diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index fe515aa..9e9d59e 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -17,7 +17,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v2
       with:
-        python-version: 3.6
+        python-version: 3.7
     - name: Pip cache
       uses: actions/cache@v1
       with:
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index edaf3bb..9055f35 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -19,7 +19,7 @@ jobs:
     strategy:
       max-parallel: 5
       matrix:
-        python-version: ["3.6", "3.7", "3.8", "3.9", "3.10"]
+        python-version: ["3.7", "3.8", "3.9", "3.10"]
     steps:
     - uses: actions/checkout@v2
     - name: Set up Python ${{ matrix.python-version }}
@@ -51,7 +51,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v2
       with:
-        python-version: 3.6
+        python-version: 3.7
     - name: Pip cache
       uses: actions/cache@v1
       with:
diff --git a/README.md b/README.md
index 44154ca..f68efd8 100644
--- a/README.md
+++ b/README.md
@@ -68,5 +68,5 @@ Install with pip:
 $ pip install respx
 ```
 
-Requires Python 3.6+ and HTTPX 0.21+.
+Requires Python 3.7+ and HTTPX 0.21+.
 See [Changelog](https://github.com/lundberg/respx/blob/master/CHANGELOG.md) for older HTTPX compatibility.
diff --git a/docs/examples.md b/docs/examples.md
index 800f0b1..6deb1de 100644
--- a/docs/examples.md
+++ b/docs/examples.md
@@ -97,7 +97,6 @@ import respx
 
 
 @respx.mock
-@pytest.mark.asyncio
 async def test_async_decorator():
     async with httpx.AsyncClient() as client:
         route = respx.get("https://example.org/")
@@ -106,7 +105,6 @@ async def test_async_decorator():
         assert response.status_code == 200
 
 
-@pytest.mark.asyncio
 async def test_async_ctx_manager():
     async with respx.mock:
         async with httpx.AsyncClient() as client:
diff --git a/docs/index.md b/docs/index.md
index ad870cb..2572564 100644
--- a/docs/index.md
+++ b/docs/index.md
@@ -68,5 +68,5 @@ Install with pip:
 $ pip install respx
 ```
 
-Requires Python 3.6+ and HTTPX 0.21+.
+Requires Python 3.7+ and HTTPX 0.21+.
 See [Changelog](https://github.com/lundberg/respx/blob/master/CHANGELOG.md) for older HTTPX compatibility.
diff --git a/docs/versions/0.14.0/mocking.md b/docs/versions/0.14.0/mocking.md
index 7f025ba..920b668 100644
--- a/docs/versions/0.14.0/mocking.md
+++ b/docs/versions/0.14.0/mocking.md
@@ -250,4 +250,3 @@ class MyTestCase(asynctest.TestCase):
                 assert request.called
                 assert response.text == "foobar"
 ```
-
diff --git a/noxfile.py b/noxfile.py
index 35adc7e..4041dc1 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -9,7 +9,7 @@
 docs_requirements = ("mkdocs", "mkdocs-material", "mkautodoc>=0.1.0")
 
 
-@nox.session(python=["3.6", "3.7", "3.8", "3.9", "3.10", "3.11"])
+@nox.session(python=["3.7", "3.8", "3.9", "3.10", "3.11"])
 def test(session):
     deps = ["pytest", "pytest-asyncio", "pytest-cov", "trio", "starlette", "flask"]
     session.install("--upgrade", *deps)
@@ -22,12 +22,12 @@ def test(session):
     session.run("pytest", "-v", *options)
 
 
-@nox.session(python="3.6")
+@nox.session(python="3.7")
 def check(session):
     session.install("--upgrade", "flake8-bugbear", "mypy", *lint_requirements)
     session.install("-e", ".")
 
-    session.run("black", "--check", "--diff", "--target-version=py36", *source_files)
+    session.run("black", "--check", "--diff", "--target-version=py37", *source_files)
     session.run("isort", "--check", "--diff", "--project=respx", *source_files)
     session.run("flake8", *source_files)
     session.run("mypy")
@@ -39,7 +39,7 @@ def lint(session):
 
     session.run("autoflake", "--in-place", "--recursive", *source_files)
     session.run("isort", "--project=respx", *source_files)
-    session.run("black", "--target-version=py36", *source_files)
+    session.run("black", "--target-version=py37", *source_files)
 
     session.notify("check")
 
diff --git a/respx/handlers.py b/respx/handlers.py
index 0d4ad40..f383678 100644
--- a/respx/handlers.py
+++ b/respx/handlers.py
@@ -9,7 +9,7 @@ def __init__(self, transport: httpx.BaseTransport) -> None:
 
     def __call__(self, request: httpx.Request) -> httpx.Response:
         if not isinstance(
-            request.stream,  # type: ignore[has-type]
+            request.stream,
             httpx.SyncByteStream,
         ):  # pragma: nocover
             raise RuntimeError("Attempted to route an async request to a sync app.")
@@ -23,7 +23,7 @@ def __init__(self, transport: httpx.AsyncBaseTransport) -> None:
 
     async def __call__(self, request: httpx.Request) -> httpx.Response:
         if not isinstance(
-            request.stream,  # type: ignore[has-type]
+            request.stream,
             httpx.AsyncByteStream,
         ):  # pragma: nocover
             raise RuntimeError("Attempted to route a sync request to an async app.")
diff --git a/respx/models.py b/respx/models.py
index cb38b17..9200817 100644
--- a/respx/models.py
+++ b/respx/models.py
@@ -35,7 +35,7 @@ def clone_response(response: httpx.Response, request: httpx.Request) -> httpx.Re
     response = httpx.Response(
         response.status_code,
         headers=response.headers,
-        stream=response.stream,  # type: ignore[has-type]
+        stream=response.stream,
         request=request,
         extensions=dict(response.extensions),
     )
diff --git a/respx/router.py b/respx/router.py
index b42926c..1d93d70 100644
--- a/respx/router.py
+++ b/respx/router.py
@@ -283,9 +283,7 @@ def resolve(self, request: httpx.Request) -> ResolvedRoute:
                     resolved.response = cast(ResolvedResponseTypes, prospect)
                     break
 
-        if resolved.response and isinstance(
-            resolved.response.stream, httpx.ByteStream  # type: ignore[has-type]
-        ):
+        if resolved.response and isinstance(resolved.response.stream, httpx.ByteStream):
             resolved.response.read()  # Pre-read stream
 
         return resolved
@@ -307,9 +305,7 @@ async def aresolve(self, request: httpx.Request) -> ResolvedRoute:
                     resolved.response = cast(ResolvedResponseTypes, prospect)
                     break
 
-        if resolved.response and isinstance(
-            resolved.response.stream, httpx.ByteStream  # type: ignore[has-type]
-        ):
+        if resolved.response and isinstance(resolved.response.stream, httpx.ByteStream):
             await resolved.response.aread()  # Pre-read stream
 
         return resolved
diff --git a/setup.cfg b/setup.cfg
index 1838f0c..a2bb004 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -3,7 +3,7 @@ universal = 1
 
 [flake8]
 max-line-length = 88
-ignore = E501,E266,E731,W503,E203,B024
+ignore = B024,C408,E203,W503
 exclude = .git
 show-source = true
 
@@ -36,7 +36,7 @@ skip_covered = True
 show_missing = True
 
 [mypy]
-python_version = 3.6
+python_version = 3.7
 files = respx,tests
 pretty = True
 
diff --git a/setup.py b/setup.py
index 04a9f0d..18963ea 100644
--- a/setup.py
+++ b/setup.py
@@ -23,7 +23,6 @@
         "Operating System :: OS Independent",
         "Programming Language :: Python",
         "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
@@ -39,6 +38,6 @@
     entry_points={"pytest11": ["respx = respx.plugin"]},
     include_package_data=True,
     zip_safe=False,
-    python_requires=">=3.6",
+    python_requires=">=3.7",
     install_requires=["httpx>=0.21.0"],
 )
diff --git a/tests/test_api.py b/tests/test_api.py
index 8b019d8..4a91442 100644
--- a/tests/test_api.py
+++ b/tests/test_api.py
@@ -14,7 +14,6 @@
 from respx.router import MockRouter
 
 
-@pytest.mark.asyncio
 async def test_http_methods(client):
     async with respx.mock:
         url = "https://foo.bar"
@@ -73,7 +72,6 @@ async def test_http_methods(client):
         assert respx.calls.call_count == 8 * 2
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "url,pattern",
     [
@@ -95,14 +93,12 @@ async def test_url_match(client, url, pattern):
         assert response.text == "baz"
 
 
-@pytest.mark.asyncio
 async def test_invalid_url_pattern():
     async with MockRouter() as respx_mock:
         with pytest.raises(TypeError):
             respx_mock.get(["invalid"])  # type: ignore[arg-type]
 
 
-@pytest.mark.asyncio
 async def test_repeated_pattern(client):
     async with MockRouter() as respx_mock:
         url = "https://foo/bar/baz/"
@@ -127,7 +123,6 @@ async def test_repeated_pattern(client):
         assert statuses == [201, 409]
 
 
-@pytest.mark.asyncio
 async def test_status_code(client):
     async with MockRouter() as respx_mock:
         url = "https://foo.bar/"
@@ -138,7 +133,6 @@ async def test_status_code(client):
     assert response.status_code == 404
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "headers,content_type,expected",
     [
@@ -166,7 +160,6 @@ async def test_headers(client, headers, content_type, expected):
         assert response.headers == httpx.Headers(expected)
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "content,expected",
     [
@@ -184,7 +177,6 @@ async def test_text_encoding(client, content, expected):
         assert response.text == expected
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "key,value,expected_content_type",
     [
@@ -214,7 +206,6 @@ async def test_content_variants(client, key, value, expected_content_type):
         assert sync_response.content is not None
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "content,headers,expected_headers",
     [
@@ -272,15 +263,11 @@ def test_json_post_body():
         assert get_route.called
 
 
-@pytest.mark.asyncio
 async def test_raising_content(client):
     async with MockRouter() as respx_mock:
         url = "https://foo.bar/"
         request = respx_mock.get(url)
-        request.side_effect = httpx.ConnectTimeout(
-            "X-P",
-            request=None,  # type: ignore[arg-type]
-        )
+        request.side_effect = httpx.ConnectTimeout("X-P", request=None)
         with pytest.raises(httpx.ConnectTimeout):
             await client.get(url)
 
@@ -301,7 +288,6 @@ async def test_raising_content(client):
             assert route.calls.last.response
 
 
-@pytest.mark.asyncio
 async def test_callable_content(client):
     async with MockRouter() as respx_mock:
         url_pattern = re.compile(r"https://foo.bar/(?P<slug>\w+)/")
@@ -327,7 +313,6 @@ def content_callback(request, slug):
         assert request.calls[-1][0].content == b'{"x": "!"}'
 
 
-@pytest.mark.asyncio
 async def test_request_callback(client):
     def callback(request, name):
         if request.url.host == "foo.bar" and request.content == b'{"foo": "bar"}':
@@ -375,7 +360,6 @@ def _callback(request):
             await client.get("https://egg.plant/")
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "using,route,expected",
     [
@@ -415,7 +399,6 @@ async def test_pass_through(client, using, route, expected):
 
 
 @respx.mock
-@pytest.mark.asyncio
 async def test_parallel_requests(client):
     def content(request, page):
         return httpx.Response(200, text=page)
@@ -433,7 +416,6 @@ def content(request, page):
     assert respx.calls.call_count == 2
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "method_str, client_method_attr",
     [
@@ -476,7 +458,6 @@ def test_pop():
 
 
 @respx.mock
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "url,params,call_url,call_params",
     [
@@ -503,7 +484,6 @@ async def test_params_match(client, url, params, call_url, call_params):
     assert response.text == "spam spam"
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "base,url",
     [
@@ -564,7 +544,6 @@ def test_respond():
             route.respond(content=Exception())  # type: ignore[arg-type]
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "kwargs",
     [
diff --git a/tests/test_mock.py b/tests/test_mock.py
index ddb85fc..5cb2b7b 100644
--- a/tests/test_mock.py
+++ b/tests/test_mock.py
@@ -11,7 +11,6 @@
 from respx.router import MockRouter
 
 
-@pytest.mark.asyncio
 @respx.mock
 async def test_decorating_test(client):
     assert respx.calls.call_count == 0
@@ -26,7 +25,6 @@ async def test_decorating_test(client):
     respx.routes["home"].calls.assert_called_once()
 
 
-@pytest.mark.asyncio
 async def test_mock_request_fixture(client, my_mock):
     assert respx.calls.call_count == 0
     assert my_mock.calls.call_count == 0
@@ -39,7 +37,6 @@ async def test_mock_request_fixture(client, my_mock):
     assert my_mock.calls.call_count == 1
 
 
-@pytest.mark.asyncio
 async def test_mock_single_session_fixture(client, mocked_foo):
     current_foo_call_count = mocked_foo.calls.call_count
     response = await client.get("https://foo.api/api/bar/")
@@ -49,7 +46,6 @@ async def test_mock_single_session_fixture(client, mocked_foo):
     assert mocked_foo.calls.call_count == current_foo_call_count + 1
 
 
-@pytest.mark.asyncio
 async def test_mock_multiple_session_fixtures(client, mocked_foo, mocked_ham):
     current_foo_call_count = mocked_foo.calls.call_count
     current_ham_call_count = mocked_ham.calls.call_count
@@ -83,7 +79,6 @@ def test():
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 async def test_global_async_decorator(client):
     @respx.mock
     async def test():
@@ -119,7 +114,6 @@ def test(respx_mock):
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize("using", ["httpcore", "httpx"])
 async def test_local_async_decorator(client, using):
     @respx.mock(using=using)
@@ -175,7 +169,6 @@ def test():
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 async def test_global_contextmanager(client):
     with respx.mock:
         assert respx.calls.call_count == 0
@@ -196,7 +189,6 @@ async def test_global_contextmanager(client):
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 async def test_local_contextmanager(client):
     with respx.mock() as respx_mock:
         assert respx_mock.calls.call_count == 0
@@ -219,7 +211,6 @@ async def test_local_contextmanager(client):
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 async def test_nested_local_contextmanager(client):
     with respx.mock() as respx_mock_1:
         get_request = respx_mock_1.get("https://foo/bar/") % 202
@@ -246,7 +237,6 @@ async def test_nested_local_contextmanager(client):
     assert len(respx.routes) == 0
 
 
-@pytest.mark.asyncio
 async def test_nested_global_contextmanager(client):
     with respx.mock:
         get_request = respx.get("https://foo/bar/") % 202
@@ -271,7 +261,6 @@ async def test_nested_global_contextmanager(client):
     assert len(respx.routes) == 0
 
 
-@pytest.mark.asyncio
 async def test_configured_decorator(client):
     @respx.mock(assert_all_called=False, assert_all_mocked=False)
     async def test(respx_mock):
@@ -298,7 +287,6 @@ async def test(respx_mock):
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 @respx.mock(base_url="https://foo.bar")
 async def test_configured_decorator_with_fixture(respx_mock, client):
     respx_mock.get("/")
@@ -306,7 +294,6 @@ async def test_configured_decorator_with_fixture(respx_mock, client):
     assert response.status_code == 200
 
 
-@pytest.mark.asyncio
 async def test_configured_router_reuse(client):
     router = respx.mock()
     route = router.get("https://foo/bar/") % 404
@@ -340,7 +327,6 @@ async def test_configured_router_reuse(client):
     assert respx.calls.call_count == 0
 
 
-@pytest.mark.asyncio
 async def test_router_return_type_misuse():
     router = respx.mock(assert_all_called=False)
     route = router.get("https://hot.dog/")
@@ -349,7 +335,6 @@ async def test_router_return_type_misuse():
         route.return_value = "not-a-httpx-response"  # type: ignore[assignment]
 
 
-@pytest.mark.asyncio
 @respx.mock(base_url="https://ham.spam/")
 async def test_nested_base_url(respx_mock):
     request = respx_mock.patch("/egg/") % dict(content="yolk")
@@ -388,7 +373,6 @@ def test_leakage(mocked_foo, mocked_ham):
     assert len(Mocker.registry["httpcore"].routers) == 2
 
 
-@pytest.mark.asyncio
 async def test_start_stop(client):
     url = "https://start.stop/"
     request = respx.get(url) % 202
@@ -418,7 +402,6 @@ async def test_start_stop(client):
         respx.stop()  # Cleanup global state on error, to not affect other tests
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "assert_all_called,do_post,raises",
     [
@@ -442,7 +425,6 @@ async def test_assert_all_called(client, assert_all_called, do_post, raises):
             assert request2.called is do_post
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "assert_all_mocked,raises",
     [(True, pytest.raises(AllMockedAssertionError)), (False, does_not_raise())],
@@ -487,7 +469,6 @@ def test_add_remove_targets():
         assert len(HTTPCoreMocker.targets) == pre_add_count
 
 
-@pytest.mark.asyncio
 async def test_proxies():
     with respx.mock:
         respx.get("https://foo.bar/") % dict(json={"foo": "bar"})
@@ -504,7 +485,6 @@ async def test_proxies():
         assert response.json() == {"foo": "bar"}
 
 
-@pytest.mark.asyncio
 async def test_uds():
     async with respx.mock:
         uds = httpx.AsyncHTTPTransport(uds="/tmp/foobar.sock")
@@ -515,7 +495,6 @@ async def test_uds():
             assert response.status_code == 202
 
 
-@pytest.mark.asyncio
 async def test_mock_using_none():
     @respx.mock(using=None)
     async def test(respx_mock):
@@ -528,7 +507,6 @@ async def test(respx_mock):
     await test()
 
 
-@pytest.mark.asyncio
 async def test_router_using__none():
     router = respx.MockRouter(using=None)
     router.get("https://example.org/") % 204
@@ -588,7 +566,6 @@ def test(respx_mock):
         test()
 
 
-@pytest.mark.asyncio
 async def test_async_httpx_mocker():
     class TestTransport(httpx.AsyncBaseTransport):
         async def handle_async_request(self, *args, **kwargs):
@@ -629,7 +606,6 @@ async def content():
         await test()
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize("using", ["httpcore", "httpx"])
 async def test_async_side_effect(client, using):
     async def effect(request, slug):
@@ -646,7 +622,6 @@ async def effect(request, slug):
         assert mock_route.called
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize("using", ["httpcore", "httpx"])
 async def test_async_side_effect__exception(client, using):
     async def effect(request):
@@ -659,7 +634,6 @@ async def effect(request):
         assert mock_route.called
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize("using", ["httpcore", "httpx"])
 async def test_async_app_route(client, using):
     from starlette.applications import Starlette
@@ -705,7 +679,6 @@ def baz():
         assert response.json() == {"ham": "spam"}
 
 
-@pytest.mark.asyncio
 @pytest.mark.parametrize(
     "url,port",
     [
@@ -733,7 +706,6 @@ async def test_httpcore_request(url, port):
             assert body == b"foobar"
 
 
-@pytest.mark.asyncio
 async def test_route_rollback():
     respx_mock = respx.mock()
 
diff --git a/tests/test_router.py b/tests/test_router.py
index f7549c0..cb6ad01 100644
--- a/tests/test_router.py
+++ b/tests/test_router.py
@@ -9,7 +9,6 @@
 from respx.patterns import Host, M, Method
 
 
-@pytest.mark.asyncio
 async def test_empty_router():
     router = Router()
 
@@ -21,7 +20,6 @@ async def test_empty_router():
         await router.aresolve(request)
 
 
-@pytest.mark.asyncio
 async def test_empty_router__auto_mocked():
     router = Router(assert_all_mocked=False)
 
@@ -178,7 +176,6 @@ def test_mod_response():
         router.route() % []  # type: ignore[operator]
 
 
-@pytest.mark.asyncio
 async def test_async_side_effect():
     router = Router()
 
diff --git a/tests/test_stats.py b/tests/test_stats.py
index 68ef6d4..9cf8099 100644
--- a/tests/test_stats.py
+++ b/tests/test_stats.py
@@ -7,7 +7,6 @@
 from respx.router import MockRouter
 
 
-@pytest.mark.asyncio
 async def test_named_route():
     async with MockRouter(assert_all_called=False) as respx_mock:
         request = respx_mock.get("https://foo.bar/", name="foobar")
diff --git a/tests/test_transports.py b/tests/test_transports.py
index 5caf155..4be1223 100644
--- a/tests/test_transports.py
+++ b/tests/test_transports.py
@@ -27,7 +27,6 @@ def test_sync_transport_handler():
             client.post(url)
 
 
-@pytest.mark.asyncio
 async def test_async_transport_handler():
     url = "https://foo.bar/"
 
@@ -47,7 +46,6 @@ async def test_async_transport_handler():
             await client.post(url)
 
 
-@pytest.mark.asyncio
 async def test_transport_assertions():
     url = "https://foo.bar/"