diff --git a/test/e2e/clusterclass_changes.go b/test/e2e/clusterclass_changes.go
index de02b673ce0a..206bfd834a21 100644
--- a/test/e2e/clusterclass_changes.go
+++ b/test/e2e/clusterclass_changes.go
@@ -177,6 +177,12 @@ func ClusterClassChangesSpec(ctx context.Context, inputGetter func() ClusterClas
 			WaitForMachineDeployments: input.E2EConfig.GetIntervals(specName, "wait-worker-nodes"),
 		})
 
+		By("Deleting a MachineDeploymentTopology in the Cluster Topology and wait for associated MachineDeployment to be deleted")
+		deleteMachineDeploymentTopologyAndWait(ctx, deleteMachineDeploymentTopologyAndWaitInput{
+			ClusterProxy:              input.BootstrapClusterProxy,
+			Cluster:                   clusterResources.Cluster,
+			WaitForMachineDeployments: input.E2EConfig.GetIntervals(specName, "wait-worker-nodes"),
+		})
 		By("PASSED!")
 	})
 
@@ -458,3 +464,42 @@ func rebaseClusterClassAndWait(ctx context.Context, input rebaseClusterClassAndW
 	Expect(afterControlPlane.GetGeneration()).To(Equal(beforeControlPlane.GetGeneration()),
 		"ControlPlane generation should not be incremented during the rebase because ControlPlane should not be affected.")
 }
+
+// deleteMachineDeploymentTopologyAndWaitInput is the input type for deleteMachineDeploymentTopologyAndWaitInput.
+type deleteMachineDeploymentTopologyAndWaitInput struct {
+	ClusterProxy              framework.ClusterProxy
+	Cluster                   *clusterv1.Cluster
+	WaitForMachineDeployments []interface{}
+}
+
+// deleteMachineDeploymentTopologyAndWait deletes a MachineDeploymentTopology from the Cluster and waits until the changes
+// are rolled out by ensuring the associated MachineDeployment is correctly deleted.
+func deleteMachineDeploymentTopologyAndWait(ctx context.Context, input deleteMachineDeploymentTopologyAndWaitInput) {
+	Expect(ctx).NotTo(BeNil(), "ctx is required for deleteMachineDeploymentTopologyAndWait")
+	Expect(input.ClusterProxy).ToNot(BeNil(), "Invalid argument. input.ClusterProxy can't be nil when calling deleteMachineDeploymentTopologyAndWait")
+	Expect(input.Cluster).ToNot(BeNil(), "Invalid argument. input.Cluster can't be nil when calling deleteMachineDeploymentTopologyAndWait")
+	Expect(len(input.Cluster.Spec.Topology.Workers.MachineDeployments)).To(BeNumerically(">", 0),
+		"Invalid Cluster. deleteMachineDeploymentTopologyAndWait requires at least one MachineDeploymentTopology to be defined in the Cluster topology")
+
+	log.Logf("Removing MachineDeploymentTopology from the Cluster Topology.")
+	patchHelper, err := patch.NewHelper(input.Cluster, input.ClusterProxy.GetClient())
+	Expect(err).ToNot(HaveOccurred())
+
+	// Remove the first MachineDeploymentTopology under input.Cluster.Spec.Topology.Workers.MachineDeployments
+	mdTopologyToDelete := input.Cluster.Spec.Topology.Workers.MachineDeployments[0]
+	input.Cluster.Spec.Topology.Workers.MachineDeployments = input.Cluster.Spec.Topology.Workers.MachineDeployments[1:]
+	Expect(patchHelper.Patch(ctx, input.Cluster)).To(Succeed())
+
+	log.Logf("Waiting for MachineDeployment to be deleted.")
+	Eventually(func() error {
+		// Get MachineDeployment for the current MachineDeploymentTopology.
+		mdList := &clusterv1.MachineDeploymentList{}
+		Expect(input.ClusterProxy.GetClient().List(ctx, mdList, client.InNamespace(input.Cluster.Namespace), client.MatchingLabels{
+			clusterv1.ClusterTopologyMachineDeploymentLabelName: mdTopologyToDelete.Name,
+		})).To(Succeed())
+		if len(mdList.Items) != 0 {
+			return errors.Errorf("expected no MachineDeployment for topology %q, but got %d", mdTopologyToDelete.Name, len(mdList.Items))
+		}
+		return nil
+	}, input.WaitForMachineDeployments...).Should(BeNil())
+}