diff --git a/sqlx-core/src/sqlite/connection/worker.rs b/sqlx-core/src/sqlite/connection/worker.rs
index b737fbf386..9bf2d825d1 100644
--- a/sqlx-core/src/sqlite/connection/worker.rs
+++ b/sqlx-core/src/sqlite/connection/worker.rs
@@ -55,13 +55,13 @@ enum Command {
         tx: flume::Sender<Result<Either<SqliteQueryResult, SqliteRow>, Error>>,
     },
     Begin {
-        tx: oneshot::Sender<Result<(), Error>>,
+        tx: rendezvous_oneshot::Sender<Result<(), Error>>,
     },
     Commit {
-        tx: oneshot::Sender<Result<(), Error>>,
+        tx: rendezvous_oneshot::Sender<Result<(), Error>>,
     },
     Rollback {
-        tx: Option<oneshot::Sender<Result<(), Error>>>,
+        tx: Option<rendezvous_oneshot::Sender<Result<(), Error>>>,
     },
     CreateCollation {
         create_collation:
@@ -116,6 +116,11 @@ impl ConnectionWorker {
                     return;
                 }
 
+                // If COMMIT or ROLLBACK is processed but not acknowledged, there would be another
+                // ROLLBACK sent when the `Transaction` drops. We need to ignore it otherwise we
+                // would rollback an already completed transaction.
+                let mut ignore_next_start_rollback = false;
+
                 for cmd in command_rx {
                     match cmd {
                         Command::Prepare { query, tx } => {
@@ -162,8 +167,27 @@ impl ConnectionWorker {
                                     .map(|_| {
                                         conn.transaction_depth += 1;
                                     });
-
-                            tx.send(res).ok();
+                            let res_ok = res.is_ok();
+
+                            if tx.blocking_send(res).is_err() && res_ok {
+                                // The BEGIN was processed but not acknowledged. This means no
+                                // `Transaction` was created and so there is no way to commit /
+                                // rollback this transaction. We need to roll it back
+                                // immediately otherwise it would remain started forever.
+                                if let Err(e) = conn
+                                    .handle
+                                    .exec(rollback_ansi_transaction_sql(depth + 1))
+                                    .map(|_| {
+                                        conn.transaction_depth -= 1;
+                                    })
+                                {
+                                    // The rollback failed. To prevent leaving the connection
+                                    // in an inconsistent state we shutdown this worker which
+                                    // causes any subsequent operation on the connection to fail.
+                                    log::error!("failed to rollback cancelled transaction: {}", e);
+                                    break;
+                                }
+                            }
                         }
                         Command::Commit { tx } => {
                             let depth = conn.transaction_depth;
@@ -177,10 +201,21 @@ impl ConnectionWorker {
                             } else {
                                 Ok(())
                             };
+                            let res_ok = res.is_ok();
 
-                            tx.send(res).ok();
+                            if tx.blocking_send(res).is_err() && res_ok {
+                                // The COMMIT was processed but not acknowledged. This means that
+                                // the `Transaction` doesn't know it was committed and will try to
+                                // rollback on drop. We need to ignore that rollback.
+                                ignore_next_start_rollback = true;
+                            }
                         }
                         Command::Rollback { tx } => {
+                            if ignore_next_start_rollback && tx.is_none() {
+                                ignore_next_start_rollback = false;
+                                continue;
+                            }
+
                             let depth = conn.transaction_depth;
 
                             let res = if depth > 0 {
@@ -193,8 +228,16 @@ impl ConnectionWorker {
                                 Ok(())
                             };
 
+                            let res_ok = res.is_ok();
+
                             if let Some(tx) = tx {
-                                tx.send(res).ok();
+                                if tx.blocking_send(res).is_err() && res_ok {
+                                    // The ROLLBACK was processed but not acknowledged. This means
+                                    // that the `Transaction` doesn't know it was rolled back and
+                                    // will try to rollback again on drop. We need to ignore that
+                                    // rollback.
+                                    ignore_next_start_rollback = true;
+                                }
                             }
                         }
                         Command::CreateCollation { create_collation } => {
@@ -268,15 +311,17 @@ impl ConnectionWorker {
     }
 
     pub(crate) async fn begin(&mut self) -> Result<(), Error> {
-        self.oneshot_cmd(|tx| Command::Begin { tx }).await?
+        self.oneshot_cmd_with_ack(|tx| Command::Begin { tx })
+            .await?
     }
 
     pub(crate) async fn commit(&mut self) -> Result<(), Error> {
-        self.oneshot_cmd(|tx| Command::Commit { tx }).await?
+        self.oneshot_cmd_with_ack(|tx| Command::Commit { tx })
+            .await?
     }
 
     pub(crate) async fn rollback(&mut self) -> Result<(), Error> {
-        self.oneshot_cmd(|tx| Command::Rollback { tx: Some(tx) })
+        self.oneshot_cmd_with_ack(|tx| Command::Rollback { tx: Some(tx) })
             .await?
     }
 
@@ -304,6 +349,20 @@ impl ConnectionWorker {
         rx.await.map_err(|_| Error::WorkerCrashed)
     }
 
+    async fn oneshot_cmd_with_ack<F, T>(&mut self, command: F) -> Result<T, Error>
+    where
+        F: FnOnce(rendezvous_oneshot::Sender<T>) -> Command,
+    {
+        let (tx, rx) = rendezvous_oneshot::channel();
+
+        self.command_tx
+            .send_async(command(tx))
+            .await
+            .map_err(|_| Error::WorkerCrashed)?;
+
+        rx.recv().await.map_err(|_| Error::WorkerCrashed)
+    }
+
     pub fn create_collation(
         &mut self,
         name: &str,
@@ -387,3 +446,41 @@ fn prepare(conn: &mut ConnectionState, query: &str) -> Result<SqliteStatement<'s
 fn update_cached_statements_size(conn: &ConnectionState, size: &AtomicUsize) {
     size.store(conn.statements.len(), Ordering::Release);
 }
+
+// A oneshot channel where send completes only after the receiver receives the value.
+mod rendezvous_oneshot {
+    use super::oneshot::{self, Canceled};
+
+    pub fn channel<T>() -> (Sender<T>, Receiver<T>) {
+        let (inner_tx, inner_rx) = oneshot::channel();
+        (Sender { inner: inner_tx }, Receiver { inner: inner_rx })
+    }
+
+    pub struct Sender<T> {
+        inner: oneshot::Sender<(T, oneshot::Sender<()>)>,
+    }
+
+    impl<T> Sender<T> {
+        pub async fn send(self, value: T) -> Result<(), Canceled> {
+            let (ack_tx, ack_rx) = oneshot::channel();
+            self.inner.send((value, ack_tx)).map_err(|_| Canceled)?;
+            ack_rx.await
+        }
+
+        pub fn blocking_send(self, value: T) -> Result<(), Canceled> {
+            futures_executor::block_on(self.send(value))
+        }
+    }
+
+    pub struct Receiver<T> {
+        inner: oneshot::Receiver<(T, oneshot::Sender<()>)>,
+    }
+
+    impl<T> Receiver<T> {
+        pub async fn recv(self) -> Result<T, Canceled> {
+            let (value, ack_tx) = self.inner.await?;
+            ack_tx.send(()).map_err(|_| Canceled)?;
+            Ok(value)
+        }
+    }
+}