diff --git a/.changelog/29671.txt b/.changelog/29671.txt
new file mode 100644
index 00000000000..76a65c79b66
--- /dev/null
+++ b/.changelog/29671.txt
@@ -0,0 +1,3 @@
+```release-note:bug
+resource/aws_sesv2_configuration_set: Allow `suppression_options.suppressed_reasons` to be an empty list (`[]`) in order to disable the suppression list
+```
diff --git a/internal/service/sesv2/configuration_set.go b/internal/service/sesv2/configuration_set.go
index 1eb3eb392f8..eff1f1c7bea 100644
--- a/internal/service/sesv2/configuration_set.go
+++ b/internal/service/sesv2/configuration_set.go
@@ -14,6 +14,7 @@ import (
 	"github.com/aws/aws-sdk-go-v2/aws/arn"
 	"github.com/aws/aws-sdk-go-v2/service/sesv2"
 	"github.com/aws/aws-sdk-go-v2/service/sesv2/types"
+	"github.com/hashicorp/go-cty/cty"
 	"github.com/hashicorp/terraform-plugin-sdk/v2/diag"
 	"github.com/hashicorp/terraform-plugin-sdk/v2/helper/retry"
 	"github.com/hashicorp/terraform-plugin-sdk/v2/helper/schema"
@@ -112,7 +113,6 @@ func ResourceConfigurationSet() *schema.Resource {
 						"suppressed_reasons": {
 							Type:     schema.TypeList,
 							Optional: true,
-							MinItems: 1,
 							Elem: &schema.Schema{
 								Type:             schema.TypeString,
 								ValidateDiagFunc: enum.Validate[types.SuppressionListReason](),
@@ -187,36 +187,46 @@ func resourceConfigurationSetCreate(ctx context.Context, d *schema.ResourceData,
 	var diags diag.Diagnostics
 	conn := meta.(*conns.AWSClient).SESV2Client(ctx)
 
-	in := &sesv2.CreateConfigurationSetInput{
+	input := &sesv2.CreateConfigurationSetInput{
 		ConfigurationSetName: aws.String(d.Get("configuration_set_name").(string)),
 		Tags:                 getTagsIn(ctx),
 	}
 
 	if v, ok := d.GetOk("delivery_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.DeliveryOptions = expandDeliveryOptions(v.([]interface{})[0].(map[string]interface{}))
+		input.DeliveryOptions = expandDeliveryOptions(v.([]interface{})[0].(map[string]interface{}))
 	}
 
 	if v, ok := d.GetOk("reputation_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.ReputationOptions = expandReputationOptions(v.([]interface{})[0].(map[string]interface{}))
+		input.ReputationOptions = expandReputationOptions(v.([]interface{})[0].(map[string]interface{}))
 	}
 
 	if v, ok := d.GetOk("sending_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.SendingOptions = expandSendingOptions(v.([]interface{})[0].(map[string]interface{}))
+		input.SendingOptions = expandSendingOptions(v.([]interface{})[0].(map[string]interface{}))
 	}
 
-	if v, ok := d.GetOk("suppression_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.SuppressionOptions = expandSuppressionOptions(v.([]interface{})[0].(map[string]interface{}))
+	if v, ok := d.GetRawConfig().AsValueMap()["suppression_options"]; ok && v.LengthInt() > 0 {
+		if v, ok := v.Index(cty.NumberIntVal(0)).AsValueMap()["suppressed_reasons"]; ok && !v.IsNull() {
+			tfMap := map[string]interface{}{
+				"suppressed_reasons": []interface{}{},
+			}
+
+			for _, v := range v.AsValueSlice() {
+				tfMap["suppressed_reasons"] = append(tfMap["suppressed_reasons"].([]interface{}), v.AsString())
+			}
+
+			input.SuppressionOptions = expandSuppressionOptions(tfMap)
+		}
 	}
 
 	if v, ok := d.GetOk("tracking_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.TrackingOptions = expandTrackingOptions(v.([]interface{})[0].(map[string]interface{}))
+		input.TrackingOptions = expandTrackingOptions(v.([]interface{})[0].(map[string]interface{}))
 	}
 
 	if v, ok := d.GetOk("vdm_options"); ok && len(v.([]interface{})) > 0 && v.([]interface{})[0] != nil {
-		in.VdmOptions = expandVDMOptions(v.([]interface{})[0].(map[string]interface{}))
+		input.VdmOptions = expandVDMOptions(v.([]interface{})[0].(map[string]interface{}))
 	}
 
-	out, err := conn.CreateConfigurationSet(ctx, in)
+	out, err := conn.CreateConfigurationSet(ctx, input)
 	if err != nil {
 		return create.AppendDiagError(diags, names.SESV2, create.ErrActionCreating, ResNameConfigurationSet, d.Get("configuration_set_name").(string), err)
 	}
@@ -648,13 +658,17 @@ func expandSuppressionOptions(tfMap map[string]interface{}) *types.SuppressionOp
 		return nil
 	}
 
-	a := &types.SuppressionOptions{}
+	apiObject := &types.SuppressionOptions{}
 
-	if v, ok := tfMap["suppressed_reasons"].([]interface{}); ok && len(v) > 0 {
-		a.SuppressedReasons = expandSuppressedReasons(v)
+	if v, ok := tfMap["suppressed_reasons"].([]interface{}); ok {
+		if len(v) > 0 {
+			apiObject.SuppressedReasons = expandSuppressedReasons(v)
+		} else {
+			apiObject.SuppressedReasons = make([]types.SuppressionListReason, 0)
+		}
 	}
 
-	return a
+	return apiObject
 }
 
 func expandSuppressedReasons(tfList []interface{}) []types.SuppressionListReason {
diff --git a/internal/service/sesv2/configuration_set_test.go b/internal/service/sesv2/configuration_set_test.go
index 0daf8c6002c..8541faca73f 100644
--- a/internal/service/sesv2/configuration_set_test.go
+++ b/internal/service/sesv2/configuration_set_test.go
@@ -218,6 +218,34 @@ func TestAccSESV2ConfigurationSet_suppressedReasons(t *testing.T) {
 	})
 }
 
+func TestAccSESV2ConfigurationSet_suppressedReasonsEmpty(t *testing.T) {
+	ctx := acctest.Context(t)
+	rName := sdkacctest.RandomWithPrefix(acctest.ResourcePrefix)
+	resourceName := "aws_sesv2_configuration_set.test"
+
+	resource.ParallelTest(t, resource.TestCase{
+		PreCheck:                 func() { acctest.PreCheck(ctx, t) },
+		ErrorCheck:               acctest.ErrorCheck(t, names.SESV2ServiceID),
+		ProtoV5ProviderFactories: acctest.ProtoV5ProviderFactories,
+		CheckDestroy:             testAccCheckConfigurationSetDestroy(ctx),
+		Steps: []resource.TestStep{
+			{
+				Config: testAccConfigurationSetConfig_suppressedReasonsEmpty(rName),
+				Check: resource.ComposeTestCheckFunc(
+					testAccCheckConfigurationSetExists(ctx, resourceName),
+					resource.TestCheckResourceAttr(resourceName, "suppression_options.#", acctest.Ct1),
+					resource.TestCheckResourceAttr(resourceName, "suppression_options.0.suppressed_reasons.#", acctest.Ct0),
+				),
+			},
+			{
+				ResourceName:      resourceName,
+				ImportState:       true,
+				ImportStateVerify: true,
+			},
+		},
+	})
+}
+
 func TestAccSESV2ConfigurationSet_engagementMetrics(t *testing.T) {
 	ctx := acctest.Context(t)
 	rName := sdkacctest.RandomWithPrefix(acctest.ResourcePrefix)
@@ -339,6 +367,17 @@ func TestAccSESV2ConfigurationSet_tags(t *testing.T) {
 	})
 }
 
+func testAccConfigurationSetConfig_suppressedReasonsEmpty(rName string) string {
+	return fmt.Sprintf(`
+resource "aws_sesv2_configuration_set" "test" {
+  configuration_set_name = %[1]q
+  suppression_options {
+    suppressed_reasons = []
+  }
+}
+`, rName)
+}
+
 func testAccCheckConfigurationSetDestroy(ctx context.Context) resource.TestCheckFunc {
 	return func(s *terraform.State) error {
 		conn := acctest.Provider.Meta().(*conns.AWSClient).SESV2Client(ctx)