diff --git a/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java b/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
index 6ee601bf8e874d..4cecf9feab2e9e 100644
--- a/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
+++ b/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
@@ -7,10 +7,13 @@
 import static org.jboss.jandex.Type.Kind.PRIMITIVE;
 import static org.jboss.resteasy.reactive.client.impl.RestClientRequestContext.DEFAULT_CONTENT_TYPE_PROP;
 import static org.jboss.resteasy.reactive.common.processor.EndpointIndexer.extractProducesConsumesValues;
+import static org.jboss.resteasy.reactive.common.processor.JandexUtil.*;
+import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.COLLECTION;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.COMPLETION_STAGE;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.CONSUMES;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.ENCODED;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.FORM_PARAM;
+import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.MAP;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.MULTI;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.OBJECT;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.PART_TYPE_NAME;
@@ -2744,28 +2747,11 @@ private void addQueryParamToWebTarget(BytecodeCreator creator, ResultHandle para
     }
 
     private boolean isCollection(Type type, IndexView index) {
-        if (type.kind() == Type.Kind.PRIMITIVE) {
-            return false;
-        }
-        ClassInfo classInfo = index.getClassByName(type.name());
-        if (classInfo == null) {
-            return false;
-        }
-        return classInfo.interfaceNames().stream().anyMatch(DotName.createSimple(Collection.class.getName())::equals);
+        return isAssignableFrom(COLLECTION, type.name(), index);
     }
 
     private boolean isMap(Type type, IndexView index) {
-        if (type.kind() == Type.Kind.PRIMITIVE) {
-            return false;
-        }
-        ClassInfo classInfo = index.getClassByName(type.name());
-        if (classInfo == null) {
-            return false;
-        }
-        if (ResteasyReactiveDotNames.MAP.equals(classInfo.name())) {
-            return true;
-        }
-        return classInfo.interfaceNames().stream().anyMatch(DotName.createSimple(Map.class.getName())::equals);
+        return isAssignableFrom(MAP, type.name(), index);
     }
 
     private void addHeaderParam(BytecodeCreator invoBuilderEnricher, AssignableResultHandle invocationBuilder,
diff --git a/extensions/resteasy-reactive/quarkus-resteasy-reactive-links/deployment/src/main/java/io/quarkus/resteasy/reactive/links/deployment/LinksContainerFactory.java b/extensions/resteasy-reactive/quarkus-resteasy-reactive-links/deployment/src/main/java/io/quarkus/resteasy/reactive/links/deployment/LinksContainerFactory.java
index 9c4ddafd41688e..2a991448e49dff 100644
--- a/extensions/resteasy-reactive/quarkus-resteasy-reactive-links/deployment/src/main/java/io/quarkus/resteasy/reactive/links/deployment/LinksContainerFactory.java
+++ b/extensions/resteasy-reactive/quarkus-resteasy-reactive-links/deployment/src/main/java/io/quarkus/resteasy/reactive/links/deployment/LinksContainerFactory.java
@@ -1,5 +1,7 @@
 package io.quarkus.resteasy.reactive.links.deployment;
 
+import static org.jboss.resteasy.reactive.common.processor.JandexUtil.isAssignableFrom;
+import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.COLLECTION;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.COMPLETABLE_FUTURE;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.COMPLETION_STAGE;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.MULTI;
@@ -17,8 +19,6 @@
 
 import org.jboss.jandex.AnnotationInstance;
 import org.jboss.jandex.AnnotationValue;
-import org.jboss.jandex.ClassInfo;
-import org.jboss.jandex.DotName;
 import org.jboss.jandex.IndexView;
 import org.jboss.jandex.MethodInfo;
 import org.jboss.jandex.ParameterizedType;
@@ -138,14 +138,7 @@ private String getAnnotationValue(AnnotationInstance annotationInstance, String
     }
 
     private boolean isCollection(Type type, IndexView index) {
-        if (type.kind() == Type.Kind.PRIMITIVE) {
-            return false;
-        }
-        ClassInfo classInfo = index.getClassByName(type.name());
-        if (classInfo == null) {
-            return false;
-        }
-        return classInfo.interfaceNames().stream().anyMatch(DotName.createSimple(Collection.class.getName())::equals);
+        return isAssignableFrom(COLLECTION, type.name(), index);
     }
 
     private Type getNonAsyncReturnType(Type returnType) {
diff --git a/independent-projects/resteasy-reactive/common/processor/src/main/java/org/jboss/resteasy/reactive/common/processor/JandexUtil.java b/independent-projects/resteasy-reactive/common/processor/src/main/java/org/jboss/resteasy/reactive/common/processor/JandexUtil.java
index 8eb2a5d725bf9a..2c8f8c37833b3e 100644
--- a/independent-projects/resteasy-reactive/common/processor/src/main/java/org/jboss/resteasy/reactive/common/processor/JandexUtil.java
+++ b/independent-projects/resteasy-reactive/common/processor/src/main/java/org/jboss/resteasy/reactive/common/processor/JandexUtil.java
@@ -5,8 +5,10 @@
 import java.lang.reflect.Modifier;
 import java.nio.file.Files;
 import java.nio.file.Path;
+import java.util.ArrayDeque;
 import java.util.ArrayList;
 import java.util.Collections;
+import java.util.Deque;
 import java.util.HashMap;
 import java.util.HashSet;
 import java.util.List;
@@ -415,4 +417,42 @@ public static boolean isImplementorOf(IndexView index, ClassInfo info, DotName n
         return isImplementorOf(index, superClass, name, additionalIgnoredSuperClasses);
     }
 
+    public static boolean isAssignableFrom(DotName superType, DotName subType, IndexView index) {
+        // java.lang.Object is assignable from any type
+        if (superType.equals(DOTNAME_OBJECT)) {
+            return true;
+        }
+        // type1 is the same as type2
+        if (superType.equals(subType)) {
+            return true;
+        }
+        // type1 is a superclass
+        return findSupertypes(subType, index).contains(superType);
+    }
+
+    private static Set<DotName> findSupertypes(DotName name, IndexView index) {
+        Set<DotName> result = new HashSet<>();
+
+        Deque<DotName> workQueue = new ArrayDeque<>();
+        workQueue.add(name);
+        while (!workQueue.isEmpty()) {
+            DotName type = workQueue.poll();
+            if (result.contains(type)) {
+                continue;
+            }
+            result.add(type);
+
+            ClassInfo clazz = index.getClassByName(type);
+            if (clazz == null) {
+                continue;
+            }
+            if (clazz.superName() != null) {
+                workQueue.add(clazz.superName());
+            }
+            workQueue.addAll(clazz.interfaceNames());
+        }
+
+        return result;
+    }
+
 }