diff --git a/docker-compose.yml b/docker-compose.yml
index b689645..cad902f 100644
--- a/docker-compose.yml
+++ b/docker-compose.yml
@@ -5,7 +5,7 @@ version: '3'
 services:
   ncbi-download:
     image: uta-update
-    command: sbin/ncbi-download /ncbi-dir
+    command: sbin/ncbi-download etc/ncbi-files.txt /ncbi-dir
     volumes:
       - .:/opt/repos/uta
       - ${UTA_ETL_NCBI_DIR}:/ncbi-dir
diff --git a/etc/ncbi-files.txt b/etc/ncbi-files.txt
new file mode 100644
index 0000000..6cb31ef
--- /dev/null
+++ b/etc/ncbi-files.txt
@@ -0,0 +1,57 @@
+# This configuration file contains the paths to the NCBI data files needed by the SeqRepo/UTA load pipelines.
+#
+#    ├── gene
+#    │   └── DATA
+#    │       ├── GENE_INFO
+#    │       │   └── Mammalia
+#    │       │       └── Homo_sapiens.gene_info.gz
+#    │       └── gene2accession.gz
+#    ├── genomes
+#    │   └── refseq
+#    │       └── vertebrate_mammalian
+#    │           └── Homo_sapiens
+#    │               └── all_assembly_versions
+#    │                   └── GCF_000001405.25_GRCh37.p13
+#    │                       ├── GCF_000001405.25_GRCh37.p13_genomic.fna.gz
+#    │                       └── GCF_000001405.25_GRCh37.p13_genomic.gff.gz
+#    └── refseq
+#        └── H_sapiens
+#            ├── historical
+#            │   └── GRCh38
+#            │       └── GCF_000001405.40-RS_2023_03_historical
+#            │           ├── GCF_000001405.40-RS_2023_03_knownrefseq_alns.gff.gz
+#            │           └── GCF_000001405.40-RS_2023_03_knownrefseq_rna.gbff.gz
+#            └── mRNA_Prot
+#                ├── human.1.protein.faa.gz
+#                ├── human.1.rna.fna.gz
+#                ├── human.1.rna.gbff.gz
+#                ├── ...
+
+## Gene Data
+gene/DATA/gene2refseq.gz
+gene/DATA/GENE_INFO/Mammalia/Homo_sapiens.gene_info.gz
+
+## RefSeq Data
+refseq/H_sapiens/mRNA_Prot/human.*.rna.gbff.gz
+refseq/H_sapiens/mRNA_Prot/human.*.rna.fna.gz
+refseq/H_sapiens/mRNA_Prot/human.*.protein.faa.gz
+
+## Historical RefSeq alignments
+refseq/H_sapiens/historical/GRCh38/GCF_000001405.40-RS_2023_03_historical/GCF_000001405.40-RS_2023_03_knownrefseq_alns.gff.gz
+refseq/H_sapiens/historical/GRCh38/GCF_000001405.40-RS_2023_03_historical/GCF_000001405.40-RS_2023_03_knownrefseq_rna.gbff.gz
+
+## Genome build and alignment data
+# Build 37
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.25_GRCh37.p13/GCF_000001405.25_GRCh37.p13_assembly_report.txt
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.25_GRCh37.p13/GCF_000001405.25_GRCh37.p13_genomic.fna.gz
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.25_GRCh37.p13/GCF_000001405.25_GRCh37.p13_genomic.gff.gz
+
+# Build 38
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.40_GRCh38.p14/GCF_000001405.40_GRCh38.p14_assembly_report.txt
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.40_GRCh38.p14/GCF_000001405.40_GRCh38.p14_genomic.fna.gz
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.40_GRCh38.p14/GCF_000001405.40_GRCh38.p14_genomic.gff.gz
+
+# T2Tv2.0
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_009914755.1_T2T-CHM13v2.0/GCF_009914755.1_T2T-CHM13v2.0_assembly_report.txt
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_009914755.1_T2T-CHM13v2.0/GCF_009914755.1_T2T-CHM13v2.0_genomic.fna.gz
+genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_009914755.1_T2T-CHM13v2.0/GCF_009914755.1_T2T-CHM13v2.0_genomic.gff.gz
diff --git a/sbin/ncbi-download b/sbin/ncbi-download
index dc445cd..09ad4c2 100755
--- a/sbin/ncbi-download
+++ b/sbin/ncbi-download
@@ -2,48 +2,22 @@
 
 # This script downloads the files needed for a UTA+SeqRepo update into to the given directory.
 #
-# DONWLOAD_DIR will have the following structure:
-#
-#    ├── gene
-#    │   └── DATA
-#    │       ├── GENE_INFO
-#    │       │   └── Mammalia
-#    │       │       └── Homo_sapiens.gene_info.gz
-#    │       └── gene2accession.gz
-#    ├── genomes
-#    │   └── refseq
-#    │       └── vertebrate_mammalian
-#    │           └── Homo_sapiens
-#    │               └── all_assembly_versions
-#    │                   └── GCF_000001405.25_GRCh37.p13
-#    │                       ├── GCF_000001405.25_GRCh37.p13_genomic.fna.gz
-#    │                       └── GCF_000001405.25_GRCh37.p13_genomic.gff.gz
-#    └── refseq
-#        └── H_sapiens
-#            └── mRNA_Prot
-#                ├── human.1.protein.faa.gz
-#                ├── human.1.rna.fna.gz
-#                └── human.1.rna.gbff.gz
+# DESTINATION_DIR will have a directory structure matching the source.
 
 set -e
 
-DOWNLOAD_DIR=$1
-DOWNLOAD_PATHS=(
-    'gene/DATA/GENE_INFO/Mammalia/Homo_sapiens.gene_info.gz'
-    'gene/DATA/gene2accession.gz'
-    'refseq/H_sapiens/mRNA_Prot/human.*.rna.gbff.gz'
-)
+FILE_PATH_CONFIG=$1
+DOWNLOAD_DIR=$2
 
-if [ -z "$DOWNLOAD_DIR" ]
+if [ -z "$FILE_PATH_CONFIG" ] || [ -z "$DOWNLOAD_DIR" ]
 then
-    echo 'Usage: sbin/ncbi-download <download_dir>'
+    echo 'Usage: sbin/ncbi-download <file path config> <download_dir> '
     exit 1
 else
     echo "Downloading files to $DOWNLOAD_DIR"
 fi
 
-for DOWNLOAD_PATH in "${DOWNLOAD_PATHS[@]}"
-do
+grep -v -e '^#' -e '^$' "$FILE_PATH_CONFIG" | while read -r DOWNLOAD_PATH; do
     # each top-level directory in NCBI is an rsync module.
     # bash parameter expansion removes all content after first slash.
     DOWNLOAD_MODULE="${DOWNLOAD_PATH%%/*}"