diff --git a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Marshalling/MarshallingGenerator.cs b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Marshalling/MarshallingGenerator.cs
index e9d81561b75a3..c8f13da707c3f 100644
--- a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Marshalling/MarshallingGenerator.cs
+++ b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Marshalling/MarshallingGenerator.cs
@@ -237,6 +237,13 @@ private static IMarshallingGenerator CreateCore(
                     {
                         throw new MarshallingNotSupportedException(info, context);
                     }
+                    if (info.IsByRef && info.ManagedType.IsAbstract)
+                    {
+                        throw new MarshallingNotSupportedException(info, context)
+                        {
+                            NotSupportedDetails = Resources.SafeHandleByRefMustBeConcrete
+                        };
+                    }
                     return new SafeHandleMarshaller(options);
 
                 // Marshalling in new model.
diff --git a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.Designer.cs b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.Designer.cs
index e86940b256c65..87fac1a3e0ffa 100644
--- a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.Designer.cs
+++ b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.Designer.cs
@@ -483,6 +483,15 @@ internal static string RefValuePropertyUnsupportedMessage {
             }
         }
         
+        /// <summary>
+        ///   Looks up a localized string similar to An abstract type derived from &apos;SafeHandle&apos; cannot be marshalled by reference. The provided type must be concrete..
+        /// </summary>
+        internal static string SafeHandleByRefMustBeConcrete {
+            get {
+                return ResourceManager.GetString("SafeHandleByRefMustBeConcrete", resourceCulture);
+            }
+        }
+        
         /// <summary>
         ///   Looks up a localized string similar to When constructor taking a Span&lt;byte&gt; is specified on the native type, the type must also have a public integer constant named StackBufferSize to provide the size of the stack-allocated buffer..
         /// </summary>
diff --git a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.resx b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.resx
index c6a5491493395..f66d2945ad7a8 100644
--- a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.resx
+++ b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/Resources.resx
@@ -259,6 +259,9 @@
   <data name="RefValuePropertyUnsupportedMessage" xml:space="preserve">
     <value>The 'Value' property on the native type '{0}' must not be a 'ref' or 'readonly ref' property.</value>
   </data>
+  <data name="SafeHandleByRefMustBeConcrete" xml:space="preserve">
+    <value>An abstract type derived from 'SafeHandle' cannot be marshalled by reference. The provided type must be concrete.</value>
+  </data>
   <data name="StackallocConstructorMustHaveStackBufferSizeConstantDescription" xml:space="preserve">
     <value>When constructor taking a Span&lt;byte&gt; is specified on the native type, the type must also have a public integer constant named StackBufferSize to provide the size of the stack-allocated buffer.</value>
   </data>
diff --git a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/TypePositionInfo.cs b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/TypePositionInfo.cs
index 9cb216590cc03..0a5d4c921b22d 100644
--- a/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/TypePositionInfo.cs
+++ b/src/libraries/System.Runtime.InteropServices/gen/DllImportGenerator/TypePositionInfo.cs
@@ -312,11 +312,10 @@ static bool TryCreateTypeBasedMarshallingInfo(ITypeSymbol type, DefaultMarshalli
                 var conversion = compilation.ClassifyCommonConversion(type, compilation.GetTypeByMetadataName(TypeNames.System_Runtime_InteropServices_SafeHandle)!);
                 if (conversion.Exists 
                     && conversion.IsImplicit 
-                    && conversion.IsReference 
-                    && !type.IsAbstract)
+                    && (conversion.IsReference || conversion.IsIdentity))
                 {
                     bool hasAccessibleDefaultConstructor = false;
-                    if (type is INamedTypeSymbol named && named.InstanceConstructors.Length > 0)
+                    if (type is INamedTypeSymbol named && !named.IsAbstract && named.InstanceConstructors.Length > 0)
                     {
                         foreach (var ctor in named.InstanceConstructors)
                         {
diff --git a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CodeSnippets.cs b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CodeSnippets.cs
index 8d630f9c2b62f..eb4cc83858fee 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CodeSnippets.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CodeSnippets.cs
@@ -843,6 +843,15 @@ public static partial void Method(
         {byRefKind} {typeName} p);
 }}";
 
+        public static string BasicParameterByValue(string typeName) => @$"
+using System.Runtime.InteropServices;
+partial class Test
+{{
+    [GeneratedDllImport(""DoesNotExist"")]
+    public static partial void Method(
+        {typeName} p);
+}}";
+
         public static string BasicReturnType(string typeName) => @$"
 using System.Runtime.InteropServices;
 partial class Test
diff --git a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CompileFails.cs b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CompileFails.cs
index 61f98f45fff8d..89622d1cdf233 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CompileFails.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/CompileFails.cs
@@ -92,6 +92,9 @@ public static IEnumerable<object[]> CodeSnippetsToCompile()
 
             // Custom type marshalling in arrays (complex case with Value property)
             yield return new object[] { CodeSnippets.ArrayMarshallingWithCustomStructElementWithValueProperty, 5, 0 };
+
+            // Abstract SafeHandle type by reference
+            yield return new object[] { CodeSnippets.BasicParameterWithByRefModifier("ref", "System.Runtime.InteropServices.SafeHandle"), 1, 0 };
         }
 
         [Theory]
diff --git a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/Compiles.cs b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/Compiles.cs
index 60d61de1d0b58..c9da24ff41a48 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/Compiles.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/DllImportGenerator.UnitTests/Compiles.cs
@@ -135,6 +135,7 @@ public static IEnumerable<object[]> CodeSnippetsToCompile()
 
             // SafeHandle
             yield return new[] { CodeSnippets.BasicParametersAndModifiers("Microsoft.Win32.SafeHandles.SafeFileHandle") };
+            yield return new[] { CodeSnippets.BasicParameterByValue("System.Runtime.InteropServices.SafeHandle") };
             yield return new[] { CodeSnippets.SafeHandleWithCustomDefaultConstructorAccessibility(privateCtor: false) };
             yield return new[] { CodeSnippets.SafeHandleWithCustomDefaultConstructorAccessibility(privateCtor: true) };