diff --git a/Core/HLE/sceKernel.cpp b/Core/HLE/sceKernel.cpp
index ec58221d7290..189337c0c1e7 100644
--- a/Core/HLE/sceKernel.cpp
+++ b/Core/HLE/sceKernel.cpp
@@ -107,6 +107,7 @@ void __KernelInit()
 		ERROR_LOG(SCEKERNEL, "Can't init kernel when kernel is running");
 		return;
 	}
+	INFO_LOG(SCEKERNEL, "Initializing kernel...");
 
 	__KernelTimeInit();
 	__InterruptsInit();
diff --git a/Core/HLE/sceKernelModule.cpp b/Core/HLE/sceKernelModule.cpp
index 0173045ce27c..486bd06bd058 100644
--- a/Core/HLE/sceKernelModule.cpp
+++ b/Core/HLE/sceKernelModule.cpp
@@ -1654,7 +1654,7 @@ void __KernelLoadReset() {
 bool __KernelLoadExec(const char *filename, u32 paramPtr, std::string *error_string) {
 	SceKernelLoadExecParam param;
 
-	PSP_SetLoading("Loading game...");
+	PSP_SetLoading("Loading exec...");
 
 	if (paramPtr)
 		Memory::ReadStruct(paramPtr, &param);
diff --git a/Core/System.cpp b/Core/System.cpp
index 29fc5e0a30b3..6f9b58ad7b5a 100644
--- a/Core/System.cpp
+++ b/Core/System.cpp
@@ -108,9 +108,9 @@ static GPUBackend gpuBackend;
 static std::string gpuBackendDevice;
 
 // Ugly!
-static bool pspIsInited = false;
-static bool pspIsIniting = false;
-static bool pspIsQuitting = false;
+static volatile bool pspIsInited = false;
+static volatile bool pspIsIniting = false;
+static volatile bool pspIsQuitting = false;
 
 void ResetUIState() {
 	globalUIState = UISTATE_MENU;
diff --git a/GPU/GLES/DrawEngineGLES.cpp b/GPU/GLES/DrawEngineGLES.cpp
index 215d80c07a2a..b07e819d4318 100644
--- a/GPU/GLES/DrawEngineGLES.cpp
+++ b/GPU/GLES/DrawEngineGLES.cpp
@@ -314,6 +314,7 @@ void DrawEngineGLES::DoFlush() {
 	if (lastRenderStepId_ != curRenderStepId) {
 		// Dirty everything that has dynamic state that will need re-recording.
 		gstate_c.Dirty(DIRTY_VIEWPORTSCISSOR_STATE | DIRTY_DEPTHSTENCIL_STATE | DIRTY_BLEND_STATE | DIRTY_RASTER_STATE);
+		textureCache_->ForgetLastTexture();
 		lastRenderStepId_ = curRenderStepId;
 	}
 
diff --git a/UI/EmuScreen.cpp b/UI/EmuScreen.cpp
index a6d5b600e104..b3557c076b94 100644
--- a/UI/EmuScreen.cpp
+++ b/UI/EmuScreen.cpp
@@ -1090,7 +1090,6 @@ void EmuScreen::CreateViews() {
 	loadingSpinner->SetTag("LoadingSpinner");
 
 	// Don't really need this, and it creates a lot of strings to translate...
-	// Maybe just show "Loading game..." only?
 	loadingTextView->SetVisibility(V_GONE);
 	loadingTextView->SetShadow(true);
 
diff --git a/Windows/GPU/WindowsGLContext.cpp b/Windows/GPU/WindowsGLContext.cpp
index dc9037a7836d..01933b27018a 100644
--- a/Windows/GPU/WindowsGLContext.cpp
+++ b/Windows/GPU/WindowsGLContext.cpp
@@ -131,8 +131,13 @@ void FormatDebugOutputARB(char outStr[], size_t outStrSize, GLenum source, GLenu
 void DebugCallbackARB(GLenum source, GLenum type, GLuint id, GLenum severity,
 											GLsizei length, const GLchar *message, GLvoid *userParam) {
 	// Ignore buffer mapping messages from NVIDIA
-	if (source == GL_DEBUG_SOURCE_API_ARB && type == GL_DEBUG_TYPE_OTHER_ARB && id == 131185)
+	if (source == GL_DEBUG_SOURCE_API_ARB && type == GL_DEBUG_TYPE_OTHER_ARB && id == 131185) {
 		return;
+	}
+	// Ignore application messages
+	if (source == GL_DEBUG_SOURCE_APPLICATION) {
+		return;
+	}
 
 	(void)length;
 	FILE *outFile = (FILE *)userParam;
@@ -366,7 +371,14 @@ bool WindowsGLContext::InitFromRenderThread(std::string *error_message) {
 
 	hRC = m_hrc;
 
-	if (g_Config.bGfxDebugOutput) {
+	bool validation = g_Config.bGfxDebugOutput;
+
+	// Always run OpenGL validation in debug mode, just like we do with Vulkan if debug layers are installed.
+#ifdef _DEBUG
+	validation = true;
+#endif
+
+	if (validation) {
 		if (wglewIsSupported("GL_KHR_debug") == 1) {
 			glGetError();
 			glDebugMessageCallback((GLDEBUGPROC)&DebugCallbackARB, nullptr);
diff --git a/ext/native/thin3d/GLQueueRunner.h b/ext/native/thin3d/GLQueueRunner.h
index 2c0d49fbe807..031c17b06f6e 100644
--- a/ext/native/thin3d/GLQueueRunner.h
+++ b/ext/native/thin3d/GLQueueRunner.h
@@ -416,6 +416,7 @@ class GLQueueRunner {
 	GLuint currentReadHandle_ = 0;
 
 	GLuint AllocTextureName();
+
 	// Texture name cache. Ripped straight from TextureCacheGLES.
 	std::vector<GLuint> nameCache_;
 	std::unordered_map<int, std::string> glStrings_;
diff --git a/ext/native/thin3d/thin3d_gl.cpp b/ext/native/thin3d/thin3d_gl.cpp
index c42b186b54a7..3a7c0f958c56 100644
--- a/ext/native/thin3d/thin3d_gl.cpp
+++ b/ext/native/thin3d/thin3d_gl.cpp
@@ -483,14 +483,16 @@ class OpenGLContext : public DrawContext {
 
 private:
 	void ApplySamplers();
+	void Unbind();
 
 	GLRenderManager renderManager_;
 
-	OpenGLSamplerState *boundSamplers_[MAX_TEXTURE_SLOTS]{};
-	OpenGLTexture *boundTextures_[MAX_TEXTURE_SLOTS]{};
 	DeviceCaps caps_{};
 
 	// Bound state
+	OpenGLSamplerState *boundSamplers_[MAX_TEXTURE_SLOTS]{};
+	OpenGLTexture *boundTextures_[MAX_TEXTURE_SLOTS]{};
+
 	OpenGLPipeline *curPipeline_ = nullptr;
 	OpenGLBuffer *curVBuffers_[4]{};
 	int curVBufferOffsets_[4]{};
@@ -610,10 +612,14 @@ void OpenGLContext::BeginFrame() {
 }
 
 void OpenGLContext::EndFrame() {
+	Unbind();
+
 	FrameData &frameData = frameData_[renderManager_.GetCurFrame()];
 	renderManager_.EndPushBuffer(frameData.push);  // upload the data!
 	renderManager_.Finish();
+}
 
+void OpenGLContext::Unbind() {
 	// Unbind stuff.
 	for (auto &texture : boundTextures_) {
 		texture = nullptr;
@@ -621,6 +627,9 @@ void OpenGLContext::EndFrame() {
 	for (auto &sampler : boundSamplers_) {
 		sampler = nullptr;
 	}
+	for (int i = 0; i < ARRAY_SIZE(boundTextures_); i++) {
+		renderManager_.BindTexture(i, nullptr);
+	}
 	curPipeline_ = nullptr;
 }
 
@@ -663,6 +672,9 @@ class OpenGLTexture : public Texture {
 	void Bind(int stage) {
 		render_->BindTexture(stage, tex_);
 	}
+	int NumMipmaps() const {
+		return mipLevels_;
+	}
 
 private:
 	void SetImageData(int x, int y, int z, int width, int height, int depth, int level, int stride, const uint8_t *data, TextureCallback callback);
@@ -679,7 +691,6 @@ class OpenGLTexture : public Texture {
 
 OpenGLTexture::OpenGLTexture(GLRenderManager *render, const TextureDesc &desc) : render_(render) {
 	generatedMips_ = false;
-	canWrap_ = true;
 	width_ = desc.width;
 	height_ = desc.height;
 	depth_ = desc.depth;
@@ -1022,7 +1033,9 @@ void OpenGLContext::ApplySamplers() {
 	for (int i = 0; i < MAX_TEXTURE_SLOTS; i++) {
 		const OpenGLSamplerState *samp = boundSamplers_[i];
 		const OpenGLTexture *tex = boundTextures_[i];
-		if (!samp || !tex) {
+		if (tex) {
+			_assert_(samp);
+		} else {
 			continue;
 		}
 		GLenum wrapS;
@@ -1037,6 +1050,7 @@ void OpenGLContext::ApplySamplers() {
 		GLenum magFilt = samp->magFilt;
 		GLenum minFilt = tex->HasMips() ? samp->mipMinFilt : samp->minFilt;
 		renderManager_.SetTextureSampler(i, wrapS, wrapT, magFilt, minFilt, 0.0f);
+		renderManager_.SetTextureLod(i, 0.0, (float)(tex->NumMipmaps() - 1), 0.0);
 	}
 }
 
@@ -1098,6 +1112,9 @@ void OpenGLContext::BindPipeline(Pipeline *pipeline) {
 		curPipeline_->depthStencil->Apply(&renderManager_, stencilRef_);
 		curPipeline_->raster->Apply(&renderManager_);
 		renderManager_.BindProgram(curPipeline_->program_);
+	} else {
+		// Wipe bound textures and samplers.
+		Unbind();
 	}
 }