diff --git a/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java b/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
index 4c2741d2092ed..361033561c391 100644
--- a/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
+++ b/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
@@ -171,14 +171,8 @@ NativeImageConfigBuildItem build(
         if (QuarkusClassLoader.isClassPresentAtRuntime("io.netty.buffer.UnpooledByteBufAllocator")) {
             builder.addRuntimeReinitializedClass("io.netty.buffer.UnpooledByteBufAllocator")
                     .addRuntimeReinitializedClass("io.netty.buffer.Unpooled")
-                    .addRuntimeReinitializedClass("io.vertx.core.http.impl.Http1xServerResponse")
                     .addRuntimeReinitializedClass("io.netty.handler.codec.http.HttpObjectAggregator")
-                    .addRuntimeReinitializedClass("io.netty.handler.codec.ReplayingDecoderByteBuf")
-                    .addRuntimeReinitializedClass("io.vertx.core.parsetools.impl.RecordParserImpl");
-
-            if (QuarkusClassLoader.isClassPresentAtRuntime("io.vertx.ext.web.client.impl.MultipartFormUpload")) {
-                builder.addRuntimeReinitializedClass("io.vertx.ext.web.client.impl.MultipartFormUpload");
-            }
+                    .addRuntimeReinitializedClass("io.netty.handler.codec.ReplayingDecoderByteBuf");
 
             if (QuarkusClassLoader
                     .isClassPresentAtRuntime("org.jboss.resteasy.reactive.client.impl.multipart.QuarkusMultipartFormUpload")) {
diff --git a/extensions/vertx/deployment/src/main/java/io/quarkus/vertx/deployment/VertxProcessor.java b/extensions/vertx/deployment/src/main/java/io/quarkus/vertx/deployment/VertxProcessor.java
index 2d69d4a6d7be9..9bd62eba808f2 100644
--- a/extensions/vertx/deployment/src/main/java/io/quarkus/vertx/deployment/VertxProcessor.java
+++ b/extensions/vertx/deployment/src/main/java/io/quarkus/vertx/deployment/VertxProcessor.java
@@ -28,6 +28,7 @@
 import io.quarkus.arc.processor.BeanInfo;
 import io.quarkus.arc.processor.BuildExtension;
 import io.quarkus.arc.processor.BuiltinScope;
+import io.quarkus.bootstrap.classloading.QuarkusClassLoader;
 import io.quarkus.deployment.Capabilities;
 import io.quarkus.deployment.Capability;
 import io.quarkus.deployment.Feature;
@@ -44,6 +45,7 @@
 import io.quarkus.deployment.builditem.LaunchModeBuildItem;
 import io.quarkus.deployment.builditem.ServiceStartBuildItem;
 import io.quarkus.deployment.builditem.ShutdownContextBuildItem;
+import io.quarkus.deployment.builditem.nativeimage.NativeImageConfigBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.ReflectiveClassBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.ServiceProviderBuildItem;
 import io.quarkus.gizmo.ClassOutput;
@@ -196,6 +198,23 @@ void faultToleranceIntegration(Capabilities capabilities, BuildProducer<ServiceP
         }
     }
 
+    /**
+     * Reinitialize vertx classes that are known to cause issues with Netty in native mode
+     */
+    @BuildStep
+    NativeImageConfigBuildItem reinitializeClassesForNetty() {
+        NativeImageConfigBuildItem.Builder builder = NativeImageConfigBuildItem.builder();
+
+        builder.addRuntimeReinitializedClass("io.vertx.core.http.impl.Http1xServerResponse")
+                .addRuntimeReinitializedClass("io.vertx.core.parsetools.impl.RecordParserImpl");
+
+        if (QuarkusClassLoader.isClassPresentAtRuntime("io.vertx.ext.web.client.impl.MultipartFormUpload")) {
+            builder.addRuntimeReinitializedClass("io.vertx.ext.web.client.impl.MultipartFormUpload");
+        }
+
+        return builder.build();
+    }
+
     private Class<?> tryLoad(String name, ClassLoader tccl) {
         try {
             return tccl.loadClass(name);