diff --git a/system/Database/MySQLi/PreparedQuery.php b/system/Database/MySQLi/PreparedQuery.php
index e9a6c6d10e30..21ab29bc9441 100644
--- a/system/Database/MySQLi/PreparedQuery.php
+++ b/system/Database/MySQLi/PreparedQuery.php
@@ -75,6 +75,8 @@ public function _execute(array $data): bool
                 $bindTypes .= 'i';
             } elseif (is_numeric($item)) {
                 $bindTypes .= 'd';
+            } elseif (is_string($item) && mb_detect_encoding($item, 'UTF-8', true) === false) {
+                $bindTypes .= 'b';
             } else {
                 $bindTypes .= 's';
             }
diff --git a/system/Database/SQLite3/PreparedQuery.php b/system/Database/SQLite3/PreparedQuery.php
index 21dc4c2fdeff..b86bd9981f49 100644
--- a/system/Database/SQLite3/PreparedQuery.php
+++ b/system/Database/SQLite3/PreparedQuery.php
@@ -75,6 +75,8 @@ public function _execute(array $data): bool
                 $bindType = SQLITE3_INTEGER;
             } elseif (is_float($item)) {
                 $bindType = SQLITE3_FLOAT;
+            } elseif (is_string($item) && mb_detect_encoding($item, 'UTF-8', true) === false) {
+                $bindType = SQLITE3_BLOB;
             } else {
                 $bindType = SQLITE3_TEXT;
             }
diff --git a/tests/system/Database/Live/PreparedQueryTest.php b/tests/system/Database/Live/PreparedQueryTest.php
index fd3b6cedb403..83eb143f1b18 100644
--- a/tests/system/Database/Live/PreparedQueryTest.php
+++ b/tests/system/Database/Live/PreparedQueryTest.php
@@ -269,4 +269,23 @@ public function testDeallocatePreparedQueryThenTryToClose(): void
 
         $this->query->close();
     }
+
+    public function testInsertBinaryData()
+    {
+        if ($this->db->DBDriver === 'Postgre' || $this->db->DBDriver === 'SQLSRV') {
+            $this->markTestSkipped('Blob not supported for Postgre and SQLSRV.');
+        }
+
+        $this->query = $this->db->prepare(static fn ($db) => $db->table('type_test')->insert([
+            'type_blob' => 'blob',
+        ]));
+
+        $fileContent = file_get_contents(TESTPATH . '_support/Images/Steveston_dusk.JPG');
+        $this->assertTrue($this->query->execute($fileContent));
+
+        $id   = $this->db->insertId();
+        $file = $this->db->table('type_test')->where('id', $id)->get()->getRow();
+
+        $this->assertSame(strlen($fileContent), strlen($file->type_blob));
+    }
 }
diff --git a/user_guide_src/source/changelogs/v4.5.6.rst b/user_guide_src/source/changelogs/v4.5.6.rst
index 569c5a542ecd..2b812ef232e7 100644
--- a/user_guide_src/source/changelogs/v4.5.6.rst
+++ b/user_guide_src/source/changelogs/v4.5.6.rst
@@ -42,6 +42,7 @@ Bugs Fixed
 - **CURLRequest:** Added support for handling proxy responses using HTTP versions other than 1.1.
 - **Database:** Fixed a bug that caused ``Postgre\Connection::reconnect()`` method to throw an error when the connection had not yet been established.
 - **Model** Fixed a bug that caused the ``Model::getIdValue()`` method to not correctly recognize the primary key in the ``Entity`` object if a data mapping for the primary key was used.
+- **Database:** Fixed a bug with handling binary data with prepared statements in SQLite3 and MySQLi drivers.
 
 See the repo's
 `CHANGELOG.md <https://github.com/codeigniter4/CodeIgniter4/blob/develop/CHANGELOG.md>`_