diff --git a/.coveragerc b/.coveragerc
index 6f2257aba5a..cc035b23826 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -1,5 +1,4 @@
 [run]
 omit =
     */tests/*
-    */setup.py
     */gen/*
diff --git a/.flake8 b/.flake8
index 9c1f4b2d41e..cd5fe860b53 100644
--- a/.flake8
+++ b/.flake8
@@ -24,3 +24,4 @@ exclude =
   docs/examples/opentelemetry-example-app/build/*
   opentelemetry-proto/build/*
   opentelemetry-proto/src/opentelemetry/proto/
+  */build/lib/*
diff --git a/RELEASING.md b/RELEASING.md
index 5ba0fcb1b48..975fdf94409 100644
--- a/RELEASING.md
+++ b/RELEASING.md
@@ -83,10 +83,8 @@ A `hotfix` is defined as a small change developed to correct a bug that should b
 3. On your local machine, update `CHANGELOG.md` with the date of the hotfix change.
 4. With administrator privileges for PyPi, manually publish the affected packages.
     1. Install [twine](https://pypi.org/project/twine/) and [build](https://pypi.org/project/build/)
-    2. Navigate to where the `setup.py` or `pyproject.toml` file exists for the package you want to publish.
-    3. To build the package:
-       - If a `setup.py` file exists, run `python setup.py sdist bdist_wheel`. You may have to install [wheel](https://pypi.org/project/wheel/) as well.
-       - Otherwise, run `python -m build`.
+    2. Navigate to where the `pyproject.toml` file exists for the package you want to publish.
+    3. To build the package: run `python -m build`.
     4. Validate your built distributions by running `twine check dist/*`.
     5. Upload distributions to PyPi by running `twine upload dist/*`.
 5. Note that since hotfixes are manually published, the build scripts for publish after creating a release are not run.
diff --git a/eachdist.ini b/eachdist.ini
index 44b1d15eb8a..5d42f3c2988 100644
--- a/eachdist.ini
+++ b/eachdist.ini
@@ -41,17 +41,6 @@ packages=
     opentelemetry-test-utils
     tests
 
-[experimental]
-version=1.10a0
-
-packages=
-    opentelemetry-exporter-prometheus-remote-write
-    opentelemetry-api
-    opentelemetry-sdk
-    opentelemetry-exporter-otlp-proto-grpc
-    opentelemetry-exporter-otlp-proto-http
-    opentelemetry-exporter-otlp
-
 [lintroots]
 extraroots=examples/*,scripts/
 subglob=*.py,tests/,test/,src/*,examples/*
diff --git a/opentelemetry-api/src/opentelemetry/propagate/__init__.py b/opentelemetry-api/src/opentelemetry/propagate/__init__.py
index f197f1f9149..a39d8a44d1f 100644
--- a/opentelemetry-api/src/opentelemetry/propagate/__init__.py
+++ b/opentelemetry-api/src/opentelemetry/propagate/__init__.py
@@ -27,7 +27,7 @@
 ``opentelemetry.trace.propagation.tracecontext.TraceContextTextMapPropagator``
 and other of type ``opentelemetry.baggage.propagation.W3CBaggagePropagator``.
 Notice that these propagator classes are defined as
-``opentelemetry_propagator`` entry points in the ``setup.cfg`` file of
+``opentelemetry_propagator`` entry points in the ``pyproject.toml`` file of
 ``opentelemetry``.
 
 Example::
diff --git a/pyproject.toml b/pyproject.toml
index 15e2fed2e5c..a20a4056752 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -5,10 +5,12 @@ exclude = '''
   /(  # generated files
     .tox|
     venv|
+    .*/build/lib/.*|
     exporter/opentelemetry-exporter-jaeger-proto-grpc/src/opentelemetry/exporter/jaeger/proto/grpc/gen|
     exporter/opentelemetry-exporter-jaeger-thrift/src/opentelemetry/exporter/jaeger/thrift/gen|
     exporter/opentelemetry-exporter-zipkin-proto-http/src/opentelemetry/exporter/zipkin/proto/http/v2/gen|
-    opentelemetry-proto/src/opentelemetry/proto/.*/.*
+    opentelemetry-proto/src/opentelemetry/proto/.*/.*|
+    scripts
   )/
 )
 '''
diff --git a/scripts/build.sh b/scripts/build.sh
index 2ba7e4c0abb..ed875838607 100755
--- a/scripts/build.sh
+++ b/scripts/build.sh
@@ -21,11 +21,9 @@ DISTDIR=dist
      echo "building $d"
      cd "$d"
      # Some ext directories (such as docker tests) are not intended to be
-     # packaged. Verify the intent by looking for a setup.py.
-     if [ -f setup.py ]; then
-      python3 setup.py sdist --dist-dir "$BASEDIR/dist/" clean --all
-     else if [ -f pyproject.toml ]; then
-      HATCH_BUILD_CLEAN=1 python3 -m build --outdir "$BASEDIR/dist/"
+     # packaged. Verify the intent by looking for a pyproject.toml.
+     if [ -f pyproject.toml ]; then
+      python3 -m build --outdir "$BASEDIR/dist/"
      fi
    )
  done
diff --git a/scripts/coverage.sh b/scripts/coverage.sh
index 72b7adec74f..df43010ec6d 100755
--- a/scripts/coverage.sh
+++ b/scripts/coverage.sh
@@ -6,7 +6,6 @@ function cov {
     if [ ${TOX_ENV_NAME:0:4} == "py34" ]
     then
         pytest \
-            --ignore-glob=*/setup.py \
             --ignore-glob=instrumentation/opentelemetry-instrumentation-opentracing-shim/tests/testbed/* \
             --cov ${1} \
             --cov-append \
@@ -15,7 +14,6 @@ function cov {
             ${1}
     else
         pytest \
-            --ignore-glob=*/setup.py \
             --cov ${1} \
             --cov-append \
             --cov-branch \
diff --git a/scripts/eachdist.py b/scripts/eachdist.py
index cd2a3938f42..dc803af4cf1 100755
--- a/scripts/eachdist.py
+++ b/scripts/eachdist.py
@@ -81,7 +81,7 @@ def parse_args(args=None):
         commands according to `format` and `--all`.
 
         Target paths are initially all Python distribution root paths
-        (as determined by the existence of setup.py, etc. files).
+        (as determined by the existence of pyproject.toml, etc. files).
         They are then augmented according to the section of the
         `PROJECT_ROOT/eachdist.ini` config file specified by the `--mode` option.
 
@@ -518,18 +518,18 @@ def lint_args(args):
 
     runsubprocess(
         args.dry_run,
-        ("black", ".") + (("--diff", "--check") if args.check_only else ()),
+        ("black", "--config", "pyproject.toml", ".") + (("--diff", "--check") if args.check_only else ()),
         cwd=rootdir,
         check=True,
     )
     runsubprocess(
         args.dry_run,
-        ("isort", ".")
+        ("isort", "--settings-path", ".isort.cfg", ".")
         + (("--diff", "--check-only") if args.check_only else ()),
         cwd=rootdir,
         check=True,
     )
-    runsubprocess(args.dry_run, ("flake8", rootdir), check=True)
+    runsubprocess(args.dry_run, ("flake8", "--config", ".flake8", rootdir), check=True)
     execute_args(
         parse_subargs(
             args, ("exec", "pylint {}", "--all", "--mode", "lintroots")
@@ -629,7 +629,7 @@ def update_dependencies(targets, version, packages):
     for pkg in packages:
         update_files(
             targets,
-            "setup.cfg",
+            "pyproject.toml",
             rf"({basename(pkg)}.*)==(.*)",
             r"\1== " + version,
         )
@@ -694,19 +694,19 @@ def test_args(args):
 
 
 def format_args(args):
-    format_dir = str(find_projectroot())
+    root_dir = format_dir = str(find_projectroot())
     if args.path:
         format_dir = os.path.join(format_dir, args.path)
 
     runsubprocess(
         args.dry_run,
-        ("black", "."),
+        ("black", "--config", f"{root_dir}/pyproject.toml", "."),
         cwd=format_dir,
         check=True,
     )
     runsubprocess(
         args.dry_run,
-        ("isort", "--profile", "black", "."),
+        ("isort", "--settings-path", f"{root_dir}/.isort.cfg", "--profile", "black", "."),
         cwd=format_dir,
         check=True,
     )