diff --git a/src/components/data-exploration/differential-expression-tool/LaunchPathwayAnalysisModal.jsx b/src/components/data-exploration/differential-expression-tool/LaunchPathwayAnalysisModal.jsx
index fe3de26b89..6077aa688f 100644
--- a/src/components/data-exploration/differential-expression-tool/LaunchPathwayAnalysisModal.jsx
+++ b/src/components/data-exploration/differential-expression-tool/LaunchPathwayAnalysisModal.jsx
@@ -226,15 +226,6 @@ const LaunchPathwayAnalysisModal = (props) => {
                 {' '}
                 will be submitted. No other information about you or your project will be sent.
               </Paragraph>
-              {externalService === pathwayServices.PANTHERDB && (
-                <Paragraph
-                  style={{
-                    margin: '1rem 0 0 0',
-                  }}
-                >
-                  PantherDB is hosted in an unsecured server (HTTP). You will see a warning when you launch the service. Click “Send anyway” to continue.
-                </Paragraph>
-              )}
             </>
           )}
         />
diff --git a/src/utils/pathwayAnalysis/pathwayConstants.js b/src/utils/pathwayAnalysis/pathwayConstants.js
index eb4db8c4c1..292b98642e 100644
--- a/src/utils/pathwayAnalysis/pathwayConstants.js
+++ b/src/utils/pathwayAnalysis/pathwayConstants.js
@@ -5,7 +5,7 @@ import {
 const pathwayServices = { PANTHERDB: 'pantherdb', ENRICHR: 'enrichr' };
 
 const serviceUrls = {
-  [pathwayServices.PANTHERDB]: 'http://pantherdb.org/webservices/go/overrep.jsp',
+  [pathwayServices.PANTHERDB]: 'https://pantherdb.org/webservices/go/overrep.jsp',
   [pathwayServices.ENRICHR]: {
     [H_SAPIENS.value]: 'https://maayanlab.cloud/Enrichr/enrich',
     [M_MUSCULUS.value]: 'https://maayanlab.cloud/Enrichr/enrich',