           "text": "bulk chemistry"
+        },
+        "amplicon sequencing assay": {
+          "text": "amplicon sequencing assay",
+          "meaning": "OBI:0002767",
+          "title": "Amplicon sequencing assay"
         }
       }
     },
@@ -4250,9 +4225,6 @@
         "Endosymbionts": {
           "text": "Endosymbionts"
         },
-        "Feedstock": {
-          "text": "Feedstock"
-        },
         "Fish": {
           "text": "Fish"
         },
@@ -4415,9 +4387,6 @@
         "Bacteria": {
           "text": "Bacteria"
         },
-        "Bacterivore": {
-          "text": "Bacterivore"
-        },
         "Bagasse": {
           "text": "Bagasse"
         },
@@ -4883,6 +4852,9 @@
         "Ootheca/Egg mass": {
           "text": "Ootheca/Egg mass"
         },
+        "Organic waste": {
+          "text": "Organic waste"
+        },
         "Outdoor Air": {
           "text": "Outdoor Air"
         },
@@ -7079,6 +7051,9 @@
         "Wart": {
           "text": "Wart"
         },
+        "Waste": {
+          "text": "Waste"
+        },
         "Wastewater": {
           "text": "Wastewater"
         },
@@ -7157,9 +7132,6 @@
         "Acid Mine Drainage": {
           "text": "Acid Mine Drainage"
         },
-        "Acid mine drainage": {
-          "text": "Acid mine drainage"
-        },
         "Acid sulfate soil": {
           "text": "Acid sulfate soil"
         },
@@ -8777,6 +8749,9 @@
         "Royal jelly": {
           "text": "Royal jelly"
         },
+        "Rubber": {
+          "text": "Rubber"
+        },
         "Rumen": {
           "text": "Rumen"
         },
@@ -9377,9 +9352,6 @@
         "Arable": {
           "text": "Arable"
         },
-        "Biochar": {
-          "text": "Biochar"
-        },
         "Biocrust": {
           "text": "Biocrust"
         },
@@ -11443,30 +11415,6 @@
       "is_a": "environment field",
       "slot_uri": "MIXS:0000094",
       "domain_of": [
-        "agriculture",
-        "air",
-        "built environment",
-        "core",
-        "food-animal and animal feed",
-        "food-farm environment",
-        "food-food production facility",
-        "food-human foods",
-        "host-associated",
-        "human-associated",
-        "human-gut",
-        "human-oral",
-        "human-skin",
-        "human-vaginal",
-        "hydrocarbon resources-cores",
-        "hydrocarbon resources-fluids_swabs",
-        "microbial mat_biofilm",
-        "miscellaneous natural or artificial environment",
-        "plant-associated",
-        "sediment",
-        "soil",
-        "symbiont-associated",
-        "wastewater_sludge",
-        "water",
         "Biosample"
       ],
       "range": "string",
@@ -11620,7 +11568,7 @@
       "title": "analysis/data type",
       "examples": [
         {
-          "value": "metagenomics; metabolomics; proteomics"
+          "value": "metagenomics; metabolomics; metaproteomics"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -13601,7 +13549,13 @@
       ],
       "examples": [
         {
-          "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+          "value": "2021-04-15"
+        },
+        {
+          "value": "2021-04"
+        },
+        {
+          "value": "2021"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -13628,7 +13582,10 @@
       ],
       "examples": [
         {
-          "value": "13:33 or 13:33:55"
+          "value": "813"
+        },
+        {
+          "value": "48835"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -13655,7 +13612,10 @@
       ],
       "examples": [
         {
-          "value": "13:33 or 13:33:55"
+          "value": "813"
+        },
+        {
+          "value": "48835"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -15480,7 +15440,7 @@
       "title": "broad-scale environmental context",
       "examples": [
         {
-          "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+          "value": "oceanic epipelagic zone biome [ENVO:01000035]"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -15512,7 +15472,7 @@
       "title": "local environmental context",
       "examples": [
         {
-          "value": "litter layer [ENVO:01000338]; Annotating a pooled sample taken from various vegetation layers in a forest consider: canopy [ENVO:00000047]|herb and fern layer [ENVO:01000337]|litter layer [ENVO:01000338]|understory [01000335]|shrub layer [ENVO:01000336]."
+          "value": "litter layer [ENVO:01000338]"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -15544,7 +15504,7 @@
       "title": "environmental medium",
       "examples": [
         {
-          "value": "soil [ENVO:00001998]; Annotating a fish swimming in the upper 100 m of the Atlantic Ocean, consider: ocean water [ENVO:00002151]. Example: Annotating a duck on a pond consider: pond water [ENVO:00002228]|air [ENVO_00002005]"
+          "value": "soil [ENVO:00001998]"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -17553,7 +17513,7 @@
       "title": "host body product",
       "examples": [
         {
-          "value": "Portion of mucus [fma66938]"
+          "value": "mucus [UBERON:0000912]"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -18656,7 +18616,7 @@
           "value": "13C glucose"
         },
         {
-          "value": "H218O"
+          "value": "18O water"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -18664,7 +18624,6 @@
         "MIXS:0000751"
       ],
       "rank": 16,
-      "string_serialization": "{termLabel} {[termID]}; {timestamp}",
       "domain_of": [
         "Biosample"
       ],
@@ -25512,7 +25471,13 @@
       ],
       "examples": [
         {
-          "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+          "value": "2021-04-15"
+        },
+        {
+          "value": "2021-04"
+        },
+        {
+          "value": "2021"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -25539,7 +25504,10 @@
       ],
       "examples": [
         {
-          "value": "13:33 or 13:33:55"
+          "value": "813"
+        },
+        {
+          "value": "48835"
         }
       ],
       "from_schema": "https://example.com/nmdc_submission_schema",
@@ -28416,11 +28384,27 @@
       "from_schema": "https://example.com/nmdc_submission_schema",
       "domain_of": [
         "MetaboliteIdentification",
-        "NamedThing"
+        "NamedThing",
+        "GeneProduct"
       ],
       "range": "uriorcurie",
       "multivalued": true,
-      "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,]*$"
+      "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,\\(\\)\\=\\#]*$"
+    },
+    "alternative_names": {
+      "name": "alternative_names",
+      "description": "A list of alternative names used to refer to the entity. The distinction between name and alternative names is application-specific.",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "exact_mappings": [
+        "dcterms:alternative",
+        "skos:altLabel"
+      ],
+      "domain_of": [
+        "OntologyClass",
+        "Study"
+      ],
+      "range": "string",
+      "multivalued": false
     },
     "core field": {
       "name": "core field",
@@ -28438,7 +28422,8 @@
       "slot_uri": "dcterms:description",
       "domain_of": [
         "ImageValue",
-        "NamedThing"
+        "NamedThing",
+        "GeneProduct"
       ],
       "range": "string",
       "multivalued": false
@@ -28490,7 +28475,8 @@
       "from_schema": "https://example.com/nmdc_submission_schema",
       "identifier": true,
       "domain_of": [
-        "NamedThing"
+        "NamedThing",
+        "GeneProduct"
       ],
       "range": "uriorcurie",
       "required": true,
@@ -28512,7 +28498,7 @@
       "domain_of": [
         "TextValue"
       ],
-      "range": "language code"
+      "range": "language_code"
     },
     "name": {
       "name": "name",
@@ -28521,7 +28507,8 @@
       "domain_of": [
         "PersonValue",
         "NamedThing",
-        "Protocol"
+        "Protocol",
+        "GeneProduct"
       ],
       "range": "string",
       "multivalued": false
@@ -28534,6 +28521,33 @@
         "Biosample"
       ]
     },
+    "object": {
+      "name": "object",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "owner": "OntologyRelation",
+      "domain_of": [
+        "OntologyRelation"
+      ],
+      "range": "string",
+      "required": true,
+      "multivalued": false
+    },
+    "predicate": {
+      "name": "predicate",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "owner": "OntologyRelation",
+      "domain_of": [
+        "OntologyRelation"
+      ],
+      "range": "string",
+      "required": true,
+      "multivalued": false
+    },
+    "subject": {
+      "name": "subject",
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "range": "GeneProduct"
+    },
     "type": {
       "name": "type",
       "description": "the class_uri of the class that has been instantiated",
@@ -28565,16 +28579,16 @@
         "PortionOfSubstance",
         "MagBin",
         "MetaboliteIdentification",
-        "PeptideQuantification",
-        "ProteinQuantification",
         "GenomeFeature",
         "FunctionalAnnotation",
         "AttributeValue",
         "NamedThing",
+        "OntologyRelation",
         "FailureCategorization",
         "Protocol",
         "CreditAssociation",
-        "Doi"
+        "Doi",
+        "GeneProduct"
       ],
       "range": "uriorcurie",
       "required": true
@@ -28716,30 +28730,6 @@
           "slot_uri": "MIXS:0000094",
           "owner": "Biosample",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -29239,7 +29229,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -30724,30 +30714,6 @@
           "alias": "alt",
           "owner": "AirInterface",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -31258,7 +31224,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -32708,7 +32674,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -33076,30 +33042,6 @@
           "slot_uri": "MIXS:0000094",
           "owner": "Biosample",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -34215,7 +34157,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -36727,30 +36669,6 @@
           "alias": "alt",
           "owner": "BiofilmInterface",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -37891,7 +37809,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -40341,7 +40259,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -40906,30 +40824,6 @@
           "slot_uri": "MIXS:0000094",
           "owner": "Biosample",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -42638,7 +42532,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -47574,30 +47468,6 @@
           "alias": "alt",
           "owner": "BuiltEnvInterface",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -49351,7 +49221,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -54192,7 +54062,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -54683,7 +54553,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -56120,7 +55990,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -60405,7 +60275,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -63573,7 +63443,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -65202,7 +65072,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -69684,7 +69554,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -72857,7 +72727,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -73121,30 +72991,6 @@
           "slot_uri": "MIXS:0000094",
           "owner": "Biosample",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -73676,7 +73522,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -74080,7 +73926,7 @@
           "title": "host body product",
           "examples": [
             {
-              "value": "Portion of mucus [fma66938]"
+              "value": "mucus [UBERON:0000912]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -75835,30 +75681,6 @@
           "alias": "alt",
           "owner": "HostAssociatedInterface",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -76402,7 +76224,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -76815,7 +76637,7 @@
           "title": "host body product",
           "examples": [
             {
-              "value": "Portion of mucus [fma66938]"
+              "value": "mucus [UBERON:0000912]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -78588,7 +78410,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -79717,7 +79539,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -80892,7 +80714,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -81989,7 +81811,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -82337,30 +82159,6 @@
           "slot_uri": "MIXS:0000094",
           "owner": "Biosample",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -83311,7 +83109,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -85166,30 +84964,6 @@
           "alias": "alt",
           "owner": "MiscEnvsInterface",
           "domain_of": [
-            "agriculture",
-            "air",
-            "built environment",
-            "core",
-            "food-animal and animal feed",
-            "food-farm environment",
-            "food-food production facility",
-            "food-human foods",
-            "host-associated",
-            "human-associated",
-            "human-gut",
-            "human-oral",
-            "human-skin",
-            "human-vaginal",
-            "hydrocarbon resources-cores",
-            "hydrocarbon resources-fluids_swabs",
-            "microbial mat_biofilm",
-            "miscellaneous natural or artificial environment",
-            "plant-associated",
-            "sediment",
-            "soil",
-            "symbiont-associated",
-            "wastewater_sludge",
-            "water",
             "Biosample",
             "AirInterface",
             "BiofilmInterface",
@@ -86161,7 +85935,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -87983,7 +87757,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -88688,7 +88462,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -88724,7 +88504,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -89043,7 +88826,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -90241,7 +90024,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -90249,7 +90032,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "owner": "Biosample",
           "domain_of": [
             "Biosample",
@@ -90262,8 +90044,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -92003,7 +91784,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -92647,7 +92434,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -92684,7 +92477,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -93011,7 +92807,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -94238,7 +94034,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -94246,7 +94042,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "alias": "isotope_exposure",
           "owner": "PlantAssociatedInterface",
           "domain_of": [
@@ -94260,8 +94055,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -96043,7 +95837,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -96248,7 +96048,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -97370,7 +97170,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -97406,7 +97212,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -98040,7 +97849,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -98544,7 +98353,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -98552,7 +98361,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "owner": "Biosample",
           "domain_of": [
             "Biosample",
@@ -98565,8 +98373,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -100809,7 +100616,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -102307,7 +102120,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -102344,7 +102163,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -102993,7 +102815,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -103508,7 +103330,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -103516,7 +103338,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "alias": "isotope_exposure",
           "owner": "SedimentInterface",
           "domain_of": [
@@ -103530,8 +103351,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -105826,7 +105646,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -106487,7 +106313,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -107386,7 +107212,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -107422,7 +107254,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -107458,7 +107293,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -107940,7 +107778,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -108743,7 +108581,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -108751,7 +108589,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "owner": "Biosample",
           "domain_of": [
             "Biosample",
@@ -108764,8 +108601,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -110943,7 +110779,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -110979,7 +110821,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -112193,7 +112038,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -112230,7 +112081,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -112267,7 +112121,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -112761,7 +112618,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -113585,7 +113442,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -113593,7 +113450,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "alias": "isotope_exposure",
           "owner": "SoilInterface",
           "domain_of": [
@@ -113607,8 +113463,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -115839,7 +115694,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -115876,7 +115737,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -116484,7 +116348,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -117288,7 +117152,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -119792,7 +119656,7 @@
           ],
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -121755,7 +121619,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -122961,7 +122825,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -122997,7 +122867,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -123787,7 +123660,7 @@
           "title": "broad-scale environmental context",
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -123836,7 +123709,7 @@
           "title": "local environmental context",
           "examples": [
             {
-              "value": "litter layer [ENVO:01000338]; Annotating a pooled sample taken from various vegetation layers in a forest consider: canopy [ENVO:00000047]|herb and fern layer [ENVO:01000337]|litter layer [ENVO:01000338]|understory [01000335]|shrub layer [ENVO:01000336]."
+              "value": "litter layer [ENVO:01000338]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -123885,7 +123758,7 @@
           "title": "environmental medium",
           "examples": [
             {
-              "value": "soil [ENVO:00001998]; Annotating a fish swimming in the upper 100 m of the Atlantic Ocean, consider: ocean water [ENVO:00002151]. Example: Annotating a duck on a pond consider: pond water [ENVO:00002228]|air [ENVO_00002005]"
+              "value": "soil [ENVO:00001998]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -124229,7 +124102,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -124237,7 +124110,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "owner": "Biosample",
           "domain_of": [
             "Biosample",
@@ -124250,8 +124122,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -126309,7 +126180,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -127862,7 +127739,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -127899,7 +127782,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -128708,7 +128594,7 @@
           "title": "broad-scale environmental context",
           "examples": [
             {
-              "value": "oceanic epipelagic zone biome [ENVO:01000033] for annotating a water sample from the photic zone in middle of the Atlantic Ocean"
+              "value": "oceanic epipelagic zone biome [ENVO:01000035]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -128758,7 +128644,7 @@
           "title": "local environmental context",
           "examples": [
             {
-              "value": "litter layer [ENVO:01000338]; Annotating a pooled sample taken from various vegetation layers in a forest consider: canopy [ENVO:00000047]|herb and fern layer [ENVO:01000337]|litter layer [ENVO:01000338]|understory [01000335]|shrub layer [ENVO:01000336]."
+              "value": "litter layer [ENVO:01000338]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -128808,7 +128694,7 @@
           "title": "environmental medium",
           "examples": [
             {
-              "value": "soil [ENVO:00001998]; Annotating a fish swimming in the upper 100 m of the Atlantic Ocean, consider: ocean water [ENVO:00002151]. Example: Annotating a duck on a pond consider: pond water [ENVO:00002228]|air [ENVO_00002005]"
+              "value": "soil [ENVO:00001998]"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -129160,7 +129046,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -129168,7 +129054,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "alias": "isotope_exposure",
           "owner": "WaterInterface",
           "domain_of": [
@@ -129182,8 +129067,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "lat_lon": {
           "name": "lat_lon",
@@ -131288,7 +131172,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -131922,7 +131812,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132096,7 +131986,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132259,7 +132149,7 @@
           "title": "analysis/data type",
           "examples": [
             {
-              "value": "metagenomics; metabolomics; proteomics"
+              "value": "metagenomics; metabolomics; metaproteomics"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132518,7 +132408,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132554,7 +132450,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132590,7 +132489,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132691,7 +132593,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -132699,7 +132601,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "owner": "Biosample",
           "domain_of": [
             "Biosample",
@@ -132712,8 +132613,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "micro_biomass_c_meth": {
           "name": "micro_biomass_c_meth",
@@ -132967,7 +132867,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133003,7 +132909,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133038,7 +132947,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133075,7 +132990,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133112,7 +133030,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133216,7 +133137,7 @@
               "value": "13C glucose"
             },
             {
-              "value": "H218O"
+              "value": "18O water"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133224,7 +133145,6 @@
             "MIXS:0000751"
           ],
           "rank": 16,
-          "string_serialization": "{termLabel} {[termID]}; {timestamp}",
           "alias": "isotope_exposure",
           "owner": "SoilMixsInspiredMixin",
           "domain_of": [
@@ -133238,8 +133158,7 @@
           "slot_group": "mixs_inspired_section",
           "range": "string",
           "recommended": true,
-          "multivalued": false,
-          "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$"
+          "multivalued": false
         },
         "micro_biomass_c_meth": {
           "name": "micro_biomass_c_meth",
@@ -133501,7 +133420,13 @@
           ],
           "examples": [
             {
-              "value": "2021-04-15, 2021-04 and 2021 are all acceptable."
+              "value": "2021-04-15"
+            },
+            {
+              "value": "2021-04"
+            },
+            {
+              "value": "2021"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133538,7 +133463,10 @@
           ],
           "examples": [
             {
-              "value": "13:33 or 13:33:55"
+              "value": "813"
+            },
+            {
+              "value": "48835"
             }
           ],
           "from_schema": "https://w3id.org/nmdc/nmdc",
@@ -133774,6 +133702,145 @@
       },
       "tree_root": true
     },
+    "GeneProduct": {
+      "name": "GeneProduct",
+      "id_prefixes": [
+        "PR",
+        "UniProtKB",
+        "gtpo"
+      ],
+      "description": "A molecule encoded by a gene that has an evolved function",
+      "notes": [
+        "we may include a more general gene product class in future to allow for ncRNA annotation"
+      ],
+      "from_schema": "https://example.com/nmdc_submission_schema",
+      "exact_mappings": [
+        "biolink:GeneProduct"
+      ],
+      "is_a": "NamedThing",
+      "attributes": {
+        "id": {
+          "name": "id",
+          "description": "A unique identifier for a thing. Must be either a CURIE shorthand for a URI or a complete URI",
+          "notes": [
+            "abstracted pattern: prefix:typecode-authshoulder-blade(.version)?(_seqsuffix)?",
+            "a minimum length of 3 characters is suggested for typecodes, but 1 or 2 characters will be accepted",
+            "typecodes must correspond 1:1 to a class in the NMDC schema. this will be checked via per-class id slot usage assertions",
+            "minting authority shoulders should probably be enumerated and checked in the pattern"
+          ],
+          "examples": [
+            {
+              "value": "nmdc:mgmag-00-x012.1_7_c1",
+              "description": "https://github.com/microbiomedata/nmdc-schema/pull/499#discussion_r1018499248"
+            }
+          ],
+          "from_schema": "https://example.com/nmdc_submission_schema",
+          "identifier": true,
+          "alias": "id",
+          "owner": "GeneProduct",
+          "domain_of": [
+            "NamedThing",
+            "GeneProduct"
+          ],
+          "range": "uriorcurie",
+          "required": true,
+          "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,]*$"
+        },
+        "name": {
+          "name": "name",
+          "description": "A human readable label for an entity",
+          "from_schema": "https://example.com/nmdc_submission_schema",
+          "alias": "name",
+          "owner": "GeneProduct",
+          "domain_of": [
+            "PersonValue",
+            "NamedThing",
+            "Protocol",
+            "GeneProduct"
+          ],
+          "range": "string",
+          "multivalued": false
+        },
+        "description": {
+          "name": "description",
+          "description": "a human-readable description of a thing",
+          "from_schema": "https://example.com/nmdc_submission_schema",
+          "slot_uri": "dcterms:description",
+          "alias": "description",
+          "owner": "GeneProduct",
+          "domain_of": [
+            "ImageValue",
+            "NamedThing",
+            "GeneProduct"
+          ],
+          "range": "string",
+          "multivalued": false
+        },
+        "alternative_identifiers": {
+          "name": "alternative_identifiers",
+          "description": "A list of alternative identifiers for the entity.",
+          "from_schema": "https://example.com/nmdc_submission_schema",
+          "alias": "alternative_identifiers",
+          "owner": "GeneProduct",
+          "domain_of": [
+            "MetaboliteIdentification",
+            "NamedThing",
+            "GeneProduct"
+          ],
+          "range": "uriorcurie",
+          "multivalued": true,
+          "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,\\(\\)\\=\\#]*$"
+        },
+        "type": {
+          "name": "type",
+          "description": "the class_uri of the class that has been instantiated",
+          "notes": [
+            "replaces legacy nmdc:type slot",
+            "makes it easier to read example data files",
+            "required for polymorphic MongoDB collections"
+          ],
+          "examples": [
+            {
+              "value": "nmdc:Biosample"
+            },
+            {
+              "value": "nmdc:Study"
+            }
+          ],
+          "from_schema": "https://example.com/nmdc_submission_schema",
+          "see_also": [
+            "https://github.com/microbiomedata/nmdc-schema/issues/1048",
+            "https://github.com/microbiomedata/nmdc-schema/issues/1233",
+            "https://github.com/microbiomedata/nmdc-schema/issues/248"
+          ],
+          "slot_uri": "rdf:type",
+          "designates_type": true,
+          "alias": "type",
+          "owner": "GeneProduct",
+          "domain_of": [
+            "EukEval",
+            "FunctionalAnnotationAggMember",
+            "MobilePhaseSegment",
+            "PortionOfSubstance",
+            "MagBin",
+            "MetaboliteIdentification",
+            "GenomeFeature",
+            "FunctionalAnnotation",
+            "AttributeValue",
+            "NamedThing",
+            "OntologyRelation",
+            "FailureCategorization",
+            "Protocol",
+            "CreditAssociation",
+            "Doi",
+            "GeneProduct"
+          ],
+          "range": "uriorcurie",
+          "required": true
+        }
+      },
+      "class_uri": "nmdc:GeneProduct"
+    },
     "NamedThing": {
       "name": "NamedThing",
       "description": "a databased entity or concept/class",
@@ -133807,7 +133874,8 @@
           "alias": "id",
           "owner": "NamedThing",
           "domain_of": [
-            "NamedThing"
+            "NamedThing",
+            "GeneProduct"
           ],
           "range": "uriorcurie",
           "required": true,
@@ -133822,7 +133890,8 @@
           "domain_of": [
             "PersonValue",
             "NamedThing",
-            "Protocol"
+            "Protocol",
+            "GeneProduct"
           ],
           "range": "string",
           "multivalued": false
@@ -133836,7 +133905,8 @@
           "owner": "NamedThing",
           "domain_of": [
             "ImageValue",
-            "NamedThing"
+            "NamedThing",
+            "GeneProduct"
           ],
           "range": "string",
           "multivalued": false
@@ -133849,11 +133919,12 @@
           "owner": "NamedThing",
           "domain_of": [
             "MetaboliteIdentification",
-            "NamedThing"
+            "NamedThing",
+            "GeneProduct"
           ],
           "range": "uriorcurie",
           "multivalued": true,
-          "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,]*$"
+          "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,\\(\\)\\=\\#]*$"
         },
         "type": {
           "name": "type",
@@ -133888,16 +133959,16 @@
             "PortionOfSubstance",
             "MagBin",
             "MetaboliteIdentification",
-            "PeptideQuantification",
-            "ProteinQuantification",
             "GenomeFeature",
             "FunctionalAnnotation",
             "AttributeValue",
             "NamedThing",
+            "OntologyRelation",
             "FailureCategorization",
             "Protocol",
             "CreditAssociation",
-            "Doi"
+            "Doi",
+            "GeneProduct"
           ],
           "range": "uriorcurie",
           "required": true
diff --git a/project/jsonschema/nmdc_submission_schema.schema.json b/project/jsonschema/nmdc_submission_schema.schema.json
index ab5d2232..b5eec779 100644
--- a/project/jsonschema/nmdc_submission_schema.schema.json
+++ b/project/jsonschema/nmdc_submission_schema.schema.json
@@ -349,7 +349,8 @@
                 "metaproteomics",
                 "metatranscriptomics",
                 "natural organic matter",
-                "bulk chemistry"
+                "bulk chemistry",
+                "amplicon sequencing assay"
             ],
             "title": "AnalysisTypeEnum",
             "type": "string"
@@ -2533,7 +2534,6 @@
                 "Cnidaria",
                 "Drugs production",
                 "Endosymbionts",
-                "Feedstock",
                 "Fish",
                 "Food production",
                 "Fungi",
@@ -3216,6 +3216,7 @@
                 "Wall",
                 "Warm (34-42C)",
                 "Wart",
+                "Waste",
                 "Wastewater",
                 "Wastewater effluent",
                 "Water",
@@ -3240,7 +3241,6 @@
                 "Agricultural land",
                 "Alpine",
                 "Arable",
-                "Biochar",
                 "Biocrust",
                 "Biofilm",
                 "Boreal forest/Taiga",
@@ -3337,7 +3337,6 @@
                 "Auditory/Hearing system",
                 "Baby formula",
                 "Bacteria",
-                "Bacterivore",
                 "Bagasse",
                 "Beans",
                 "Benign tumor",
@@ -3493,6 +3492,7 @@
                 "Olfactory system",
                 "Oomycetes",
                 "Ootheca/Egg mass",
+                "Organic waste",
                 "Outdoor Air",
                 "Oxymonads",
                 "Oyster",
@@ -4163,6 +4163,55 @@
             "title": "GenderRestroomEnum",
             "type": "string"
         },
+        "GeneProduct": {
+            "additionalProperties": false,
+            "description": "A molecule encoded by a gene that has an evolved function",
+            "properties": {
+                "alternative_identifiers": {
+                    "description": "A list of alternative identifiers for the entity.",
+                    "items": {
+                        "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,\\(\\)\\=\\#]*$",
+                        "type": "string"
+                    },
+                    "type": [
+                        "array",
+                        "null"
+                    ]
+                },
+                "description": {
+                    "description": "a human-readable description of a thing",
+                    "type": [
+                        "string",
+                        "null"
+                    ]
+                },
+                "id": {
+                    "description": "A unique identifier for a thing. Must be either a CURIE shorthand for a URI or a complete URI",
+                    "pattern": "^[a-zA-Z0-9][a-zA-Z0-9_\\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\\-\\/\\.,]*$",
+                    "type": "string"
+                },
+                "name": {
+                    "description": "A human readable label for an entity",
+                    "type": [
+                        "string",
+                        "null"
+                    ]
+                },
+                "type": {
+                    "description": "the class_uri of the class that has been instantiated",
+                    "enum": [
+                        "nmdc:GeneProduct"
+                    ],
+                    "type": "string"
+                }
+            },
+            "required": [
+                "id",
+                "type"
+            ],
+            "title": "GeneProduct",
+            "type": "object"
+        },
         "GrowthFacilEnum": {
             "description": "",
             "enum": [
@@ -6252,8 +6301,12 @@
             "enum": [
                 "female",
                 "hermaphrodite",
+                "non-binary",
                 "male",
-                "neuter"
+                "transgender",
+                "transgender (female to male)",
+                "transgender (male to female)",
+                "undeclared"
             ],
             "title": "HostSexEnum",
             "type": "string"
@@ -7623,7 +7676,6 @@
                 },
                 "isotope_exposure": {
                     "description": "List isotope exposure or addition applied to your sample.",
-                    "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$",
                     "type": [
                         "string",
                         "null"
@@ -8760,7 +8812,6 @@
                 },
                 "isotope_exposure": {
                     "description": "List isotope exposure or addition applied to your sample.",
-                    "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$",
                     "type": [
                         "string",
                         "null"
@@ -9679,7 +9730,6 @@
                 },
                 "isotope_exposure": {
                     "description": "List isotope exposure or addition applied to your sample.",
-                    "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$",
                     "type": [
                         "string",
                         "null"
@@ -10226,7 +10276,6 @@
                 "Abyssal plane",
                 "Abyssopelagic/Abyssal zone",
                 "Acid Mine Drainage",
-                "Acid mine drainage",
                 "Acid sulfate soil",
                 "Acid-saline drainage",
                 "Acidic",
@@ -10766,6 +10815,7 @@
                 "Room surface",
                 "Rosacea",
                 "Royal jelly",
+                "Rubber",
                 "Rumen",
                 "Rumen fluid",
                 "Rumen mucosa",
@@ -12145,7 +12195,6 @@
                 },
                 "isotope_exposure": {
                     "description": "List isotope exposure or addition applied to your sample.",
-                    "pattern": "^\\S+.*\\S+ \\[[a-zA-Z]{2,}:\\d+\\]; ([\\+-]?\\d{4}(?!\\d{2}\\b))((-?)((0[1-9]|1[0-2])(\\3([12]\\d|0[1-9]|3[01]))?|W([0-4]\\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\\d|[12]\\d{2}|3([0-5]\\d|6[1-6])))([T\\s]((([01]\\d|2[0-3])((:?)[0-5]\\d)?|24\\:?00)([\\.,]\\d+(?!:))?)?(\\17[0-5]\\d([\\.,]\\d+)?)?([zZ]|([\\+-])([01]\\d|2[0-3]):?([0-5]\\d)?)?)?)?$",
                     "type": [
                         "string",
                         "null"
diff --git a/project/thirdparty/GoldEcosystemTree.json b/project/thirdparty/GoldEcosystemTree.json
index 50be49b5..ae3d03ba 100644
--- a/project/thirdparty/GoldEcosystemTree.json
+++ b/project/thirdparty/GoldEcosystemTree.json
@@ -2,7 +2,7 @@
 "name": "Ecosystems", 
 "children": [ 
  
-{"name": "Engineered", "count": "18171" , "url": "search?Biosample.Ecosystem=Engineered"  , "children" : [  
+{"name": "Engineered", "count": "18314" , "url": "search?Biosample.Ecosystem=Engineered"  , "children" : [  
 		{"name": "Animal feed production" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Animal feed production"  , "children" : [  
 			{"name": "Fermentation" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Animal feed production&Biosample.Ecosystem+Type=Fermentation"  , "children" : [  
 				{"name": "Swine waste with corn" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Animal feed production&Biosample.Ecosystem+Type=Fermentation&Biosample.Ecosystem+Subtype=Swine waste with corn"  , "children" : [  
@@ -21,7 +21,7 @@
 }]
 },
   
-		{"name": "Artificial ecosystem" , "count": "2070" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem"  , "children" : [  
+		{"name": "Artificial ecosystem" , "count": "2111" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem"  , "children" : [  
 			{"name": "Aquaculture" , "count": "16" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Aquaculture"  , "children" : [  
 				{"name": "Algae raceway pond" , "count": "4" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Aquaculture&Biosample.Ecosystem+Subtype=Algae raceway pond"  , "children" : [  
 				{"name": "Pond scum" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Aquaculture&Biosample.Ecosystem+Subtype=Algae raceway pond&Biosample.Specific Ecosystem=Pond scum" },
@@ -134,13 +134,13 @@
 }]
 },
   
-			{"name": "Microcosm" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm"  , "children" : [  
+			{"name": "Microcosm" , "count": "41" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm"  , "children" : [  
 				{"name": "Freshwater" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Freshwater"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Freshwater&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Soil" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Soil"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Soil&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Soil" , "count": "41" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Soil"  , "children" : [  
+				{"name": "Unclassified" , "count": "41" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Soil&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Artificial ecosystem&Biosample.Ecosystem+Type=Microcosm&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
@@ -261,7 +261,7 @@
 }]
 },
   
-		{"name": "Bioreactor" , "count": "2512" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor"  , "children" : [  
+		{"name": "Bioreactor" , "count": "2587" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor"  , "children" : [  
 			{"name": "Aerobic" , "count": "163" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Aerobic"  , "children" : [  
 				{"name": "AGS (Aerobic granular sludge)" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Aerobic&Biosample.Ecosystem+Subtype=AGS (Aerobic granular sludge)"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Aerobic&Biosample.Ecosystem+Subtype=AGS (Aerobic granular sludge)&Biosample.Specific Ecosystem=Unclassified" }]
@@ -280,7 +280,7 @@
 }]
 },
   
-			{"name": "Anaerobic" , "count": "1964" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic"  , "children" : [  
+			{"name": "Anaerobic" , "count": "2039" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic"  , "children" : [  
 				{"name": "Biofilm" , "count": "3" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Biofilm"  , "children" : [  
 				{"name": "Unclassified" , "count": "3" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Biofilm&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -327,8 +327,8 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Thermophilic digester&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "1038" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "1038" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "1113" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "1113" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Wastewater" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Anaerobic&Biosample.Ecosystem+Subtype=Wastewater"  , "children" : [  
@@ -472,7 +472,13 @@
   
 			{"name": "Semi-continuous" , "count": "16" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous"  , "children" : [  
 				{"name": "Anaerobic" , "count": "16" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Anaerobic"  , "children" : [  
-				{"name": "Digestate" , "count": "16" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Anaerobic&Biosample.Specific Ecosystem=Digestate" }]
+				{"name": "Digestate" , "count": "16" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Anaerobic&Biosample.Specific Ecosystem=Digestate" },
+  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Anaerobic&Biosample.Specific Ecosystem=Unclassified" }]
+},
+  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Bioreactor&Biosample.Ecosystem+Type=Semi-continuous&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -961,15 +967,7 @@
 }]
 },
   
-		{"name": "Feedstock" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Feedstock"  , "children" : [  
-			{"name": "Composting" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Feedstock&Biosample.Ecosystem+Type=Composting"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Feedstock&Biosample.Ecosystem+Type=Composting&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Feedstock&Biosample.Ecosystem+Type=Composting&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
-}]
-}]
-},
-  
-		{"name": "Food production" , "count": "2632" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production"  , "children" : [  
+		{"name": "Food production" , "count": "2639" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production"  , "children" : [  
 			{"name": "Baby formula" , "count": "31" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Baby formula"  , "children" : [  
 				{"name": "Unclassified" , "count": "31" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Baby formula&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
 				{"name": "Unclassified" , "count": "31" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Baby formula&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
@@ -1164,13 +1162,13 @@
 }]
 },
   
-			{"name": "Plant products" , "count": "119" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products"  , "children" : [  
+			{"name": "Plant products" , "count": "123" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products"  , "children" : [  
 				{"name": "Morphine" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Morphine"  , "children" : [  
 				{"name": "Heroin" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Morphine&Biosample.Specific Ecosystem=Heroin" }]
 },
   
-				{"name": "Unclassified" , "count": "119" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "119" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "123" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "123" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Plant products&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -1208,9 +1206,9 @@
 }]
 },
   
-			{"name": "Spices" , "count": "18" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices"  , "children" : [  
-				{"name": "Unclassified" , "count": "18" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "18" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Spices" , "count": "21" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices"  , "children" : [  
+				{"name": "Unclassified" , "count": "21" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "21" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Food production&Biosample.Ecosystem+Type=Spices&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -1227,10 +1225,10 @@
 }]
 },
   
-		{"name": "Industrial production" , "count": "774" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production"  , "children" : [  
-			{"name": "Biochar" , "count": "5" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar"  , "children" : [  
-				{"name": "Unclassified" , "count": "5" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "5" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+		{"name": "Industrial production" , "count": "770" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production"  , "children" : [  
+			{"name": "Biochar" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar"  , "children" : [  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Biochar&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -1276,15 +1274,15 @@
 }]
 },
   
-			{"name": "Engineered product" , "count": "197" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product"  , "children" : [  
+			{"name": "Engineered product" , "count": "198" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product"  , "children" : [  
 				{"name": "Aviation fuel" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Aviation fuel"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Aviation fuel&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Bioanode" , "count": "25" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Bioanode"  , "children" : [  
+				{"name": "Bioanode" , "count": "26" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Bioanode"  , "children" : [  
 				{"name": "Biofilm" , "count": "4" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Bioanode&Biosample.Specific Ecosystem=Biofilm" },
   
-				{"name": "Unclassified" , "count": "21" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Bioanode&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "22" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Bioanode&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Biocathode" , "count": "9" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Industrial production&Biosample.Ecosystem+Type=Engineered product&Biosample.Ecosystem+Subtype=Biocathode"  , "children" : [  
@@ -1339,8 +1337,8 @@
 }]
 },
   
-		{"name": "Lab culture" , "count": "196" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture"  , "children" : [  
-			{"name": "Culture media" , "count": "196" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media"  , "children" : [  
+		{"name": "Lab culture" , "count": "216" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture"  , "children" : [  
+			{"name": "Culture media" , "count": "216" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media"  , "children" : [  
 				{"name": "Algae" , "count": "6" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Algae"  , "children" : [  
 				{"name": "Contaminated" , "count": "6" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Algae&Biosample.Specific Ecosystem=Contaminated" }]
 },
@@ -1351,10 +1349,10 @@
 				{"name": "Unclassified" , "count": "2" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Archaea&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Bacteria" , "count": "117" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria"  , "children" : [  
+				{"name": "Bacteria" , "count": "137" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria"  , "children" : [  
 				{"name": "Co-culture" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria&Biosample.Specific Ecosystem=Co-culture" },
   
-				{"name": "Contaminated" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria&Biosample.Specific Ecosystem=Contaminated" },
+				{"name": "Contaminated" , "count": "28" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria&Biosample.Specific Ecosystem=Contaminated" },
   
 				{"name": "Unclassified" , "count": "109" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab culture&Biosample.Ecosystem+Type=Culture media&Biosample.Ecosystem+Subtype=Bacteria&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -1377,14 +1375,14 @@
 }]
 },
   
-		{"name": "Lab enrichment" , "count": "287" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment"  , "children" : [  
-			{"name": "Defined media" , "count": "250" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media"  , "children" : [  
+		{"name": "Lab enrichment" , "count": "288" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment"  , "children" : [  
+			{"name": "Defined media" , "count": "251" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media"  , "children" : [  
 				{"name": "Aerobic media" , "count": "7" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Aerobic media"  , "children" : [  
 				{"name": "Unclassified" , "count": "7" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Aerobic media&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Anaerobic media" , "count": "65" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Anaerobic media"  , "children" : [  
-				{"name": "Unclassified" , "count": "65" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Anaerobic media&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Anaerobic media" , "count": "66" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Anaerobic media"  , "children" : [  
+				{"name": "Unclassified" , "count": "66" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Anaerobic media&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Marine media" , "count": "5" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Lab enrichment&Biosample.Ecosystem+Type=Defined media&Biosample.Ecosystem+Subtype=Marine media"  , "children" : [  
@@ -1443,7 +1441,7 @@
 }]
 },
   
-		{"name": "Modeled" , "count": "839" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled"  , "children" : [  
+		{"name": "Modeled" , "count": "840" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled"  , "children" : [  
 			{"name": "Simulated communities (DNA mixture)" , "count": "64" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (DNA mixture)"  , "children" : [  
 				{"name": "Unclassified" , "count": "64" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (DNA mixture)&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
 				{"name": "Unclassified" , "count": "64" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (DNA mixture)&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
@@ -1456,13 +1454,13 @@
 }]
 },
   
-			{"name": "Simulated communities (microbial mixture)" , "count": "742" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)"  , "children" : [  
+			{"name": "Simulated communities (microbial mixture)" , "count": "743" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)"  , "children" : [  
 				{"name": "Plant nodule" , "count": "14" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Plant nodule"  , "children" : [  
 				{"name": "Unclassified" , "count": "14" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Plant nodule&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "728" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "728" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "729" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "729" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Modeled&Biosample.Ecosystem+Type=Simulated communities (microbial mixture)&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -1515,7 +1513,7 @@
 }]
 },
   
-		{"name": "Solid waste" , "count": "416" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste"  , "children" : [  
+		{"name": "Solid waste" , "count": "424" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste"  , "children" : [  
 			{"name": "Agricultural waste" , "count": "4" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Agricultural waste"  , "children" : [  
 				{"name": "Composting" , "count": "4" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Agricultural waste&Biosample.Ecosystem+Subtype=Composting"  , "children" : [  
 				{"name": "Sugarcane filter cake" , "count": "2" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Agricultural waste&Biosample.Ecosystem+Subtype=Composting&Biosample.Specific Ecosystem=Sugarcane filter cake" },
@@ -1718,6 +1716,16 @@
   
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Mixed feedstock&Biosample.Ecosystem+Subtype=Composting&Biosample.Specific Ecosystem=Unclassified" }]
 }]
+},
+  
+			{"name": "Organic waste" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Organic waste"  , "children" : [  
+				{"name": "Biochar" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Organic waste&Biosample.Ecosystem+Subtype=Biochar"  , "children" : [  
+				{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Organic waste&Biosample.Ecosystem+Subtype=Biochar&Biosample.Specific Ecosystem=Unclassified" }]
+},
+  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Organic waste&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Organic waste&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+}]
 },
   
 			{"name": "Plastic waste" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Solid waste&Biosample.Ecosystem+Type=Plastic waste"  , "children" : [  
@@ -1867,10 +1875,10 @@
 }]
 },
   
-		{"name": "Wastewater" , "count": "2754" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater"  , "children" : [  
-			{"name": "Activated Sludge" , "count": "484" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge"  , "children" : [  
-				{"name": "Unclassified" , "count": "484" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "484" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+		{"name": "Wastewater" , "count": "2755" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater"  , "children" : [  
+			{"name": "Activated Sludge" , "count": "485" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge"  , "children" : [  
+				{"name": "Unclassified" , "count": "485" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "485" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Activated Sludge&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -1881,10 +1889,10 @@
 },
   
 			{"name": "Industrial wastewater" , "count": "618" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater"  , "children" : [  
-				{"name": "Acid mine drainage" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage"  , "children" : [  
-				{"name": "Sediment" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Acid mine drainage" , "count": "9" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage"  , "children" : [  
+				{"name": "Sediment" , "count": "1" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Acid mine drainage&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Agricultural wastewater" , "count": "3" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Agricultural wastewater"  , "children" : [  
@@ -1915,12 +1923,10 @@
 				{"name": "Poultry processing wastewater" , "count": "15" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Meat/Poultry processing plant&Biosample.Specific Ecosystem=Poultry processing wastewater" }]
 },
   
-				{"name": "Mine water" , "count": "111" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water"  , "children" : [  
-				{"name": "Acid mine drainage" , "count": "8" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water&Biosample.Specific Ecosystem=Acid mine drainage" },
-  
+				{"name": "Mine water" , "count": "102" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water"  , "children" : [  
 				{"name": "Produced water" , "count": "27" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water&Biosample.Specific Ecosystem=Produced water" },
   
-				{"name": "Sediment" , "count": "6" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Sediment" , "count": "5" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water&Biosample.Specific Ecosystem=Sediment" },
   
 				{"name": "Unclassified" , "count": "70" , "url": "search?Biosample.Ecosystem=Engineered&Biosample.Ecosystem+Category=Wastewater&Biosample.Ecosystem+Type=Industrial wastewater&Biosample.Ecosystem+Subtype=Mine water&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -2040,7 +2046,7 @@
 }]
 }
 ,  
-{"name": "Environmental", "count": "97038" , "url": "search?Biosample.Ecosystem=Environmental"  , "children" : [  
+{"name": "Environmental", "count": "97613" , "url": "search?Biosample.Ecosystem=Environmental"  , "children" : [  
 		{"name": "Air" , "count": "1638" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Air"  , "children" : [  
 			{"name": "Indoor Air" , "count": "349" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Air&Biosample.Ecosystem+Type=Indoor Air"  , "children" : [  
 				{"name": "Air scrubber" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Air&Biosample.Ecosystem+Type=Indoor Air&Biosample.Ecosystem+Subtype=Air scrubber"  , "children" : [  
@@ -2083,7 +2089,7 @@
 }]
 },
   
-		{"name": "Aquatic" , "count": "56104" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic"  , "children" : [  
+		{"name": "Aquatic" , "count": "56412" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic"  , "children" : [  
 			{"name": "Acidic" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Acidic"  , "children" : [  
 				{"name": "Acidic hypersaline lake" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Acidic&Biosample.Ecosystem+Subtype=Acidic hypersaline lake"  , "children" : [  
 				{"name": "Microbial mat" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Acidic&Biosample.Ecosystem+Subtype=Acidic hypersaline lake&Biosample.Specific Ecosystem=Microbial mat" },
@@ -2210,7 +2216,7 @@
 }]
 },
   
-			{"name": "Freshwater" , "count": "19875" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater"  , "children" : [  
+			{"name": "Freshwater" , "count": "20255" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater"  , "children" : [  
 				{"name": "Agricultural field" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Agricultural field"  , "children" : [  
 				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Agricultural field&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -2317,7 +2323,7 @@
 				{"name": "Unclassified" , "count": "3" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Harbor&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Ice" , "count": "594" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice"  , "children" : [  
+				{"name": "Ice" , "count": "593" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice"  , "children" : [  
 				{"name": "Cryoconite" , "count": "51" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice&Biosample.Specific Ecosystem=Cryoconite" },
   
 				{"name": "Glacial lake" , "count": "306" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice&Biosample.Specific Ecosystem=Glacial lake" },
@@ -2332,14 +2338,14 @@
   
 				{"name": "Snow" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice&Biosample.Specific Ecosystem=Snow" },
   
-				{"name": "Unclassified" , "count": "11" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "10" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Ice&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Kettle hole" , "count": "98" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Kettle hole"  , "children" : [  
 				{"name": "Unclassified" , "count": "98" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Kettle hole&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Lake" , "count": "9166" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake"  , "children" : [  
+				{"name": "Lake" , "count": "9186" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake"  , "children" : [  
 				{"name": "Algal bloom" , "count": "8" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Algal bloom" },
   
 				{"name": "Anoxic zone" , "count": "27" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Anoxic zone" },
@@ -2368,9 +2374,9 @@
   
 				{"name": "Microbial mats" , "count": "32" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Microbial mats" },
   
-				{"name": "Sediment" , "count": "1445" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Sediment" , "count": "1446" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "6675" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "6694" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lake&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Lentic" , "count": "101" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Lentic"  , "children" : [  
@@ -2421,7 +2427,7 @@
 				{"name": "Unclassified" , "count": "292" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Reservoir&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "River" , "count": "4007" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River"  , "children" : [  
+				{"name": "River" , "count": "4027" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River"  , "children" : [  
 				{"name": "Microbial mats" , "count": "203" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River&Biosample.Specific Ecosystem=Microbial mats" },
   
 				{"name": "Periphyton" , "count": "9" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River&Biosample.Specific Ecosystem=Periphyton" },
@@ -2432,7 +2438,7 @@
   
 				{"name": "Sediment" , "count": "859" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "2783" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "2803" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=River&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Sediment" , "count": "95" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Sediment"  , "children" : [  
@@ -2485,15 +2491,15 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Transient pool&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "1365" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "1365" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "1702" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "1702" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Water tank" , "count": "54" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Water tank"  , "children" : [  
 				{"name": "Unclassified" , "count": "54" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Water tank&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Wetlands" , "count": "865" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands"  , "children" : [  
+				{"name": "Wetlands" , "count": "869" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands"  , "children" : [  
 				{"name": "Bog" , "count": "42" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Bog" },
   
 				{"name": "Fen" , "count": "65" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Fen" },
@@ -2502,17 +2508,17 @@
   
 				{"name": "Microbial mat" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Microbial mat" },
   
-				{"name": "Sediment" , "count": "538" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Sediment" , "count": "540" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Sediment" },
   
 				{"name": "Soil" , "count": "141" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Soil" },
   
 				{"name": "Swamp" , "count": "4" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Swamp" },
   
-				{"name": "Unclassified" , "count": "75" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "77" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Freshwater&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
-			{"name": "Marine" , "count": "27380" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine"  , "children" : [  
+			{"name": "Marine" , "count": "27637" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine"  , "children" : [  
 				{"name": "Abyssopelagic" , "count": "7" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Abyssopelagic"  , "children" : [  
 				{"name": "Unclassified" , "count": "7" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Abyssopelagic&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -2537,8 +2543,8 @@
 				{"name": "Wood fall" , "count": "6" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic&Biosample.Specific Ecosystem=Wood fall" }]
 },
   
-				{"name": "Benthic zone" , "count": "6" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic zone"  , "children" : [  
-				{"name": "Sediment" , "count": "6" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic zone&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Benthic zone" , "count": "7" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic zone"  , "children" : [  
+				{"name": "Sediment" , "count": "7" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic zone&Biosample.Specific Ecosystem=Sediment" },
   
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Benthic zone&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -2549,14 +2555,14 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Biofouling&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Coastal" , "count": "4693" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal"  , "children" : [  
+				{"name": "Coastal" , "count": "4778" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal"  , "children" : [  
 				{"name": "Brine" , "count": "12" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal&Biosample.Specific Ecosystem=Brine" },
   
 				{"name": "Phytoplankton bloom" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal&Biosample.Specific Ecosystem=Phytoplankton bloom" },
   
 				{"name": "Sediment" , "count": "572" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "4109" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "4194" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Coastal lagoon" , "count": "76" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Coastal lagoon"  , "children" : [  
@@ -2586,7 +2592,7 @@
   
 				{"name": "Sediment" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Deep subsurface&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Deep subsurface&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "14" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Deep subsurface&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Deepwater/Brine lake" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Deepwater/Brine lake"  , "children" : [  
@@ -2599,8 +2605,8 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Demersal zone&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Epipelagic" , "count": "1058" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Epipelagic"  , "children" : [  
-				{"name": "Unclassified" , "count": "1058" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Epipelagic&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Epipelagic" , "count": "1059" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Epipelagic"  , "children" : [  
+				{"name": "Unclassified" , "count": "1059" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Epipelagic&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Fjord" , "count": "225" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Fjord"  , "children" : [  
@@ -2627,7 +2633,7 @@
 				{"name": "Unclassified" , "count": "477" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Harbor&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Hydrothermal vents" , "count": "847" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents"  , "children" : [  
+				{"name": "Hydrothermal vents" , "count": "849" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents"  , "children" : [  
 				{"name": "Black smokers" , "count": "25" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Black smokers" },
   
 				{"name": "Diffuse flow" , "count": "261" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Diffuse flow" },
@@ -2636,7 +2642,7 @@
   
 				{"name": "Microbial mats" , "count": "75" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Microbial mats" },
   
-				{"name": "Sediment" , "count": "122" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Sediment" , "count": "124" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Sediment" },
   
 				{"name": "Tubeworm bush" , "count": "15" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Hydrothermal vents&Biosample.Specific Ecosystem=Tubeworm bush" },
   
@@ -2653,16 +2659,16 @@
 				{"name": "Unclassified" , "count": "1278" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Inlet&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Intertidal zone" , "count": "3520" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone"  , "children" : [  
+				{"name": "Intertidal zone" , "count": "3684" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone"  , "children" : [  
 				{"name": "Beach/Shore" , "count": "750" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Beach/Shore" },
   
 				{"name": "Coral reef" , "count": "229" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Coral reef" },
   
-				{"name": "Estuary" , "count": "842" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Estuary" },
+				{"name": "Estuary" , "count": "960" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Estuary" },
   
 				{"name": "Estuary: Microbial mat" , "count": "13" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Estuary: Microbial mat" },
   
-				{"name": "Estuary: Sediment" , "count": "129" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Estuary: Sediment" },
+				{"name": "Estuary: Sediment" , "count": "167" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Estuary: Sediment" },
   
 				{"name": "Mangrove area" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Mangrove area" },
   
@@ -2678,7 +2684,7 @@
   
 				{"name": "Oil-contaminated sediment" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Oil-contaminated sediment" },
   
-				{"name": "Salt marsh" , "count": "535" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Salt marsh" },
+				{"name": "Salt marsh" , "count": "543" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Salt marsh" },
   
 				{"name": "Salt marsh sediment" , "count": "197" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Intertidal zone&Biosample.Specific Ecosystem=Salt marsh sediment" },
   
@@ -2771,7 +2777,7 @@
 				{"name": "Unclassified" , "count": "80" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Ocean trench&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Oceanic" , "count": "5972" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic"  , "children" : [  
+				{"name": "Oceanic" , "count": "5974" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic"  , "children" : [  
 				{"name": "Abyssal plane" , "count": "77" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic&Biosample.Specific Ecosystem=Abyssal plane" },
   
 				{"name": "Aphotic zone" , "count": "64" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic&Biosample.Specific Ecosystem=Aphotic zone" },
@@ -2796,21 +2802,21 @@
   
 				{"name": "Sediment" , "count": "383" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "5061" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "5063" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oceanic&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Oil seeps" , "count": "8" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oil seeps"  , "children" : [  
 				{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Oil seeps&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Pelagic zone" , "count": "925" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone"  , "children" : [  
+				{"name": "Pelagic zone" , "count": "926" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone"  , "children" : [  
 				{"name": "Abyssopelagic/Abyssal zone" , "count": "27" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Abyssopelagic/Abyssal zone" },
   
 				{"name": "Bathypelagic/Bathyal zone" , "count": "5" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Bathypelagic/Bathyal zone" },
   
-				{"name": "Epipelagic/Euphotic zone" , "count": "302" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Epipelagic/Euphotic zone" },
+				{"name": "Epipelagic/Euphotic zone" , "count": "303" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Epipelagic/Euphotic zone" },
   
-				{"name": "Hadopelagic zone/Ocean trenches" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Hadopelagic zone/Ocean trenches" },
+				{"name": "Hadopelagic zone/Ocean trenches" , "count": "39" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Hadopelagic zone/Ocean trenches" },
   
 				{"name": "Mesopelagic/Twilight zone" , "count": "10" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Pelagic zone&Biosample.Specific Ecosystem=Mesopelagic/Twilight zone" },
   
@@ -2863,14 +2869,22 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Supratidal zone&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "5249" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "5249" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "5250" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "5250" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Volcanic" , "count": "25" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Volcanic"  , "children" : [  
 				{"name": "Unclassified" , "count": "25" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Volcanic&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
+				{"name": "Waste" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Waste"  , "children" : [  
+				{"name": "Plastic" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Waste&Biosample.Specific Ecosystem=Plastic" },
+  
+				{"name": "Rubber" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Waste&Biosample.Specific Ecosystem=Rubber" },
+  
+				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Waste&Biosample.Specific Ecosystem=Unclassified" }]
+},
+  
 				{"name": "Wetlands" , "count": "443" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Wetlands"  , "children" : [  
 				{"name": "Sediment" , "count": "328" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Marine&Biosample.Ecosystem+Subtype=Wetlands&Biosample.Specific Ecosystem=Sediment" },
   
@@ -2878,7 +2892,7 @@
 }]
 },
   
-			{"name": "Non-marine Saline and Alkaline" , "count": "1695" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline"  , "children" : [  
+			{"name": "Non-marine Saline and Alkaline" , "count": "1696" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline"  , "children" : [  
 				{"name": "Alkaline" , "count": "51" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Alkaline"  , "children" : [  
 				{"name": "Carbonate" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Alkaline&Biosample.Specific Ecosystem=Carbonate" },
   
@@ -2985,10 +2999,10 @@
 				{"name": "Unclassified" , "count": "77" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt crystallizer ponds&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Salt marsh" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt marsh"  , "children" : [  
+				{"name": "Salt marsh" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt marsh"  , "children" : [  
 				{"name": "Sediment" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt marsh&Biosample.Specific Ecosystem=Sediment" },
   
-				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt marsh&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Salt marsh&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Soda lake" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Non-marine Saline and Alkaline&Biosample.Ecosystem+Subtype=Soda lake"  , "children" : [  
@@ -3038,7 +3052,7 @@
 }]
 },
   
-			{"name": "Thermal springs" , "count": "3518" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs"  , "children" : [  
+			{"name": "Thermal springs" , "count": "3524" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs"  , "children" : [  
 				{"name": "Acid lake" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Acid lake"  , "children" : [  
 				{"name": "Sediment" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Acid lake&Biosample.Specific Ecosystem=Sediment" },
   
@@ -3051,7 +3065,7 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Geothermal pool/Hot lake&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Hot (42-90C)" , "count": "3148" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)"  , "children" : [  
+				{"name": "Hot (42-90C)" , "count": "3153" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)"  , "children" : [  
 				{"name": "Acidic" , "count": "350" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Acidic" },
   
 				{"name": "Alkaline" , "count": "16" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Alkaline" },
@@ -3060,13 +3074,13 @@
   
 				{"name": "Neutral" , "count": "23" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Neutral" },
   
-				{"name": "Sediment" , "count": "1273" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Sediment" },
+				{"name": "Sediment" , "count": "1278" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Sediment" },
   
 				{"name": "Unclassified" , "count": "558" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Hot (42-90C)&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Microbial mats" , "count": "10" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Microbial mats"  , "children" : [  
-				{"name": "Unclassified" , "count": "10" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Microbial mats&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Microbial mats" , "count": "11" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Microbial mats"  , "children" : [  
+				{"name": "Unclassified" , "count": "11" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Microbial mats&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Near-boiling (>90C)" , "count": "20" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Thermal springs&Biosample.Ecosystem+Subtype=Near-boiling (>90C)"  , "children" : [  
@@ -3112,14 +3126,14 @@
 }]
 },
   
-			{"name": "Unclassified" , "count": "364" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "364" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "364" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Unclassified" , "count": "28" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "28" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "28" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Aquatic&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 }]
 },
   
-		{"name": "Terrestrial" , "count": "39296" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial"  , "children" : [  
+		{"name": "Terrestrial" , "count": "39563" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial"  , "children" : [  
 			{"name": "Agricultural field" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Agricultural field"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Agricultural field&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Agricultural field&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
@@ -3148,7 +3162,7 @@
 }]
 },
   
-			{"name": "Deep subsurface" , "count": "759" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface"  , "children" : [  
+			{"name": "Deep subsurface" , "count": "762" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface"  , "children" : [  
 				{"name": "Aquifer" , "count": "88" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Aquifer"  , "children" : [  
 				{"name": "Rock core/Sediment" , "count": "62" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Aquifer&Biosample.Specific Ecosystem=Rock core/Sediment" },
   
@@ -3187,8 +3201,8 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Mine&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Oil well" , "count": "80" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Oil well"  , "children" : [  
-				{"name": "Unclassified" , "count": "80" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Oil well&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Oil well" , "count": "83" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Oil well"  , "children" : [  
+				{"name": "Unclassified" , "count": "83" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Oil well&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Rock" , "count": "18" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Deep subsurface&Biosample.Ecosystem+Subtype=Rock"  , "children" : [  
@@ -3226,13 +3240,13 @@
 }]
 },
   
-			{"name": "Desert" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert"  , "children" : [  
+			{"name": "Desert" , "count": "4" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert"  , "children" : [  
 				{"name": "Salt pan/flat" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Salt pan/flat"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Salt pan/flat&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "4" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "4" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Desert&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -3338,13 +3352,13 @@
 }]
 },
   
-			{"name": "Plant litter" , "count": "895" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter"  , "children" : [  
+			{"name": "Plant litter" , "count": "896" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter"  , "children" : [  
 				{"name": "Decayed wood" , "count": "12" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Decayed wood"  , "children" : [  
 				{"name": "Unclassified" , "count": "12" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Decayed wood&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Litterfall" , "count": "71" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Litterfall"  , "children" : [  
-				{"name": "Leaves" , "count": "71" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Litterfall&Biosample.Specific Ecosystem=Leaves" }]
+				{"name": "Litterfall" , "count": "72" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Litterfall"  , "children" : [  
+				{"name": "Leaves" , "count": "72" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Litterfall&Biosample.Specific Ecosystem=Leaves" }]
 },
   
 				{"name": "Unclassified" , "count": "812" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Plant litter&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
@@ -3384,11 +3398,11 @@
 }]
 },
   
-			{"name": "Soil" , "count": "36262" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil"  , "children" : [  
-				{"name": "Agricultural land" , "count": "7441" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Agricultural land"  , "children" : [  
+			{"name": "Soil" , "count": "36522" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil"  , "children" : [  
+				{"name": "Agricultural land" , "count": "7442" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Agricultural land"  , "children" : [  
 				{"name": "Bulk soil" , "count": "4306" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Agricultural land&Biosample.Specific Ecosystem=Bulk soil" },
   
-				{"name": "Unclassified" , "count": "3135" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Agricultural land&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "3136" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Agricultural land&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Alpine" , "count": "15" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Alpine"  , "children" : [  
@@ -3399,10 +3413,6 @@
 				{"name": "Agricultural land" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Arable&Biosample.Specific Ecosystem=Agricultural land" }]
 },
   
-				{"name": "Biochar" , "count": "3" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Biochar"  , "children" : [  
-				{"name": "Agricultural land" , "count": "3" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Biochar&Biosample.Specific Ecosystem=Agricultural land" }]
-},
-  
 				{"name": "Biocrust" , "count": "83" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Biocrust"  , "children" : [  
 				{"name": "Unclassified" , "count": "83" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Biocrust&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -3531,12 +3541,12 @@
 				{"name": "Unclassified" , "count": "94" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Glacier&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Grasslands" , "count": "3582" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands"  , "children" : [  
+				{"name": "Grasslands" , "count": "3583" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands"  , "children" : [  
 				{"name": "Bulk soil" , "count": "354" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands&Biosample.Specific Ecosystem=Bulk soil" },
   
 				{"name": "Pasture" , "count": "137" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands&Biosample.Specific Ecosystem=Pasture" },
   
-				{"name": "Unclassified" , "count": "3091" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "3092" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Grasslands&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Gravesite" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Gravesite"  , "children" : [  
@@ -3711,8 +3721,8 @@
 				{"name": "Unclassified" , "count": "2" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Salt flat/Salt pan&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Sand" , "count": "351" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Sand"  , "children" : [  
-				{"name": "Desert" , "count": "216" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Sand&Biosample.Specific Ecosystem=Desert" },
+				{"name": "Sand" , "count": "308" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Sand"  , "children" : [  
+				{"name": "Desert" , "count": "173" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Sand&Biosample.Specific Ecosystem=Desert" },
   
 				{"name": "Forest soil" , "count": "9" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Sand&Biosample.Specific Ecosystem=Forest soil" },
   
@@ -3755,7 +3765,7 @@
 				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Tailings&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Temperate forest" , "count": "3942" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest"  , "children" : [  
+				{"name": "Temperate forest" , "count": "3986" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest"  , "children" : [  
 				{"name": "A horizon/Topsoil" , "count": "12" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=A horizon/Topsoil" },
   
 				{"name": "B horizon/Subsoil" , "count": "11" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=B horizon/Subsoil" },
@@ -3768,11 +3778,11 @@
   
 				{"name": "Humus" , "count": "33" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=Humus" },
   
-				{"name": "Mineral soil" , "count": "354" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=Mineral soil" },
+				{"name": "Mineral soil" , "count": "394" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=Mineral soil" },
   
 				{"name": "O horizon/Organic" , "count": "472" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=O horizon/Organic" },
   
-				{"name": "Unclassified" , "count": "488" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "492" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Temperate forest&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Tree plantation" , "count": "111" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Tree plantation"  , "children" : [  
@@ -3809,7 +3819,7 @@
 				{"name": "Unclassified" , "count": "455" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Tundra&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "10472" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "10732" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
 				{"name": "Agricultural land" , "count": "1325" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Agricultural land" },
   
 				{"name": "Alpine" , "count": "46" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Alpine" },
@@ -3848,7 +3858,7 @@
   
 				{"name": "Tropical rainforest" , "count": "86" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Tropical rainforest" },
   
-				{"name": "Unclassified" , "count": "6882" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "7142" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Urban forest" , "count": "0" , "url": "search?Biosample.Ecosystem=Environmental&Biosample.Ecosystem+Category=Terrestrial&Biosample.Ecosystem+Type=Soil&Biosample.Ecosystem+Subtype=Urban forest"  , "children" : [  
@@ -3924,7 +3934,7 @@
 }]
 }
 ,  
-{"name": "Host-associated", "count": "95659" , "url": "search?Biosample.Ecosystem=Host-associated"  , "children" : [  
+{"name": "Host-associated", "count": "95681" , "url": "search?Biosample.Ecosystem=Host-associated"  , "children" : [  
 		{"name": "Algae" , "count": "667" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Algae"  , "children" : [  
 			{"name": "Biocrust" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Algae&Biosample.Ecosystem+Type=Biocrust"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Algae&Biosample.Ecosystem+Type=Biocrust&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
@@ -4059,7 +4069,7 @@
 }]
 },
   
-		{"name": "Amphibia" , "count": "23" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia"  , "children" : [  
+		{"name": "Amphibia" , "count": "24" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia"  , "children" : [  
 			{"name": "Digestive system" , "count": "20" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Digestive system"  , "children" : [  
 				{"name": "Biliary tract" , "count": "7" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract"  , "children" : [  
 				{"name": "Liver" , "count": "7" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract&Biosample.Specific Ecosystem=Liver" }]
@@ -4082,9 +4092,9 @@
 }]
 },
   
-			{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Amphibia&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -4391,7 +4401,7 @@
 }]
 },
   
-		{"name": "Arthropoda: Insects" , "count": "2406" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects"  , "children" : [  
+		{"name": "Arthropoda: Insects" , "count": "2414" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects"  , "children" : [  
 			{"name": "Abdomen" , "count": "152" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Abdomen"  , "children" : [  
 				{"name": "Metasoma" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Abdomen&Biosample.Ecosystem+Subtype=Metasoma"  , "children" : [  
 				{"name": "Gaster" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Abdomen&Biosample.Ecosystem+Subtype=Metasoma&Biosample.Specific Ecosystem=Gaster" }]
@@ -4522,17 +4532,17 @@
 }]
 },
   
-			{"name": "Larva" , "count": "267" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva"  , "children" : [  
+			{"name": "Larva" , "count": "275" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva"  , "children" : [  
 				{"name": "Abdomen" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Abdomen"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Abdomen&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Gut" , "count": "89" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut"  , "children" : [  
+				{"name": "Gut" , "count": "97" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut"  , "children" : [  
 				{"name": "Frass" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut&Biosample.Specific Ecosystem=Frass" },
   
 				{"name": "Gastric caeca" , "count": "2" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut&Biosample.Specific Ecosystem=Gastric caeca" },
   
-				{"name": "Unclassified" , "count": "87" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "95" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Gut&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Head" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Arthropoda: Insects&Biosample.Ecosystem+Type=Larva&Biosample.Ecosystem+Subtype=Head"  , "children" : [  
@@ -5483,7 +5493,7 @@
 }]
 },
   
-		{"name": "Invertebrates" , "count": "816" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates"  , "children" : [  
+		{"name": "Invertebrates" , "count": "819" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates"  , "children" : [  
 			{"name": "Bryozoans" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Bryozoans"  , "children" : [  
 				{"name": "Gymnolaemates" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Bryozoans&Biosample.Ecosystem+Subtype=Gymnolaemates"  , "children" : [  
 				{"name": "Unclassified" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Bryozoans&Biosample.Ecosystem+Subtype=Gymnolaemates&Biosample.Specific Ecosystem=Unclassified" }]
@@ -5494,15 +5504,15 @@
 }]
 },
   
-			{"name": "Cnidaria" , "count": "644" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria"  , "children" : [  
-				{"name": "Coral" , "count": "372" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral"  , "children" : [  
-				{"name": "Mucus" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Mucus" },
+			{"name": "Cnidaria" , "count": "646" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria"  , "children" : [  
+				{"name": "Coral" , "count": "374" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral"  , "children" : [  
+				{"name": "Mucus" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Mucus" },
   
 				{"name": "Surface" , "count": "6" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Surface" },
   
 				{"name": "Tissue" , "count": "99" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Tissue" },
   
-				{"name": "Unclassified" , "count": "267" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "268" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Coral&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Unclassified" , "count": "272" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Cnidaria&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
@@ -5534,13 +5544,13 @@
 }]
 },
   
-			{"name": "Nematoda" , "count": "25" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda"  , "children" : [  
+			{"name": "Nematoda" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda"  , "children" : [  
 				{"name": "Digestive system" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Digestive system"  , "children" : [  
 				{"name": "Intestine" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Digestive system&Biosample.Specific Ecosystem=Intestine" }]
 },
   
-				{"name": "Unclassified" , "count": "25" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "25" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Invertebrates&Biosample.Ecosystem+Type=Nematoda&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -5563,7 +5573,7 @@
 }]
 },
   
-		{"name": "Mammals" , "count": "10522" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals"  , "children" : [  
+		{"name": "Mammals" , "count": "10526" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals"  , "children" : [  
 			{"name": "Abdominal cavity" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Abdominal cavity"  , "children" : [  
 				{"name": "Ascites" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Abdominal cavity&Biosample.Ecosystem+Subtype=Ascites"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Abdominal cavity&Biosample.Ecosystem+Subtype=Ascites&Biosample.Specific Ecosystem=Unclassified" }]
@@ -5664,7 +5674,7 @@
 }]
 },
   
-			{"name": "Digestive system" , "count": "9603" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system"  , "children" : [  
+			{"name": "Digestive system" , "count": "9607" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system"  , "children" : [  
 				{"name": "Biliary tract" , "count": "6" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract"  , "children" : [  
 				{"name": "Bile" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract&Biosample.Specific Ecosystem=Bile" },
   
@@ -5685,7 +5695,7 @@
 				{"name": "Rumen" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Foregut&Biosample.Specific Ecosystem=Rumen" }]
 },
   
-				{"name": "Large intestine" , "count": "6988" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine"  , "children" : [  
+				{"name": "Large intestine" , "count": "6989" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine"  , "children" : [  
 				{"name": "Anal canal" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Anal canal" },
   
 				{"name": "Anal canal mucosa" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Anal canal mucosa" },
@@ -5700,7 +5710,7 @@
   
 				{"name": "Colon mucosa" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Colon mucosa" },
   
-				{"name": "Fecal" , "count": "6355" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Fecal" },
+				{"name": "Fecal" , "count": "6356" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Fecal" },
   
 				{"name": "Meconium" , "count": "21" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Meconium" },
   
@@ -5761,17 +5771,17 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Pancreas&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Small intestine" , "count": "200" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine"  , "children" : [  
+				{"name": "Small intestine" , "count": "202" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine"  , "children" : [  
 				{"name": "Duodenum" , "count": "62" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine&Biosample.Specific Ecosystem=Duodenum" },
   
 				{"name": "Ileum" , "count": "64" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine&Biosample.Specific Ecosystem=Ileum" },
   
 				{"name": "Jejunum" , "count": "50" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine&Biosample.Specific Ecosystem=Jejunum" },
   
-				{"name": "Unclassified" , "count": "24" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Small intestine&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Stomach" , "count": "2179" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach"  , "children" : [  
+				{"name": "Stomach" , "count": "2180" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach"  , "children" : [  
 				{"name": "Abomasum" , "count": "49" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=Abomasum" },
   
 				{"name": "C1/Glandular saccules" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=C1/Glandular saccules" },
@@ -5794,7 +5804,7 @@
   
 				{"name": "Reticulum" , "count": "12" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=Reticulum" },
   
-				{"name": "Rumen" , "count": "952" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=Rumen" },
+				{"name": "Rumen" , "count": "953" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=Rumen" },
   
 				{"name": "Rumen fluid" , "count": "1097" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Stomach&Biosample.Specific Ecosystem=Rumen fluid" },
   
@@ -6285,7 +6295,7 @@
 }]
 },
   
-		{"name": "Mammals: Human" , "count": "51926" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human"  , "children" : [  
+		{"name": "Mammals: Human" , "count": "51929" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human"  , "children" : [  
 			{"name": "Abdominal/Peritoneal cavity" , "count": "17" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Abdominal/Peritoneal cavity"  , "children" : [  
 				{"name": "Abscess" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Abdominal/Peritoneal cavity&Biosample.Ecosystem+Subtype=Abscess"  , "children" : [  
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Abdominal/Peritoneal cavity&Biosample.Ecosystem+Subtype=Abscess&Biosample.Specific Ecosystem=Unclassified" }]
@@ -6540,7 +6550,7 @@
 }]
 },
   
-			{"name": "Digestive system" , "count": "43246" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system"  , "children" : [  
+			{"name": "Digestive system" , "count": "43249" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system"  , "children" : [  
 				{"name": "Biliary tract" , "count": "21" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract"  , "children" : [  
 				{"name": "Bile" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Biliary tract&Biosample.Specific Ecosystem=Bile" },
   
@@ -6563,7 +6573,7 @@
 				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Esophagus&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Large intestine" , "count": "40720" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine"  , "children" : [  
+				{"name": "Large intestine" , "count": "40723" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine"  , "children" : [  
 				{"name": "Anal canal" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Anal canal" },
   
 				{"name": "Anal canal mucosa" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Anal canal mucosa" },
@@ -6582,7 +6592,7 @@
   
 				{"name": "Descending colon" , "count": "1" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Descending colon" },
   
-				{"name": "Fecal" , "count": "40020" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Fecal" },
+				{"name": "Fecal" , "count": "40023" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Fecal" },
   
 				{"name": "Hepatic flexure" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mammals: Human&Biosample.Ecosystem+Type=Digestive system&Biosample.Ecosystem+Subtype=Large intestine&Biosample.Specific Ecosystem=Hepatic flexure" },
   
@@ -7549,16 +7559,10 @@
 }]
 },
   
-		{"name": "Microbial" , "count": "546" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial"  , "children" : [  
-			{"name": "Bacteria" , "count": "544" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria"  , "children" : [  
-				{"name": "Unclassified" , "count": "544" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "544" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
-}]
-},
-  
-			{"name": "Bacterivore" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacterivore"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacterivore&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacterivore&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+		{"name": "Microbial" , "count": "547" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial"  , "children" : [  
+			{"name": "Bacteria" , "count": "545" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria"  , "children" : [  
+				{"name": "Unclassified" , "count": "545" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "545" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Microbial&Biosample.Ecosystem+Type=Bacteria&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
@@ -7674,11 +7678,15 @@
   
 			{"name": "Respiratory system" , "count": "124" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system"  , "children" : [  
 				{"name": "Gills" , "count": "81" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills"  , "children" : [  
-				{"name": "Extracellular" , "count": "6" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Extracellular" },
+				{"name": "Extracellular" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Extracellular" },
+  
+				{"name": "Intracellular" , "count": "50" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Intracellular" },
+  
+				{"name": "Surface" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Surface" },
   
-				{"name": "Intracellular" , "count": "52" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Intracellular" },
+				{"name": "Tissue" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Tissue" },
   
-				{"name": "Unclassified" , "count": "23" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "31" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Gills&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
 				{"name": "Unclassified" , "count": "43" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Respiratory system&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
@@ -7704,20 +7712,20 @@
 }]
 },
   
-			{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "26" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "8" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
-			{"name": "Whole body" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Whole body" , "count": "18" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body"  , "children" : [  
+				{"name": "Unclassified" , "count": "18" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "18" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Mollusca&Biosample.Ecosystem+Type=Whole body&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 }]
 },
   
-		{"name": "Plants" , "count": "23300" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants"  , "children" : [  
+		{"name": "Plants" , "count": "23301" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants"  , "children" : [  
 			{"name": "Bryophytes" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Bryophytes"  , "children" : [  
 				{"name": "Hornworts" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Bryophytes&Biosample.Ecosystem+Subtype=Hornworts"  , "children" : [  
 				{"name": "Rhizoids" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Bryophytes&Biosample.Ecosystem+Subtype=Hornworts&Biosample.Specific Ecosystem=Rhizoids" },
@@ -7908,7 +7916,7 @@
 }]
 },
   
-			{"name": "Roots" , "count": "17767" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots"  , "children" : [  
+			{"name": "Roots" , "count": "17768" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots"  , "children" : [  
 				{"name": "Aerial root" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Aerial root"  , "children" : [  
 				{"name": "Mucilage" , "count": "0" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Aerial root&Biosample.Specific Ecosystem=Mucilage" },
   
@@ -7937,8 +7945,8 @@
 				{"name": "Unclassified" , "count": "112" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizoplane&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Rhizosphere" , "count": "11936" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizosphere"  , "children" : [  
-				{"name": "Soil" , "count": "2860" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizosphere&Biosample.Specific Ecosystem=Soil" },
+				{"name": "Rhizosphere" , "count": "11937" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizosphere"  , "children" : [  
+				{"name": "Soil" , "count": "2861" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizosphere&Biosample.Specific Ecosystem=Soil" },
   
 				{"name": "Unclassified" , "count": "9076" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Plants&Biosample.Ecosystem+Type=Roots&Biosample.Ecosystem+Subtype=Rhizosphere&Biosample.Specific Ecosystem=Unclassified" }]
 },
@@ -7995,20 +8003,20 @@
 }]
 },
   
-		{"name": "Porifera" , "count": "610" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera"  , "children" : [  
-			{"name": "Sponge" , "count": "550" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge"  , "children" : [  
-				{"name": "Tissue" , "count": "63" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Tissue"  , "children" : [  
-				{"name": "Unclassified" , "count": "63" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Tissue&Biosample.Specific Ecosystem=Unclassified" }]
+		{"name": "Porifera" , "count": "611" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera"  , "children" : [  
+			{"name": "Sponge" , "count": "555" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge"  , "children" : [  
+				{"name": "Tissue" , "count": "66" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Tissue"  , "children" : [  
+				{"name": "Unclassified" , "count": "66" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Tissue&Biosample.Specific Ecosystem=Unclassified" }]
 },
   
-				{"name": "Unclassified" , "count": "487" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "487" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+				{"name": "Unclassified" , "count": "489" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "489" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Sponge&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 },
   
-			{"name": "Unclassified" , "count": "60" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "60" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
-				{"name": "Unclassified" , "count": "60" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
+			{"name": "Unclassified" , "count": "56" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "56" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified"  , "children" : [  
+				{"name": "Unclassified" , "count": "56" , "url": "search?Biosample.Ecosystem=Host-associated&Biosample.Ecosystem+Category=Porifera&Biosample.Ecosystem+Type=Unclassified&Biosample.Ecosystem+Subtype=Unclassified&Biosample.Specific Ecosystem=Unclassified" }]
 }]
 }]
 },
diff --git a/src/nmdc_submission_schema/datamodel/nmdc_submission_schema.py b/src/nmdc_submission_schema/datamodel/nmdc_submission_schema.py
index ed7521e5..5abc8943 100644
--- a/src/nmdc_submission_schema/datamodel/nmdc_submission_schema.py
+++ b/src/nmdc_submission_schema/datamodel/nmdc_submission_schema.py
@@ -1,5 +1,5 @@
 # Auto generated from nmdc_submission_schema.yaml by pythongen.py version: 0.0.1
-# Generation date: 2024-11-14T12:57:10
+# Generation date: 2024-12-09T10:01:01
 # Schema: nmdc_submission_schema
 #
 # id: https://example.com/nmdc_submission_schema
@@ -66,6 +66,7 @@
 dataclasses._init_fn = dataclasses_init_fn_with_kwargs
 
 # Namespaces
+BFO = CurieNamespace('BFO', 'http://purl.obolibrary.org/obo/BFO_')
 CATH = CurieNamespace('CATH', 'https://bioregistry.io/cath:')
 CHEBI = CurieNamespace('CHEBI', 'http://purl.obolibrary.org/obo/CHEBI_')
 CHEMBL_COMPOUND = CurieNamespace('CHEMBL_COMPOUND', 'https://bioregistry.io/chembl.compound:')
@@ -145,6 +146,7 @@
 NEON_SCHEMA = CurieNamespace('neon_schema', 'http://example.org/neon/schema/')
 NMDC = CurieNamespace('nmdc', 'https://w3id.org/nmdc/')
 NMDC_SUB_SCHEMA = CurieNamespace('nmdc_sub_schema', 'https://example.com/nmdc_sub_schema/')
+OWL = CurieNamespace('owl', 'http://www.w3.org/2002/07/owl#')
 PROV = CurieNamespace('prov', 'http://www.w3.org/ns/prov#')
 QUD = CurieNamespace('qud', 'http://qudt.org/1.1/schema/qudt#')
 RDF = CurieNamespace('rdf', 'http://www.w3.org/1999/02/22-rdf-syntax-ns#')
@@ -183,14 +185,6 @@ class LanguageCode(str):
     type_model_uri = NMDC_SUB_SCHEMA.LanguageCode
 
 
-class Decimal(Decimal):
-    """ A real number with arbitrary precision that conforms to the xsd:decimal specification """
-    type_class_uri = XSD["decimal"]
-    type_class_curie = "xsd:decimal"
-    type_name = "decimal"
-    type_model_uri = NMDC_SUB_SCHEMA.Decimal
-
-
 class Double(float):
     """ A real number that conforms to the xsd:double specification """
     type_class_uri = XSD["double"]
@@ -199,6 +193,30 @@ class Double(float):
     type_model_uri = NMDC_SUB_SCHEMA.Double
 
 
+class DecimalDegree(float):
+    """ A decimal degree expresses latitude or longitude as decimal fractions. """
+    type_class_uri = XSD["decimal"]
+    type_class_curie = "xsd:decimal"
+    type_name = "decimal_degree"
+    type_model_uri = NMDC_SUB_SCHEMA.DecimalDegree
+
+
+class Uriorcurie(URIorCURIE):
+    """ a URI or a CURIE """
+    type_class_uri = XSD["anyURI"]
+    type_class_curie = "xsd:anyURI"
+    type_name = "uriorcurie"
+    type_model_uri = NMDC_SUB_SCHEMA.Uriorcurie
+
+
+class Float(float):
+    """ A real number that conforms to the xsd:float specification """
+    type_class_uri = XSD["float"]
+    type_class_curie = "xsd:float"
+    type_name = "float"
+    type_model_uri = NMDC_SUB_SCHEMA.Float
+
+
 class Integer(int):
     """ An integer """
     type_class_uri = XSD["integer"]
@@ -207,6 +225,14 @@ class Integer(int):
     type_model_uri = NMDC_SUB_SCHEMA.Integer
 
 
+class LanguageCode(str):
+    """ A language code conforming to ISO_639-1 """
+    type_class_uri = XSD["language"]
+    type_class_curie = "xsd:language"
+    type_name = "language_code"
+    type_model_uri = NMDC_SUB_SCHEMA.LanguageCode
+
+
 class String(str):
     """ A character string """
     type_class_uri = XSD["string"]
@@ -215,20 +241,12 @@ class String(str):
     type_model_uri = NMDC_SUB_SCHEMA.String
 
 
-class Float(float):
-    """ A real number that conforms to the xsd:float specification """
-    type_class_uri = XSD["float"]
-    type_class_curie = "xsd:float"
-    type_name = "float"
-    type_model_uri = NMDC_SUB_SCHEMA.Float
-
-
-class Uriorcurie(URIorCURIE):
-    """ a URI or a CURIE """
-    type_class_uri = XSD["anyURI"]
-    type_class_curie = "xsd:anyURI"
-    type_name = "uriorcurie"
-    type_model_uri = NMDC_SUB_SCHEMA.Uriorcurie
+class Decimal(Decimal):
+    """ A real number with arbitrary precision that conforms to the xsd:decimal specification """
+    type_class_uri = XSD["decimal"]
+    type_class_curie = "xsd:decimal"
+    type_name = "decimal"
+    type_model_uri = NMDC_SUB_SCHEMA.Decimal
 
 
 class Boolean(Bool):
@@ -344,6 +362,10 @@ class NamedThingId(URIorCURIE):
     pass
 
 
+class GeneProductId(NamedThingId):
+    pass
+
+
 @dataclass(repr=False)
 class DhMultiviewCommonColumnsMixin(YAMLRoot):
     """
@@ -9738,6 +9760,58 @@ def __post_init__(self, *_: List[str], **kwargs: Dict[str, Any]):
         super().__post_init__(**kwargs)
 
 
+    def __new__(cls, *args, **kwargs):
+
+        type_designator = "type"
+        if not type_designator in kwargs:
+            return super().__new__(cls,*args,**kwargs)
+        else:
+            type_designator_value = kwargs[type_designator]
+            target_cls = cls._class_for("class_class_curie", type_designator_value)
+
+
+            if target_cls is None:
+                target_cls = cls._class_for("class_class_uri", type_designator_value)
+
+
+            if target_cls is None:
+                target_cls = cls._class_for("class_model_uri", type_designator_value)
+
+
+            if target_cls is None:
+                raise ValueError(f"Wrong type designator value: class {cls.__name__} "
+                                 f"has no subclass with ['class_class_curie', 'class_class_uri', 'class_model_uri']='{kwargs[type_designator]}'")
+            return super().__new__(target_cls,*args,**kwargs)
+
+
+
+@dataclass(repr=False)
+class GeneProduct(NamedThing):
+    """
+    A molecule encoded by a gene that has an evolved function
+    """
+    _inherited_slots: ClassVar[List[str]] = []
+
+    class_class_uri: ClassVar[URIRef] = NMDC["GeneProduct"]
+    class_class_curie: ClassVar[str] = "nmdc:GeneProduct"
+    class_name: ClassVar[str] = "GeneProduct"
+    class_model_uri: ClassVar[URIRef] = NMDC_SUB_SCHEMA.GeneProduct
+
+    id: Union[str, GeneProductId] = None
+    type: Union[str, URIorCURIE] = None
+
+    def __post_init__(self, *_: List[str], **kwargs: Dict[str, Any]):
+        if self._is_empty(self.id):
+            self.MissingRequiredField("id")
+        if not isinstance(self.id, GeneProductId):
+            self.id = GeneProductId(self.id)
+
+        super().__post_init__(**kwargs)
+        if self._is_empty(self.type):
+            self.MissingRequiredField("type")
+        self.type = str(self.class_class_curie)
+
+
 # Enumerations
 class BioticRelationshipEnum(EnumDefinitionImpl):
 
@@ -11774,12 +11848,22 @@ class HostSexEnum(EnumDefinitionImpl):
     female = PermissibleValue(text="female")
     hermaphrodite = PermissibleValue(text="hermaphrodite")
     male = PermissibleValue(text="male")
-    neuter = PermissibleValue(text="neuter")
+    transgender = PermissibleValue(text="transgender")
+    undeclared = PermissibleValue(text="undeclared")
 
     _defn = EnumDefinition(
         name="HostSexEnum",
     )
 
+    @classmethod
+    def _addvals(cls):
+        setattr(cls, "non-binary",
+            PermissibleValue(text="non-binary"))
+        setattr(cls, "transgender (female to male)",
+            PermissibleValue(text="transgender (female to male)"))
+        setattr(cls, "transgender (male to female)",
+            PermissibleValue(text="transgender (male to female)"))
+
 class AnalysisTypeEnum(EnumDefinitionImpl):
 
     metabolomics = PermissibleValue(text="metabolomics")
@@ -11802,6 +11886,10 @@ def _addvals(cls):
             PermissibleValue(text="natural organic matter"))
         setattr(cls, "bulk chemistry",
             PermissibleValue(text="bulk chemistry"))
+        setattr(cls, "amplicon sequencing assay",
+            PermissibleValue(
+                text="amplicon sequencing assay",
+                meaning=OBI["0002767"]))
 
 class DNASampleFormatEnum(EnumDefinitionImpl):
 
@@ -11887,7 +11975,6 @@ class EcosystemCategoryEnum(EnumDefinitionImpl):
     Cephalochordata = PermissibleValue(text="Cephalochordata")
     Cnidaria = PermissibleValue(text="Cnidaria")
     Endosymbionts = PermissibleValue(text="Endosymbionts")
-    Feedstock = PermissibleValue(text="Feedstock")
     Fish = PermissibleValue(text="Fish")
     Fungi = PermissibleValue(text="Fungi")
     Invertebrates = PermissibleValue(text="Invertebrates")
@@ -11959,7 +12046,6 @@ class EcosystemTypeEnum(EnumDefinitionImpl):
     Aquaculture = PermissibleValue(text="Aquaculture")
     Ascidians = PermissibleValue(text="Ascidians")
     Bacteria = PermissibleValue(text="Bacteria")
-    Bacterivore = PermissibleValue(text="Bacterivore")
     Bagasse = PermissibleValue(text="Bagasse")
     Beans = PermissibleValue(text="Beans")
     Beverages = PermissibleValue(text="Beverages")
@@ -12291,6 +12377,8 @@ def _addvals(cls):
             PermissibleValue(text="Olfactory system"))
         setattr(cls, "Ootheca/Egg mass",
             PermissibleValue(text="Ootheca/Egg mass"))
+        setattr(cls, "Organic waste",
+            PermissibleValue(text="Organic waste"))
         setattr(cls, "Outdoor Air",
             PermissibleValue(text="Outdoor Air"))
         setattr(cls, "Peat moss",
@@ -12698,6 +12786,7 @@ class EcosystemSubtypeEnum(EnumDefinitionImpl):
     Volcanic = PermissibleValue(text="Volcanic")
     Wall = PermissibleValue(text="Wall")
     Wart = PermissibleValue(text="Wart")
+    Waste = PermissibleValue(text="Waste")
     Wastewater = PermissibleValue(text="Wastewater")
     Water = PermissibleValue(text="Water")
     Watershed = PermissibleValue(text="Watershed")
@@ -13612,6 +13701,7 @@ class SpecificEcosystemEnum(EnumDefinitionImpl):
     Rock = PermissibleValue(text="Rock")
     Rocks = PermissibleValue(text="Rocks")
     Rosacea = PermissibleValue(text="Rosacea")
+    Rubber = PermissibleValue(text="Rubber")
     Rumen = PermissibleValue(text="Rumen")
     Runoff = PermissibleValue(text="Runoff")
     Sabkha = PermissibleValue(text="Sabkha")
@@ -13701,8 +13791,6 @@ def _addvals(cls):
             PermissibleValue(text="Abyssopelagic/Abyssal zone"))
         setattr(cls, "Acid Mine Drainage",
             PermissibleValue(text="Acid Mine Drainage"))
-        setattr(cls, "Acid mine drainage",
-            PermissibleValue(text="Acid mine drainage"))
         setattr(cls, "Acid sulfate soil",
             PermissibleValue(text="Acid sulfate soil"))
         setattr(cls, "Acid-saline drainage",
@@ -14658,7 +14746,6 @@ class EcosystemSubtypeForSoilEnum(EnumDefinitionImpl):
 
     Alpine = PermissibleValue(text="Alpine")
     Arable = PermissibleValue(text="Arable")
-    Biochar = PermissibleValue(text="Biochar")
     Biocrust = PermissibleValue(text="Biocrust")
     Biofilm = PermissibleValue(text="Biofilm")
     Chaparral = PermissibleValue(text="Chaparral")
@@ -17220,7 +17307,10 @@ class slots:
 
 slots.alternative_identifiers = Slot(uri=NMDC_SUB_SCHEMA.alternative_identifiers, name="alternative_identifiers", curie=NMDC_SUB_SCHEMA.curie('alternative_identifiers'),
                    model_uri=NMDC_SUB_SCHEMA.alternative_identifiers, domain=None, range=Optional[Union[Union[str, URIorCURIE], List[Union[str, URIorCURIE]]]],
-                   pattern=re.compile(r'^[a-zA-Z0-9][a-zA-Z0-9_\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\-\/\.,]*$'))
+                   pattern=re.compile(r'^[a-zA-Z0-9][a-zA-Z0-9_\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\-\/\.,\(\)\=\#]*$'))
+
+slots.alternative_names = Slot(uri=NMDC_SUB_SCHEMA.alternative_names, name="alternative_names", curie=NMDC_SUB_SCHEMA.curie('alternative_names'),
+                   model_uri=NMDC_SUB_SCHEMA.alternative_names, domain=None, range=Optional[str])
 
 slots.core_field = Slot(uri=NMDC_SUB_SCHEMA.core_field, name="core field", curie=NMDC_SUB_SCHEMA.curie('core_field'),
                    model_uri=NMDC_SUB_SCHEMA.core_field, domain=None, range=Optional[str])
@@ -17250,6 +17340,15 @@ class slots:
 slots.nucleic_acid_sequence_source_field = Slot(uri=NMDC_SUB_SCHEMA.nucleic_acid_sequence_source_field, name="nucleic acid sequence source field", curie=NMDC_SUB_SCHEMA.curie('nucleic_acid_sequence_source_field'),
                    model_uri=NMDC_SUB_SCHEMA.nucleic_acid_sequence_source_field, domain=None, range=Optional[str])
 
+slots.object = Slot(uri=NMDC_SUB_SCHEMA.object, name="object", curie=NMDC_SUB_SCHEMA.curie('object'),
+                   model_uri=NMDC_SUB_SCHEMA.object, domain=None, range=str)
+
+slots.predicate = Slot(uri=NMDC_SUB_SCHEMA.predicate, name="predicate", curie=NMDC_SUB_SCHEMA.curie('predicate'),
+                   model_uri=NMDC_SUB_SCHEMA.predicate, domain=None, range=str)
+
+slots.subject = Slot(uri=NMDC_SUB_SCHEMA.subject, name="subject", curie=NMDC_SUB_SCHEMA.curie('subject'),
+                   model_uri=NMDC_SUB_SCHEMA.subject, domain=None, range=Optional[Union[str, GeneProductId]])
+
 slots.type = Slot(uri=RDF.type, name="type", curie=RDF.curie('type'),
                    model_uri=NMDC_SUB_SCHEMA.type, domain=None, range=Union[str, URIorCURIE])
 
@@ -19879,8 +19978,7 @@ class slots:
                    model_uri=NMDC_SUB_SCHEMA.PlantAssociatedInterface_humidity_regm, domain=PlantAssociatedInterface, range=Optional[str])
 
 slots.PlantAssociatedInterface_isotope_exposure = Slot(uri=NMDC['nmdc/isotope_exposure'], name="PlantAssociatedInterface_isotope_exposure", curie=NMDC.curie('nmdc/isotope_exposure'),
-                   model_uri=NMDC_SUB_SCHEMA.PlantAssociatedInterface_isotope_exposure, domain=PlantAssociatedInterface, range=Optional[str],
-                   pattern=re.compile(r'^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$'))
+                   model_uri=NMDC_SUB_SCHEMA.PlantAssociatedInterface_isotope_exposure, domain=PlantAssociatedInterface, range=Optional[str])
 
 slots.PlantAssociatedInterface_lat_lon = Slot(uri=MIXS['0000009'], name="PlantAssociatedInterface_lat_lon", curie=MIXS.curie('0000009'),
                    model_uri=NMDC_SUB_SCHEMA.PlantAssociatedInterface_lat_lon, domain=PlantAssociatedInterface, range=str,
@@ -20213,8 +20311,7 @@ class slots:
                    model_uri=NMDC_SUB_SCHEMA.SedimentInterface_humidity_regm, domain=SedimentInterface, range=Optional[str])
 
 slots.SedimentInterface_isotope_exposure = Slot(uri=NMDC['nmdc/isotope_exposure'], name="SedimentInterface_isotope_exposure", curie=NMDC.curie('nmdc/isotope_exposure'),
-                   model_uri=NMDC_SUB_SCHEMA.SedimentInterface_isotope_exposure, domain=SedimentInterface, range=Optional[str],
-                   pattern=re.compile(r'^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$'))
+                   model_uri=NMDC_SUB_SCHEMA.SedimentInterface_isotope_exposure, domain=SedimentInterface, range=Optional[str])
 
 slots.SedimentInterface_lat_lon = Slot(uri=MIXS['0000009'], name="SedimentInterface_lat_lon", curie=MIXS.curie('0000009'),
                    model_uri=NMDC_SUB_SCHEMA.SedimentInterface_lat_lon, domain=SedimentInterface, range=str,
@@ -20622,8 +20719,7 @@ class slots:
                    pattern=re.compile(r'^(?:(?:[0-9]|[1-9][0-9]|9[0-9]|0[0-9]|0[0-5][0-9]):[0-5][0-9]:[0-5][0-9])(?:;(?:[0-9]|[1-9][0-9]|9[0-9]|0[0-9]|0[0-5][0-9]):[0-5][0-9]:[0-5][0-9])*$'))
 
 slots.SoilInterface_isotope_exposure = Slot(uri=NMDC['nmdc/isotope_exposure'], name="SoilInterface_isotope_exposure", curie=NMDC.curie('nmdc/isotope_exposure'),
-                   model_uri=NMDC_SUB_SCHEMA.SoilInterface_isotope_exposure, domain=SoilInterface, range=Optional[str],
-                   pattern=re.compile(r'^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$'))
+                   model_uri=NMDC_SUB_SCHEMA.SoilInterface_isotope_exposure, domain=SoilInterface, range=Optional[str])
 
 slots.SoilInterface_lat_lon = Slot(uri=MIXS['0000009'], name="SoilInterface_lat_lon", curie=MIXS.curie('0000009'),
                    model_uri=NMDC_SUB_SCHEMA.SoilInterface_lat_lon, domain=SoilInterface, range=str,
@@ -21268,8 +21364,7 @@ class slots:
                    model_uri=NMDC_SUB_SCHEMA.WaterInterface_humidity_regm, domain=WaterInterface, range=Optional[str])
 
 slots.WaterInterface_isotope_exposure = Slot(uri=NMDC['nmdc/isotope_exposure'], name="WaterInterface_isotope_exposure", curie=NMDC.curie('nmdc/isotope_exposure'),
-                   model_uri=NMDC_SUB_SCHEMA.WaterInterface_isotope_exposure, domain=WaterInterface, range=Optional[str],
-                   pattern=re.compile(r'^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$'))
+                   model_uri=NMDC_SUB_SCHEMA.WaterInterface_isotope_exposure, domain=WaterInterface, range=Optional[str])
 
 slots.WaterInterface_lat_lon = Slot(uri=MIXS['0000009'], name="WaterInterface_lat_lon", curie=MIXS.curie('0000009'),
                    model_uri=NMDC_SUB_SCHEMA.WaterInterface_lat_lon, domain=WaterInterface, range=Optional[str],
@@ -21537,8 +21632,7 @@ class slots:
                    model_uri=NMDC_SUB_SCHEMA.SoilMixsInspiredMixin_filter_method, domain=None, range=Optional[str])
 
 slots.SoilMixsInspiredMixin_isotope_exposure = Slot(uri=NMDC['nmdc/isotope_exposure'], name="SoilMixsInspiredMixin_isotope_exposure", curie=NMDC.curie('nmdc/isotope_exposure'),
-                   model_uri=NMDC_SUB_SCHEMA.SoilMixsInspiredMixin_isotope_exposure, domain=None, range=Optional[str],
-                   pattern=re.compile(r'^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$'))
+                   model_uri=NMDC_SUB_SCHEMA.SoilMixsInspiredMixin_isotope_exposure, domain=None, range=Optional[str])
 
 slots.SoilMixsInspiredMixin_micro_biomass_c_meth = Slot(uri=NMDC['nmdc/micro_biomass_c_meth'], name="SoilMixsInspiredMixin_micro_biomass_c_meth", curie=NMDC.curie('nmdc/micro_biomass_c_meth'),
                    model_uri=NMDC_SUB_SCHEMA.SoilMixsInspiredMixin_micro_biomass_c_meth, domain=None, range=Optional[str])
diff --git a/src/nmdc_submission_schema/schema/nmdc_submission_schema.yaml b/src/nmdc_submission_schema/schema/nmdc_submission_schema.yaml
index 43f6bb13..50b938be 100644
--- a/src/nmdc_submission_schema/schema/nmdc_submission_schema.yaml
+++ b/src/nmdc_submission_schema/schema/nmdc_submission_schema.yaml
@@ -271,67 +271,14 @@ prefixes:
   MIXS_yaml:
     prefix_prefix: MIXS_yaml
     prefix_reference: https://raw.githubusercontent.com/microbiomedata/mixs/main/model/schema/
+  BFO:
+    prefix_prefix: BFO
+    prefix_reference: http://purl.obolibrary.org/obo/BFO_
+  owl:
+    prefix_prefix: owl
+    prefix_reference: http://www.w3.org/2002/07/owl#
 default_prefix: nmdc_sub_schema
 default_range: string
-subsets:
-  mixs_environmental_triad:
-    name: mixs_environmental_triad
-    title: MIxS Environmental Triad
-    from_schema: https://example.com/nmdc_submission_schema
-  mixs extension:
-    name: mixs extension
-    from_schema: https://example.com/nmdc_submission_schema
-  checklist:
-    name: checklist
-    description: A MIxS checklist. These can be combined with packages
-    from_schema: https://example.com/nmdc_submission_schema
-  package:
-    name: package
-    description: A MIxS package. These can be combined with checklists
-    from_schema: https://example.com/nmdc_submission_schema
-  checklist_package_combination:
-    name: checklist_package_combination
-    description: A combination of a checklist and a package
-    from_schema: https://example.com/nmdc_submission_schema
-  data object subset:
-    name: data object subset
-    description: Subset consisting of the data objects that either inputs or outputs
-      of processes or workflows.
-    from_schema: https://example.com/nmdc_submission_schema
-  data_portal_subset:
-    name: data_portal_subset
-    description: Subset consisting of entities that Kitware/nmdc-server use to populate
-      the data portal.
-    comments:
-    - Schema authors are responsible for alerting and supporting Kitware and nmdc-server
-      authors about changes they will have to make if entities labeled with data_portal_subset
-      are modified.
-    - Assignment of the data_portal_subset is incomplete in the schema.
-    from_schema: https://example.com/nmdc_submission_schema
-  environment:
-    name: environment
-    from_schema: https://example.com/nmdc_submission_schema
-  investigation:
-    name: investigation
-    from_schema: https://example.com/nmdc_submission_schema
-  nucleic acid sequence source:
-    name: nucleic acid sequence source
-    from_schema: https://example.com/nmdc_submission_schema
-  proteases:
-    name: proteases
-    from_schema: https://example.com/nmdc_submission_schema
-  sample subset:
-    name: sample subset
-    description: Subset consisting of entities linked to the processing of samples.  Currently,
-      this subset consists of study, omics process, and biosample.
-    from_schema: https://example.com/nmdc_submission_schema
-  sequencing:
-    name: sequencing
-    from_schema: https://example.com/nmdc_submission_schema
-  workflow subset:
-    name: workflow subset
-    description: Subset consisting of just the workflow execution activities
-    from_schema: https://example.com/nmdc_submission_schema
 types:
   unit:
     name: unit
@@ -356,18 +303,6 @@ types:
     from_schema: https://example.com/nmdc_submission_schema
     base: str
     uri: xsd:language
-  decimal:
-    name: decimal
-    description: A real number with arbitrary precision that conforms to the xsd:decimal
-      specification
-    notes:
-    - If you are authoring schemas in LinkML YAML, the type is referenced with the
-      lower case "decimal".
-    from_schema: https://example.com/nmdc_submission_schema
-    broad_mappings:
-    - schema:Number
-    base: Decimal
-    uri: xsd:decimal
   double:
     name: double
     description: A real number that conforms to the xsd:double specification
@@ -379,6 +314,35 @@ types:
     - schema:Float
     base: float
     uri: xsd:double
+  decimal_degree:
+    name: decimal_degree
+    description: A decimal degree expresses latitude or longitude as decimal fractions.
+    from_schema: https://example.com/nmdc_submission_schema
+    see_also:
+    - https://en.wikipedia.org/wiki/Decimal_degrees
+    base: float
+    uri: xsd:decimal
+  uriorcurie:
+    name: uriorcurie
+    description: a URI or a CURIE
+    notes:
+    - If you are authoring schemas in LinkML YAML, the type is referenced with the
+      lower case "uriorcurie".
+    from_schema: https://example.com/nmdc_submission_schema
+    base: URIorCURIE
+    uri: xsd:anyURI
+    repr: str
+  float:
+    name: float
+    description: A real number that conforms to the xsd:float specification
+    notes:
+    - If you are authoring schemas in LinkML YAML, the type is referenced with the
+      lower case "float".
+    from_schema: https://example.com/nmdc_submission_schema
+    exact_mappings:
+    - schema:Float
+    base: float
+    uri: xsd:float
   integer:
     name: integer
     description: An integer
@@ -390,6 +354,14 @@ types:
     - schema:Integer
     base: int
     uri: xsd:integer
+  language_code:
+    name: language_code
+    description: A language code conforming to ISO_639-1
+    from_schema: https://example.com/nmdc_submission_schema
+    see_also:
+    - https://en.wikipedia.org/wiki/ISO_639-1
+    base: str
+    uri: xsd:language
   string:
     name: string
     description: A character string
@@ -402,27 +374,18 @@ types:
     - schema:Text
     base: str
     uri: xsd:string
-  float:
-    name: float
-    description: A real number that conforms to the xsd:float specification
-    notes:
-    - If you are authoring schemas in LinkML YAML, the type is referenced with the
-      lower case "float".
-    from_schema: https://example.com/nmdc_submission_schema
-    exact_mappings:
-    - schema:Float
-    base: float
-    uri: xsd:float
-  uriorcurie:
-    name: uriorcurie
-    description: a URI or a CURIE
+  decimal:
+    name: decimal
+    description: A real number with arbitrary precision that conforms to the xsd:decimal
+      specification
     notes:
     - If you are authoring schemas in LinkML YAML, the type is referenced with the
-      lower case "uriorcurie".
+      lower case "decimal".
     from_schema: https://example.com/nmdc_submission_schema
-    base: URIorCURIE
-    uri: xsd:anyURI
-    repr: str
+    broad_mappings:
+    - schema:Number
+    base: Decimal
+    uri: xsd:decimal
   boolean:
     name: boolean
     description: A binary (true or false) value
@@ -2769,10 +2732,18 @@ enums:
         text: female
       hermaphrodite:
         text: hermaphrodite
+      non-binary:
+        text: non-binary
       male:
         text: male
-      neuter:
-        text: neuter
+      transgender:
+        text: transgender
+      transgender (female to male):
+        text: transgender (female to male)
+      transgender (male to female):
+        text: transgender (male to female)
+      undeclared:
+        text: undeclared
   AnalysisTypeEnum:
     name: AnalysisTypeEnum
     from_schema: https://example.com/nmdc_submission_schema
@@ -2795,6 +2766,10 @@ enums:
         text: natural organic matter
       bulk chemistry:
         text: bulk chemistry
+      amplicon sequencing assay:
+        text: amplicon sequencing assay
+        meaning: OBI:0002767
+        title: Amplicon sequencing assay
   DNASampleFormatEnum:
     name: DNASampleFormatEnum
     from_schema: https://example.com/nmdc_submission_schema
@@ -2907,8 +2882,6 @@ enums:
         text: Drugs production
       Endosymbionts:
         text: Endosymbionts
-      Feedstock:
-        text: Feedstock
       Fish:
         text: Fish
       Food production:
@@ -3016,8 +2989,6 @@ enums:
         text: Baby formula
       Bacteria:
         text: Bacteria
-      Bacterivore:
-        text: Bacterivore
       Bagasse:
         text: Bagasse
       Beans:
@@ -3328,6 +3299,8 @@ enums:
         text: Oomycetes
       Ootheca/Egg mass:
         text: Ootheca/Egg mass
+      Organic waste:
+        text: Organic waste
       Outdoor Air:
         text: Outdoor Air
       Oxymonads:
@@ -4791,6 +4764,8 @@ enums:
         text: Warm (34-42C)
       Wart:
         text: Wart
+      Waste:
+        text: Waste
       Wastewater:
         text: Wastewater
       Wastewater effluent:
@@ -4842,8 +4817,6 @@ enums:
         text: Abyssopelagic/Abyssal zone
       Acid Mine Drainage:
         text: Acid Mine Drainage
-      Acid mine drainage:
-        text: Acid mine drainage
       Acid sulfate soil:
         text: Acid sulfate soil
       Acid-saline drainage:
@@ -5922,6 +5895,8 @@ enums:
         text: Rosacea
       Royal jelly:
         text: Royal jelly
+      Rubber:
+        text: Rubber
       Rumen:
         text: Rumen
       Rumen fluid:
@@ -6318,8 +6293,6 @@ enums:
         text: Alpine
       Arable:
         text: Arable
-      Biochar:
-        text: Biochar
       Biocrust:
         text: Biocrust
       Biofilm:
@@ -7767,30 +7740,6 @@ slots:
     is_a: environment field
     slot_uri: MIXS:0000094
     domain_of:
-    - agriculture
-    - air
-    - built environment
-    - core
-    - food-animal and animal feed
-    - food-farm environment
-    - food-food production facility
-    - food-human foods
-    - host-associated
-    - human-associated
-    - human-gut
-    - human-oral
-    - human-skin
-    - human-vaginal
-    - hydrocarbon resources-cores
-    - hydrocarbon resources-fluids_swabs
-    - microbial mat_biofilm
-    - miscellaneous natural or artificial environment
-    - plant-associated
-    - sediment
-    - soil
-    - symbiont-associated
-    - wastewater_sludge
-    - water
     - Biosample
     range: string
     multivalued: false
@@ -7901,7 +7850,7 @@ slots:
     description: Select all the data types associated or available for this biosample
     title: analysis/data type
     examples:
-    - value: metagenomics; metabolomics; proteomics
+    - value: metagenomics; metabolomics; metaproteomics
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIxS:investigation_type
@@ -9380,7 +9329,9 @@ slots:
     - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and 2021
       are all acceptable.
     examples:
-    - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+    - value: '2021-04-15'
+    - value: 2021-04
+    - value: '2021'
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000011
@@ -9400,7 +9351,8 @@ slots:
     comments:
     - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter: https://www.worldtimebuddy.com/pst-to-gmt-converter'
     examples:
-    - value: 13:33 or 13:33:55
+    - value: '813'
+    - value: '48835'
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000011
@@ -9421,7 +9373,8 @@ slots:
     comments:
     - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter: https://www.worldtimebuddy.com/pst-to-gmt-converter'
     examples:
-    - value: 13:33 or 13:33:55
+    - value: '813'
+    - value: '48835'
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000011
@@ -10794,8 +10747,7 @@ slots:
       EnvO documentation about how to use the field: https://github.com/EnvironmentOntology/envo/wiki/Using-ENVO-with-MIxS'
     title: broad-scale environmental context
     examples:
-    - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-        sample from the photic zone in middle of the Atlantic Ocean
+    - value: oceanic epipelagic zone biome [ENVO:01000035]
     from_schema: https://example.com/nmdc_submission_schema
     aliases:
     - broad-scale environmental context
@@ -10831,10 +10783,7 @@ slots:
       are accepted in this field. EnvO documentation about how to use the field: https://github.com/EnvironmentOntology/envo/wiki/Using-ENVO-with-MIxS.'
     title: local environmental context
     examples:
-    - value: 'litter layer [ENVO:01000338]; Annotating a pooled sample taken from
-        various vegetation layers in a forest consider: canopy [ENVO:00000047]|herb
-        and fern layer [ENVO:01000337]|litter layer [ENVO:01000338]|understory [01000335]|shrub
-        layer [ENVO:01000336].'
+    - value: litter layer [ENVO:01000338]
     from_schema: https://example.com/nmdc_submission_schema
     aliases:
     - local environmental context
@@ -10870,9 +10819,7 @@ slots:
       (e.g. a tree, a leaf, a table top).'
     title: environmental medium
     examples:
-    - value: 'soil [ENVO:00001998]; Annotating a fish swimming in the upper 100 m
-        of the Atlantic Ocean, consider: ocean water [ENVO:00002151]. Example: Annotating
-        a duck on a pond consider: pond water [ENVO:00002228]|air [ENVO_00002005]'
+    - value: soil [ENVO:00001998]
     from_schema: https://example.com/nmdc_submission_schema
     aliases:
     - environmental medium
@@ -12366,7 +12313,7 @@ slots:
       or https://www.ebi.ac.uk/ols/ontologies/uberon
     title: host body product
     examples:
-    - value: Portion of mucus [fma66938]
+    - value: mucus [UBERON:0000912]
     from_schema: https://example.com/nmdc_submission_schema
     aliases:
     - host body product
@@ -13182,12 +13129,11 @@ slots:
       labeled compounds
     examples:
     - value: 13C glucose
-    - value: H218O
+    - value: 18O water
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000751
     rank: 16
-    string_serialization: '{termLabel} {[termID]}; {timestamp}'
     domain_of:
     - Biosample
     slot_group: MIxS Inspired
@@ -18317,7 +18263,9 @@ slots:
     - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and 2021
       are all acceptable.
     examples:
-    - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+    - value: '2021-04-15'
+    - value: 2021-04
+    - value: '2021'
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000011
@@ -18337,7 +18285,8 @@ slots:
     comments:
     - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter: https://www.worldtimebuddy.com/pst-to-gmt-converter'
     examples:
-    - value: 13:33 or 13:33:55
+    - value: '813'
+    - value: '48835'
     from_schema: https://example.com/nmdc_submission_schema
     see_also:
     - MIXS:0000011
@@ -20431,7 +20380,20 @@ slots:
     - NamedThing
     range: uriorcurie
     multivalued: true
-    pattern: ^[a-zA-Z0-9][a-zA-Z0-9_\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\-\/\.,]*$
+    pattern: ^[a-zA-Z0-9][a-zA-Z0-9_\.]+:[a-zA-Z0-9_][a-zA-Z0-9_\-\/\.,\(\)\=\#]*$
+  alternative_names:
+    name: alternative_names
+    description: A list of alternative names used to refer to the entity. The distinction
+      between name and alternative names is application-specific.
+    from_schema: https://example.com/nmdc_submission_schema
+    exact_mappings:
+    - dcterms:alternative
+    - skos:altLabel
+    domain_of:
+    - OntologyClass
+    - Study
+    range: string
+    multivalued: false
   core field:
     name: core field
     description: basic fields
@@ -20508,7 +20470,7 @@ slots:
     from_schema: https://example.com/nmdc_submission_schema
     domain_of:
     - TextValue
-    range: language code
+    range: language_code
   name:
     name: name
     description: A human readable label for an entity
@@ -20525,6 +20487,28 @@ slots:
     abstract: true
     domain_of:
     - Biosample
+  object:
+    name: object
+    from_schema: https://example.com/nmdc_submission_schema
+    owner: OntologyRelation
+    domain_of:
+    - OntologyRelation
+    range: string
+    required: true
+    multivalued: false
+  predicate:
+    name: predicate
+    from_schema: https://example.com/nmdc_submission_schema
+    owner: OntologyRelation
+    domain_of:
+    - OntologyRelation
+    range: string
+    required: true
+    multivalued: false
+  subject:
+    name: subject
+    from_schema: https://example.com/nmdc_submission_schema
+    range: GeneProduct
   type:
     name: type
     description: the class_uri of the class that has been instantiated
@@ -20549,12 +20533,11 @@ slots:
     - PortionOfSubstance
     - MagBin
     - MetaboliteIdentification
-    - PeptideQuantification
-    - ProteinQuantification
     - GenomeFeature
     - FunctionalAnnotation
     - AttributeValue
     - NamedThing
+    - OntologyRelation
     - FailureCategorization
     - Protocol
     - CreditAssociation
@@ -20684,30 +20667,6 @@ classes:
         slot_uri: MIXS:0000094
         owner: Biosample
         domain_of:
-        - agriculture
-        - air
-        - built environment
-        - core
-        - food-animal and animal feed
-        - food-farm environment
-        - food-food production facility
-        - food-human foods
-        - host-associated
-        - human-associated
-        - human-gut
-        - human-oral
-        - human-skin
-        - human-vaginal
-        - hydrocarbon resources-cores
-        - hydrocarbon resources-fluids_swabs
-        - microbial mat_biofilm
-        - miscellaneous natural or artificial environment
-        - plant-associated
-        - sediment
-        - soil
-        - symbiont-associated
-        - wastewater_sludge
-        - water
         - Biosample
         slot_group: mixs_modified_section
         range: string
@@ -21056,8 +21015,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -22173,30 +22131,6 @@ classes:
         slot_uri: MIXS:0000094
         owner: Biosample
         domain_of:
-        - agriculture
-        - air
-        - built environment
-        - core
-        - food-animal and animal feed
-        - food-farm environment
-        - food-food production facility
-        - food-human foods
-        - host-associated
-        - human-associated
-        - human-gut
-        - human-oral
-        - human-skin
-        - human-vaginal
-        - hydrocarbon resources-cores
-        - hydrocarbon resources-fluids_swabs
-        - microbial mat_biofilm
-        - miscellaneous natural or artificial environment
-        - plant-associated
-        - sediment
-        - soil
-        - symbiont-associated
-        - wastewater_sludge
-        - water
         - Biosample
         slot_group: mixs_modified_section
         range: string
@@ -22956,8 +22890,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -24887,30 +24820,6 @@ classes:
         slot_uri: MIXS:0000094
         owner: Biosample
         domain_of:
-        - agriculture
-        - air
-        - built environment
-        - core
-        - food-animal and animal feed
-        - food-farm environment
-        - food-food production facility
-        - food-human foods
-        - host-associated
-        - human-associated
-        - human-gut
-        - human-oral
-        - human-skin
-        - human-vaginal
-        - hydrocarbon resources-cores
-        - hydrocarbon resources-fluids_swabs
-        - microbial mat_biofilm
-        - miscellaneous natural or artificial environment
-        - plant-associated
-        - sediment
-        - soil
-        - symbiont-associated
-        - wastewater_sludge
-        - water
         - Biosample
         slot_group: mixs_modified_section
         range: string
@@ -26146,8 +26055,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -30609,8 +30517,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -33838,8 +33745,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -36092,30 +35998,6 @@ classes:
         slot_uri: MIXS:0000094
         owner: Biosample
         domain_of:
-        - agriculture
-        - air
-        - built environment
-        - core
-        - food-animal and animal feed
-        - food-farm environment
-        - food-food production facility
-        - food-human foods
-        - host-associated
-        - human-associated
-        - human-gut
-        - human-oral
-        - human-skin
-        - human-vaginal
-        - hydrocarbon resources-cores
-        - hydrocarbon resources-fluids_swabs
-        - microbial mat_biofilm
-        - miscellaneous natural or artificial environment
-        - plant-associated
-        - sediment
-        - soil
-        - symbiont-associated
-        - wastewater_sludge
-        - water
         - Biosample
         slot_group: mixs_modified_section
         range: string
@@ -36486,8 +36368,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -36780,7 +36661,7 @@ classes:
           or https://www.ebi.ac.uk/ols/ontologies/uberon
         title: host body product
         examples:
-        - value: Portion of mucus [fma66938]
+        - value: mucus [UBERON:0000912]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - host body product
@@ -39267,30 +39148,6 @@ classes:
         slot_uri: MIXS:0000094
         owner: Biosample
         domain_of:
-        - agriculture
-        - air
-        - built environment
-        - core
-        - food-animal and animal feed
-        - food-farm environment
-        - food-food production facility
-        - food-human foods
-        - host-associated
-        - human-associated
-        - human-gut
-        - human-oral
-        - human-skin
-        - human-vaginal
-        - hydrocarbon resources-cores
-        - hydrocarbon resources-fluids_swabs
-        - microbial mat_biofilm
-        - miscellaneous natural or artificial environment
-        - plant-associated
-        - sediment
-        - soil
-        - symbiont-associated
-        - wastewater_sludge
-        - water
         - Biosample
         slot_group: mixs_modified_section
         range: string
@@ -39937,8 +39794,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -41508,7 +41364,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -41534,7 +41392,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -41767,8 +41626,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -42666,12 +42524,11 @@ classes:
           labeled compounds
         examples:
         - value: 13C glucose
-        - value: H218O
+        - value: 18O water
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000751
         rank: 16
-        string_serialization: '{termLabel} {[termID]}; {timestamp}'
         owner: Biosample
         domain_of:
         - Biosample
@@ -42679,7 +42536,6 @@ classes:
         range: string
         recommended: true
         multivalued: false
-        pattern: ^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$
       lat_lon:
         name: lat_lon
         annotations:
@@ -43914,7 +43770,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -44746,7 +44604,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -44772,7 +44632,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -45216,8 +45077,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -45576,12 +45436,11 @@ classes:
           labeled compounds
         examples:
         - value: 13C glucose
-        - value: H218O
+        - value: 18O water
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000751
         rank: 16
-        string_serialization: '{termLabel} {[termID]}; {timestamp}'
         owner: Biosample
         domain_of:
         - Biosample
@@ -45589,7 +45448,6 @@ classes:
         range: string
         recommended: true
         multivalued: false
-        pattern: ^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$
       lat_lon:
         name: lat_lon
         annotations:
@@ -47074,7 +46932,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -48099,7 +47959,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -48125,7 +47987,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -48151,7 +48014,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -48506,8 +48370,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -49091,12 +48954,11 @@ classes:
           labeled compounds
         examples:
         - value: 13C glucose
-        - value: H218O
+        - value: 18O water
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000751
         rank: 16
-        string_serialization: '{termLabel} {[termID]}; {timestamp}'
         owner: Biosample
         domain_of:
         - Biosample
@@ -49104,7 +48966,6 @@ classes:
         range: string
         recommended: true
         multivalued: false
-        pattern: ^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$
       lat_lon:
         name: lat_lon
         annotations:
@@ -50617,7 +50478,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -50643,7 +50506,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -51543,8 +51407,7 @@ classes:
         - range changed to enumeration late in makefile, so this is modified (but
           "sample ID" anyway)
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -53597,7 +53460,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -53623,7 +53488,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -54178,8 +54044,7 @@ classes:
           about how to use the field: https://github.com/EnvironmentOntology/envo/wiki/Using-ENVO-with-MIxS'
         title: broad-scale environmental context
         examples:
-        - value: oceanic epipelagic zone biome [ENVO:01000033] for annotating a water
-            sample from the photic zone in middle of the Atlantic Ocean
+        - value: oceanic epipelagic zone biome [ENVO:01000035]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - broad-scale environmental context
@@ -54221,10 +54086,7 @@ classes:
           the field: https://github.com/EnvironmentOntology/envo/wiki/Using-ENVO-with-MIxS.'
         title: local environmental context
         examples:
-        - value: 'litter layer [ENVO:01000338]; Annotating a pooled sample taken from
-            various vegetation layers in a forest consider: canopy [ENVO:00000047]|herb
-            and fern layer [ENVO:01000337]|litter layer [ENVO:01000338]|understory
-            [01000335]|shrub layer [ENVO:01000336].'
+        - value: litter layer [ENVO:01000338]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - local environmental context
@@ -54266,9 +54128,7 @@ classes:
           (e.g. a tree, a leaf, a table top).'
         title: environmental medium
         examples:
-        - value: 'soil [ENVO:00001998]; Annotating a fish swimming in the upper 100
-            m of the Atlantic Ocean, consider: ocean water [ENVO:00002151]. Example:
-            Annotating a duck on a pond consider: pond water [ENVO:00002228]|air [ENVO_00002005]'
+        - value: soil [ENVO:00001998]
         from_schema: https://w3id.org/nmdc/nmdc
         aliases:
         - environmental medium
@@ -54502,12 +54362,11 @@ classes:
           labeled compounds
         examples:
         - value: 13C glucose
-        - value: H218O
+        - value: 18O water
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000751
         rank: 16
-        string_serialization: '{termLabel} {[termID]}; {timestamp}'
         owner: Biosample
         domain_of:
         - Biosample
@@ -54515,7 +54374,6 @@ classes:
         range: string
         recommended: true
         multivalued: false
-        pattern: ^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$
       lat_lon:
         name: lat_lon
         annotations:
@@ -55874,7 +55732,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56313,7 +56173,7 @@ classes:
         description: Select all the data types associated or available for this biosample
         title: analysis/data type
         examples:
-        - value: metagenomics; metabolomics; proteomics
+        - value: metagenomics; metabolomics; metaproteomics
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIxS:investigation_type
@@ -56464,7 +56324,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56490,7 +56352,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56516,7 +56379,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56587,12 +56451,11 @@ classes:
           labeled compounds
         examples:
         - value: 13C glucose
-        - value: H218O
+        - value: 18O water
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000751
         rank: 16
-        string_serialization: '{termLabel} {[termID]}; {timestamp}'
         owner: Biosample
         domain_of:
         - Biosample
@@ -56600,7 +56463,6 @@ classes:
         range: string
         recommended: true
         multivalued: false
-        pattern: ^\S+.*\S+ \[[a-zA-Z]{2,}:\d+\]; ([\+-]?\d{4}(?!\d{2}\b))((-?)((0[1-9]|1[0-2])(\3([12]\d|0[1-9]|3[01]))?|W([0-4]\d|5[0-2])(-?[1-7])?|(00[1-9]|0[1-9]\d|[12]\d{2}|3([0-5]\d|6[1-6])))([T\s]((([01]\d|2[0-3])((:?)[0-5]\d)?|24\:?00)([\.,]\d+(?!:))?)?(\17[0-5]\d([\.,]\d+)?)?([zZ]|([\+-])([01]\d|2[0-3]):?([0-5]\d)?)?)?)?$
       micro_biomass_c_meth:
         name: micro_biomass_c_meth
         description: Reference or method used in determining microbial biomass carbon
@@ -56782,7 +56644,9 @@ classes:
         - Date should be formatted as YYYY(-MM(-DD)). Ie, 2021-04-15, 2021-04 and
           2021 are all acceptable.
         examples:
-        - value: 2021-04-15, 2021-04 and 2021 are all acceptable.
+        - value: '2021-04-15'
+        - value: 2021-04
+        - value: '2021'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56808,7 +56672,8 @@ classes:
         - 'Time should be entered as HH:MM(:SS) in GMT. See here for a converter:
           https://www.worldtimebuddy.com/pst-to-gmt-converter'
         examples:
-        - value: 13:33 or 13:33:55
+        - value: '813'
+        - value: '48835'
         from_schema: https://w3id.org/nmdc/nmdc
         see_also:
         - MIXS:0000011
@@ -56850,6 +56715,21 @@ classes:
     - jgi_mg_data
     - jgi_mt_data
     tree_root: true
+  GeneProduct:
+    name: GeneProduct
+    id_prefixes:
+    - PR
+    - UniProtKB
+    - gtpo
+    description: A molecule encoded by a gene that has an evolved function
+    notes:
+    - we may include a more general gene product class in future to allow for ncRNA
+      annotation
+    from_schema: https://example.com/nmdc_submission_schema
+    exact_mappings:
+    - biolink:GeneProduct
+    is_a: NamedThing
+    class_uri: nmdc:GeneProduct
   NamedThing:
     name: NamedThing
     description: a databased entity or concept/class