diff --git a/matlab/CMakeLists.txt b/matlab/CMakeLists.txt
index d8ed65ce92b13..a39acd1488e6f 100644
--- a/matlab/CMakeLists.txt
+++ b/matlab/CMakeLists.txt
@@ -34,9 +34,17 @@ function(build_arrow)
 
   set(ARROW_PREFIX "${CMAKE_CURRENT_BINARY_DIR}/arrow_ep-prefix")
   set(ARROW_BINARY_DIR "${CMAKE_CURRENT_BINARY_DIR}/arrow_ep-build")
+  # Supply -DARROW_CXXFLAGS=-D_DISABLE_CONSTEXPR_MUTEX_CONSTRUCTOR to 
+  # workaround windows-2022 GitHub Runner bug involving the VC Runtime:
+  # 
+  # See issues below for details:
+  #
+  # https://github.com/actions/runner-images/issues/10020
+  # https://github.com/actions/runner-images/issues/10004
   set(ARROW_CMAKE_ARGS
       "-DCMAKE_INSTALL_PREFIX=${ARROW_PREFIX}" "-DCMAKE_INSTALL_LIBDIR=lib"
-      "-DARROW_BUILD_STATIC=OFF" "-DARROW_CSV=ON")
+      "-DARROW_BUILD_STATIC=OFF" "-DARROW_CSV=ON"
+      "-DARROW_CXXFLAGS=-D_DISABLE_CONSTEXPR_MUTEX_CONSTRUCTOR")
 
   add_library(arrow_shared SHARED IMPORTED)
   set(ARROW_LIBRARY_TARGET arrow_shared)