diff --git a/tests/Integration/Database/EloquentTransactionWithAfterCommitUsingRefreshDatabaseOnMultipleConnectionsTest.php b/tests/Integration/Database/EloquentTransactionWithAfterCommitUsingRefreshDatabaseOnMultipleConnectionsTest.php
index 18b57be0dca..07ee59434ff 100644
--- a/tests/Integration/Database/EloquentTransactionWithAfterCommitUsingRefreshDatabaseOnMultipleConnectionsTest.php
+++ b/tests/Integration/Database/EloquentTransactionWithAfterCommitUsingRefreshDatabaseOnMultipleConnectionsTest.php
@@ -9,6 +9,18 @@
 #[WithConfig('database.connections.second', ['driver' => 'sqlite', 'database' => ':memory:', 'foreign_key_constraints' => false])]
 class EloquentTransactionWithAfterCommitUsingRefreshDatabaseOnMultipleConnectionsTest extends EloquentTransactionWithAfterCommitUsingRefreshDatabaseTest
 {
+    /** {@inheritDoc} */
+    protected function setUp(): void
+    {
+        $this->afterApplicationCreated(function () {
+            $this->markTestSkippedWhen(
+                $this->usesSqliteInMemoryDatabaseConnection(), 'Skipped when default database is configured to use In-Memory SQLite Database'
+            );
+        });
+
+        parent::setUp();
+
+    }
     /** {@inheritDoc} */
     protected function connectionsToTransact()
     {