diff --git a/paper/paper.md b/paper/paper.md index ca4903e..3f28bfd 100644 --- a/paper/paper.md +++ b/paper/paper.md @@ -114,6 +114,15 @@ For example, if a cluster of plasmids were identified in both _Escherichia coli_ As a result, any taxonomic signature from these plasmids is both specific enough to the target taxon and general enough to help avoid any misidentifications. +Finally, it is important to mention that the chromosomes of three significant pathogens are not included in the list of chromosomes, but their plasmids are listed: +_Shigella_, _Yersinia pestis_, and _Bacillus anthracis_. +These taxa have chromosome backbones with very high identity to +_Escherichia coli_, _Yersinia pseudotuberculosis_, and _Bacillus cereus_, respectively. +If these chromosomes were present in a metagenomics analysis, +then any matches against, e.g., _B. cereus_, would match against multiple species thereby giving less helpful genus-level results, e.g., _Bacillus_. +Instead with the current design of Kalamari, a user would receive results +for both _B. cereus_ and _B. anthracis_, giving a more informative signal. + ### taxonomy Kalamari uses the NCBI Taxonomy database as a baseline.