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SOPRANO

Selection On PRotein ANnotated regiOns

This can be accessed via the webserver: soprano-app

Main Tests Dev Tests Python 3.10|11

The SOPRANO method was developed to quantify selection in specific regions of the genome. It calculates ON- and OFF-target dN/dS using a set of annotated somatic point mutations and a transcript coordinates file.

This repository is a Python reimplementation of the original method with two main offerings:

  1. An application interface to easily pre-process the relevant input files.
  2. A scalable command line utility to run the SOPRANO pipeline for dN/dS, serving local and high-performance computing environments, distributed over MPI.

Quick links

  • Documentation is available on this site.

  • Issues should be raised here.

  • Reference the SOPRANO method with Zapata et al.

  • View the original repository here.