diff --git a/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/TransactionConfiguration.java b/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/TransactionConfiguration.java
index 197668742f743..4b0ad5df6dd59 100644
--- a/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/TransactionConfiguration.java
+++ b/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/TransactionConfiguration.java
@@ -31,4 +31,19 @@
      * @return The transaction timeout in seconds.
      */
     int timeout() default UNSET_TIMEOUT;
+
+    String UNSET_TIMEOUT_CONFIG_PROPERTY = "<<unset>>";
+
+    /**
+     * The configuration property to use in order to determine the value of the timeout in seconds.
+     * If the property exists, it must be an integer value representing the transaction timeout in seconds.
+     *
+     * An example configuration in {@code application.properties} could be: {@code my-transaction.timeout=5}.
+     *
+     * If both {@code timeoutFromConfigProperty} and {@code timeout} are set, then Quarkus will attempt to resolve
+     * {@code timeoutFromConfigProperty} and if a value for it has been provided, the timeout is set to that value.
+     * If no value has been provided at runtime for the property, then the value of {@code timeout} will be used
+     * as the fallback.
+     */
+    String timeoutFromConfigProperty() default UNSET_TIMEOUT_CONFIG_PROPERTY;
 }
diff --git a/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/interceptor/TransactionalInterceptorBase.java b/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/interceptor/TransactionalInterceptorBase.java
index 6910628258eaa..22e9554c3982e 100644
--- a/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/interceptor/TransactionalInterceptorBase.java
+++ b/extensions/narayana-jta/runtime/src/main/java/io/quarkus/narayana/jta/runtime/interceptor/TransactionalInterceptorBase.java
@@ -15,6 +15,8 @@
 import javax.transaction.TransactionManager;
 import javax.transaction.Transactional;
 
+import org.eclipse.microprofile.config.ConfigProvider;
+import org.jboss.logging.Logger;
 import org.jboss.tm.usertx.client.ServerVMClientUserTransaction;
 import org.reactivestreams.Publisher;
 
@@ -34,6 +36,7 @@
 public abstract class TransactionalInterceptorBase implements Serializable {
 
     private static final long serialVersionUID = 1L;
+    private static final Logger log = Logger.getLogger(TransactionalInterceptorBase.class);
 
     @Inject
     TransactionManager transactionManager;
@@ -106,16 +109,33 @@ protected Object invokeInOurTx(InvocationContext ic, TransactionManager tm, Runn
 
         TransactionConfiguration configAnnotation = getTransactionConfiguration(ic);
         int currentTmTimeout = ((CDIDelegatingTransactionManager) transactionManager).getTransactionTimeout();
-        if (configAnnotation != null && configAnnotation.timeout() != TransactionConfiguration.UNSET_TIMEOUT) {
-            tm.setTransactionTimeout(configAnnotation.timeout());
+        boolean restoreTimeout = false;
+        if (configAnnotation != null) {
+            Integer newTimeout = null;
+            if (!configAnnotation.timeoutFromConfigProperty().equals(TransactionConfiguration.UNSET_TIMEOUT_CONFIG_PROPERTY)) {
+                Optional<Integer> configTimeout = ConfigProvider.getConfig()
+                        .getOptionalValue(configAnnotation.timeoutFromConfigProperty(), Integer.class);
+                if (configTimeout.isPresent()) {
+                    newTimeout = configTimeout.get();
+                } else if (log.isDebugEnabled()) {
+                    log.debug("Configuration property '" + configAnnotation.timeoutFromConfigProperty()
+                            + "' was not provided, so it will not affect the transaction's timeout.");
+                }
+            }
+            if ((newTimeout == null) && (configAnnotation.timeout() != TransactionConfiguration.UNSET_TIMEOUT)) {
+                newTimeout = configAnnotation.timeout();
+            }
+            if (newTimeout != null) {
+                tm.setTransactionTimeout(newTimeout);
+                restoreTimeout = true;
+            }
         }
         Transaction tx;
         try {
             tm.begin();
             tx = tm.getTransaction();
         } finally {
-            if (configAnnotation != null && configAnnotation.timeout() != TransactionConfiguration.UNSET_TIMEOUT) {
-                //restore the default behaviour
+            if (restoreTimeout) {
                 tm.setTransactionTimeout(currentTmTimeout);
             }
         }
@@ -263,7 +283,9 @@ protected Object invokeInNoTx(InvocationContext ic) throws Exception {
 
     private void checkConfiguration(InvocationContext ic) {
         TransactionConfiguration configAnnotation = getTransactionConfiguration(ic);
-        if (configAnnotation != null && configAnnotation.timeout() != TransactionConfiguration.UNSET_TIMEOUT) {
+        if (configAnnotation != null && ((configAnnotation.timeout() != TransactionConfiguration.UNSET_TIMEOUT)
+                || !TransactionConfiguration.UNSET_TIMEOUT_CONFIG_PROPERTY
+                        .equals(configAnnotation.timeoutFromConfigProperty()))) {
             throw new RuntimeException("Changing timeout via @TransactionConfiguration can only be done " +
                     "at the entry level of a transaction");
         }
diff --git a/integration-tests/jpa-h2/src/main/java/io/quarkus/it/jpa/h2/proxy/ProxyTestEndpoint.java b/integration-tests/jpa-h2/src/main/java/io/quarkus/it/jpa/h2/proxy/ProxyTestEndpoint.java
index d870b85879101..f9d23b81c847b 100644
--- a/integration-tests/jpa-h2/src/main/java/io/quarkus/it/jpa/h2/proxy/ProxyTestEndpoint.java
+++ b/integration-tests/jpa-h2/src/main/java/io/quarkus/it/jpa/h2/proxy/ProxyTestEndpoint.java
@@ -13,6 +13,7 @@
 import javax.servlet.http.HttpServletResponse;
 import javax.transaction.Transactional;
 
+import io.quarkus.narayana.jta.runtime.TransactionConfiguration;
 import io.quarkus.runtime.StartupEvent;
 
 @WebServlet(urlPatterns = "/jpa-h2/testproxy")
@@ -23,6 +24,7 @@ public class ProxyTestEndpoint extends HttpServlet {
     EntityManager entityManager;
 
     @Transactional
+    @TransactionConfiguration(timeoutFromConfigProperty = "dummy.transaction.timeout")
     public void setup(@Observes StartupEvent startupEvent) {
         Pet pet = new Pet();
         pet.setId(1);
diff --git a/integration-tests/jpa-h2/src/main/resources/application.properties b/integration-tests/jpa-h2/src/main/resources/application.properties
index bf4226d2762fd..34e4a396fab1f 100644
--- a/integration-tests/jpa-h2/src/main/resources/application.properties
+++ b/integration-tests/jpa-h2/src/main/resources/application.properties
@@ -1 +1,2 @@
 quarkus.datasource.jdbc.max-size=8
+dummy.transaction.timeout=30