diff --git a/src/__test__/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.test.jsx b/src/__test__/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.test.jsx
index cfd0833e78..6d80c887b2 100644
--- a/src/__test__/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.test.jsx
+++ b/src/__test__/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.test.jsx
@@ -1,4 +1,6 @@
 import { render, screen } from '@testing-library/react';
+import { mount } from 'enzyme';
+import { within } from '@testing-library/dom';
 import userEvent from '@testing-library/user-event';
 import fetchMock, { enableFetchMocks } from 'jest-fetch-mock';
 import _ from 'lodash';
@@ -14,6 +16,8 @@ import expressionDataFAKEGENE from '__test__/data/gene_expression_FAKEGENE.json'
 import markerGenesData2 from '__test__/data/marker_genes_2.json';
 import markerGenesData5 from '__test__/data/marker_genes_5.json';
 
+import { Tree } from 'antd';
+
 import preloadAll from 'jest-next-dynamic';
 
 import fake from '__test__/test-utils/constants';
@@ -23,6 +27,8 @@ import mockAPI, {
   statusResponse,
 } from '__test__/test-utils/mockAPI';
 import createTestComponentFactory from '__test__/test-utils/testComponentFactory';
+import waitForComponentToPaint from '__test__/test-utils/waitForComponentToPaint';
+import { arrayMoveImmutable } from 'utils/array-move';
 
 jest.mock('components/header/UserButton', () => () => <></>);
 jest.mock('react-resize-detector', () => (props) => {
@@ -81,6 +87,23 @@ const getDisplayedGenes = (container) => {
   return Array.from(genesNodeList).map((gene) => gene.textContent);
 };
 
+// Helper function to get genes held within the tree
+const getTreeGenes = (container) => {
+  const treeNodeList = container.querySelectorAll('span[class*=ant-tree-title]');
+  return Array.from(treeNodeList).map((node) => node.firstChild.firstChild.textContent);
+};
+
+// Helper function to get current order of displayed genes in enzyme tests
+const getCurrentGeneOrder = (component) => {
+  const treeNodes = component.find('div.ant-tree-treenode');
+  const newOrder = []
+  treeNodes.forEach((node) => {
+    newOrder.push(node.text());
+  });
+  newOrder.splice(0, 1);
+  return newOrder;
+}
+
 const renderHeatmapPage = async (store) => {
   await act(async () => (
     render(
@@ -91,6 +114,14 @@ const renderHeatmapPage = async (store) => {
   ));
 };
 
+const renderHeatmapPageForEnzyme = async (store) => (
+  mount(
+    <Provider store={store}>
+      {heatmapPageFactory()}
+    </Provider>,
+  )
+);
+
 describe('Marker heatmap plot', () => {
   beforeAll(async () => {
     await preloadAll();
@@ -275,4 +306,143 @@ describe('Marker heatmap plot', () => {
     // The list of displayed genes should be in the same order as the displayed genes
     expect(_.isEqual(genesListAfterRemoval, genesListBeforeRemoval)).toEqual(true);
   });
+
+  it('loads the tabs under gene selection', async () => {
+    await renderHeatmapPage(storeState);
+
+    expect(screen.getByText(/Add\/Remove genes/i)).toBeInTheDocument();
+    expect(screen.getByText(/Re-order genes/i)).toBeInTheDocument();
+  });
+
+  it('switches tabs and removes genes within the tree', async () => {
+    await renderHeatmapPage(storeState);
+
+    await act(async () => {
+      userEvent.click(screen.getByText('Re-order genes'));
+    });
+    // note: clicking another tab doesn't remove previous tab from screen
+    // screen.getByText will find multiples of the same gene -> use within(geneTree)
+
+    const geneTree = screen.getByRole('tree');
+
+    // The genes in Data 5 should be in the tree
+    markerGenesData5.order.forEach((geneName) => {
+      expect(within(geneTree).getByText(geneName)).toBeInTheDocument();
+    });
+
+    // Remove a gene using the X button
+    const genesListBeforeRemoval = getTreeGenes(geneTree);
+
+    const geneToRemove = within(geneTree).getByText(genesListBeforeRemoval[1]);
+
+    const geneRemoveButton = geneToRemove.nextSibling.firstChild;
+
+    userEvent.click(geneRemoveButton);
+
+    const genesListAfterRemoval = getTreeGenes(geneTree);
+
+    // remove element from list manually to compare
+    genesListBeforeRemoval.splice(1, 1);
+
+    // The gene should be deleted from the list
+    expect(_.isEqual(genesListAfterRemoval, genesListBeforeRemoval)).toEqual(true);
+  });
+
+  describe('Drag and drop enzyme tests', () => {
+    let component;
+    let tree;
+
+    beforeEach(async () => {
+      component = await renderHeatmapPageForEnzyme(storeState);
+
+      await waitForComponentToPaint(component);
+
+      await act(async () => {
+        // needs to find specifically the tab button to click
+        const reorderTab = component.find('div.ant-tabs-tab-btn');
+        reorderTab.at(1).simulate('click');
+      });
+
+      component.update();
+
+      // this finds 5 elements, use the first one
+      tree = component.find({ 'data-testid': 'HierachicalTreeGenes' });
+    });
+
+    it('changes nothing on drop in place', async () => {
+      // default genes are in the tree
+      markerGenesData5.order.forEach((geneName) => {
+        expect(tree.at(0).containsMatchingElement(geneName));
+      });
+
+      // dropping in place does nothing
+      const info = {
+        dragNode: { key: 1, pos: '0-1' },
+        node: { key: 1, pos: '0-1' },
+        dropPosition: 1,
+        dropToGap: true,
+      };
+
+      tree.at(0).getElement().props.onDrop(info);
+
+      await act(async () => {
+        component.update();
+      });
+
+      const newOrder = getCurrentGeneOrder(component);
+
+      expect(_.isEqual(newOrder, markerGenesData5.order)).toEqual(true);
+    });
+
+    it('changes nothing when not dropped in gap', async () => {
+      // default genes are in the tree
+      markerGenesData5.order.forEach((geneName) => {
+        expect(tree.at(0).containsMatchingElement(geneName));
+      });
+
+      // not dropping to gap does nothing
+      const info = {
+        dragNode: { key: 1, pos: '0-1' },
+        node: { key: 3, pos: '0-3' },
+        dropPosition: 4,
+        dropToGap: false,
+      };
+
+      tree.at(0).getElement().props.onDrop(info);
+
+      await act(async () => {
+        component.update();
+      });
+
+      const newOrder = getCurrentGeneOrder(component);
+
+      expect(_.isEqual(newOrder, markerGenesData5.order)).toEqual(true);
+    });
+
+    it('re-orders genes correctly', async () => {
+      // default genes are in the tree
+      markerGenesData5.order.forEach((geneName) => {
+        expect(tree.at(0).containsMatchingElement(geneName));
+      });
+      // dropping to gap re-orders genes
+      const info = {
+        dragNode: { key: 1, pos: '0-1' },
+        node: { key: 3, pos: '0-3' },
+        dropPosition: 4,
+        dropToGap: true,
+      };
+
+      tree.at(0).getElement().props.onDrop(info);
+
+      await act(async () => {
+        component.update();
+      });
+
+      const newOrder = getCurrentGeneOrder(component);
+
+      const expectedOrder = arrayMoveImmutable(markerGenesData5.order, 1, 3);
+
+      expect(_.isEqual(newOrder, expectedOrder)).toEqual(true);
+    });
+  });
 });
diff --git a/src/components/plots/GeneReorderTool.jsx b/src/components/plots/GeneReorderTool.jsx
new file mode 100644
index 0000000000..c95023b65d
--- /dev/null
+++ b/src/components/plots/GeneReorderTool.jsx
@@ -0,0 +1,106 @@
+import React, { useEffect, useState } from 'react';
+import { useDispatch, useSelector } from 'react-redux';
+import PropTypes from 'prop-types';
+
+import { arrayMoveImmutable } from 'utils/array-move';
+import { updatePlotConfig } from 'redux/actions/componentConfig';
+import { loadGeneExpression } from 'redux/actions/genes';
+import HierarchicalTreeGenes from 'components/plots/hierarchical-tree-genes/HierarchicalTreeGenes';
+
+import { Space, Button } from 'antd';
+import { CloseOutlined } from '@ant-design/icons';
+
+const GeneReorderTool = (props) => {
+  const { plotUuid } = (props);
+
+  const dispatch = useDispatch();
+
+  const config = useSelector((state) => state.componentConfig[plotUuid]?.config);
+
+  const experimentId = useSelector((state) => state.componentConfig[plotUuid]?.experimentId);
+
+  const loadedMarkerGenes = useSelector(
+    (state) => state.genes.expression.views[plotUuid]?.data,
+  );
+
+  // Tree from antd requires format [{key: , title: }], made from gene names from loadedMarkerGenes and config
+  const composeGeneTree = (treeGenes) => {
+    if (!treeGenes) {
+      return [];
+    }
+
+    const data = [];
+    Object.entries(treeGenes).forEach(([key, value]) => {
+      data.push({ key: `${key}`, title: `${value}` });
+    });
+    return data;
+  };
+
+  const [geneTreeData, setGeneTreeData] = useState(composeGeneTree(loadedMarkerGenes));
+
+  useEffect(() => {
+    setGeneTreeData(composeGeneTree(config?.selectedGenes));
+  }, [config?.selectedGenes]);
+
+  // geneKey is equivalent to it's index, moves a gene from pos geneKey to newPosition
+  // dispatches an action to update selectedGenes in config
+  const onGeneReorder = (geneKey, newPosition) => {
+    const oldOrder = geneTreeData.map((treeNode) => treeNode.title);
+
+    const newOrder = arrayMoveImmutable(Object.values(oldOrder), geneKey, newPosition);
+
+    dispatch(updatePlotConfig(plotUuid, { selectedGenes: newOrder }));
+  };
+
+  const onNodeDelete = (geneKey) => {
+    const genes = geneTreeData.map((treeNode) => treeNode.title);
+    genes.splice(geneKey, 1);
+
+    dispatch(loadGeneExpression(experimentId, genes, plotUuid));
+  };
+
+  const renderTitles = (data) => {
+    // replace every title (gene name) in tree data with a modified title (name + button)
+    const toRender = data.map((treeNode) => {
+      // modified needs to be a copy of a given node
+      const modified = { ...treeNode };
+      modified.title = (
+        <Space>
+          {treeNode.title}
+          <Button
+            type='text'
+            onClick={() => {
+              onNodeDelete(treeNode.key);
+            }}
+          >
+            <CloseOutlined />
+          </Button>
+        </Space>
+      );
+      return modified;
+    });
+    return toRender;
+  };
+
+  const [renderedTreeData, setRenderedTreeData] = useState([]);
+
+  useEffect(() => {
+    setRenderedTreeData(renderTitles(geneTreeData));
+  }, [geneTreeData]);
+
+  return (
+    <HierarchicalTreeGenes
+      treeData={renderedTreeData}
+      onGeneReorder={onGeneReorder}
+      onNodeDelete={onNodeDelete}
+    />
+  );
+};
+
+GeneReorderTool.defaultProps = {};
+
+GeneReorderTool.propTypes = {
+  plotUuid: PropTypes.string.isRequired,
+};
+
+export default GeneReorderTool;
diff --git a/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.css b/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.css
new file mode 100644
index 0000000000..c2a17c31c3
--- /dev/null
+++ b/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.css
@@ -0,0 +1,3 @@
+.ant-tree-list-holder-inner {
+    background-color: #f5f8fa;
+  }
\ No newline at end of file
diff --git a/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.jsx b/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.jsx
new file mode 100644
index 0000000000..687876c0e4
--- /dev/null
+++ b/src/components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.jsx
@@ -0,0 +1,51 @@
+import React from 'react';
+import PropTypes from 'prop-types';
+import { Tree, Skeleton } from 'antd';
+
+import 'components/plots/hierarchical-tree-genes/HierarchicalTreeGenes.css';
+import { ConsoleLogger } from '@aws-amplify/core';
+
+const HierarchicalTreeGenes = (props) => {
+  const {
+    treeData,
+    onGeneReorder,
+  } = props;
+
+  const onDrop = (info) => {
+    const {
+      dragNode, node, dropPosition, dropToGap,
+    } = info;
+
+    // if dropped in place, ignore
+    // dragNode.key is str, dropPosition is int
+    if (dragNode.key == dropPosition) return;
+
+    // If not dropped in gap, ignore
+    if (!dropToGap) return;
+
+    let newPosition = dropPosition - (dragNode.key < dropPosition ? 1 : 0);
+    newPosition = Math.max(0, newPosition);
+
+    onGeneReorder(dragNode.key, newPosition);
+  };
+
+  if (!treeData) return <Skeleton active />;
+
+  return (
+    <Tree
+      data-testid='HierachicalTreeGenes'
+      draggable
+      treeData={treeData}
+      onDrop={onDrop}
+    />
+  );
+};
+
+HierarchicalTreeGenes.defaultProps = {};
+
+HierarchicalTreeGenes.propTypes = {
+  treeData: PropTypes.array.isRequired,
+  onGeneReorder: PropTypes.func.isRequired,
+};
+
+export default HierarchicalTreeGenes;
diff --git a/src/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.jsx b/src/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.jsx
index 963d6a802f..6d072ad958 100644
--- a/src/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.jsx
+++ b/src/pages/experiments/[experimentId]/plots-and-tables/marker-heatmap/index.jsx
@@ -6,6 +6,7 @@ import {
   Empty,
   Select,
   Radio,
+  Tabs,
 } from 'antd';
 import _ from 'lodash';
 import { useSelector, useDispatch } from 'react-redux';
@@ -33,9 +34,12 @@ import Loader from 'components/Loader';
 import populateHeatmapData from 'components/plots/helpers/heatmap/populateHeatmapData';
 import { plotNames } from 'utils/constants';
 
+import GeneReorderTool from 'components/plots/GeneReorderTool';
+
 const { Panel } = Collapse;
 const plotUuid = 'markerHeatmapPlotMain';
 const plotType = 'markerHeatmap';
+const { TabPane } = Tabs;
 
 const MarkerHeatmap = ({ experimentId }) => {
   const dispatch = useDispatch();
@@ -300,26 +304,34 @@ const MarkerHeatmap = ({ experimentId }) => {
   const renderExtraPanels = () => (
     <>
       <Panel header='Gene selection' key='gene-selection'>
-        <Space direction='vertical' size='small'>
-          <MarkerGeneSelection
-            config={config}
-            onUpdate={updatePlotWithChanges}
-            onGeneEnter={onGeneEnter}
-            onReset={onReset}
-          />
-          <div>
-            <p>Gene labels:</p>
-            <Radio.Group
-              onChange={
-                (e) => updatePlotWithChanges({ showGeneLabels: e.target.value })
-              }
-              value={config.showGeneLabels}
-            >
-              <Radio value>Show</Radio>
-              <Radio value={false}>Hide</Radio>
-            </Radio.Group>
-          </div>
-        </Space>
+        <Tabs defaultActiveKey='1'>
+          <TabPane tab='Add/Remove genes' key='1'>
+            <MarkerGeneSelection
+              config={config}
+              onUpdate={updatePlotWithChanges}
+              onGeneEnter={onGeneEnter}
+              onReset={onReset}
+            />
+            <div>
+              <p>Gene labels:</p>
+              <Radio.Group
+                onChange={
+                  (e) => updatePlotWithChanges({ showGeneLabels: e.target.value })
+                }
+                value={config.showGeneLabels}
+              >
+                <Radio value>Show</Radio>
+                <Radio value={false}>Hide</Radio>
+              </Radio.Group>
+            </div>
+          </TabPane>
+          <TabPane tab='Re-order genes' key='2'>
+            <p>Drag and drop genes to re-order them in the heatmap.</p>
+            <GeneReorderTool
+              plotUuid={plotUuid}
+            />
+          </TabPane>
+        </Tabs>
       </Panel>
       <Panel header='Select data' key='select-data'>
         <Space direction='vertical' size='small'>